PNMT(phenylethanolamine N-methyltransferase)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

17q12
基因染色体位置图

基因简述

基因简述

The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

[中文简述(自动翻译):]  该基因的产物催化儿茶酚胺生物合成途径，其甲基化去甲肾上腺素而形成肾上腺素的最后一步。所述酶还具有β-咔啉2N-甲基转移酶活性。该基因被认为在调节肾上腺素生产的关键步骤。另外剪接转录变体也发现了这种基因。 [通过的RefSeq，2012十一月提供]

OMIM数据库中对PNMT基因的介绍     Wikipedia数据库中对PNMT基因的介绍

基因序列

基因序列

PNMT基因的碱基序列：[NCBI]

基因突变

基因突变

PNMT基因的碱基突变：           显示全部snp
rs407307       rs113202383       rs115337207       rs531902874       rs532994520       rs542647923       rs550312890       rs551184045       rs571754699       rs5638       rs5639       rs5640       rs5641       rs5642       rs5643       rs5644       rs200173       rs876493       rs1053651       rs1107794       rs2934965       rs2934966       rs2941523       rs3194794       rs3764351       rs4646319       rs9903907       rs11569779       rs11569780       rs11569781       rs13306008       rs34341496       rs34530498       rs36060376       rs45459794       rs45495400       rs45500896      
rs45506294       rs45509691       rs45521334       rs45540732       rs45576834       rs45592941       rs45593534       rs45598738       rs45614332       rs56678809       rs56873336       rs56947829       rs57866506       rs58657554       rs58867445       rs59923806       rs60183446       rs60599834       rs60871117       rs62639962       rs71147369       rs72554032       rs72554033       rs72554034       rs72554035       rs75107531       rs111272760       rs112409382       rs112440947       rs112505294       rs117209774       rs138770528       rs139376924       rs139957551       rs141839081       rs141973736       rs141979030       rs142592104       rs143544820       rs143786115       rs147503632       rs148138984       rs148717901       rs149585781       rs150317672       rs150323544       rs150643373       rs151192070       rs151291086       rs183877110       rs185210946       rs186492981       rs186960939       rs188485997       rs188530675       rs189745941       rs191595124       rs199695327       rs199955002       rs200333339       rs200707337       rs200718504       rs201626166       rs201886594       rs202003692       rs202144149       rs367593603       rs367800560       rs368175101       rs368193954       rs368391083       rs369038928       rs369267376       rs369408767       rs369625768       rs370447646       rs370785052       rs371069275       rs371470612       rs371590499       rs371769078       rs371912750       rs372872618       rs372919628       rs373267238       rs373672278       rs373901554       rs374841344       rs374886575       rs375815275       rs375843419       rs375992662       rs377043499       rs377545756       rs377675734       rs377726208       rs397516864       rs397897576       rs398030821       rs527672675       rs528402849       rs528658560       rs529426506       rs529636697       rs529897184       rs530678712       rs532000115       rs533288414       rs533351474       rs534241743       rs534551291       rs535900756       rs538957535       rs540138692       rs540398026       rs540471624       rs541398245       rs543827423       rs544396613       rs544458593       rs544632392       rs545175900       rs546458301       rs547681004       rs547818396       rs548081211       rs549992716       rs550956308       rs551097340       rs552052540       rs552377351       rs553054280       rs553353838       rs554308696       rs556495330       rs556631070       rs557417977       rs557692952       rs558423755       rs558480997       rs558774503       rs558790192       rs559039101       rs559315591       rs560295199       rs561877688       rs562961764       rs563828480       rs564271932       rs564391893       rs564721121       rs564811279       rs565822397       rs567091685       rs567127156       rs567301884       rs567522887       rs568612217       rs569522916       rs569660642       rs570638610       rs570829460       rs571366329       rs573387485       rs574161880       rs575196671       rs575907312       rs576039966       rs576357311       rs576829617       rs577303207       rs578016923       rs745511887       rs745566717       rs745764912       rs745979546       rs746013633       rs746166458       rs746246451       rs746631121       rs746663414       rs746755946       rs747036918       rs747090033       rs747181655       rs747347081       rs747546514       rs747904710       rs747980015       rs748023681       rs748311791       rs748358368       rs748365337       rs748715315       rs748756615       rs748960978       rs749119532       rs749180585       rs749290196       rs749507897       rs749578209       rs749683736       rs749685550       rs749817987       rs749998830       rs750320268       rs750672546       rs750742633       rs750970132       rs751110265       rs751816765       rs751894562       rs752380835       rs752722896       rs753084211       rs753474527       rs753507399       rs753862728       rs754512941       rs754532488       rs754655823       rs754894436       rs755016927       rs755395354       rs755435728       rs755454757       rs755539784       rs755874758       rs755923959       rs756538357       rs756591344       rs757161040       rs757246042       rs757480097       rs757533607       rs757921962       rs758623328       rs759006270       rs759059564       rs759592290       rs759933925       rs760242109       rs760247206       rs760444719       rs760633852       rs760778798       rs761341506       rs761470398       rs761498487       rs761754208       rs762231229       rs762406790       rs762794960       rs762850913       rs762976588       rs763211008       rs763805072       rs763965899       rs764565558       rs764635476       rs764992218       rs765116695       rs765213037       rs765346287       rs765484721       rs765682050       rs765721857       rs765737103       rs765862908       rs765921525       rs766139488       rs766195733       rs766530928       rs767233934       rs767390373       rs767449597       rs767776530       rs767980118       rs768158325       rs768713506       rs768739658       rs768764559       rs768942598       rs768949164       rs769078465       rs769352250       rs769755357       rs769800632       rs769882061       rs770032044       rs770087879       rs770416988       rs770474316       rs770655775       rs770935029       rs771072422       rs771072855       rs771235184       rs771363240       rs771451039       rs771798788       rs771971196       rs772028272       rs772083153       rs772606092       rs772730659       rs772788887       rs772853041       rs773317399       rs773516001       rs773653957       rs774119929       rs774121502       rs774268653       rs774447573       rs774470868       rs775372549       rs775446824       rs775499918       rs775565944       rs775624321       rs775776706       rs776138210       rs776198366       rs776371742       rs776814563       rs776854721       rs777159954       rs777463910       rs777817968       rs778066861       rs778205956       rs778535767       rs778551106       rs778874230       rs778923678       rs779217085       rs779251327       rs779719254       rs780196747       rs780544264       rs780875737       rs780930631       rs781387013       rs781391114       rs781509331       rs781730093      

基因表达

基因表达

PNMT基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TACCTCCGCAACAACTACG
60
AACCAATGTCGATGAGGGT
59
TCAACTGGAGCATGTACAG
57
CTTATCCTGCCAGCATTCC
58
TTCAACTGGAGCATGTACAG
58
TTATCCTGCCAGCATTCCC
59
CTTCAACTGGAGCATGTACAG
59
TTATCCTGCCAGCATTCCC
59
CAACTGGAGCATGTACAGC
58
TTATCCTGCCAGCATTCCC
59
TTCAACTGGAGCATGTACAG
58
CTTATCCTGCCAGCATTCC
58
TACCTCCGCAACAACTACG
60
ACCAATGTCGATGAGGGTG
60
TCAACTGGAGCATGTACAG
57
CTTATCCTGCCAGCATTCC
58
CAACTGGAGCATGTACAGC
59
CTTATCCTGCCAGCATTCC
58
TTCAACTGGAGCATGTACAG
58
CTTATCCTGCCAGCATTCC
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

PNMT基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

PNMT基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0008168
A8MT87(UniProtKB)
IEA
GO:0032259
A8MT87(UniProtKB)
IEA
GO:0008168
J3QRI3(UniProtKB)
IEA
GO:0032259
J3QRI3(UniProtKB)
IEA
GO:0004603
P11086(UniProtKB)
TAS
GO:0005829
P11086(UniProtKB)
TAS
GO:0032259
P11086(UniProtKB)
IEA
GO:0042418
P11086(UniProtKB)
IEA
GO:0042423
P11086(UniProtKB)
TAS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控PNMT基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Hypertensive disease 0.090639772 6 0 BeFree_GAD_LHGDN_RGD
Diabetes Mellitus, Experimental 0.08 1 0 RGD
Hypoglycemia 0.08 1 0 RGD
Multiple Sclerosis 0.005362824 1 0 BeFree_GAD_LHGDN
Attention deficit hyperactivity disorder 0.004734064 2 1 GAD
Alzheimer's Disease 0.002638474 1 0 BeFree_GAD
Kidney Failure, Acute 0.002638474 1 0 BeFree_GAD
Obesity 0.002638474 1 0 BeFree_GAD
Weight Loss Adverse Event 0.002367032 1 0 GAD
Pheochromocytoma 0.001357209 5 0 BeFree
Von Hippel-Lindau Syndrome 0.000542884 2 0 BeFree
Multiple Endocrine Neoplasia Type 2a 0.000542884 2 0 BeFree
Essential Hypertension 0.000542884 2 0 BeFree
Malignant neoplasm of breast 0.000271442 1 0 BeFree
Myocardial Infarction 0.000271442 1 0 BeFree
Neuroblastoma 0.000271442 1 0 BeFree
Cerebrovascular accident 0.000271442 1 0 BeFree
Chronic heart failure 0.000271442 1 0 BeFree
Breast Carcinoma 0.000271442 1 0 BeFree
Central neuroblastoma 0.000271442 1 0 BeFree
Post MI 0.000271442 1 0 BeFree

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因评论

基因评论

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