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The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
[中文简述(自动翻译):]  由该基因编码的蛋白质中含有富含亮氨酸重复和死亡域。这种蛋白已经显示出与其它死亡结构域的蛋白质,如中Fas(TNFRSF6)通过死亡结构域(FADD)相关和MAP激酶活化死亡结构域的蛋白(MADD)相互作用,并且因此可以作为一个适配器蛋白质发挥功能细胞死亡相关的信令进程。该基因的小鼠对应物的表达已经发现由肿瘤抑制基因p53被正调控,并诱导细胞凋亡响应于DNA损伤,这表明对于该基因作为p53依赖性细胞凋亡的效应的作用。选择性剪接结果在多个抄本变形。 [由RefSeq的,2010年8月提供]
PIDD1基因(以及对应的蛋白质)的细胞分布位置:
PIDD1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Renal Cell Carcinoma | 0.12 | 1 | 0 | CTD_human |
Squamous cell carcinoma | 0.00272435 | 1 | 0 | LHGDN |
Cessation of life | 0.00272435 | 1 | 0 | LHGDN |
Leukopenia | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Neutropenia | 0.000271442 | 1 | 0 | BeFree |
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