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This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  此基因编码尿激酶纤溶酶原激活剂受体和,鉴于其在定位和促进纤维蛋白溶酶的形成,有可能影响与细胞表面纤溶酶原激活和细胞外基质的局部降解许多正常和病理过程中的作用。它结合两个原蛋白和尿激酶纤溶酶原激活剂的成熟形式,并允许通过纤溶酶的受体结合亲酶的激活。该蛋白质缺少跨膜或细胞质结构域,并且可以被固定到由下面接近其羧基末端新生多肽的切割的糖基磷脂酰肌醇(GPI)部分质膜。然而,可溶性蛋白也在某些类型的细胞产生的。在多个转录剪接变异体导致编码不同亚型。原蛋白经历尚未被完全定义几个翻译后裂解反应。 [由RefSeq的,2008年7月提供]
PLAUR基因(以及对应的蛋白质)的细胞分布位置:
PLAUR基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Neoplasm Invasiveness | 0.2 | 2 | 0 | CTD_human_RGD |
| Neoplasm Metastasis | 0.134154703 | 17 | 0 | BeFree_CTD_human_LHGDN |
| Prostatic Neoplasms | 0.128173051 | 4 | 0 | CTD_human_LHGDN |
| Inflammation | 0.12272435 | 2 | 0 | CTD_human_LHGDN |
| Autistic Disorder | 0.12 | 2 | 0 | CTD_human |
| Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
| Juvenile arthritis | 0.12 | 1 | 0 | CTD_human |
| Myocardial Infarction | 0.085362824 | 3 | 0 | BeFree_GAD_LHGDN_RGD |
| Chronic Obstructive Airway Disease | 0.082367032 | 2 | 0 | GAD_RGD |
| Status Epilepticus | 0.08 | 1 | 0 | RGD |
| Anoxia | 0.013621751 | 5 | 0 | LHGDN |
| Lung Neoplasms | 0.010897401 | 4 | 0 | LHGDN |
| Stomach Neoplasms | 0.008173051 | 3 | 0 | LHGDN |
| Mammary Neoplasms | 0.008173051 | 3 | 0 | LHGDN |
| Glioblastoma | 0.005991584 | 4 | 0 | BeFree_LHGDN |
| Pancreatic Neoplasm | 0.005991584 | 4 | 0 | BeFree_LHGDN |
| Bladder Neoplasm | 0.005720142 | 2 | 0 | BeFree_LHGDN |
| Squamous cell carcinoma | 0.005720142 | 3 | 0 | BeFree_LHGDN |
| melanoma | 0.005720142 | 3 | 0 | BeFree_LHGDN |
| Meningioma | 0.005720142 | 2 | 0 | BeFree_LHGDN |
| Atherosclerosis | 0.0054487 | 2 | 0 | LHGDN |
| Colonic Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
| Colorectal Neoplasms | 0.0054487 | 2 | 0 | LHGDN |
| Asthma | 0.005276948 | 3 | 0 | BeFree_GAD |
| Malignant neoplasm of lung | 0.005005506 | 2 | 0 | BeFree_GAD |
| Premature Birth | 0.004734064 | 2 | 0 | GAD |
| Adenocarcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Renal Cell Carcinoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Carcinoma, Transitional Cell | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Diphtheria | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Leukemia, Myelocytic, Acute | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Systemic Scleroderma | 0.002909916 | 2 | 1 | BeFree_GAD |
| Malignant neoplasm of ovary | 0.002909916 | 3 | 0 | BeFree_GAD |
| Acquired Immunodeficiency Syndrome | 0.00272435 | 1 | 0 | LHGDN |
| Dermatitis | 0.00272435 | 1 | 0 | LHGDN |
| Dermatitis, Atopic | 0.00272435 | 1 | 0 | LHGDN |
| Hyperplasia | 0.00272435 | 1 | 0 | LHGDN |
| Kidney Diseases | 0.00272435 | 1 | 0 | LHGDN |
| Polycystic Ovary Syndrome | 0.00272435 | 1 | 0 | LHGDN |
| Carcinoma, Lobular | 0.00272435 | 1 | 0 | LHGDN |
| Prostatic Intraepithelial Neoplasias | 0.00272435 | 1 | 0 | LHGDN |
| Dementia | 0.00272435 | 1 | 0 | LHGDN |
| ovarian neoplasm | 0.00272435 | 1 | 0 | LHGDN |
| Sarcoma | 0.00272435 | 1 | 0 | LHGDN |
| Liver carcinoma | 0.00272435 | 1 | 0 | LHGDN |
| Infection | 0.00272435 | 1 | 0 | LHGDN |
| Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
| Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
| Premature Obstetric Labor | 0.002367032 | 1 | 0 | GAD |
| Placenta Disorders | 0.002367032 | 1 | 0 | GAD |
| Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
| Vascular Diseases | 0.002367032 | 1 | 1 | GAD |
| Bronchial Hyperreactivity | 0.002367032 | 1 | 0 | GAD |
| Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
| Malignant neoplasm of breast | 0.001357209 | 5 | 0 | BeFree |
| Prostate carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Breast Carcinoma | 0.001357209 | 5 | 0 | BeFree |
| Malignant tumor of colon | 0.001085767 | 4 | 0 | BeFree |
| Colorectal Carcinoma | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000814326 | 3 | 0 | BeFree |
| Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
| Colon Carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Colorectal Cancer | 0.000814326 | 3 | 0 | BeFree |
| Glioma | 0.000542884 | 2 | 0 | BeFree |
| HIV Infections | 0.000542884 | 2 | 0 | BeFree |
| Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Small cell carcinoma of lung | 0.000542884 | 2 | 3 | BeFree |
| Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Scleroderma | 0.000271442 | 1 | 0 | BeFree |
| Atrial Septal Defects | 0.000271442 | 1 | 1 | BeFree |
| Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
| Pancreatitis | 0.000271442 | 1 | 0 | BeFree |
| Polycythemia Vera | 0.000271442 | 1 | 0 | BeFree |
| Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
| Thyroid Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
| Medullary carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Common Migraine | 0.000271442 | 1 | 1 | BeFree |
| Large cell carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
| Epithelial ovarian cancer | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
| Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Cardiomyopathy, Familial Idiopathic | 0.000271442 | 1 | 0 | BeFree |
| Neoplasms, Intracranial | 0.000271442 | 1 | 0 | BeFree |
| Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
| Meningioma, benign, no ICD-O subtype | 0.000271442 | 1 | 0 | BeFree |
| Laryngeal cleft | 0.000271442 | 1 | 0 | BeFree |
| Triple Negative Breast Neoplasms | 0.000271442 | 1 | 0 | BeFree |
| Experimental Organism Basal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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