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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]
[中文简述(自动翻译):]  的26S蛋白酶体是一个multicatalytic蛋白酶复合带的2复合物构成的高度有序的结构,20S芯和19S调节器。 20S的核心是由4个环,28个非相同亚基组成; 2环由7个α亚和2环由7个β亚基。的19S调节器是由一个基地,它包含6 ATP酶亚基和2个非ATP酶亚基,和一个盖,其中含有多达10个非ATP酶亚基的。蛋白酶在整个真核细胞中分布以高浓度和裂开的肽在一个ATP /泛素依赖的过程在非溶酶体途径。修饰的蛋白酶,免疫蛋白酶,的一个重要功能是MHC I类肽的处理。这个基因编码19S调节器的非ATP酶亚基。已发现该基因编码的两种不同亚型三个抄本变形。 [由RefSeq的,2012年5月提供]
PSMD9基因(以及对应的蛋白质)的细胞分布位置:
PSMD9基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Malignant neoplasm of breast | 0.013572094 | 50 | 0 | BeFree |
Breast Carcinoma | 0.01302921 | 48 | 0 | BeFree |
Carcinogenesis | 0.00868614 | 32 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.005895776 | 13 | 1 | BeFree_GAD |
Liver carcinoma | 0.005428837 | 20 | 0 | BeFree |
Glioma | 0.004624443 | 8 | 0 | BeFree_LHGDN |
Stomach Carcinoma | 0.004614512 | 17 | 0 | BeFree |
Colorectal Carcinoma | 0.00434307 | 16 | 0 | BeFree |
Neoplasm Metastasis | 0.003800186 | 14 | 0 | BeFree |
Squamous cell carcinoma | 0.003528744 | 13 | 0 | BeFree |
Colorectal Cancer | 0.003528744 | 13 | 0 | BeFree |
Gastrointestinal Stromal Tumors | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Lymphoma | 0.003257302 | 12 | 0 | BeFree |
Malignant neoplasm of stomach | 0.003257302 | 12 | 0 | BeFree |
Tumor Progression | 0.002985861 | 11 | 0 | BeFree |
Mental Depression | 0.002909916 | 3 | 5 | BeFree_GAD |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Pituitary Diseases | 0.002442977 | 9 | 0 | BeFree |
Malignant neoplasm of lung | 0.002442977 | 9 | 2 | BeFree |
Prostate carcinoma | 0.002442977 | 9 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.002171535 | 8 | 0 | BeFree |
melanoma | 0.002171535 | 8 | 0 | BeFree |
Malignant neoplasm of prostate | 0.002171535 | 8 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.002171535 | 8 | 1 | BeFree |
Adenoma | 0.001900093 | 7 | 0 | BeFree |
Ovarian Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Cervix carcinoma | 0.001900093 | 7 | 0 | BeFree |
Carcinoma of lung | 0.001900093 | 7 | 2 | BeFree |
Squamous cell carcinoma of the head and neck | 0.001900093 | 7 | 0 | BeFree |
Glioblastoma | 0.001628651 | 6 | 0 | BeFree |
Pituitary Neoplasms | 0.001628651 | 6 | 0 | BeFree |
Retinoblastoma | 0.001628651 | 6 | 0 | BeFree |
Endometrial Carcinoma | 0.001628651 | 6 | 0 | BeFree |
Mammary Neoplasms | 0.001628651 | 6 | 0 | BeFree |
Renal Cell Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.001357209 | 5 | 0 | BeFree |
Liver neoplasms | 0.001357209 | 5 | 0 | BeFree |
Pancreatic carcinoma | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of ovary | 0.001357209 | 5 | 0 | BeFree |
Malignant tumor of colon | 0.001085767 | 4 | 0 | BeFree |
Malignant tumor of cervix | 0.001085767 | 4 | 0 | BeFree |
Diabetes | 0.001085767 | 4 | 0 | BeFree |
Diabetes Mellitus | 0.001085767 | 4 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.001085767 | 4 | 0 | BeFree |
Pituitary Adenoma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of mouth | 0.001085767 | 4 | 1 | BeFree |
Squamous cell carcinoma of esophagus | 0.001085767 | 4 | 0 | BeFree |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.001085767 | 4 | 0 | BeFree |
Thyroid carcinoma | 0.001085767 | 4 | 0 | BeFree |
Colon Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.001085767 | 4 | 0 | BeFree |
Anaplasia | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000814326 | 3 | 0 | BeFree |
Hypercholesterolemia | 0.000814326 | 3 | 0 | BeFree |
Kidney Diseases | 0.000814326 | 3 | 0 | BeFree |
leukemia | 0.000814326 | 3 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000814326 | 3 | 0 | BeFree |
Multiple Endocrine Neoplasia | 0.000814326 | 3 | 0 | BeFree |
Neuroblastoma | 0.000814326 | 3 | 0 | BeFree |
Uterine Fibroids | 0.000814326 | 3 | 0 | BeFree |
B-Cell Lymphomas | 0.000814326 | 3 | 0 | BeFree |
Cholangiocarcinoma | 0.000814326 | 3 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.000814326 | 3 | 1 | BeFree |
Malignant Glioma | 0.000814326 | 3 | 0 | BeFree |
Central neuroblastoma | 0.000814326 | 3 | 0 | BeFree |
ovarian neoplasm | 0.000814326 | 3 | 0 | BeFree |
Tumor Promotion | 0.000814326 | 3 | 0 | BeFree |
Astrocytoma | 0.000542884 | 2 | 0 | BeFree |
Rectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Depressive disorder | 0.000542884 | 2 | 5 | BeFree |
Endometriosis | 0.000542884 | 2 | 0 | BeFree |
HIV Infections | 0.000542884 | 2 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000542884 | 2 | 0 | BeFree |
Multiple Endocrine Neoplasia Type 1 | 0.000542884 | 2 | 0 | BeFree |
Mesothelioma | 0.000542884 | 2 | 0 | BeFree |
Multiple Myeloma | 0.000542884 | 2 | 0 | BeFree |
Pheochromocytoma | 0.000542884 | 2 | 0 | BeFree |
Thyroid Neoplasm | 0.000542884 | 2 | 0 | BeFree |
Tuberculosis | 0.000542884 | 2 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Cystadenocarcinoma, Serous | 0.000542884 | 2 | 0 | BeFree |
Inverted Papilloma | 0.000542884 | 2 | 0 | BeFree |
Restenosis | 0.000542884 | 2 | 1 | BeFree |
Maturity onset diabetes mellitus in young | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of liver | 0.000542884 | 2 | 0 | BeFree |
Oropharynx (excludes nasopharynx) | 0.000542884 | 2 | 0 | BeFree |
Leukemogenesis | 0.000542884 | 2 | 0 | BeFree |
Epithelial ovarian cancer | 0.000542884 | 2 | 0 | BeFree |
Alzheimer's Disease | 0.000271442 | 1 | 0 | BeFree |
Anxiety Disorders | 0.000271442 | 1 | 0 | BeFree |
Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Atherosclerosis | 0.000271442 | 1 | 0 | BeFree |
Depression, Bipolar | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000271442 | 1 | 0 | BeFree |
Bladder Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Carpal Tunnel Syndrome | 0.000271442 | 1 | 0 | BeFree |
Primary biliary cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000271442 | 1 | 1 | BeFree |
Coronary heart disease | 0.000271442 | 1 | 1 | BeFree |
Hepatitis D Infection | 0.000271442 | 1 | 0 | BeFree |
Diabetic Nephropathy | 0.000271442 | 1 | 1 | BeFree |
Hamartoma | 0.000271442 | 1 | 0 | BeFree |
Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
Hypertensive disease | 0.000271442 | 1 | 0 | BeFree |
Lipodystrophy | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Follicular | 0.000271442 | 1 | 0 | BeFree |
Medulloblastoma | 0.000271442 | 1 | 0 | BeFree |
Premature Menopause | 0.000271442 | 1 | 0 | BeFree |
Myeloproliferative disease | 0.000271442 | 1 | 0 | BeFree |
Acoustic Neuroma | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Tuberous Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Ureteral obstruction | 0.000271442 | 1 | 0 | BeFree |
Vascular Diseases | 0.000271442 | 1 | 0 | BeFree |
Ovarian Failure, Premature | 0.000271442 | 1 | 0 | BeFree |
Chronic gastritis | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Hepatoblastoma | 0.000271442 | 1 | 0 | BeFree |
gliosarcoma | 0.000271442 | 1 | 0 | BeFree |
Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Fibrosis, Liver | 0.000271442 | 1 | 0 | BeFree |
Mucosa-Associated Lymphoid Tissue Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Epithelial inclusion cyst | 0.000271442 | 1 | 0 | BeFree |
Generalized Anxiety Disorder | 0.000271442 | 1 | 0 | BeFree |
Coinfection | 0.000271442 | 1 | 0 | BeFree |
Transitional cell carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
Hyperplastic Polyp | 0.000271442 | 1 | 0 | BeFree |
Malignant mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Malignant melanoma of ciliary body | 0.000271442 | 1 | 0 | BeFree |
Overweight | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Chronic myeloproliferative disorder | 0.000271442 | 1 | 0 | BeFree |
Breast Cancer Model | 0.000271442 | 1 | 0 | BeFree |
Rash and Dermatitis Adverse Event Associated with Chemoradiation | 0.000271442 | 1 | 0 | BeFree |
Inverted Squamous Cell Papilloma | 0.000271442 | 1 | 0 | BeFree |
Coronary Artery Disease | 0.000271442 | 1 | 1 | BeFree |
Chronic ulcerative colitis | 0.000271442 | 1 | 0 | BeFree |
Clear-cell metastatic renal cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
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