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cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  cAMP的是一个信号分子对各种细胞功能很重要的。 cAMP的施加通过激活cAMP依赖性蛋白激酶,其通过不同的靶蛋白的磷酸化将信号传递其作用。非活动激酶全酶是两个调控和两个催化亚基组成的四聚体。的cAMP导致非活动全酶的解离成结合到四个cAMP和两个自由单体催化亚基调节亚基的二聚体。四种不同的调节亚基和三个催化亚基在人类已确定。由该基因编码的蛋白质是调节亚基中的一个。此亚基可由活化的催化亚基被磷酸化。这种亚单位已被证明与交互,并且在活化的T细胞抑制cAMP反应元件结合蛋白1(CREB1)的转录活性。在小鼠中敲除研究表明,这种亚单元可以在调节能量平衡和肥胖症中起重要作用。该研究还表明,这种亚基可以介导的基因诱导和由氟哌啶醇诱导的僵住症的行为。 [由RefSeq的,2008年7月提供]
PRKAR2B基因(以及对应的蛋白质)的细胞分布位置:
PRKAR2B基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Obesity | 0.12 | 1 | 0 | CTD_human |
| Lupus Erythematosus, Systemic | 0.00272435 | 1 | 0 | LHGDN |
| Polycystic Ovary Syndrome | 0.00272435 | 1 | 0 | LHGDN |
| Osteoarthritis, Knee | 0.002367032 | 1 | 0 | GAD |
| Degenerative polyarthritis | 0.000271442 | 1 | 0 | BeFree |
| Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
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