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This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]
[中文简述(自动翻译):]  这个基因编码属于分泌型磷脂酶A2家族,其成员包括蜂毒酶的蛋白质。脂质代谢的编码酶的功能和催化磷脂释放花生四烯酸和溶血磷脂的sn-2酰基键的钙依赖性水解。这种酶充当ciliogenesis的负调节,并可能通过刺激肿瘤细胞生长和血管生成在癌症发展中的作用。该基因与氧化应激有关,并且在该基因多态性链接到阿尔茨海默氏病的风险。 [由RefSeq的,2014年4月提供]
PLA2G3基因(以及对应的蛋白质)的细胞分布位置:
PLA2G3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Atherosclerosis | 0.00272435 | 1 | 0 | LHGDN |
HIV Infections | 0.002367032 | 1 | 0 | GAD |
Cerebrovascular accident | 0.002367032 | 1 | 0 | GAD |
Subarachnoid Hemorrhage | 0.002367032 | 1 | 0 | GAD |
Intracranial Hemorrhages | 0.002367032 | 1 | 0 | GAD |
Cerebral Hemorrhage | 0.002367032 | 1 | 0 | GAD |
Colorectal Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Colorectal Cancer | 0.000814326 | 3 | 0 | BeFree |
Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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