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This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码的胞质磷脂酶A2组第??IV族的一个成员。酶催化膜磷脂的水解以释放花生四烯酸,随后代谢成花生酸类。花生酸类,包括前列腺素和白三烯,是调节血流动力学基于脂质的细胞激素,炎症反应,和其它细胞内通路。水解反应也产生了被转换成血小板活化因子溶血磷脂。酶是由增加的细胞内钙激活(2+)水平和磷酸化,导致从细胞质和细胞核的核周囊泡其易位。 [由RefSeq的,2008年7月提供]
PLA2G4A基因(以及对应的蛋白质)的细胞分布位置:
PLA2G4A基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Amyotrophic Lateral Sclerosis | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Duodenal Ulcer | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Autistic Disorder | 0.12 | 1 | 0 | CTD_human |
Blood Platelet Disorders | 0.12 | 1 | 0 | CTD_human |
Dermatitis | 0.12 | 1 | 0 | CTD_human |
Inborn Errors of Metabolism | 0.12 | 1 | 0 | CTD_human |
Respiratory Distress Syndrome, Adult | 0.12 | 1 | 0 | CTD_human |
Mammary Neoplasms | 0.12 | 1 | 0 | CTD_human |
Asthma | 0.08554839 | 5 | 0 | BeFree_GAD_RGD |
Inflammation | 0.084734064 | 3 | 0 | GAD_RGD |
Sepsis | 0.080542884 | 3 | 0 | BeFree_RGD |
Carcinoma, Transitional Cell | 0.080271442 | 2 | 0 | BeFree_RGD |
Brain Ischemia | 0.08 | 1 | 0 | RGD |
Fever | 0.08 | 1 | 0 | RGD |
Hyperalgesia | 0.08 | 1 | 0 | RGD |
Hyperglycemia | 0.08 | 1 | 0 | RGD |
Polycystic Kidney Diseases | 0.08 | 1 | 0 | RGD |
Liver Cirrhosis, Experimental | 0.08 | 1 | 0 | RGD |
Papilloma | 0.08 | 1 | 0 | RGD |
Reperfusion Injury | 0.08 | 1 | 0 | RGD |
Wallerian Degeneration | 0.08 | 1 | 0 | RGD |
Metabolic Syndrome X | 0.08 | 1 | 0 | RGD |
Schizophrenia | 0.026360994 | 19 | 2 | BeFree_GAD_LHGDN |
Premature Birth | 0.007101096 | 3 | 0 | GAD |
Diabetes Mellitus, Non-Insulin-Dependent | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
Alzheimer's Disease | 0.005276948 | 4 | 0 | BeFree_GAD |
Colonic Neoplasms | 0.003267234 | 2 | 0 | BeFree_LHGDN |
Degenerative polyarthritis | 0.003267234 | 3 | 1 | BeFree_LHGDN |
Adenocarcinoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Rheumatoid Arthritis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Bacterial Infections | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Liver neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Leukemia, Myelocytic, Acute | 0.00272435 | 1 | 0 | LHGDN |
Psychotic Disorders | 0.00272435 | 1 | 0 | LHGDN |
HIV Infections | 0.002638474 | 2 | 0 | BeFree_GAD |
Bipolar Disorder | 0.002367032 | 1 | 0 | GAD |
Connective Tissue Diseases | 0.002367032 | 1 | 0 | GAD |
Mental Depression | 0.002367032 | 1 | 0 | GAD |
Fetal Diseases | 0.002367032 | 1 | 0 | GAD |
Musculoskeletal Diseases | 0.002367032 | 1 | 0 | GAD |
Pregnancy Complications, Hematologic | 0.002367032 | 1 | 0 | GAD |
Dermatologic disorders | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Osteoarthritis, Knee | 0.002367032 | 1 | 1 | GAD |
Major Depressive Disorder | 0.002367032 | 1 | 0 | GAD |
Infection | 0.002367032 | 1 | 0 | GAD |
Colorectal Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Colorectal Cancer | 0.001900093 | 7 | 0 | BeFree |
Malignant tumor of colon | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of lung | 0.001085767 | 4 | 0 | BeFree |
Carcinogenesis | 0.001085767 | 4 | 0 | BeFree |
Carcinoma of lung | 0.001085767 | 4 | 0 | BeFree |
Colon Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Cerebral Ischemia | 0.000814326 | 3 | 0 | BeFree |
Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
Astrocytoma | 0.000542884 | 2 | 0 | BeFree |
Atherosclerosis | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of breast | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cerebral Infarction | 0.000542884 | 2 | 0 | BeFree |
Experimental Autoimmune Encephalomyelitis | 0.000542884 | 2 | 0 | BeFree |
Ischemia | 0.000542884 | 2 | 0 | BeFree |
melanoma | 0.000542884 | 2 | 0 | BeFree |
Multiple Sclerosis | 0.000542884 | 2 | 0 | BeFree |
Myocardial Infarction | 0.000542884 | 2 | 1 | BeFree |
Obesity | 0.000542884 | 2 | 0 | BeFree |
Septicemia | 0.000542884 | 2 | 0 | BeFree |
Isovaleryl-CoA dehydrogenase deficiency | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
Arthritis | 0.000271442 | 1 | 0 | BeFree |
Arthritis, Psoriatic | 0.000271442 | 1 | 0 | BeFree |
Cardiovascular Diseases | 0.000271442 | 1 | 1 | BeFree |
Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Enteritis | 0.000271442 | 1 | 0 | BeFree |
Flushing | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Acute monocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
Metabolic Diseases | 0.000271442 | 1 | 0 | BeFree |
Mycosis Fungoides | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
nervous system disorder | 0.000271442 | 1 | 0 | BeFree |
Pneumonia | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Bronchial Hyperreactivity | 0.000271442 | 1 | 0 | BeFree |
Liver Failure | 0.000271442 | 1 | 0 | BeFree |
Cataract | 0.000271442 | 1 | 0 | BeFree |
Primary ulcer of intestine | 0.000271442 | 1 | 0 | BeFree |
Allergic asthma | 0.000271442 | 1 | 0 | BeFree |
Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Memory impairment | 0.000271442 | 1 | 0 | BeFree |
Extrapyramidal sign | 0.000271442 | 1 | 0 | BeFree |
Infantile Neuroaxonal Dystrophy | 0.000271442 | 1 | 0 | BeFree |
Anaplastic Oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
Impaired cognition | 0.000271442 | 1 | 0 | BeFree |
Glaucoma, Primary Open Angle | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Aqueous Humor Disorders | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
cardiac event | 0.000271442 | 1 | 1 | BeFree |
Well Differentiated Oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
Allergic bronchitis | 0.000271442 | 1 | 0 | BeFree |
Precursor B-cell lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
M5b Acute differentiated monocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Coronary Artery Disease | 0.000271442 | 1 | 2 | BeFree |
Urothelial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Neurodegeneration with brain iron accumulation (NBIA) | 0.000271442 | 1 | 0 | BeFree |
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