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Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]
[中文简述(自动翻译):]  Plastins是在整个真核生物进化保守,并表示在高等真核生物的大多数组织中的肌动蛋白结合蛋白的一个家族。在人类中,二无处不plastin亚型(L和T)已经确定。由该基因编码的蛋白质是一个第三独特plastin亚型,这是专门以高水平在小肠中表达。可变剪接转录物变体不同的5‘端非编码区,但编码相同的蛋白质,已发现这种基因。该基因的假基因是在[由RefSeq的,2010年2月提供] 11号染色体发现
PLS1基因(以及对应的蛋白质)的细胞分布位置:
PLS1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Liver neoplasms | 0.12 | 1 | 0 | CTD_human |
Diabetes Mellitus, Non-Insulin-Dependent | 0.002367032 | 1 | 1 | GAD |
Influenza | 0.000542884 | 2 | 0 | BeFree |
Otitis Media | 0.000271442 | 1 | 0 | BeFree |
Papillon-Lefevre Disease | 0.000271442 | 1 | 0 | BeFree |
Motor Neuron Disease | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Infectious Otitis Media | 0.000271442 | 1 | 0 | BeFree |
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