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This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011]
[中文简述(自动翻译):] 该基因编码的类固醇受体超家族的一个成员。所编码的蛋白质介导孕酮,它在与建立和妊娠的维护相关的生殖事件中心作用的生理作用。该基因使用两个不同的启动子和翻译起始位点的第一外显子,以产生两个同种型,A和B这两个同工型是除了在同种型B的N末端发现的附加165个氨基酸相同且介导其自身的响应的基因和生理的影响几乎没有重叠。 [由RefSeq的,2011年1月提供]
PGR基因(以及对应的蛋白质)的细胞分布位置:
PGR基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Endometriosis | 0.24796418 | 45 | 4 | BeFree_CTD_human_GAD_LHGDN_RGD |
Mammary Neoplasms | 0.208390952 | 93 | 0 | BeFree_CTD_human_GAD_LHGDN |
Endometrial Neoplasms | 0.15126293 | 13 | 0 | CTD_human_GAD_LHGDN |
Malignant neoplasm of breast | 0.132074704 | 426 | 25 | BeFree_GAD |
Meningioma | 0.125981653 | 15 | 0 | BeFree_CTD_human_LHGDN |
Adenocarcinoma | 0.122714419 | 11 | 0 | BeFree_CTD_human |
Animal Mammary Neoplasms | 0.122367032 | 2 | 0 | CTD_human_GAD |
Mammary Neoplasms, Experimental | 0.12 | 1 | 0 | CTD_human |
Mesothelioma | 0.12 | 1 | 0 | CTD_human |
Polycystic Ovary Syndrome | 0.085276948 | 4 | 0 | BeFree_GAD_RGD |
Breast Carcinoma | 0.08 | 395 | 25 | BeFree |
Malignant neoplasm of ovary | 0.027817893 | 27 | 1 | BeFree_GAD |
Fibroid Tumor | 0.023784653 | 24 | 0 | BeFree_GAD_LHGDN |
Endometrial Carcinoma | 0.018306158 | 51 | 0 | BeFree_GAD |
Premature Birth | 0.016569224 | 7 | 0 | GAD |
Triple Negative Breast Neoplasms | 0.016286512 | 60 | 0 | BeFree |
Malignant neoplasm of prostate | 0.011096779 | 9 | 0 | BeFree_GAD |
Ovarian Carcinoma | 0.010510288 | 31 | 1 | BeFree_GAD |
Malignant neoplasm of endometrium | 0.009500466 | 35 | 0 | BeFree |
Uterine Corpus Cancer | 0.009500466 | 35 | 0 | BeFree |
Uterine Fibroids | 0.008143256 | 30 | 0 | BeFree |
ovarian neoplasm | 0.008087174 | 4 | 0 | BeFree_GAD_LHGDN |
Secondary malignant neoplasm of lymph node | 0.007871814 | 29 | 2 | BeFree |
Epithelial ovarian cancer | 0.007719925 | 13 | 0 | BeFree_GAD |
Inflammation | 0.007458414 | 3 | 0 | GAD_LHGDN |
Abortion, Habitual | 0.007101096 | 3 | 0 | GAD |
Female infertility | 0.007101096 | 3 | 0 | GAD |
Migraine Disorders | 0.006362715 | 7 | 0 | BeFree_GAD |
Colorectal Cancer | 0.00554839 | 5 | 0 | BeFree_GAD |
Panic Disorder | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
Neoplasm Metastasis | 0.004885954 | 18 | 1 | BeFree |
Tobacco Use Disorder | 0.004734064 | 2 | 0 | GAD |
Uterine Neoplasms | 0.004734064 | 2 | 0 | GAD |
Malignant neoplasm of lung | 0.003995683 | 7 | 0 | BeFree_GAD |
Obesity | 0.003452799 | 5 | 0 | BeFree_GAD |
Mammographic Density | 0.003452799 | 4 | 0 | BeFree_GAD |
Carcinogenesis | 0.003257302 | 12 | 0 | BeFree |
melanoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Prostatic Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
B-Cell Lymphomas | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Adrenal Cortical Adenoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Neuroendocrine Tumors | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Rheumatoid Arthritis | 0.002909916 | 2 | 0 | BeFree_GAD |
Spontaneous abortion | 0.00272435 | 1 | 0 | LHGDN |
Carpal Tunnel Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Choriocarcinoma | 0.00272435 | 1 | 0 | LHGDN |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
granulosa cell tumor | 0.00272435 | 1 | 0 | LHGDN |
Premature Obstetric Labor | 0.00272435 | 1 | 0 | LHGDN |
Metaplasia | 0.00272435 | 1 | 0 | LHGDN |
Leiomyomatosis | 0.00272435 | 1 | 0 | LHGDN |
Invasive breast carcinoma | 0.002714419 | 10 | 0 | BeFree |
Uterine Diseases | 0.002638474 | 2 | 0 | BeFree_GAD |
Adenocarcinoma Of Esophagus | 0.002638474 | 1 | 0 | BeFree_GAD |
Progesterone Resistance | 0.002442977 | 9 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.002367032 | 1 | 0 | GAD |
Connective Tissue Diseases | 0.002367032 | 1 | 0 | GAD |
Endocrine System Diseases | 0.002367032 | 1 | 0 | GAD |
Fetal Diseases | 0.002367032 | 1 | 0 | GAD |
Chronic Obstructive Airway Disease | 0.002367032 | 1 | 0 | GAD |
Lymphoma, Non-Hodgkin | 0.002367032 | 1 | 0 | GAD |
Musculoskeletal Diseases | 0.002367032 | 1 | 0 | GAD |
Osteoporosis | 0.002367032 | 1 | 0 | GAD |
Pregnancy Complications, Hematologic | 0.002367032 | 1 | 0 | GAD |
Proteinuria | 0.002367032 | 1 | 0 | GAD |
Delayed Puberty | 0.002367032 | 1 | 0 | GAD |
Precocious Puberty | 0.002367032 | 1 | 0 | GAD |
Dermatologic disorders | 0.002367032 | 1 | 0 | GAD |
Uterine Prolapse | 0.002367032 | 1 | 0 | GAD |
Ovarian Failure, Premature | 0.002367032 | 1 | 0 | GAD |
Erectile dysfunction | 0.002367032 | 1 | 0 | GAD |
Thrombophilia | 0.002367032 | 1 | 0 | GAD |
Hematocrit level | 0.002367032 | 1 | 1 | GAD |
Pregnancy loss | 0.002367032 | 1 | 0 | GAD |
Pregnancy associated hypertension | 0.002367032 | 1 | 0 | GAD |
Venous Thromboembolism | 0.002367032 | 1 | 0 | GAD |
Proteinuria Adverse Event | 0.002367032 | 1 | 0 | GAD |
Infection | 0.002367032 | 1 | 0 | GAD |
Noninfiltrating Intraductal Carcinoma | 0.002171535 | 8 | 0 | BeFree |
Endometrial adenocarcinoma | 0.002171535 | 8 | 0 | BeFree |
Meningioma, benign, no ICD-O subtype | 0.002171535 | 8 | 0 | BeFree |
Invasive Ductal Breast Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Prostate carcinoma | 0.001628651 | 6 | 0 | BeFree |
Carcinoma, Endometrioid | 0.001357209 | 5 | 0 | BeFree |
Carcinoma breast stage IV | 0.001357209 | 5 | 0 | BeFree |
Inflammatory Breast Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Carcinoma of lung | 0.001357209 | 5 | 0 | BeFree |
Astrocytoma | 0.001085767 | 4 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Tumor Progression | 0.001085767 | 4 | 0 | BeFree |
Ductal Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Sporadic Breast Carcinoma | 0.001085767 | 4 | 0 | BeFree |
Female Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Mucinous Adenocarcinoma | 0.000814326 | 3 | 0 | BeFree |
Colorectal Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Cystadenocarcinoma, Serous | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of female breast | 0.000814326 | 3 | 0 | BeFree |
Adenocarcinoma, Endometrioid | 0.000814326 | 3 | 0 | BeFree |
Adenoma | 0.000542884 | 2 | 0 | BeFree |
Anaplasia | 0.000542884 | 2 | 0 | BeFree |
Endometrial Hyperplasia | 0.000542884 | 2 | 0 | BeFree |
Lymphatic Metastasis | 0.000542884 | 2 | 0 | BeFree |
Ovarian Diseases | 0.000542884 | 2 | 0 | BeFree |
polyps | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of gallbladder | 0.000542884 | 2 | 0 | BeFree |
Endometriosis of ovary | 0.000542884 | 2 | 0 | BeFree |
Agenesis of corpus callosum | 0.000542884 | 2 | 0 | BeFree |
Endometrial Stromal Sarcoma | 0.000542884 | 2 | 0 | BeFree |
Comedone | 0.000542884 | 2 | 0 | BeFree |
Gallbladder Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Carcinoma of Male Breast | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of male breast | 0.000542884 | 2 | 0 | BeFree |
Endometriosis of uterus | 0.000542884 | 2 | 0 | BeFree |
Tumor Initiation | 0.000542884 | 2 | 0 | BeFree |
Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cardiomyopathy, Familial Idiopathic | 0.000542884 | 2 | 0 | BeFree |
Mammary Tumorigenesis | 0.000542884 | 2 | 0 | BeFree |
Ductal Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Endometrial Polyp | 0.000542884 | 2 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000542884 | 2 | 0 | BeFree |
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1 | 0.000542884 | 2 | 0 | BeFree |
malignant neoplasm of breast staging | 0.000542884 | 2 | 0 | BeFree |
Basal-Like Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Congenital Abnormality | 0.000271442 | 1 | 0 | BeFree |
Adenovirus Infections | 0.000271442 | 1 | 0 | BeFree |
Aortic Valve Insufficiency | 0.000271442 | 1 | 0 | BeFree |
Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Charcot-Marie-Tooth Disease | 0.000271442 | 1 | 0 | BeFree |
Chordoma | 0.000271442 | 1 | 0 | BeFree |
Craniopharyngioma | 0.000271442 | 1 | 0 | BeFree |
Cyst | 0.000271442 | 1 | 0 | BeFree |
Diabetes Insipidus | 0.000271442 | 1 | 0 | BeFree |
Psychosexual identity disorder | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Gonadal Dysgenesis | 0.000271442 | 1 | 0 | BeFree |
Cardiac Arrest | 0.000271442 | 1 | 0 | BeFree |
Mammary Ductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Kidney Neoplasm | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Chloasma | 0.000271442 | 1 | 0 | BeFree |
Myoma | 0.000271442 | 1 | 0 | BeFree |
Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
neurofibroma | 0.000271442 | 1 | 0 | BeFree |
Oligospermia | 0.000271442 | 1 | 0 | BeFree |
Pain | 0.000271442 | 1 | 0 | BeFree |
Paraganglioma | 0.000271442 | 1 | 0 | BeFree |
Tension Headache | 0.000271442 | 1 | 3 | BeFree |
Seizures | 0.000271442 | 1 | 0 | BeFree |
Seminoma | 0.000271442 | 1 | 0 | BeFree |
Thromboembolism | 0.000271442 | 1 | 0 | BeFree |
Turner Syndrome | 0.000271442 | 1 | 0 | BeFree |
Vertigo | 0.000271442 | 1 | 0 | BeFree |
Hepatitis E | 0.000271442 | 1 | 0 | BeFree |
Uterine Cancer | 0.000271442 | 1 | 0 | BeFree |
Aortic Aneurysm, Abdominal | 0.000271442 | 1 | 0 | BeFree |
Russell-Silver syndrome | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma, Tubular | 0.000271442 | 1 | 0 | BeFree |
Adrenocortical carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cervical Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
Nerve Sheath Tumors | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Papillary thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Impaired glucose tolerance | 0.000271442 | 1 | 0 | BeFree |
Stage III Breast Cancer AJCC v6 | 0.000271442 | 1 | 0 | BeFree |
Recurrent Endometrial Cancer | 0.000271442 | 1 | 0 | BeFree |
Lobular carcinoma in situ of breast | 0.000271442 | 1 | 0 | BeFree |
Invasive Lobular Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cervical Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Non-infiltrating lobular carcinoma | 0.000271442 | 1 | 0 | BeFree |
Anaplastic astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Breast Cancer, Familial | 0.000271442 | 1 | 0 | BeFree |
Atypical Endometrial Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Pulmonary lymphangioleiomyomatosis | 0.000271442 | 1 | 0 | BeFree |
Overweight | 0.000271442 | 1 | 0 | BeFree |
Hashimoto Disease | 0.000271442 | 1 | 0 | BeFree |
Progressive Neoplastic Disease | 0.000271442 | 1 | 0 | BeFree |
Malignant Female Reproductive System Neoplasm | 0.000271442 | 1 | 0 | BeFree |
early pregnancy | 0.000271442 | 1 | 0 | BeFree |
Stage I Endometrial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Placental Choriocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Stromal Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Contralateral breast cancer | 0.000271442 | 1 | 0 | BeFree |
Benign cystic nephroma | 0.000271442 | 1 | 0 | BeFree |
Atypical Ductal Breast Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Primary Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Well Differentiated Pancreatic Endocrine Tumor | 0.000271442 | 1 | 0 | BeFree |
Metastatic Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Breast Cancer Model | 0.000271442 | 1 | 0 | BeFree |
Apocrine Gland Carcinoma | 0.000271442 | 1 | 0 | BeFree |
SMITH-MCCORT DYSPLASIA | 0.000271442 | 1 | 0 | BeFree |
PANIC DISORDER 1 | 0.000271442 | 1 | 0 | BeFree |
Endometrial sarcoma | 0.000271442 | 1 | 0 | BeFree |
Stage III Breast Cancer AJCC v7 | 0.000271442 | 1 | 0 | BeFree |
Progressive cGVHD | 0.000271442 | 1 | 0 | BeFree |
High grade serous carcinoma | 0.000271442 | 1 | 0 | BeFree |
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