PLEKHA1(pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1)

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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10q26.3
基因染色体位置图

This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010]

[中文简述(自动翻译):]  该基因编码一个pleckstrin同源结构域的衔接蛋白。所编码的蛋白质被定位到它特异性结合磷脂3,4-二磷酸质膜。此蛋白质可能参与在质膜信令复合物的形成。在这种基因多态性与年龄相关性黄斑变性有关。选择性剪接结果在多个抄本变形。该基因的假基因是在[由RefSeq的,2010年9月提供] 5号染色体发现

PLEKHA1基因的碱基序列:[NCBI]
PLEKHA1基因的碱基突变:           显示全部snp
rs2421015       rs2421023       rs4311997       rs4612730       rs4752694       rs7091221       rs7913140       rs7921860       rs10887150       rs10887151       rs11200619       rs11200621       rs11200622       rs11200623       rs11292175       rs12241685       rs12241691       rs12256448       rs12259242       rs17103522       rs28423379       rs34532774       rs35402390       rs35777422       rs41302731       rs41307060       rs61324841       rs61871742       rs72832707       rs72832710       rs73367723       rs73367725       rs76268075       rs77631193       rs80008349       rs111508543       rs111904426      
rs113616086       rs114756362       rs115111943       rs115821949       rs139551282       rs139767619       rs141097962       rs141415220       rs141447844       rs142109757       rs142675999       rs142888907       rs143036226       rs144228951       rs144387888       rs144949162       rs145184191       rs145818469       rs147833620       rs148728872       rs150258970       rs151319189       rs181367337       rs182230745       rs182305092       rs182553817       rs183462950       rs183891256       rs185399741       rs185666400       rs185881999       rs185916001       rs186821049       rs188302441       rs188517623       rs188759021       rs188962768       rs189784415       rs190030736       rs190404754       rs191226437       rs191255513       rs191761271       rs192015516       rs193206159       rs199577766       rs199972260       rs200642902       rs201401419       rs201572969       rs201686891       rs369287824       rs369754524       rs370806533       rs372828875       rs373282276       rs375190744       rs376964644       rs527616782       rs528223872       rs528299506       rs528794800       rs528833420       rs529828632       rs530506961       rs530649378       rs531600560       rs532198953       rs532811812       rs533737290       rs534610965       rs534663456       rs534886232       rs534890275       rs536566892       rs537049158       rs537253060       rs537716402       rs538159520       rs538635495       rs538852979       rs539351130       rs539819584       rs539923563       rs540208918       rs540808041       rs540867540       rs541065282       rs542021811       rs542073789       rs543097094       rs543285911       rs543452714       rs544083846       rs544267365       rs545031155       rs545061568       rs545321783       rs545665431       rs546676118       rs547066859       rs547130175       rs547164207       rs548403217       rs548489248       rs548751210       rs549445626       rs549994293       rs550576527       rs551013971       rs551801219       rs552395784       rs552789952       rs553117654       rs553224946       rs553822956       rs554509897       rs554602921       rs554664616       rs555772565       rs556243322       rs556380894       rs556754230       rs557359957       rs557702956       rs558055525       rs558626751       rs559131166       rs559467341       rs559597946       rs559686871       rs560232328       rs560565324       rs560845316       rs561761980       rs561895917       rs562043411       rs562055511       rs562711745       rs564073329       rs564486071       rs565013399       rs565251015       rs565617627       rs566235451       rs566251020       rs566842453       rs566978558       rs567286024       rs568286863       rs568800110       rs568933704       rs569771698       rs570900694       rs571296132       rs571953298       rs572066043       rs572430708       rs572687826       rs573220099       rs573263540       rs573451784       rs574246275       rs574443874       rs574640011       rs574728529       rs575522546       rs576000745       rs576499002       rs576511552       rs576580493       rs577184303       rs578079375       rs746718212       rs748416070       rs749849894       rs750441311       rs751366744       rs752750413       rs754662579       rs755508722       rs756835574       rs756963358       rs758398648       rs760136895       rs760947533       rs762015082       rs762065899       rs763025972       rs763254943       rs764082337       rs765226392       rs767199139       rs767691632       rs769073318       rs769674341       rs770168045       rs773244869       rs773368228       rs774682239       rs774731312       rs775575246       rs775954328       rs776397310       rs777706859       rs779531537       rs780658053       rs780793292       rs4751891       rs4751892       rs72180292       rs72194447       rs112634421       rs114529456       rs117933625       rs142473166       rs146766909       rs147953307       rs181959969       rs183661952       rs186207174       rs188029385       rs190409841       rs200256740       rs375856091       rs376616221       rs376958947       rs528896982       rs529963952       rs533145413       rs534321333       rs538847626       rs545145439       rs549548745       rs558633544       rs560843277       rs563111438       rs565810583       rs569477114       rs571118511       rs571917684       rs572546223       rs574374667       rs574432621       rs749045956       rs751657827       rs752979944       rs753876935       rs757265329       rs759958057       rs765689264       rs768428285       rs771030769       rs771579441       rs771877618       rs772884073       rs774439862       rs775993762       rs777703869       rs778565320       rs778811045       rs779914382       rs781091466       rs952508       rs1004946       rs1045216       rs2292623       rs2292624       rs2292625       rs2292626       rs2421016       rs2421017       rs2421018       rs2421019       rs2421020       rs2421021       rs2421022       rs2901306       rs2901308       rs3037926       rs3037938       rs3736472       rs3817277       rs3838776       rs3850765       rs4146894       rs4345899       rs4405249       rs4532972       rs4551693       rs4565845       rs4598609       rs4751889       rs4751890       rs4752691       rs4752692       rs4752693       rs5013920       rs5788545       rs5788548       rs5788549       rs5788554       rs6585826       rs6585827       rs7068487       rs7068629       rs7079774       rs7079976       rs7084349       rs7084421       rs7084593       rs7084703       rs7084718       rs7085688       rs7086465       rs7087144       rs7087505       rs7087646       rs7088058       rs7089398       rs7090725       rs7097701       rs7098059       rs7098266       rs7350442       rs7900012       rs7902176       rs7904876       rs7905479       rs7908662       rs7914912       rs7918867       rs7919241       rs8181474       rs9783213       rs9887977       rs9988734       rs10082462       rs10082476       rs10399971       rs10400157       rs10617127       rs10653605       rs10685898       rs10749466       rs10749467       rs10788284       rs10887145       rs10887147       rs10887148       rs10887149       rs11200591       rs11200592       rs11200594       rs11200595       rs11200598       rs11200599       rs11200600       rs11200601       rs11200602       rs11200603       rs11200604       rs11200605       rs11200606       rs11200607       rs11200608       rs11200609       rs11200611       rs11200614       rs11200615       rs11200616       rs11200617       rs11200618       rs11200624       rs11335400       rs11367637       rs11428964       rs11483746       rs11592338       rs11596594       rs11598463       rs11816354       rs11816996       rs12164740       rs12218910       rs12242543       rs12258692       rs12259249       rs12260810       rs12263377       rs12263466       rs12267573       rs12269536       rs12269675       rs12359913       rs12571218       rs17103488       rs17103498       rs17103541       rs17649042       rs28367093       rs28369109       rs28680677       rs28826947       rs34483104       rs34783530       rs35198501       rs35620141       rs35968799       rs36012040       rs41302729       rs41306858       rs41310276       rs41317040       rs45519541       rs56781870       rs57033439       rs57106019       rs58210803       rs59343401       rs61757728       rs61871718       rs61871721       rs61871722       rs66495644       rs66844101       rs67641967       rs67952302       rs67969182       rs71026017       rs71026019       rs71189177       rs71482702       rs71486609       rs71486610       rs71486612       rs72830779       rs72830780       rs72830784       rs72830788       rs72830790       rs72830792       rs72830795       rs72830799       rs72830800       rs72830801       rs72832703       rs72832715       rs72832716       rs72832718       rs73366068       rs73366070       rs73366082       rs73366090       rs73366091       rs73366098       rs73367710       rs73367711       rs73367716       rs73367717       rs74159125       rs74159126       rs74159127       rs74779091       rs74826486       rs74913710       rs75145773       rs75199021       rs75277276       rs75284977       rs75443993       rs75616535       rs75695674       rs75859051       rs76007243       rs76111603       rs76215047       rs76265795       rs76352203       rs76415193       rs76419497       rs76432564       rs76542839       rs76797659       rs76918165       rs76923723       rs76935275       rs76973513       rs77101676       rs77388384       rs77432748       rs77506352       rs77565352       rs77756951       rs77871367       rs77954371       rs78012312       rs78019016       rs78030497       rs78060785       rs78323524       rs78355505       rs78599430       rs78619578       rs78832427       rs78974352       rs78979535       rs79072796       rs79131172       rs79273677       rs79462224       rs79508005       rs79581661       rs79844126       rs80123520       rs80156494       rs80224005       rs80271676       rs111291775       rs111356428       rs111542149       rs111798491       rs111800050       rs111907912       rs112139584       rs112141229       rs112188952       rs112386743       rs112599210       rs112601954       rs112793343       rs112820281       rs113001610       rs113003393       rs113052139       rs113251542       rs113306148       rs113411352       rs113470060       rs113499943       rs113641950       rs113652616       rs113811329       rs113953612       rs114002585       rs114126480       rs114181791       rs114185678       rs114266251       rs114473901       rs114678049       rs114749377       rs114879490       rs115255831       rs115353620       rs115416675       rs115456781       rs115589819       rs115958612       rs116011385       rs116208008       rs116278133       rs116342490       rs116920524       rs116977187       rs117105663       rs117169865       rs117243314       rs117304075       rs117319301       rs117345836       rs117433153       rs117547834       rs117688760       rs117705466       rs117802070       rs117811194       rs117835675       rs117874982       rs118066715       rs138054087       rs138126795       rs138167350       rs138215886       rs138316855       rs138342268       rs138394797       rs138445331       rs138574693       rs138643724       rs138689140       rs138724832       rs138811749       rs139065353       rs139080289       rs139101261       rs139191322       rs139525120       rs139528046       rs139620098       rs139625075       rs139633829       rs139711972       rs139760870       rs139763215       rs139789617       rs139874755       rs139958052       rs140517789       rs140596182       rs140626928       rs140770590       rs140780715       rs140909909       rs140998994       rs141036642       rs141146882       rs141327284       rs141351328       rs141365067       rs141375379       rs141408761       rs141610427       rs141668866       rs141676803       rs141904579       rs141906623       rs142005373       rs142146743       rs142167375       rs142262758       rs142393120       rs142424532       rs142451005       rs142526749       rs142554621       rs142604705       rs142621780       rs142724785       rs142809846       rs142848367       rs142937708       rs142997097       rs143086805       rs143179248       rs143348662       rs143727045       rs143773736       rs143836607       rs143973156       rs144061437       rs144186919       rs144243343       rs144334664       rs144368375       rs144417657       rs144457389       rs144557500       rs144558158       rs144689418       rs144739429       rs144761336       rs144795187       rs144802353       rs144931779       rs145183269       rs145230469       rs145368529       rs145371091       rs145478100       rs145549006       rs145614918       rs145751122       rs145778830       rs145905449       rs145936349       rs145958099       rs146002762       rs146068359       rs146301036       rs146346722       rs146430549       rs146509918       rs146635571       rs146648937       rs146655841       rs146745389       rs146798241       rs146880160       rs147040357       rs147044708       rs147190525       rs147206309       rs147404763       rs147421264       rs147507132       rs147523594       rs147706669       rs147788259       rs148009862       rs148063454       rs148106312       rs148168938       rs148182721       rs148265390       rs148317227       rs148422691       rs148581818       rs148676416       rs148710576       rs148750033       rs148775257       rs148817741       rs148900049       rs148971350       rs149066590       rs149072744       rs149288509       rs149340711       rs149340882       rs149458771       rs149470062       rs149650141       rs149768814       rs149810045       rs149967879       rs149999096       rs150030254       rs150031012       rs150036059       rs150105161       rs150197828       rs150206203       rs150353694       rs150387497       rs150396222       rs150400781       rs150515357       rs150636123       rs150948692       rs150992832       rs151233996       rs151317895       rs180804698       rs180850552       rs180897711       rs181039160       rs181112317       rs181125584       rs181141531       rs181359492       rs181364707       rs181373842       rs181510377       rs181557111       rs181579876       rs181588260       rs181692939       rs181765026       rs181773658       rs181776797       rs181879339       rs181966472       rs182226529       rs182241752       rs182320227       rs182539862       rs182556048       rs182571315       rs182648238       rs182682991       rs182835822       rs182872057       rs182875182       rs182902724       rs183145516       rs183164158       rs183417023       rs183431321       rs183642835       rs183670720       rs183690207       rs183738269       rs183876616       rs183902773       rs183910407       rs184033217       rs184195338       rs184333321       rs184354002       rs184388858       rs184390467       rs184522199       rs184566182       rs184589753       rs184686914       rs184788086       rs184794827       rs184800107       rs184816905       rs184831093       rs184898504       rs184903680       rs184934784       rs185056601       rs185067055       rs185081457       rs185389234       rs185403069       rs185452805       rs185459148       rs185599176       rs185636210       rs185650644       rs185747297       rs185764957       rs185846619       rs185889435       rs185894200       rs185939971       rs186009338       rs186031985       rs186147520       rs186159708       rs186190548       rs186224852       rs186442608       rs186560966       rs186626899       rs186780568       rs186856570       rs186972975       rs187013131       rs187015051       rs187019168       rs187227319       rs187238752       rs187243172       rs187243559       rs187333162       rs187365223       rs187444668       rs187692982       rs187694806       rs187742559       rs187876771       rs187894449       rs187904813       rs187969790       rs188005404       rs188044502       rs188214091       rs188232995       rs188257282       rs188291595       rs188483395       rs188522906       rs188686823       rs188749012       rs188778073       rs188795140       rs188934715       rs188950585       rs189046621       rs189199733       rs189302860       rs189321827       rs189324576       rs189573493       rs189577667       rs189622197       rs189766344       rs189831356       rs190002823       rs190021105       rs190042093       rs190095456       rs190158465       rs190171459       rs190282331       rs190656986       rs190690550       rs190694486       rs190696392       rs190913493       rs190934698       rs190935301       rs191221425       rs191246949       rs191250160       rs191494102       rs191499750       rs191508943       rs191738465       rs191752798       rs191771476       rs191986203       rs191996654       rs192018728       rs192031472       rs192246188       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rs574195822       rs574263567       rs574349398       rs574406412       rs574567357       rs574578597       rs574596432       rs574755045       rs574757291       rs574777459       rs574910512       rs575153269       rs575174538       rs575221621       rs575270026       rs575413807       rs575423889       rs575470036       rs575568198       rs575737329       rs575769823       rs575871349       rs575924067       rs576044951       rs576150148       rs576256557       rs576258862       rs576401408       rs576687716       rs576744232       rs576783312       rs576786765       rs576850940       rs576863306       rs576873107       rs576907032       rs577002385       rs577092694       rs577115542       rs577177537       rs577298607       rs577337539       rs577346637       rs577474564       rs577477390       rs577495841       rs577607219       rs577633621       rs577733790       rs577745945       rs577778943       rs577936655       rs578134562       rs578184409       rs578188406       rs745598795       rs745669003       rs745946664       rs746379324       rs746420780       rs746458998       rs746534987       rs746706972       rs747002691       rs747060121       rs747361166       rs747412267       rs747628586       rs747800861       rs748057794       rs748193232       rs748361102       rs748497042       rs748712489       rs748716013       rs748846761       rs749018267       rs749116967       rs749334078       rs749346634       rs749388819       rs749605655       rs749891618       rs749948712       rs750106176       rs750159521       rs750207772       rs750507595       rs750738983       rs750783981       rs750838678       rs750890154       rs751225289       rs751281950       rs751335255       rs751421870       rs751473227       rs751558300       rs752501285       rs752558332       rs752790697       rs752973072       rs753031626       rs753554975       rs754127533       rs754392607       rs754758519       rs754804384       rs755134240       rs755153770       rs755189692       rs755283019       rs755480994       rs755505145       rs755554481       rs755813070       rs755826779       rs755979042       rs756076206       rs756107690       rs756371119       rs756381341       rs756434320       rs756485720       rs756679449       rs756909997       rs757211980       rs757255339       rs757625482       rs757740700       rs757769443       rs757825820       rs757847678       rs758093671       rs758204274       rs758404052       rs758438533       rs758490041       rs758862706       rs758917797       rs758934862       rs759152323       rs759179981       rs759228810       rs759230843       rs759280155       rs759484111       rs759638457       rs759836734       rs760283125       rs760408168       rs760581842       rs761036207       rs761231016       rs761333033       rs761367931       rs761887849       rs762083068       rs762174778       rs762370509       rs762464671       rs762504718       rs762772398       rs762974425       rs763082881       rs763198997       rs763258892       rs763570458       rs763632256       rs763713208       rs763759138       rs764139833       rs764204600       rs764259881       rs764510600       rs764610376       rs764832005       rs764907044       rs765221054       rs765383748       rs765452530       rs765456729       rs765659507       rs766064071       rs766147554       rs766479242       rs766650576       rs766806594       rs766816711       rs766902089       rs767145828       rs767196705       rs767270954       rs767290978       rs767527919       rs767532797       rs768043080       rs768161012       rs768688134       rs768727525       rs768906121       rs768998431       rs769179533       rs769315504       rs769642619       rs769696094       rs770115815       rs770167119       rs770200027       rs770251129       rs770770601       rs770795729       rs770827869       rs770873749       rs771208792       rs771299297       rs771484933       rs772065354       rs772095368       rs772298288       rs772494815       rs772547643       rs772707373       rs772712392       rs772828737       rs772906411       rs772960451       rs773554752       rs773668732       rs773923567       rs774089419       rs774369323       rs774511164       rs774736178       rs774786276       rs774887552       rs775522109       rs775638694       rs775697813       rs775749313       rs775804976       rs775805095       rs776220818       rs776393314       rs776442495       rs776494841       rs776659208       rs776939699       rs777377728       rs777813294       rs777822008       rs777824004       rs778040157       rs778239588       rs778346978       rs778393011       rs778395067       rs778716594       rs778904317       rs779176876       rs779315038       rs779529048       rs779661762       rs779697091       rs779939732       rs780036397       rs780043505       rs780267746       rs780371311       rs780423831       rs780565198       rs780602865       rs780994554       rs781683861       rs781692166       rs868140900       rs869144229      

PLEKHA1基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CTTCGAAGGTACTTCATACTGG
58
TCCAGAAGGTAGGTTCTGTG
59
TCTTCGAAGGTACTTCATACTG
58
CCAGAAGGTAGGTTCTGTG
57
AGGAATGTAAGCAAAGCGAC
59
CCTGCACATAGAAAGTTCGA
58
GGAATGTAAGCAAAGCGAC
57
ACCTGCACATAGAAAGTTCG
58
TCTTCGAAGGTACTTCATACTGG
60
CCAGAAGGTAGGTTCTGTGG
60
AGGAATGTAAGCAAAGCGAC
59
CCTGCACATAGAAAGTTCGAG
59
      尚未收录相关数据

PLEKHA1基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

PLEKHA1基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0001553
Q9HB21(UniProtKB)
IEA
GO:0005515
Q9HB21(UniProtKB)
IPI
GO:0005515
Q9HB21(UniProtKB)
IPI
GO:0005654
Q9HB21(UniProtKB)
IDA
GO:0005737
Q9HB21(UniProtKB)
IDA
GO:0005737
Q9HB21(UniProtKB)
IDA
GO:0005737
Q9HB21(UniProtKB)
IDA
GO:0005886
Q9HB21(UniProtKB)
IDA
GO:0005886
Q9HB21(UniProtKB)
IDA
GO:0007283
Q9HB21(UniProtKB)
IEA
GO:0008209
Q9HB21(UniProtKB)
IEA
GO:0008210
Q9HB21(UniProtKB)
IEA
GO:0009791
Q9HB21(UniProtKB)
IEA
GO:0014065
Q9HB21(UniProtKB)
IDA
GO:0030165
Q9HB21(UniProtKB)
IPI
GO:0030165
Q9HB21(UniProtKB)
IPI
GO:0030165
Q9HB21(UniProtKB)
IPI
GO:0031529
Q9HB21(UniProtKB)
IDA
GO:0032587
Q9HB21(UniProtKB)
IDA
GO:0033327
Q9HB21(UniProtKB)
IEA
GO:0035264
Q9HB21(UniProtKB)
IEA
GO:0043325
Q9HB21(UniProtKB)
IDA
GO:0043325
Q9HB21(UniProtKB)
IDA
GO:0045184
Q9HB21(UniProtKB)
IDA
GO:0048008
Q9HB21(UniProtKB)
IEA
GO:0048705
Q9HB21(UniProtKB)
IEA
GO:0050853
Q9HB21(UniProtKB)
IDA
GO:0051898
Q9HB21(UniProtKB)
IMP
GO:0060021
Q9HB21(UniProtKB)
IEA
GO:0060325
Q9HB21(UniProtKB)
IEA
GO:0070062
Q9HB21(UniProtKB)
IDA
GO:0070301
Q9HB21(UniProtKB)
IDA
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控PLEKHA1基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Macular Degeneration, Age-Related, 1 0.12 0 0 CTD_human
Age related macular degeneration 0.022279435 13 9 BeFree_GAD_LHGDN
Atherosclerosis 0.002367032 1 0 GAD
Exudative age-related macular degeneration 0.000542884 2 0 BeFree
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