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Phosphatidylserine decarboxylases (PSDs; EC 4.1.1.65) catalyze the formation of phosphatidylethanolamine (PE) by decarboxylation of phosphatidylserine (PS). Type I PSDs, such as PISD, are targeted to the inner mitochondrial membrane by an N-terminal targeting sequence. PISD also contains a conserved LGST motif that functions as an autocatalytic cleavage site where the proenzyme is split into mature alpha and beta subunits (Schuiki and Daum, 2009 [PubMed 19165886]).[supplied by OMIM, Jul 2010]
[中文简述(自动翻译):]  磷脂酰丝氨酸脱羧酶(月台幕门; EC 4.1.1.65)催化磷脂酰乙醇胺(PE)的磷脂所(PS)的脱羧形成。 I型的PSD,如PISD,定位到由N-末端定位序列线粒体内膜。 PISD还包含一个保守LGST基序,其功能如同一个自催化切割位点,其中酶原被分成成熟的α和β亚基(Schuiki和Daum的,2009年[搜索PubMed 19165886])。[由OMIM,2010年7月供给]
PISD基因(以及对应的蛋白质)的细胞分布位置:
PISD基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Acquired Immunodeficiency Syndrome | 0.002367032 | 1 | 0 | GAD |
Schizophrenia | 0.001085767 | 4 | 0 | BeFree |
Mental disorders | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Autistic Disorder | 0.000271442 | 1 | 0 | BeFree |
Ulcerative Colitis | 0.000271442 | 1 | 0 | BeFree |
Atrial Septal Defects | 0.000271442 | 1 | 0 | BeFree |
Unipolar Depression | 0.000271442 | 1 | 0 | BeFree |
Speech Delay | 0.000271442 | 1 | 0 | BeFree |
Protein S Deficiency | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Major Depressive Disorder | 0.000271442 | 1 | 0 | BeFree |
Autism Spectrum Disorders | 0.000271442 | 1 | 0 | BeFree |
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