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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
[中文简述(自动翻译):]  蛋白酶体是一个multicatalytic蛋白酶复杂与高度有序的环形20S核心结构。核心结构是由4个环,28个非相同亚基组成; 2环由7个α亚和2环由7个β亚基。蛋白酶在整个真核细胞中分布以高浓度和裂开的肽在一个ATP /泛素依赖的过程在非溶酶体途径。修饰的蛋白酶,免疫蛋白酶,的一个重要功能是MHC I类肽的处理。该基因编码的蛋白酶B型家族的成员,也称为T1B家族,这是一个20S核心β亚基。已发现该基因编码不同亚型多重选择性剪接转录变异体。 [由RefSeq的,2010年12月提供]
PSMB2基因(以及对应的蛋白质)的细胞分布位置:
PSMB2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Bladder Neoplasm | 0.12 | 1 | 0 | CTD_human |
Glomerular filtration rate finding | 0.002367032 | 1 | 1 | GAD |
Exanthema | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Spots on skin | 0.000271442 | 1 | 0 | BeFree |
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