PSEN2(presenilin 2) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

1q42.13
基因染色体位置图

基因简述

基因简述

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  阿尔茨海默氏病（AD）患者在早老蛋白的疾病进位突变（PSEN1或PSEN2）或淀粉样前体蛋白（APP）的一种遗传形式。这些疾病相关的突变导致生产淀粉样蛋白-β（公元大脑中淀粉样蛋白沉积的主要成分）的较长形式的增加。早老被假定通过其对γ-分泌酶的作用来调节APP处理，酶劈开APP。此外，可以认为，在早老参与Notch受体的裂解，使得它们可以直接调节γ-分泌酶活性，或本身的行为是蛋白酶。两个可变剪接转录变异体PSEN2的编码不同亚型已经确定。 [由RefSeq的，2008年7月提供]

OMIM数据库中对PSEN2基因的介绍     Wikipedia数据库中对PSEN2基因的介绍

基因序列

基因序列

PSEN2基因的碱基序列：[NCBI]

基因突变

基因突变

PSEN2基因的碱基突变：           显示全部snp
rs1295645       rs1295646       rs1296171       rs6660082       rs6665033       rs12093600       rs12758915       rs77467343       rs77656347       rs77868244       rs78421766       rs78849289       rs80212838       rs111297484       rs111901133       rs113807334       rs114982010       rs115016070       rs115270813       rs115790700       rs115799957       rs116187190       rs116407447       rs116602204       rs118121323       rs139669161       rs141267340       rs141887613       rs143476339       rs145582210       rs149858236       rs150618255       rs181366732       rs181905006       rs182206986       rs183214129       rs183557498      
rs186006379       rs186308126       rs186618435       rs186817723       rs187632263       rs188476312       rs189353108       rs189698229       rs191052430       rs191119504       rs191334283       rs192550908       rs200695481       rs201944966       rs371124752       rs372253386       rs527645461       rs527809286       rs528853091       rs529020153       rs529065814       rs529406499       rs529561202       rs531732284       rs531824360       rs533076166       rs533129077       rs534272310       rs535351856       rs535571429       rs535949101       rs537128144       rs537994260       rs538900224       rs539937828       rs540141552       rs540458381       rs540505114       rs542283623       rs543086662       rs543862825       rs544497401       rs545100918       rs545656958       rs546018115       rs547245408       rs549465841       rs550475611       rs550587444       rs550697435       rs551165348       rs551748079       rs552771770       rs552980297       rs553710955       rs554196312       rs555630501       rs555721241       rs556146007       rs556146702       rs557950838       rs559946328       rs560485304       rs560494344       rs561252866       rs561682737       rs561916511       rs561922325       rs562330349       rs563081961       rs563084524       rs564108200       rs564939007       rs564994558       rs565339593       rs569243184       rs570376319       rs570935609       rs571164889       rs571284635       rs571493341       rs571669587       rs572786012       rs572850843       rs572916841       rs573117441       rs574018683       rs574466325       rs575292737       rs575645321       rs575765554       rs577571926       rs578098038       rs7962       rs8383       rs4653470       rs7512986       rs16846619       rs63750110       rs63750666       rs77567779       rs111906419       rs113600895       rs115974666       rs116807339       rs117145200       rs138494303       rs138924167       rs142772982       rs143059995       rs144289421       rs144318314       rs145129440       rs151048692       rs180909178       rs182900763       rs185868258       rs186288674       rs189614935       rs191081231       rs191115973       rs199547508       rs199676786       rs200016565       rs200161165       rs200164062       rs200169735       rs200358385       rs200427880       rs200923178       rs201399057       rs201424233       rs201914773       rs201922151       rs201982084       rs371315050       rs371693894       rs376697912       rs531253119       rs534447699       rs536075387       rs537735641       rs537889666       rs538637821       rs541006636       rs541168117       rs542471629       rs544889430       rs549584732       rs550113178       rs552007162       rs554722100       rs559491058       rs560839401       rs561437447       rs565813250       rs571670427       rs571949639       rs572008951       rs576260882       rs578035347       rs746930366       rs747074838       rs748435174       rs749755334       rs751025333       rs755273692       rs756609078       rs758582618       rs758586194       rs759282140       rs764998593       rs766859560       rs768312153       rs769644784       rs769663194       rs770838733       rs772105831       rs773754382       rs774092766       rs775164469       rs775252540       rs776603544       rs777716175       rs778005647       rs779830498       rs780297845       rs6759       rs7961       rs11405       rs732479       rs743601       rs743602       rs1046240       rs1295621       rs1295638       rs1295640       rs1295641       rs1295642       rs1295643       rs1295644       rs1295647       rs1295648       rs1297990       rs1782530       rs1794038       rs1800675       rs1800678       rs1800679       rs1800680       rs1800681       rs2073488       rs2073489       rs2105822       rs2236910       rs2236912       rs2236913       rs2236914       rs2236915       rs2246221       rs2793461       rs2793462       rs2802267       rs2855559       rs2855560       rs2855561       rs2855562       rs2855563       rs3213436       rs3213437       rs3820649       rs3829979       rs3831497       rs4653469       rs6426553       rs6426554       rs6661000       rs6671059       rs6675452       rs6677801       rs6677908       rs6678839       rs6678940       rs6680042       rs7519422       rs7522645       rs7523790       rs7525819       rs7537037       rs7539017       rs7539119       rs7539221       rs7546338       rs7555739       rs10693643       rs10753428       rs11582894       rs11588886       rs11804915       rs12027512       rs12057618       rs12058836       rs12069540       rs12070751       rs12071324       rs12091957       rs12097722       rs12123818       rs12130732       rs12401969       rs12562405       rs12563525       rs12747261       rs12760155       rs16846584       rs16846590       rs17391089       rs28936380       rs34844805       rs35353885       rs35519961       rs41309643       rs41314274       rs58855513       rs58973334       rs59683545       rs60232264       rs61730652       rs61757781       rs61837798       rs63750048       rs63750197       rs63750207       rs63750880       rs72758660       rs72758667       rs74502648       rs74521736       rs75041180       rs75357954       rs75612539       rs75681714       rs75702362       rs75733498       rs75764929       rs75827833       rs76153780       rs76155874       rs76157777       rs76161302       rs76221906       rs76336502       rs76397544       rs76420763       rs76655190       rs76732250       rs76766807       rs77015702       rs77754809       rs77871405       rs77875620       rs78254425       rs78439943       rs78557397       rs78777332       rs79121491       rs79343667       rs79540408       rs79578214       rs79812497       rs79822981       rs80008032       rs80125697       rs111366321       rs111382438       rs111483776       rs111567390       rs111643955       rs111777599       rs111910427       rs112009316       rs112062360       rs112130067       rs112809286       rs112971145       rs113061270       rs113149123       rs113235155       rs113439784       rs113478201       rs113958123       rs114076393       rs114127255       rs114194538       rs114263106       rs114334281       rs114543513       rs114778691       rs114815412       rs114816603       rs115236371       rs115304948       rs115529149       rs115598326       rs115652716       rs115681617       rs115699328       rs115752022       rs115851013       rs116003409       rs116171245       rs116344544       rs116529536       rs116567356       rs116635380       rs116728405       rs116760649       rs117025103       rs117236763       rs117310559       rs117314062       rs117368833       rs117399735       rs117456084       rs117724727       rs117856985       rs118067884       rs118147159       rs137981702       rs138051819       rs138251565       rs138316025       rs138774925       rs138833114       rs138836272       rs138981581       rs139184944       rs139250934       rs139309459       rs139332886       rs139498276       rs139573101       rs139576184       rs139656438       rs139748552       rs139832281       rs139972151       rs140221267       rs140239784       rs140415143       rs140501902       rs140562931       rs140812381       rs141303900       rs141487628       rs141577748       rs141848347       rs141941207       rs142086801       rs142231816       rs142407400       rs142421813       rs142444752       rs142445855       rs142546082       rs142690225       rs142892469       rs142995247       rs143061887       rs143227762       rs143259081       rs143501870       rs143549266       rs143649336       rs143798253       rs143876830       rs143912759       rs144159827       rs144277432       rs144629723       rs144696679       rs144791481       rs144928658       rs145010538       rs145259934       rs145400391       rs145498605       rs145513230       rs145649324       rs145671982       rs145720978       rs146203177       rs146662886       rs146666649       rs146718524       rs146894466       rs147050055       rs147066272       rs147301577       rs147318268       rs147326133       rs147467284       rs147612731       rs147702142       rs148238688       rs148243400       rs148366519       rs148547900       rs148598799       rs148721936       rs148920786       rs148996705       rs149053799       rs149106598       rs149172004       rs149354305       rs149375801       rs149428641       rs149590162       rs149734051       rs149910285       rs150136828       rs150207043       rs150400387       rs150475531       rs150780392       rs150877518       rs150930019       rs150931933       rs151212920       rs180685271       rs180765094       rs181176083       rs181276264       rs181533346       rs181544023       rs182084017       rs182226938       rs182357168       rs182512234       rs182893958       rs182918620       rs183044548       rs183504909       rs183708912       rs183725807       rs184098505       rs184252827       rs184316899       rs184551016       rs184944359       rs185076251       rs185211228       rs185271841       rs185312343       rs185380274       rs185396731       rs185921179       rs186151996       rs186767369       rs186956454       rs187488467       rs187630675       rs187866408       rs187967479       rs188463784       rs188572962       rs188598190       rs188629369       rs188721291       rs189129471       rs189333497       rs189372290       rs189438491       rs190032978       rs190108721       rs190183646       rs190242286       rs190477948       rs190645105       rs190951446       rs191440796       rs191744468       rs191770060       rs191914317       rs192142511       rs192389510       rs192472758       rs192827066       rs192912133       rs192939593       rs193234598       rs199538648       rs199538967       rs199587016       rs199644116       rs199652777       rs199689738       rs199707432       rs199714082       rs199760083       rs199767316       rs199854075       rs199881176       rs199882991       rs199963095       rs199968912       rs199997144       rs200034510       rs200037771       rs200123982       rs200173519       rs200177715       rs200228068       rs200326485       rs200332829       rs200350640       rs200459699       rs200463582       rs200501733       rs200506152       rs200555636       rs200572479       rs200607063       rs200610057       rs200617488       rs200636353       rs200670135       rs200691879       rs200739890       rs200748438       rs200801915       rs200824392       rs200852140       rs200853904       rs200878942       rs200894274       rs200922381       rs200924879       rs200954447       rs200977587       rs201018913       rs201032114       rs201055590       rs201093218       rs201117237       rs201119121       rs201191318       rs201196514       rs201378322       rs201403206       rs201403983       rs201407396       rs201563279       rs201563376       rs201590095       rs201606093       rs201613477       rs201663855       rs201672346       rs201683508       rs201788938       rs201806443       rs201820913       rs201892898       rs201919671       rs201985133       rs202003390       rs202005802       rs202031936       rs202069038       rs202106330       rs202111966       rs202112948       rs202133351       rs202142711       rs202178897       rs202196437       rs202197781       rs367645069       rs367855127       rs367875222       rs368035858       rs368961675       rs369268719       rs369274454       rs369277606       rs369429245       rs369697148       rs370607299       rs370677428       rs371097422       rs371475270       rs371541473       rs371542146       rs371562367       rs371574453       rs371686514       rs372305083       rs372616074       rs373007480       rs373254101       rs373334489       rs373934941       rs373976810       rs374055800       rs374649333       rs375011189       rs375443581       rs375520284       rs375609936       rs376721586       rs377096583       rs377258087       rs377406802       rs377489312       rs377494557       rs377628773       rs527316021       rs527859263       rs528042597       rs528056595       rs528220024       rs528577540       rs528980926       rs529129866       rs529146535       rs529315020       rs529330961       rs529574118       rs529740499       rs529798877       rs529925218       rs529960232       rs530065304       rs530272850       rs530300727       rs530383300       rs530641432       rs530650914       rs530708486       rs530979472       rs531094539       rs531130450       rs531484658       rs531490023       rs531521495       rs531693835       rs532060308       rs532249514       rs532261426       rs532285087       rs532288189       rs532490879       rs532635035       rs532695077       rs532697278       rs533050660       rs533201718       rs533388448       rs533450453       rs533545630       rs533598396       rs533813519       rs534025859       rs534060807       rs534201499       rs534434147       rs534507840       rs534694170       rs534795975       rs535423166       rs535474711       rs535558431       rs535718848       rs535755290       rs535780590       rs535973879       rs536237320       rs536317786       rs536513631       rs536693717       rs536726339       rs536845657       rs536892251       rs537485568       rs537527025       rs537558441       rs537764045       rs538122490       rs538285636       rs538329197       rs538359198       rs538472488       rs538487258       rs538511268       rs538682723       rs538926736       rs539061345       rs539288524       rs539352597       rs539453707       rs539477280       rs539693192       rs539696910       rs539755915       rs539899828       rs540263371       rs540264416       rs540463755       rs540572061       rs540689339       rs540823786       rs540854872       rs540860628       rs540877930       rs540921564       rs541000538       rs541242045       rs541495335       rs541841648       rs541845163       rs541905012       rs542016786       rs542050023       rs542079957       rs542091913       rs542115191       rs542407861       rs542445029       rs542724267       rs542761034       rs543028016       rs543075403       rs543213706       rs543275191       rs543515097       rs543669793       rs543838797       rs543937422       rs544298463       rs544341324       rs544542759       rs544580457       rs544616246       rs544679629       rs544854371       rs544856899       rs545168461       rs545212226       rs545410798       rs545470666       rs545689378       rs545753620       rs545803706       rs545803771       rs545835072       rs545839923       rs545853854       rs545864548       rs545976076       rs546014559       rs546022966       rs546428854       rs546499567       rs546589385       rs546674909       rs546857990       rs547009120       rs547057687       rs547219518       rs547385828       rs547494670       rs547635369       rs547731225       rs547810104       rs547938061       rs548028652       rs548047960       rs548161965       rs548202261       rs548247524       rs548451231       rs548590028       rs548760500       rs548935197       rs549190861       rs549342652       rs549378958       rs549584436       rs549710509       rs550374916       rs550487955       rs550526840       rs550725883       rs550781017       rs550942069       rs551015756       rs551156932       rs551265862       rs551362310       rs551438819       rs551956925       rs552167698       rs552169540       rs552254325       rs552406611       rs552911783       rs553004631       rs553116343       rs553153420       rs553162115       rs553495122       rs553500994       rs553940955       rs554306827       rs554436706       rs554601665       rs554642690       rs554971982       rs555327999       rs555412538       rs555418377       rs555487068       rs555696629       rs555715656       rs555809980       rs555910501       rs556110064       rs556465620       rs556475273       rs556563472       rs556600310       rs556729169       rs556936832       rs556961523       rs557094637       rs557331036       rs557474258       rs557668822       rs557703394       rs557912834       rs557967261       rs558125621       rs558129400       rs558507594       rs558581398       rs558662610       rs558686637       rs559059154       rs559098901       rs559263302       rs559311441       rs559617407       rs559707409       rs559871614       rs559908308       rs560015017       rs560048229       rs560432627       rs560610682       rs560681838       rs560839429       rs560874052       rs560884566       rs560937821       rs561137601       rs561441805       rs561482615       rs561644668       rs561680440       rs562037428       rs562189455       rs562490583       rs563053551       rs563240019       rs563298009       rs563299031       rs563542221       rs563820064       rs564294405       rs564330817       rs564358528       rs564477648       rs564485432       rs564681436       rs564865937       rs565423615       rs565448044       rs565463456       rs565487231       rs565637526       rs565678429       rs565698726       rs565767836       rs565804599       rs565851017       rs566240109       rs566279977       rs566361436       rs566632100       rs566636763       rs566651455       rs566676288       rs566875696       rs566913583       rs566997959       rs567034768       rs567036599       rs567157206       rs567428287       rs567813104       rs567977265       rs568126638       rs568198282       rs568214418       rs568298873       rs568379401       rs568451095       rs569028801       rs569036388       rs569037365       rs569192494       rs569285417       rs569328988       rs569606575       rs569668866       rs569793520       rs570121361       rs570281565       rs570321339       rs570360751       rs570484457       rs570569600       rs570850485       rs570851844       rs570888869       rs571004527       rs571019582       rs571042110       rs571611932       rs571877833       rs572118237       rs572427015       rs572516237       rs572649526       rs572810729       rs572813408       rs572837407       rs572881834       rs573064271       rs573163131       rs573201931       rs573240121       rs573434985       rs573503654       rs573515900       rs573659675       rs574125890       rs574135266       rs574184673       rs574252913       rs574272931       rs574374875       rs574523822       rs574590764       rs574690711       rs574813788       rs575265724       rs575302343       rs575395926       rs575526047       rs575604347       rs575830396       rs575875179       rs575912514       rs576501285       rs576749534       rs577086775       rs577809107       rs578247756       rs745572658       rs745582651       rs745591174       rs745616954       rs745958627       rs745980421       rs746117072       rs746182253       rs746463508       rs746664513       rs746956724       rs747296921       rs747631214       rs747738607       rs747932826       rs748154107       rs748397935       rs748437025       rs748453717       rs748504448       rs748521246       rs748572509       rs748576189       rs748872069       rs749015914       rs749034384       rs749301595       rs749533069       rs749888836       rs750095720       rs750116511       rs750266631       rs750376346       rs750424014       rs750428132       rs750723436       rs750726916       rs750785455       rs750941167       rs750959403       rs751014475       rs751024219       rs751120699       rs751261061       rs751424049       rs751577358       rs751593722       rs751858667       rs751902749       rs752002301       rs752249936       rs752478177       rs752748804       rs752960820       rs753009383       rs753130659       rs753188472       rs753371172       rs753499090       rs753503617       rs753608837       rs753615781       rs753721866       rs753847484       rs753871802       rs753933727       rs754102235       rs754221199       rs754571073       rs754756496       rs754836755       rs754935826       rs755095033       rs755101354       rs755495216       rs755514702       rs756024386       rs756117413       rs756137748       rs756225509       rs756296193       rs756315272       rs756346917       rs756614549       rs756649903       rs756899463       rs757136131       rs757152552       rs757163236       rs757169630       rs757273954       rs757319285       rs757491002       rs757852923       rs757955974       rs758086169       rs758259518       rs758364204       rs758452815       rs758887516       rs758966634       rs758985161       rs759079072       rs759194805       rs759669954       rs759720367       rs759850465       rs760011841       rs760099712       rs760178182       rs760299337       rs760376643       rs760698293       rs760793548       rs760890655       rs760961297       rs760977533       rs761057590       rs761147472       rs761306181       rs761384293       rs761470677       rs761540700       rs761557286       rs761844882       rs761909852       rs762485322       rs762609255       rs762674312       rs762697051       rs762769497       rs762936893       rs763029340       rs763295042       rs763629376       rs763738488       rs764086543       rs764165210       rs764253265       rs764596194       rs764692293       rs764718172       rs764832142       rs765011483       rs765023751       rs765039787       rs765090618       rs765144719       rs765312050       rs765372829       rs765420103       rs765464734       rs765795079       rs766159571       rs766446160       rs766544235       rs766705508       rs766724245       rs766853710       rs766991296       rs767127577       rs767181943       rs767523385       rs767577993       rs767751554       rs767829568       rs767835970       rs767982599       rs768163661       rs768506041       rs768523579       rs768931743       rs768941393       rs769025026       rs769031756       rs769066300       rs769386876       rs769574014       rs769715316       rs770080595       rs770238439       rs770519379       rs770677085       rs770806400       rs770896224       rs770934706       rs771373304       rs771375988       rs771658370       rs771938561       rs772255843       rs772372158       rs772451160       rs772480664       rs772564348       rs772626008       rs772893473       rs773059327       rs773090604       rs773094480       rs773410250       rs773522773       rs773597667       rs773731966       rs773820169       rs773925469       rs774269158       rs774513973       rs774588853       rs774601959       rs774972844       rs775145486       rs775235673       rs775674310       rs775692311       rs775935657       rs776289096       rs776347122       rs776454542       rs776484892       rs776770770       rs776842226       rs776874000       rs776970096       rs776980191       rs777235854       rs777323657       rs777396999       rs777639021       rs777803617       rs778247625       rs778255578       rs778373938       rs778393774       rs778824612       rs778936527       rs779024767       rs779026658       rs779414075       rs779431743       rs779463423       rs779522932       rs779618448       rs779684855       rs779804692       rs780103765       rs780284265       rs780375882       rs780445641       rs780464244       rs780721688       rs780738564       rs781053654       rs781111649       rs781116134       rs781146542       rs781191111       rs781365270       rs781436525       rs781506963       rs781543554       rs781597971       rs781669984      

基因表达

基因表达

PSEN2基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CTGTGTATGATCTCGTGGC
58
GGGAATATGGGCTCATTTCTC
59
AGGCCACAGAGCTAAAGTG
60
GTCTGAGAAGTCCCACGTC
60
TTCTACAGTGTGCTGGTGG
60
CAGACACAAGCCAATGAGG
59
TCCCTGCCCTGATATACTC
58
AGTCTTCTTCCATCTCCGG
59
CGGAGATGGAAGAAGACTC
57
TTTCCTCCTCTTCCTCCAG
58
GGAGATGGAAGACTCCTATGAC
60
GCACACTGTAGAAGATGAAGTC
59
CGTAGAGGAGAATCGCCTG
60
TCATAGGAGTCTTCTTTCACCC
59
AAGTGTCCGGGATTCAGAC
59
GTCAGAGGCCATGAATGTG
59
AAGTGTCCGGGATTCAGAC
59
CAGAGGCCATGAATGTGAG
58
GGAGATGGAAGACTCCTATGAC
60
CACACTGTAGAAGATGAAGTCC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

PSEN2基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

PSEN2基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0000139
B1AP22(UniProtKB)
IEA
GO:0004190
B1AP22(UniProtKB)
IEA
GO:0005789
B1AP22(UniProtKB)
IEA
GO:0007219
B1AP22(UniProtKB)
IEA
GO:0016021
B1AP22(UniProtKB)
IEA
GO:0016485
B1AP22(UniProtKB)
IEA
GO:0035556
B1AP22(UniProtKB)
IEA
GO:0000139
E5RFW4(UniProtKB)
IEA
GO:0004190
E5RFW4(UniProtKB)
IEA
GO:0005789
E5RFW4(UniProtKB)
IEA
GO:0007219
E5RFW4(UniProtKB)
IEA
GO:0016021
E5RFW4(UniProtKB)
IEA
GO:0016485
E5RFW4(UniProtKB)
IEA
GO:0035556
E5RFW4(UniProtKB)
IEA
GO:0000139
E5RG63(UniProtKB)
IEA
GO:0004190
E5RG63(UniProtKB)
IEA
GO:0005789
E5RG63(UniProtKB)
IEA
GO:0007219
E5RG63(UniProtKB)
IEA
GO:0016021
E5RG63(UniProtKB)
IEA
GO:0016485
E5RG63(UniProtKB)
IEA
GO:0035556
E5RG63(UniProtKB)
IEA
GO:0004190
E5RHT1(UniProtKB)
IEA
GO:0005622
E5RHT1(UniProtKB)
IEA
GO:0016021
E5RHT1(UniProtKB)
IEA
GO:0016485
E5RHT1(UniProtKB)
IEA
GO:0035556
E5RHT1(UniProtKB)
IEA
GO:0000139
P49810(UniProtKB)
IEA
GO:0000776
P49810(UniProtKB)
IDA
GO:0001666
P49810(UniProtKB)
IEA
GO:0004175
P49810(UniProtKB)
IBA
GO:0004190
P49810(UniProtKB)
IEA
GO:0005515
P49810(UniProtKB)
IPI
GO:0005515
P49810(UniProtKB)
IPI
GO:0005515
P49810(UniProtKB)
IPI
GO:0005515
P49810(UniProtKB)
IPI
GO:0005515
P49810(UniProtKB)
IPI
GO:0005515
P49810(UniProtKB)
IPI
GO:0005515
P49810(UniProtKB)
IPI
GO:0005515
P49810(UniProtKB)
IPI
GO:0005637
P49810(UniProtKB)
IDA
GO:0005783
P49810(UniProtKB)
IDA
GO:0005789
P49810(UniProtKB)
IEA
GO:0005794
P49810(UniProtKB)
IDA
GO:0005813
P49810(UniProtKB)
IDA
GO:0005886
P49810(UniProtKB)
TAS
GO:0005886
P49810(UniProtKB)
TAS
GO:0005886
P49810(UniProtKB)
TAS
GO:0005886
P49810(UniProtKB)
TAS
GO:0005886
P49810(UniProtKB)
TAS
GO:0005886
P49810(UniProtKB)
TAS
GO:0005886
P49810(UniProtKB)
TAS
GO:0005886
P49810(UniProtKB)
TAS
GO:0005887
P49810(UniProtKB)
IDA
GO:0005938
P49810(UniProtKB)
IBA
GO:0006509
P49810(UniProtKB)
IDA
GO:0006816
P49810(UniProtKB)
IBA
GO:0007219
P49810(UniProtKB)
TAS
GO:0007219
P49810(UniProtKB)
TAS
GO:0007220
P49810(UniProtKB)
TAS
GO:0007220
P49810(UniProtKB)
TAS
GO:0016020
P49810(UniProtKB)
IDA
GO:0016324
P49810(UniProtKB)
IBA
GO:0016485
P49810(UniProtKB)
IDA
GO:0030018
P49810(UniProtKB)
IBA
GO:0031293
P49810(UniProtKB)
TAS
GO:0035556
P49810(UniProtKB)
IEA
GO:0042987
P49810(UniProtKB)
TAS
GO:0043025
P49810(UniProtKB)
IBA
GO:0043065
P49810(UniProtKB)
TAS
GO:0043066
P49810(UniProtKB)
IBA
GO:0043085
P49810(UniProtKB)
IDA
GO:0043234
P49810(UniProtKB)
IDA
GO:0048013
P49810(UniProtKB)
TAS
GO:0048471
P49810(UniProtKB)
IBA
GO:0050435
P49810(UniProtKB)
IBA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控PSEN2基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
ALZHEIMER DISEASE 4 0.36 3 9 CLINVAR_CTD_human_UNIPROT
Alzheimer's Disease 0.312520889 58 4 BeFree_CLINVAR_CTD_human_GAD_LHGDN
Cardiomyopathy, Dilated, 1V 0.24 0 1 CLINVAR_CTD_human
Cardiomyopathy, Dilated 0.120271442 1 0 BeFree_CTD_human
Asphyxia Neonatorum 0.12 1 0 CTD_human
Malignant neoplasm of breast 0.010314791 38 0 BeFree
Breast Carcinoma 0.009500466 35 1 BeFree
Dementia 0.008620127 14 3 BeFree_GAD_LHGDN
Familial Alzheimer Disease (FAD) 0.005428837 20 2 BeFree
Frontotemporal dementia 0.003724241 6 3 BeFree_GAD
Presenile dementia 0.003528744 13 3 BeFree
Adenocarcinoma 0.002995792 2 0 BeFree_LHGDN
Mammary Neoplasms 0.002995792 2 0 BeFree_LHGDN
Amnesia 0.002909916 3 1 BeFree_GAD
Alzheimer Disease, Early Onset 0.002714419 10 2 BeFree
Narcolepsy 0.002367032 1 0 GAD
Oppositional Defiant Disorder 0.002367032 1 0 GAD
Attention Deficit Disorder 0.002367032 1 0 GAD
Conduct Disorder 0.002367032 1 0 GAD
Age related macular degeneration 0.002367032 1 0 GAD
Neuroblastoma 0.001357209 5 0 BeFree
Central neuroblastoma 0.001357209 5 0 BeFree
Schizophrenia 0.001085767 4 1 BeFree
Neurofibrillary degeneration (morphologic abnormality) 0.001085767 4 2 BeFree
Pick Disease of the Brain 0.001085767 4 0 BeFree
Senile Plaques 0.001085767 4 0 BeFree
Plaque, Amyloid 0.000814326 3 0 BeFree
Bipolar Disorder 0.000542884 2 0 BeFree
Glioma 0.000542884 2 0 BeFree
Language Disorders 0.000542884 2 2 BeFree
Ovarian Carcinoma 0.000542884 2 0 BeFree
Carcinogenesis 0.000542884 2 0 BeFree
Stomach Carcinoma 0.000542884 2 0 BeFree
Memory Loss 0.000542884 2 1 BeFree
Malignant neoplasm of ovary 0.000542884 2 0 BeFree
Mild cognitive disorder 0.000542884 2 1 BeFree
Liver carcinoma 0.000542884 2 0 BeFree
Brain Neoplasms 0.000271442 1 0 BeFree
Colorectal Carcinoma 0.000271442 1 0 BeFree
Confusion 0.000271442 1 0 BeFree
Crohn Disease 0.000271442 1 0 BeFree
Cystadenoma 0.000271442 1 0 BeFree
Dermatitis, Atopic 0.000271442 1 0 BeFree
Down Syndrome 0.000271442 1 0 BeFree
Eczema 0.000271442 1 0 BeFree
Epilepsy 0.000271442 1 0 BeFree
Epilepsy, Temporal Lobe 0.000271442 1 0 BeFree
Heart failure 0.000271442 1 0 BeFree
Congestive heart failure 0.000271442 1 0 BeFree
Hypertensive disease 0.000271442 1 0 BeFree
insulinoma 0.000271442 1 0 BeFree
Lung Neoplasms 0.000271442 1 0 BeFree
Malignant neoplasm of stomach 0.000271442 1 0 BeFree
Neoplasm Metastasis 0.000271442 1 0 BeFree
Osteosarcoma 0.000271442 1 0 BeFree
Pancreatitis 0.000271442 1 0 BeFree
Peptic Ulcer 0.000271442 1 0 BeFree
Precancerous Conditions 0.000271442 1 0 BeFree
Seizures 0.000271442 1 0 BeFree
Disorientation 0.000271442 1 0 BeFree
Memory impairment 0.000271442 1 0 BeFree
Mucosal ulcer 0.000271442 1 0 BeFree
Carcinoma of Male Breast 0.000271442 1 0 BeFree
Impaired glucose tolerance 0.000271442 1 1 BeFree
Inflammatory Breast Carcinoma 0.000271442 1 0 BeFree
Transitional cell carcinoma of bladder 0.000271442 1 0 BeFree
Impaired cognition 0.000271442 1 0 BeFree
Malignant mesothelioma 0.000271442 1 0 BeFree
Malignant neoplasm of prostate 0.000271442 1 0 BeFree
Alzheimer Disease, Late Onset 0.000271442 1 0 BeFree
Recurrent tumor 0.000271442 1 0 BeFree
Neurodegenerative Disorders 0.000271442 1 0 BeFree
Malignant Glioma 0.000271442 1 0 BeFree
Osteosarcoma of bone 0.000271442 1 0 BeFree
Prostate carcinoma 0.000271442 1 0 BeFree
Secondary malignant neoplasm of lymph node 0.000271442 1 0 BeFree
Frontotemporal Lobar Degeneration 0.000271442 1 0 BeFree
Psychotic symptom 0.000271442 1 0 BeFree
Cardiomyopathies 0.000271442 1 0 BeFree
ovarian neoplasm 0.000271442 1 0 BeFree
Non-Neoplastic Disorder 0.000271442 1 0 BeFree
Familial encephalopathy with neuroserpin inclusion bodies 0.000271442 1 0 BeFree
ALZHEIMER DISEASE 5 0.000271442 1 0 BeFree
Dementia, familial British 0.000271442 1 0 BeFree
Amyloid angiopathy 0.000271442 1 1 BeFree
Mammary adenocarcinoma 0.000271442 1 0 BeFree
ALZHEIMER DISEASE 18 0.000271442 1 0 BeFree
GRN-related frontotemporal dementia 0.000271442 1 0 BeFree

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