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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]
[中文简述(自动翻译):]  的26S蛋白酶体是一个multicatalytic蛋白酶复合带的2复合物构成的高度有序的结构,20S芯和19S调节器。 20S的核心是由4个环,28个非相同亚基组成; 2环由7个α亚和2环由7个β亚基。的19S调节器是由一个基地,它包含6 ATP酶亚基和2个非ATP酶亚基,和一个盖,其中含有多达10个非ATP酶亚基的。蛋白酶在整个真核细胞中分布以高浓度和裂开的肽在一个ATP /泛素依赖的过程在非溶酶体途径。修饰的蛋白酶,免疫蛋白酶,的一个重要功能是MHC I类肽的处理。该基因编码的ATP酶亚基之一,三A家族,其具有分子伴侣活性ATP酶的成员。这种亚单位已被证明与几个基础转录因子的相互作用是这样,除了在蛋白酶体功能的参与,这亚基可能参与转录的调节。此亚基也可以与PSMC3竞争结合的HIV Tat蛋白调节病毒蛋白和转录复杂的相互作用。在多个转录剪接变异体结果不同编码的亚型。 [由RefSeq的,2011年3月提供]
PSMC2基因(以及对应的蛋白质)的细胞分布位置:
PSMC2基因的本体(GO)信息:
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