PLA2G2A(phospholipase A2, group IIA (platelets, synovial fluid)) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

1p35
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]

[中文简述(自动翻译):]  由该基因编码的蛋白是磷脂酶A2家族（PLA 2）的成员。 PLA2s构成酶的不同家庭对于序列，功能，定位，和二价阳离子的要求。该基因产物属于第二组，其中含有PLA2，具有低分子量，并且需要钙离子为催化细胞外酶的分泌形式。它催化磷酸甘油酯的sn-2脂肪酸酰基酯键的水解，释放出游离脂肪酸和溶血磷脂，并认为参与生物膜磷脂代谢的调节。用不同的5‘非编码区的几个可变剪接转录变异体也发现了这种基因。[由RefSeq的，2009年09月提供]

OMIM数据库中对PLA2G2A基因的介绍     Wikipedia数据库中对PLA2G2A基因的介绍

基因序列

基因序列

PLA2G2A基因的碱基序列：[NCBI]

基因突变

基因突变

PLA2G2A基因的碱基突变：           显示全部snp
rs4744       rs11677       rs14945       rs818958       rs876018       rs955587       rs1774131       rs1796923       rs1804275       rs2236769       rs2236770       rs2236771       rs2236772       rs2307245       rs2307246       rs3753827       rs3767221       rs3930568       rs6675678       rs10732279       rs10916684       rs11539239       rs11573134       rs11573135       rs11573136       rs11573137       rs11573138       rs11573139       rs11573140       rs11573141       rs11573142       rs11573143       rs11573144       rs11573145       rs11573146       rs11573147       rs11573148      
rs11573150       rs11573151       rs11573152       rs11573153       rs11573154       rs11573155       rs11573156       rs11573157       rs11573158       rs11573159       rs11573160       rs11573161       rs11573162       rs11573163       rs11573164       rs11573165       rs11573166       rs11573167       rs11573168       rs11573169       rs11573170       rs11573171       rs11573172       rs11573173       rs11573174       rs11573175       rs11573176       rs11573177       rs12567971       rs12568211       rs12721465       rs34568801       rs56794374       rs71645476       rs74920743       rs78900567       rs79952454       rs80074825       rs112347332       rs112502576       rs113302620       rs113722293       rs114737405       rs115523403       rs116241550       rs116836381       rs117772421       rs138131988       rs138476699       rs138698409       rs139648506       rs140072352       rs140616974       rs141213403       rs141532150       rs141564535       rs142075138       rs142811196       rs142941380       rs143028101       rs144466251       rs144665182       rs146136959       rs146836568       rs147835464       rs147990426       rs148271639       rs148324464       rs149024426       rs150841518       rs150897496       rs150999850       rs181571933       rs181622845       rs182546388       rs182860096       rs183706364       rs184053330       rs184321168       rs184574468       rs185036959       rs185271856       rs185365913       rs187038951       rs187041297       rs188474100       rs188659785       rs189084413       rs189085526       rs189548933       rs190260839       rs190656601       rs191889874       rs192157076       rs199570209       rs200105968       rs200281231       rs200556518       rs200602721       rs201198661       rs201366888       rs201469795       rs201624342       rs201812865       rs368026126       rs368095710       rs368964488       rs369207290       rs369677905       rs369804777       rs370053983       rs370123202       rs370832312       rs370952850       rs372228289       rs372467984       rs374105365       rs374719882       rs375416486       rs376040344       rs376385347       rs377235266       rs377294515       rs377531807       rs377616086       rs397979468       rs527457976       rs527475477       rs527522886       rs527743566       rs527804602       rs528707257       rs529418216       rs530635027       rs531118203       rs531707871       rs531779658       rs531841895       rs532719591       rs533345781       rs533482384       rs533921680       rs533987300       rs534864900       rs534934175       rs535710258       rs535834205       rs536106481       rs536109080       rs537898118       rs538220931       rs538778213       rs539053535       rs539181399       rs540092395       rs540220608       rs540221761       rs540357666       rs540491457       rs540550737       rs541569364       rs541689606       rs541747023       rs542434084       rs542773828       rs543663002       rs544079746       rs544318332       rs544527744       rs544541374       rs544856016       rs546100001       rs546411294       rs546613936       rs546846615       rs547124629       rs547845435       rs547878928       rs547986952       rs548745305       rs549972860       rs550078999       rs550283178       rs550571939       rs550761637       rs551224695       rs551429973       rs552082565       rs552365189       rs552675181       rs553211960       rs553450204       rs554619670       rs554751986       rs555961681       rs556523321       rs556875616       rs557214896       rs558415351       rs559030861       rs559809650       rs560060510       rs560891360       rs560902006       rs560950718       rs562032684       rs562300796       rs562522906       rs562663581       rs562897019       rs563390194       rs563547409       rs564203554       rs564455541       rs564917080       rs565229910       rs565361597       rs565555329       rs566286751       rs566292759       rs566374991       rs566559502       rs567479516       rs567561280       rs568463709       rs570262475       rs570506198       rs570913446       rs571509235       rs571687819       rs571772693       rs572091318       rs572711942       rs572978094       rs573210770       rs573678019       rs573855267       rs574397845       rs575060353       rs575074000       rs575123478       rs575583994       rs575696971       rs576262638       rs576529332       rs577489367       rs577730156       rs587776800       rs745359887       rs746213193       rs746301366       rs747288065       rs747371301       rs748028386       rs748116263       rs748323052       rs748583368       rs748650954       rs748673303       rs749082503       rs749457372       rs750291388       rs750572606       rs751200649       rs751409999       rs751929615       rs752114767       rs752587520       rs753236597       rs753247582       rs754028216       rs754217205       rs754342276       rs754486062       rs754678279       rs754951974       rs755729647       rs756149138       rs756423670       rs757990679       rs758065887       rs758526072       rs758590838       rs758939360       rs759126977       rs759318787       rs760059850       rs760149909       rs760504874       rs760567505       rs761179419       rs761785554       rs761875368       rs762196749       rs762432235       rs762718766       rs764003555       rs764069579       rs764640871       rs764670008       rs764775830       rs765402751       rs765431164       rs765988887       rs766185925       rs767234605       rs767608899       rs768321062       rs769168214       rs769845280       rs770347260       rs770437316       rs770631666       rs771166136       rs771678574       rs771722097       rs772752135       rs772763613       rs773216312       rs773298275       rs773715153       rs773992543       rs774586632       rs774806298       rs775196287       rs775203755       rs775857179       rs776253119       rs776668415       rs777744543       rs777849139       rs778125360       rs779263473       rs779631054       rs779725066       rs779758986       rs780362171       rs780409037       rs780859735       rs780972834       rs781284957       rs781473940       rs781614932       rs781659203      

基因表达

基因表达

PLA2G2A基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
CTGTCTCCAAACAGAGGGA
59
GGACTCCAGAGTTGTATCCC
59
GATCTTTGGCCTACTGCAG
58
GAAGCCATAACTGAGTGCG
59
AAGACCCTCCTACTGTTGG
58
AGAAGCCATAACTGAGTGC
58
GATCTTTGGCCTACTGCAG
58
AGAAGCCATAACTGAGTGC
58
GATCTTTGGCCTACTGCAG
58
AGAAGCCATAACTGAGTGC
57
GAAGACCCTCCTACTGTTGG
60
GAAGCCATAACTGAGTGCG
59
TGATCTTTGGCCTACTGCA
59
GAAGCCATAACTGAGTGCG
59
GATCTTTGGCCTACTGCAG
58
GAAGCCATAACTGAGTGCG
59
TCACCCAAGAACTCTTACCA
58
TTCAAAGATCATGATCACTGCC
59
TGTCTCCAAACAGAGGGAG
59
GGACTCCAGAGTTGTATCCC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

PLA2G2A基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

PLA2G2A基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004623
P14555(UniProtKB)
IDA
GO:0004623
P14555(UniProtKB)
TAS
GO:0004623
P14555(UniProtKB)
TAS
GO:0004623
P14555(UniProtKB)
TAS
GO:0004623
P14555(UniProtKB)
TAS
GO:0004623
P14555(UniProtKB)
TAS
GO:0004623
P14555(UniProtKB)
TAS
GO:0004623
P14555(UniProtKB)
TAS
GO:0004623
P14555(UniProtKB)
TAS
GO:0004623
P14555(UniProtKB)
TAS
GO:0004623
P14555(UniProtKB)
TAS
GO:0004623
P14555(UniProtKB)
TAS
GO:0004623
P14555(UniProtKB)
TAS
GO:0005509
P14555(UniProtKB)
IEA
GO:0005543
P14555(UniProtKB)
IDA
GO:0005576
P14555(UniProtKB)
TAS
GO:0005576
P14555(UniProtKB)
TAS
GO:0005576
P14555(UniProtKB)
TAS
GO:0005576
P14555(UniProtKB)
TAS
GO:0005576
P14555(UniProtKB)
TAS
GO:0005576
P14555(UniProtKB)
TAS
GO:0005615
P14555(UniProtKB)
IDA
GO:0005615
P14555(UniProtKB)
IDA
GO:0005783
P14555(UniProtKB)
IDA
GO:0005789
P14555(UniProtKB)
TAS
GO:0005789
P14555(UniProtKB)
TAS
GO:0005789
P14555(UniProtKB)
TAS
GO:0005789
P14555(UniProtKB)
TAS
GO:0005789
P14555(UniProtKB)
TAS
GO:0005789
P14555(UniProtKB)
TAS
GO:0006644
P14555(UniProtKB)
IDA
GO:0006654
P14555(UniProtKB)
TAS
GO:0010744
P14555(UniProtKB)
TAS
GO:0016042
P14555(UniProtKB)
IEA
GO:0030141
P14555(UniProtKB)
IEA
GO:0034374
P14555(UniProtKB)
TAS
GO:0036148
P14555(UniProtKB)
TAS
GO:0036149
P14555(UniProtKB)
TAS
GO:0036150
P14555(UniProtKB)
TAS
GO:0036151
P14555(UniProtKB)
TAS
GO:0036152
P14555(UniProtKB)
TAS
GO:0046473
P14555(UniProtKB)
IDA
GO:0047498
P14555(UniProtKB)
TAS
GO:0048471
P14555(UniProtKB)
IEA
GO:0050729
P14555(UniProtKB)
TAS
GO:0050830
P14555(UniProtKB)
TAS
GO:0070062
P14555(UniProtKB)
IDA
GO:0070374
P14555(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控PLA2G2A基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Atherosclerosis 0.126524536 16 0 BeFree_CTD_human_LHGDN
Colorectal Neoplasms 0.120542884 2 0 BeFree_CTD_human
Endometriosis 0.12 1 0 CTD_human
Reperfusion Injury 0.12 1 0 CTD_human
Myocardial Ischemia 0.12 1 0 CTD_human
Adrenal gland hypofunction 0.08 1 0 RGD
Acute Lung Injury 0.08 1 0 RGD
Coronary Artery Disease 0.009434452 16 0 BeFree_GAD_LHGDN
Neoplasm Metastasis 0.007077352 6 0 BeFree_LHGDN
Colorectal Cancer 0.006091273 6 1 BeFree_GAD
Stomach Neoplasms 0.0054487 2 0 LHGDN
Myocardial Infarction 0.004614512 17 0 BeFree
Adenomatous Polyposis Coli 0.004353001 7 0 BeFree_LHGDN
Cerebrovascular accident 0.00408156 6 0 BeFree_LHGDN
Arteriosclerosis 0.004071628 15 0 BeFree
Coronary heart disease 0.004071628 15 0 BeFree
Coronary Arteriosclerosis 0.003800186 14 0 BeFree
Schizophrenia 0.003724241 6 0 BeFree_GAD
Malignant neoplasm of lung 0.003724241 6 0 BeFree_GAD
Sepsis 0.003452799 4 4 BeFree_GAD
Alzheimer's Disease 0.002995792 2 0 BeFree_LHGDN
Diabetes Mellitus 0.002995792 2 0 BeFree_LHGDN
Cystic Fibrosis 0.00272435 1 0 LHGDN
Dementia, Vascular 0.00272435 1 0 LHGDN
Chronic Obstructive Airway Disease 0.002638474 2 0 BeFree_GAD
Malignant neoplasm of urinary bladder 0.002367032 1 0 GAD
HIV Infections 0.002367032 1 0 GAD
Mood Disorders 0.002367032 1 0 GAD
Cardiovascular Diseases 0.002171535 8 0 BeFree
Carcinogenesis 0.002171535 8 0 BeFree
Malignant neoplasm of prostate 0.001628651 6 0 BeFree
Prostate carcinoma 0.001628651 6 0 BeFree
Malignant neoplasm of stomach 0.001357209 5 0 BeFree
Carcinoma of lung 0.001357209 5 0 BeFree
Stomach Carcinoma 0.001357209 5 0 BeFree
Asthma 0.001085767 4 0 BeFree
Colorectal Carcinoma 0.001085767 4 0 BeFree
Coronary Thrombosis 0.001085767 4 0 BeFree
Crohn Disease 0.001085767 4 0 BeFree
Neuroblastoma 0.001085767 4 0 BeFree
Septicemia 0.001085767 4 4 BeFree
Arterial thrombosis 0.001085767 4 0 BeFree
Acute Coronary Syndrome 0.001085767 4 1 BeFree
Arthritis 0.000814326 3 0 BeFree
Diabetes Mellitus, Non-Insulin-Dependent 0.000814326 3 0 BeFree
melanoma 0.000814326 3 0 BeFree
Central neuroblastoma 0.000814326 3 0 BeFree
androgen independent prostate cancer 0.000814326 3 0 BeFree
Adenocarcinoma 0.000542884 2 0 BeFree
Astrocytoma 0.000542884 2 0 BeFree
Malignant neoplasm of breast 0.000542884 2 0 BeFree
Malignant tumor of colon 0.000542884 2 0 BeFree
Colonic Neoplasms 0.000542884 2 0 BeFree
Depressive disorder 0.000542884 2 0 BeFree
Eclampsia 0.000542884 2 0 BeFree
Intestinal Neoplasms 0.000542884 2 0 BeFree
Intestinal Polyps 0.000542884 2 0 BeFree
Mycoses 0.000542884 2 0 BeFree
polyps 0.000542884 2 0 BeFree
Prostatic Neoplasms 0.000542884 2 0 BeFree
Respiratory Distress Syndrome, Newborn 0.000542884 2 0 BeFree
Seizures 0.000542884 2 0 BeFree
Thromboembolism 0.000542884 2 0 BeFree
Idiopathic Membranous Glomerulonephritis 0.000542884 2 0 BeFree
Deep Vein Thrombosis 0.000542884 2 0 BeFree
Acute myocardial infarction 0.000542884 2 0 BeFree
Teratocarcinoma 0.000542884 2 0 BeFree
Isovaleryl-CoA dehydrogenase deficiency 0.000542884 2 0 BeFree
Squamous cell carcinoma of esophagus 0.000542884 2 0 BeFree
Restenosis 0.000542884 2 0 BeFree
Breast Carcinoma 0.000542884 2 0 BeFree
Cholesterol gallstones 0.000542884 2 0 BeFree
Ischemic stroke 0.000542884 2 0 BeFree
Liver carcinoma 0.000542884 2 0 BeFree
Acute pancreatitis 0.000271442 1 0 BeFree
Adenoma 0.000271442 1 0 BeFree
Anthrax disease 0.000271442 1 0 BeFree
Rheumatoid Arthritis 0.000271442 1 0 BeFree
Autoimmune Diseases 0.000271442 1 0 BeFree
Bipolar Disorder 0.000271442 1 0 BeFree
Non-Small Cell Lung Carcinoma 0.000271442 1 0 BeFree
Chest Pain 0.000271442 1 0 BeFree
Cholangitis 0.000271442 1 0 BeFree
Cholestasis 0.000271442 1 0 BeFree
Craniosynostosis 0.000271442 1 0 BeFree
Cystitis 0.000271442 1 0 BeFree
Down Syndrome 0.000271442 1 0 BeFree
Experimental Autoimmune Encephalomyelitis 0.000271442 1 0 BeFree
Membranous glomerulonephritis 0.000271442 1 0 BeFree
Graves Disease 0.000271442 1 0 BeFree
Heart Diseases 0.000271442 1 0 BeFree
Hypercholesterolemia 0.000271442 1 0 BeFree
Hyperglycemia 0.000271442 1 0 BeFree
Ischemia 0.000271442 1 0 BeFree
Kidney Failure, Chronic 0.000271442 1 0 BeFree
leukemia 0.000271442 1 0 BeFree
Myeloid Leukemia 0.000271442 1 0 BeFree
Liver Cirrhosis 0.000271442 1 0 BeFree
Liver neoplasms 0.000271442 1 0 BeFree
Lung diseases 0.000271442 1 0 BeFree
Lung Neoplasms 0.000271442 1 0 BeFree
Lupus Erythematosus, Systemic 0.000271442 1 0 BeFree
Multiple Sclerosis 0.000271442 1 0 BeFree
Nasal Polyps 0.000271442 1 0 BeFree
nervous system disorder 0.000271442 1 0 BeFree
Optic Neuritis 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Pancreatitis 0.000271442 1 0 BeFree
Psoriasis 0.000271442 1 0 BeFree
Kidney Failure 0.000271442 1 0 BeFree
Subarachnoid Hemorrhage 0.000271442 1 0 BeFree
Giant Cell Arteritis 0.000271442 1 0 BeFree
Thrombasthenia 0.000271442 1 0 BeFree
Vascular Diseases 0.000271442 1 0 BeFree
Polyendocrinopathies, Autoimmune 0.000271442 1 0 BeFree
Ataxia, Spinocerebellar 0.000271442 1 0 BeFree
Genital ulceration 0.000271442 1 0 BeFree
Deep thrombophlebitis 0.000271442 1 0 BeFree
Murray valley encephalitis 0.000271442 1 0 BeFree
Papillary thyroid carcinoma 0.000271442 1 0 BeFree
Coronary Stenosis 0.000271442 1 0 BeFree
Myxoma of the Endocardium 0.000271442 1 0 BeFree
Epithelial hyperplasia of skin 0.000271442 1 0 BeFree
Fibrosis of pancreas 0.000271442 1 0 BeFree
Heparin-induced thrombocytopenia 0.000271442 1 0 BeFree
Adenomatous goiter 0.000271442 1 0 BeFree
Multiple polyps 0.000271442 1 0 BeFree
Adenocarcinoma of colon 0.000271442 1 0 BeFree
Chronic liver disease 0.000271442 1 0 BeFree
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site 0.000271442 1 0 BeFree
Thrombophilia 0.000271442 1 0 BeFree
Neurodegenerative Disorders 0.000271442 1 0 BeFree
Carotid Atherosclerosis 0.000271442 1 0 BeFree
Epithelial ovarian cancer 0.000271442 1 0 BeFree
Colon Carcinoma 0.000271442 1 0 BeFree
Thrombocytosis 0.000271442 1 0 BeFree
Adenomatous polyp of colon 0.000271442 1 0 BeFree
Invasive breast carcinoma 0.000271442 1 0 BeFree
Endothelial dysfunction 0.000271442 1 0 BeFree
Breast adenocarcinoma 0.000271442 1 0 BeFree
Enzyme inhibition disorder 0.000271442 1 0 BeFree
Allergic bronchitis 0.000271442 1 0 BeFree
Alloimmune thrombocytopenia 0.000271442 1 0 BeFree
Adenoma of large intestine 0.000271442 1 0 BeFree
Cirrhosis 0.000271442 1 0 BeFree
FRAGILE X TREMOR/ATAXIA SYNDROME 0.000271442 1 0 BeFree
Neonatal alloimmune thrombocytopenia (NAIT) 0.000271442 1 0 BeFree
Heparin induced thrombocytopenia (HIT) 0.000271442 1 0 BeFree
FAMILIAL ADENOMATOUS POLYPOSIS, ATTENUATED (disorder) 0.000271442 1 0 BeFree
Allergic disposition 0.000271442 1 0 BeFree

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