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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. [provided by RefSeq, Mar 2010]
[中文简述(自动翻译):]  蛋白酶体是一个multicatalytic蛋白酶复杂与高度有序的环形20S核心结构。核心结构是由4个环,28个非相同亚基组成; 2环由7个α亚和2环由7个β亚基。蛋白酶在整个真核细胞中分布以高浓度和裂开的肽在一个ATP /泛素依赖的过程在非溶酶体途径。修饰的蛋白酶,免疫蛋白酶,的一个重要功能是MHC I类肽的处理。该基因编码的蛋白酶B型家族的成员,也称为T1B家族,这是一个20S核心β亚基。该基因位于MHC(主要组织相容性复合体)的II类区域。这个基因的表达是通过γ干扰素诱导的和该基因产物取代在免疫蛋白酶催化亚基1(蛋白酶测试6亚基)。需要蛋白水解加工以产生成熟亚基。 [由RefSeq的,2010年3月提供]
PSMB9基因(以及对应的蛋白质)的细胞分布位置:
PSMB9基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
Peptic Esophagitis | 0.08 | 1 | 0 | RGD |
Mammary Neoplasms | 0.08 | 1 | 0 | RGD |
Diabetes Mellitus, Insulin-Dependent | 0.015287959 | 8 | 0 | BeFree_GAD |
Psoriasis | 0.007729856 | 2 | 0 | BeFree_GAD_LHGDN |
Ankylosing spondylitis | 0.006362715 | 8 | 0 | BeFree_GAD |
Juvenile arthritis | 0.005276948 | 4 | 0 | BeFree_GAD |
Multiple Sclerosis | 0.005005506 | 2 | 0 | BeFree_GAD |
Alzheimer's Disease | 0.004734064 | 2 | 0 | GAD |
Uterine Cervical Neoplasm | 0.004734064 | 2 | 0 | GAD |
Nasopharyngeal carcinoma | 0.002985861 | 11 | 0 | BeFree |
Spondylarthropathies | 0.002909916 | 3 | 0 | BeFree_GAD |
Colonic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Extrinsic allergic alveolitis | 0.002638474 | 1 | 0 | BeFree_GAD |
Rheumatoid Arthritis | 0.002638474 | 2 | 0 | BeFree_GAD |
Graves Disease | 0.002638474 | 1 | 0 | BeFree_GAD |
Hypoglycemia | 0.002638474 | 1 | 0 | BeFree_GAD |
Malaria | 0.002638474 | 1 | 0 | BeFree_GAD |
Colorectal Cancer | 0.002638474 | 1 | 10 | BeFree_GAD |
Brucellosis | 0.002367032 | 1 | 0 | GAD |
Dermatitis, Atopic | 0.002367032 | 1 | 0 | GAD |
IGA Glomerulonephritis | 0.002367032 | 1 | 0 | GAD |
Hepatitis B | 0.002367032 | 1 | 0 | GAD |
Hypertensive disease | 0.002367032 | 1 | 0 | GAD |
Lupus Erythematosus, Systemic | 0.002367032 | 1 | 0 | GAD |
Acute Coronary Syndrome | 0.002367032 | 1 | 0 | GAD |
Papillomavirus Infections | 0.002367032 | 1 | 0 | GAD |
Arthritis | 0.001085767 | 4 | 0 | BeFree |
Epstein-Barr Virus Infections | 0.001085767 | 4 | 0 | BeFree |
Acute anterior uveitis | 0.001085767 | 4 | 0 | BeFree |
Renal Cell Carcinoma | 0.000814326 | 3 | 0 | BeFree |
melanoma | 0.000814326 | 3 | 0 | BeFree |
LATERAL MENINGOCELE SYNDROME | 0.000814326 | 3 | 0 | BeFree |
Autoimmune Diseases | 0.000542884 | 2 | 0 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 10 | BeFree |
Crohn Disease | 0.000542884 | 2 | 0 | BeFree |
Hodgkin Disease | 0.000542884 | 2 | 0 | BeFree |
Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Leiomyosarcoma of uterus | 0.000542884 | 2 | 0 | BeFree |
Spondylarthritis | 0.000542884 | 2 | 0 | BeFree |
Juvenile rheumatoid arthritis | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Arthritis, Psoriatic | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
Disorder of eye | 0.000271442 | 1 | 0 | BeFree |
Hydatidiform Mole | 0.000271442 | 1 | 0 | BeFree |
Infectious Mononucleosis | 0.000271442 | 1 | 0 | BeFree |
Arthropathy | 0.000271442 | 1 | 0 | BeFree |
Fibroid Tumor | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Non-Hodgkin | 0.000271442 | 1 | 0 | BeFree |
Rheumatism | 0.000271442 | 1 | 0 | BeFree |
Tuberculosis | 0.000271442 | 1 | 0 | BeFree |
Tuberculosis, Pulmonary | 0.000271442 | 1 | 0 | BeFree |
Uterine Fibroids | 0.000271442 | 1 | 0 | BeFree |
Uveitis | 0.000271442 | 1 | 0 | BeFree |
Vitiligo | 0.000271442 | 1 | 0 | BeFree |
Cancer of Nasopharynx | 0.000271442 | 1 | 0 | BeFree |
Coinfection | 0.000271442 | 1 | 0 | BeFree |
Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
Hydatidiform Mole, Partial | 0.000271442 | 1 | 0 | BeFree |
Hypothyroidism, Autoimmune | 0.000271442 | 1 | 0 | BeFree |
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Post-transplant lymphoproliferative disorder | 0.000271442 | 1 | 0 | BeFree |
Leukemogenesis | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
Hashimoto Disease | 0.000271442 | 1 | 0 | BeFree |
Complete hydatidiform mole | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Acquired hypothyroidism | 0.000271442 | 1 | 0 | BeFree |
ovarian neoplasm | 0.000271442 | 1 | 0 | BeFree |
West Nile viral infection | 0.000271442 | 1 | 0 | BeFree |
Classical Hodgkin's Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 0.000271442 | 1 | 0 | BeFree |
HYDATIDIFORM MOLE, RECURRENT, 1 | 0.000271442 | 1 | 0 | BeFree |
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