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The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白参与合成和果糖-2,6-二磷酸,它控制在真核生物糖酵解的调节分子的降解两者。所编码的蛋白质具有6-磷酸-2-激酶,其催化果糖-2,6-二磷酸的合成活性和果糖-2,6- biphosphatase活性催化的降解果糖-2,6-二磷酸。该蛋白质调节在心脏果糖-2,6-二磷酸的水平,而由不同的基因编码的相关酶调节在肝脏和肌肉果糖-2,6-二磷酸的水平。这种酶的功能如同二聚体。已发现该基因编码的两种不同亚型的两个转录变异体。 [由RefSeq的,2008年7月提供]
PFKFB2基因(以及对应的蛋白质)的细胞分布位置:
PFKFB2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Diabetic Nephropathy | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
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