PIGA基因详情-基因数据库-基因云馆

PIGA(phosphatidylinositol glycan anchor biosynthesis, class A) 转至新版数据库

基因简称(symbol)

PIGA [HGNC] [GeneCards] [NCBI]

基因种类(locus group)

protein-coding gene

同源简称(alias symbol)

GPI3

基因家族代码(gene_family_id)

427|680 [HGNC] [GenScript]

omim代码

311770

entrez码

5277 [Vega]

vega基因码

OTTHUMG00000021174

ensembl基因码

ENSG00000165195 [Ensembl]

基因家族(gene family)

Glycosyl transferases group 1 domain containing|Phosphatidylinositol glycan anchor biosynthesis

refseq数据库代号

NM_002641

更多...

基因种类(locus_type)

gene with protein product

基因名称状态(status)

Approved

location_sortable

Xp22.1

同源基因名称(alias name)

paroxysmal nocturnal hemoglobinuria|phosphatidylinositol N-acetylglucosaminyltransferase

基因名称批准使用时间(date_approved_reserved)

1993-10-28T00:00:00Z

基因简称更名时间(date_symbol_changed)

基因名称更名时间(date_name_changed)

2008-07-31T00:00:00Z

更新时间(date_modified)

2015-04-22T00:00:00Z

ucsc码

uc004cwr.3

ena

BC038236

ccds数据码

CCDS14165|CCDS48086|CCDS48086

uniprot数据码

P37287

pubmed代码

8500164

mgd码

MGI:99461

rgd码

RGD:1589723

生命科学数据库(lsdb)

Mental Retardation database|http://grenada.lumc.nl/LOVD2/MR/home.php?select_db=PIGA|LRG_160|http://www.lrg-sequence.org/LRG/LRG_160

更新时间(date modified)

2015-04-22T00:00:00Z

cosmic

PIGA

mirbase

基因曾用简称(prev symbol)

基因曾用名称(prev name)

phosphatidylinositol glycan, class A (paroxysmal nocturnal hemoglobinuria)

homeodb

cosmic

PIGA

snornabase

bioparadigms slc

orphanet

231527

假基因信息(pseudogeneorg)

horde id

merops

imgt

iuphar

kznf基因类别

mamit-trnadb

cd

LncRNA数据库

酶代码

2.4.1.198

中间纤维数据库

收起

Xp22.1

This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010]

[中文简述(自动翻译):] 此基因编码N-乙酰磷脂酰肌醇（GlcNAc的-PI）的合成所需要的蛋白质，在GPI锚定的生物合成途径的第一个中间产物。 GPI锚是许多血细胞和其用于锚定蛋白在细胞表面发现的糖脂。阵发性夜间血红蛋白尿，所获取的血液学病症，已经显示出在这个基因的突变造成的。替代剪接变体已被表征。一个相关的假基因位于[由RefSeq的，2010年6月提供] 12号染色体

OMIM数据库中对PIGA基因的介绍 Wikipedia数据库中对PIGA基因的介绍

PIGA基因的碱基序列：[NCBI]

PIGA基因的碱基突变：显示全部snp

rs781671410 rs781217221 rs781304220 rs781511231 rs780815350 rs781095752 rs781102936 rs780781506 rs780532806 rs780237513 rs780409314 rs780199481 rs780079117 rs780064238 rs779978038 rs779973968 rs779690504 rs779396472 rs779205409 rs779308669 rs779389596 rs779117183 rs778929951 rs778728775 rs778868089 rs778602062 rs778697396 rs778582145 rs778444082 rs778339279 rs778172480 rs778249480 rs777979999 rs777892004 rs777795093 rs777674120 rs777695844

rs777616497 rs777440179 rs777229565 rs776982166 rs776651457 rs776963693 rs776453997 rs776383761 rs776297061 rs776262909 rs776182358 rs776208133 rs776021621 rs775827461 rs775805589 rs775827251 rs775729705 rs775223277 rs775224755 rs775330646 rs775206996 rs775133265 rs775119170 rs775133099 rs775052996 rs774946182 rs774887892 rs774874699 rs774644659 rs774746671 rs774858458 rs774546648 rs774306554 rs774484425 rs774149144 rs773967133 rs773540574 rs773613528 rs773455617 rs773441211 rs773426413 rs773280603 rs773179357 rs772936689 rs772977032 rs772788254 rs772745563 rs772668943 rs772695695 rs772697889 rs772462881 rs772225061 rs772079875 rs771904881 rs771850332 rs771690457 rs771651858 rs771529477 rs771272495 rs771453060 rs771172779 rs771058274 rs770931215 rs770713954 rs770570366 rs770553764 rs770304439 rs770266710 rs770182050 rs770179893 rs769987255 rs770084627 rs769936615 rs769839030 rs769592599 rs769478872 rs769429933 rs769147622 rs769125619 rs769061128 rs768875061 rs768749706 rs768711210 rs768601360 rs768321389 rs768524297 rs768231310 rs768226030 rs767911783 rs768103761 rs767875599 rs767538745 rs767487046 rs767478652 rs767474092 rs767388361 rs767123305 rs767006913 rs766935616 rs766741654 rs766602742 rs766651571 rs766109827 rs766304305 rs766346470 rs765971227 rs765737309 rs765961204 rs765502766 rs765534842 rs765630620 rs765442540 rs765183231 rs765282774 rs765142919 rs765007273 rs764988988 rs764915161 rs764914636 rs764561323 rs764607688 rs764210969 rs764031509 rs764056527 rs763958111 rs763950698 rs763507394 rs763505541 rs763470538 rs763486051 rs763427382 rs762862377 rs762891698 rs762765205 rs762754076 rs762748091 rs762694967 rs762634376 rs762204203 rs762365211 rs762528292 rs762178998 rs761968382 rs762120893 rs761800409 rs761798245 rs761613346 rs761710196 rs761535527 rs761116405 rs761508674 rs761102163 rs761039585 rs761007687 rs760990927 rs760953001 rs760861409 rs760770680 rs760771145 rs760720803 rs760464527 rs760266545 rs760392691 rs759900292 rs760051182 rs759894472 rs759800595 rs759697480 rs759531443 rs759641568 rs759519919 rs759443446 rs759324105 rs758986672 rs759255949 rs758981206 rs758929349 rs758769627 rs758863767 rs758880066 rs758741668 rs758629184 rs758351965 rs758277994 rs757835670 rs757925303 rs757971968 rs757286803 rs757482806 rs757687594 rs757157177 rs757121631 rs756816136 rs756907346 rs756703907 rs756660446 rs756641878 rs756463073 rs756332722 rs756212857 rs756127617 rs756127566 rs756109149 rs755924625 rs755799077 rs755718762 rs755002887 rs754979626 rs754943149 rs754887902 rs754561270 rs754782099 rs754401169 rs754131684 rs754354834 rs754066745 rs753941641 rs754050083 rs753691551 rs753672974 rs753657072 rs753582028 rs753475633 rs753578311 rs753272427 rs753146952 rs752766593 rs752798208 rs752713326 rs752522903 rs752443757 rs752395232 rs752431843 rs752174333 rs752168392 rs752002690 rs751869806 rs751644316 rs751621287 rs751261624 rs751436894 rs751544968 rs751097596 rs751012566 rs750934671 rs750871914 rs750784049 rs750805327 rs750724224 rs750555194 rs750536084 rs750515462 rs750452394 rs750365775 rs750216116 rs750276693 rs749940563 rs749926056 rs749891915 rs749653128 rs749702985 rs749581242 rs749272770 rs749191978 rs749080220 rs749082199 rs748902332 rs748829790 rs748766986 rs748760635 rs748741841 rs748415632 rs748469949 rs748161988 rs748327854 rs748000270 rs747959988 rs747894664 rs747835228 rs747726050 rs747568374 rs747638534 rs747555906 rs747478493 rs747319141 rs747022578 rs746975124 rs746713740 rs746705485 rs746412962 rs746591138 rs746156474 rs745868147 rs745866722 rs745709217 rs745603139 rs745560847 rs587777398 rs745329977 rs562879532 rs561138542 rs560790298 rs548787521 rs539199104 rs530761726 rs377145946 rs530212232 rs375401655 rs377014685 rs375371562 rs373138445 rs374810452 rs372983281 rs373094239 rs370967074 rs371466959 rs372966902 rs370316738 rs369768957 rs368899509 rs367893617 rs368384134 rs202201866 rs202161781 rs201873136 rs201783559 rs201361742 rs201119959 rs200475470 rs200439632 rs200262277 rs199526805 rs193105327 rs192931358 rs192637577 rs192547960 rs192475811 rs191803242 rs191791153 rs191766139 rs191761801 rs191468095 rs191256206 rs191310937 rs191202907 rs191092182 rs190996733 rs190545953 rs190478278 rs190230543 rs190198304 rs189924091 rs189685495 rs189664854 rs189662580 rs189441442 rs189421978 rs189280831 rs188917467 rs188913202 rs188912075 rs188783414 rs188238486 rs188108382 rs188058821 rs188029530 rs187622248 rs187525197 rs187274512 rs187040067 rs186797489 rs186678527 rs186556374 rs186529328 rs186411782 rs186341063 rs186122831 rs185958311 rs185874005 rs185641569 rs185387615 rs185347946 rs185228076 rs184828250 rs184640309 rs184415629 rs184337037 rs184179352 rs184103769 rs184099983 rs184041443 rs183815750 rs183467475 rs183227989 rs183207361 rs183106783 rs182885467 rs182527237 rs182297451 rs182140906 rs182080016 rs181907120 rs181883852 rs181664443 rs181449072 rs181380655 rs181021689 rs180987927 rs180732569 rs180705464 rs150753172 rs150526981 rs150283589 rs149950708 rs149972103 rs149808821 rs149183347 rs148833809 rs148778432 rs148660178 rs147912228 rs147718914 rs147126062 rs147110145 rs146801580 rs145491730 rs144162396 rs144543734 rs143565005 rs144139057 rs143481117 rs143454545 rs143341719 rs143032312 rs142820663 rs142772459 rs142514131 rs142320414 rs142178534 rs141914240 rs141714461 rs140606572 rs141093019 rs140288127 rs139991272 rs139989459 rs139205667 rs139149663 rs138954722 rs113204630 rs137949460 rs111750388 rs73635084 rs73635083 rs73447255 rs73447251 rs73447250 rs73447247 rs73189542 rs62580243 rs61760986 rs61730287 rs61751426 rs61730284 rs61565825 rs45538433 rs35388853 rs35222742 rs35186894 rs34422225 rs34315787 rs16979819 rs12850790 rs12849933 rs11798242 rs7050041 rs7049772 rs6632348 rs6653609 rs6632344 rs6632329 rs6632314 rs6628992 rs6628991 rs6628990 rs6628988 rs6527494 rs6527492 rs6527489 rs6527487 rs5980148 rs5978726 rs5935955 rs5935954 rs5935951 rs5935953 rs5934235 rs5934236 rs4830938 rs3087965 rs3661 rs3434 rs2543

PIGA基因在不同组织中的表达： [UniProt]

正向引物序列

正向引物Tm值

反向引物序列

反向引物Tm值

rank

TGGTTTACAGGTATATGACCG

57

CAGTGAGAAATAAGTCTGTCCA

57

TGGAACTCACCGGTAATAGAG

59

GAGAGTGTAGCTGAGGCAC

59

GAATACCTCCCTTACTGAAGC

58

AACTCTGGTACTTACAACCTG

57

GGAACTCACCGGTAATAGAGG

59

GAGAGTGTAGCTGAGGCAC

59

TTTCTGAATACCTCCCTTACTG

57

CCGGTCATATACCTGTAAACC

58

ATACCTCCCTTACTGAAGCA

57

CAACTCTGGTACTTACAACCTG

58

AATACCTCCCTTACTGAAGCA

58

TGATACCCGGTCATATACCTG

58

AACTCACCGGTAATAGAGGAC

59

GAGAGTGTAGCTGAGGCAC

59

TTTCTGAATACCTCCCTTACTG

57

GGTACTTACAACCTGTAAACCA

58

尚未收录相关数据

PIGA基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

溶酶体
内涵体
细胞核
细胞质
液泡
细胞膜
细胞外基质
内质网
线粒体
高尔基体
细胞骨架

PIGA基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0016021

A0A0U1RQM9(UniProtKB)

IEA

GO:0006506

A0A0U1RQW8(UniProtKB)

IEA

GO:0006506

A0A0U1RRE8(UniProtKB)

IEA

GO:0006506

A8K382(UniProtKB)

IEA

GO:0000506

P37287(UniProtKB)

IDA

GO:0005515

P37287(UniProtKB)

IPI

GO:0005789

P37287(UniProtKB)

IDA

GO:0005789

P37287(UniProtKB)

TAS

GO:0006506

P37287(UniProtKB)

TAS

GO:0008194

P37287(UniProtKB)

TAS

GO:0009893

P37287(UniProtKB)

TAS

GO:0016020

P37287(UniProtKB)

IDA

GO:0016021

P37287(UniProtKB)

IEA

GO:0016254

P37287(UniProtKB)

TAS

GO:0017176

P37287(UniProtKB)

TAS

序号	作用方式	资源库来源/分值	基因名称	基因名称

可能调控PIGA基因的相关microRNA：

hsa-miR-26b hsa-miR-326

通路基因列表

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
MULTIPLE CONGENITAL ANOMALIES-HYPOTONIA-SEIZURES SYNDROME 2	0.36	2	7	CLINVAR_ORPHANET_UNIPROT
PAROXYSMAL NOCTURNAL HEMOGLOBINURIA 1	0.24	4	10	CLINVAR_UNIPROT
Paroxysmal nocturnal hemoglobinuria	0.154201676	126	1	BeFree_ORPHANET
Hemoglobinuria, Paroxysmal	0.1254487	4	0	CTD_human_LHGDN
West Syndrome	0.12	0	0	ORPHANET
Aplastic Anemia	0.008434561	12	0	BeFree_LHGDN
Intravascular hemolysis	0.001357209	5	0	BeFree
Hematological Disease	0.001085767	4	0	BeFree
Leukemia, Myelocytic, Acute	0.000814326	3	0	BeFree
Congenital Abnormality	0.000542884	2	0	BeFree
Anemia, Hemolytic, Acquired	0.000542884	2	0	BeFree
leukemia	0.000542884	2	0	BeFree
Pancytopenia	0.000542884	2	0	BeFree
Protein Deficiency	0.000542884	2	0	BeFree
Hemolytic disorder	0.000542884	2	0	BeFree
CD59 Deficiency	0.000542884	2	0	BeFree
Atypical Hemolytic Uremic Syndrome	0.000542884	2	0	BeFree
Anemia, Hemolytic	0.000271442	1	0	BeFree
Burkitt Lymphoma	0.000271442	1	0	BeFree
Dental caries	0.000271442	1	0	BeFree
Dystonia	0.000271442	1	0	BeFree
Epilepsy	0.000271442	1	0	BeFree
Absence Epilepsy	0.000271442	1	0	BeFree
HIV Infections	0.000271442	1	0	BeFree
Multiple Myeloma	0.000271442	1	0	BeFree
Plasmacytoma	0.000271442	1	0	BeFree
Miller Dieker syndrome	0.000271442	1	0	BeFree
Early myoclonic encephalopathy	0.000271442	1	0	BeFree
Iron Overload	0.000271442	1	0	BeFree
Obesity, Abdominal	0.000271442	1	0	BeFree
Caries (morphologic abnormality)	0.000271442	1	0	BeFree
Developmental delay (disorder)	0.000271442	1	0	BeFree
Epileptic encephalopathy	0.000271442	1	0	BeFree
Congenital malformation syndrome	0.000271442	1	0	BeFree
Non-Neoplastic Disorder	0.000271442	1	0	BeFree
Plasma Cell Neoplasm	0.000271442	1	0	BeFree
Thrombotic Microangiopathies	0.000271442	1	0	BeFree
Bone Marrow failure syndromes	0.000271442	1	0	BeFree
Myeloid neoplasm	0.000271442	1	0	BeFree
Intellectual Disability	0.000271442	1	0	BeFree