PFKFB2(6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2)

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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1q31-q32.2
基因染色体位置图

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  由该基因编码的蛋白参与合成和果糖-2,6-二磷酸,它控制在真核生物糖酵解的调节分子的降解两者。所编码的蛋白质具有6-磷酸-2-激酶,其催化果糖-2,6-二磷酸的合成活性和果糖-2,6- biphosphatase活性催化的降解果糖-2,6-二磷酸。该蛋白质调节在心脏果糖-2,6-二磷酸的水平,而由不同的基因编码的相关酶调节在肝脏和肌肉果糖-2,6-二磷酸的水平。这种酶的功能如同二聚体。已发现该基因编码的两种不同亚型的两个转录变异体。 [由RefSeq的,2008年7月提供]

PFKFB2基因的碱基序列:[NCBI]
PFKFB2基因的碱基突变:           显示全部snp
rs1683223       rs1683224       rs1770375       rs1770376       rs1843350       rs2629673       rs2629674       rs2629675       rs2629676       rs2629677       rs2791712       rs2842732       rs2842733       rs74148939       rs74381794       rs77885822       rs79112133       rs79168343       rs79242479       rs115465863       rs138182350       rs138863725       rs138909539       rs142019500       rs143312142       rs145580624       rs145642008       rs148873335       rs149403231       rs149738584       rs150686829       rs181146090       rs181632077       rs184892168       rs189999173       rs192636086       rs368331612      
rs376636014       rs527488459       rs529632228       rs533551942       rs533669160       rs535744806       rs535780983       rs537534488       rs538182405       rs538451724       rs540651060       rs540763108       rs542509147       rs544037735       rs544334986       rs545017016       rs546974458       rs547138695       rs551499344       rs556029884       rs556311391       rs560497186       rs564617454       rs564735214       rs564772155       rs569558163       rs571110242       rs571820903       rs573178165       rs573375321       rs1560       rs1565       rs760418       rs873140       rs923109       rs1044145       rs1060286       rs1060287       rs1385611       rs1564879       rs1843349       rs2016939       rs2054779       rs2054780       rs2075863       rs2075864       rs2075865       rs2086950       rs2243816       rs2243821       rs2247227       rs2294151       rs2306714       rs2495255       rs2629639       rs2629662       rs2629663       rs2629664       rs2629665       rs2629666       rs2629668       rs2629669       rs2629670       rs2629671       rs2629672       rs2791694       rs2791695       rs2791696       rs2808448       rs2808449       rs2808451       rs2808454       rs2808455       rs2808459       rs2808460       rs2808461       rs2808462       rs2808463       rs2842734       rs2842735       rs2842737       rs2842738       rs2842739       rs2842740       rs2842741       rs2842742       rs2842751       rs2842752       rs2883211       rs3122006       rs3123020       rs3123021       rs3123022       rs3123023       rs3123024       rs3223018       rs3748671       rs3748672       rs3790619       rs3790620       rs3943180       rs4844372       rs4844565       rs6660341       rs6667268       rs6673109       rs6673422       rs6681069       rs7518420       rs7533554       rs7533742       rs7537730       rs7537842       rs9651116       rs10494893       rs10592048       rs10864035       rs11120092       rs11120093       rs11120096       rs11120103       rs11120106       rs11120132       rs11120137       rs11120138       rs11120148       rs11410821       rs11450882       rs11453040       rs11579764       rs11585761       rs11586959       rs11587070       rs11799614       rs11802037       rs12023977       rs12032074       rs12032180       rs12036080       rs12038734       rs12068090       rs12079709       rs12083861       rs12084230       rs12087244       rs12088135       rs12088688       rs12091658       rs12123107       rs12134333       rs12135736       rs12403925       rs12565951       rs17020154       rs17020177       rs17020241       rs17020246       rs17258711       rs17258746       rs34037939       rs34234509       rs34296817       rs34554658       rs34713211       rs34918838       rs35127634       rs35425352       rs36109022       rs41277168       rs41277170       rs56246017       rs56394126       rs57202133       rs57639876       rs58542431       rs59508076       rs59574192       rs59605013       rs59632371       rs59644154       rs59797299       rs60207276       rs60532078       rs60785875       rs61238361       rs61815042       rs61815043       rs61815044       rs67811376       rs71152502       rs71154803       rs71585862       rs71635120       rs71635121       rs71635122       rs72741388       rs72741390       rs72741394       rs72741396       rs74148940       rs74148941       rs74148954       rs74148964       rs74148965       rs74148966       rs74443579       rs74641571       rs74675284       rs74863032       rs74955624       rs75079916       rs75135370       rs75138554       rs75151836       rs75238705       rs75248492       rs75270349       rs75460793       rs75567902       rs75688200       rs75771971       rs75823532       rs76002912       rs76037296       rs76184547       rs76197836       rs76218475       rs76468397       rs76703655       rs77048645       rs77124580       rs77126663       rs77477276       rs77525039       rs77560413       rs77563599       rs77757597       rs77823746       rs77890788       rs77948961       rs78043860       rs78285730       rs78295730       rs78380553       rs78391991       rs78428289       rs78453485       rs78516387       rs78559703       rs78603860       rs78685887       rs78783521       rs78819617       rs78949186       rs78975419       rs79178367       rs79241934       rs79390089       rs79573332       rs80072806       rs80181065       rs111432079       rs111495074       rs111601138       rs111839978       rs111887797       rs111914593       rs111917867       rs111921730       rs111977500       rs112109800       rs112345013       rs112358170       rs112364288       rs112394959       rs112445778       rs112637563       rs112640250       rs112721961       rs112726801       rs112930070       rs112977358       rs113179854       rs113202550       rs113271843       rs113286154       rs113333059       rs113484476       rs113542550       rs113599718       rs113744370       rs113854529       rs113944518       rs113962276       rs114028317       rs114103143       rs114130383       rs114159306       rs114412380       rs114463741       rs114605640       rs114863905       rs114882700       rs114895372       rs115166198       rs115190692       rs115215260       rs115304126       rs115575628       rs115609680       rs115628600       rs115681425       rs115740223       rs115834779       rs115843166       rs115936855       rs115940287       rs116045064       rs116080852       rs116086996       rs116151410       rs116219970       rs116259799       rs116343847       rs116464956       rs116491777       rs116505937       rs116535482       rs116572563       rs116690867       rs116800649       rs116812862       rs116873749       rs117346480       rs117467160       rs117981509       rs137871267       rs138090851       rs138175215       rs138296069       rs138501759       rs138514623       rs138596532       rs138795471       rs138861272       rs138871764       rs139005215       rs139022558       rs139102708       rs139136253       rs139216194       rs139358134       rs139415738       rs139434104       rs139486178       rs139506084       rs139569764       rs139596812       rs139906712       rs139940261       rs140030854       rs140342917       rs140502878       rs140513718       rs140542364       rs140605738       rs140617763       rs140689140       rs140730046       rs140764704       rs140854483       rs140893848       rs140927801       rs140961819       rs141180301       rs141264336       rs141275871       rs141308420       rs141412483       rs141454250       rs141529894       rs141568066       rs141734566       rs141882001       rs141978310       rs142240027       rs142279758       rs142322124       rs142341535       rs142450533       rs142580422       rs142650834       rs142689863       rs142733751       rs142767185       rs142806334       rs142924765       rs142943270       rs143097222       rs143313693       rs143371487       rs143414381       rs143485437       rs143555970       rs143736099       rs143770601       rs143803309       rs143845015       rs143927581       rs143987031       rs143996234       rs144097232       rs144314283       rs144416667       rs144490826       rs144526589       rs144556613       rs144563941       rs144594752       rs144651649       rs144692490       rs144799602       rs144839602       rs144906173       rs144995332       rs145001863       rs145022644       rs145041417       rs145281846       rs145329872       rs145353324       rs145388036       rs145648377       rs145692263       rs145706392       rs145860401       rs145865857       rs145907760       rs145911185       rs145983193       rs146025508       rs146046568       rs146105658       rs146150824       rs146170578       rs146474253       rs146491575       rs146594783       rs146616886       rs146650687       rs146715119       rs146798316       rs146922991       rs146985955       rs147014775       rs147092580       rs147109113       rs147110080       rs147146509       rs147170880       rs147250602       rs147267978       rs147279128       rs147358194       rs147497310       rs147656233       rs147745326       rs147748093       rs147760629       rs148018717       rs148045204       rs148081224       rs148113978       rs148168219       rs148212144       rs148220409       rs148377657       rs148503601       rs148553616       rs148571910       rs148606497       rs148747964       rs148838761       rs148855767       rs149028478       rs149056956       rs149134237       rs149244901       rs149323408       rs149331734       rs149366245       rs149458015       rs149526634       rs149614308       rs149721272       rs149860441       rs149896688       rs150054502       rs150195628       rs150246998       rs150334113       rs150389224       rs150425160       rs150442637       rs150517912       rs150533135       rs150621612       rs150722402       rs150777774       rs150812063       rs151060645       rs151137785       rs180697561       rs180712901       rs181106826       rs181127052       rs181219769       rs181246147       rs181296362       rs181345198       rs181354659       rs181387785       rs181492527       rs181516816       rs181523616       rs181644645       rs181845723       rs181886214       rs182027125       rs182317232       rs182324387       rs182408520       rs182467663       rs182580914       rs182629763       rs182653857       rs182679214       rs182694371       rs182698323       rs182715009       rs182963209       rs183196967       rs183242880       rs183562469       rs183807217       rs183890131       rs183914038       rs184092237       rs184432317       rs184442347       rs184482841       rs184610923       rs184620546       rs184740839       rs184742290       rs184869891       rs184947630       rs184974554       rs184985494       rs185002447       rs185224884       rs185236021       rs185240385       rs185282414       rs185311785       rs185430541       rs185548161       rs185684609       rs185780040       rs186012605       rs186125518       rs186192051       rs186259720       rs186328207       rs186453644       rs186658965       rs186935958       rs186959823       rs186984695       rs187015867       rs187044828       rs187127494       rs187221078       rs187310574       rs187526385       rs187528909       rs187562256       rs187621173       rs187782465       rs187817091       rs187843324       rs188058305       rs188152706       rs188221724       rs188258683       rs188283496       rs188381658       rs188426402       rs188444521       rs188912033       rs189063582       rs189071790       rs189128815       rs189210736       rs189355581       rs189455551       rs189580921       rs189699475       rs189699872       rs189716265       rs189908523       rs189937703       rs189949494       rs189953197       rs190212060       rs190276601       rs190277486       rs190352771       rs190389935       rs190495140       rs190598841       rs190614303       rs190672989       rs190698633       rs190830483       rs190838906       rs191019928       rs191032412       rs191093352       rs191240209       rs191270782       rs191646445       rs191658180       rs191676694       rs191850113       rs191885151       rs191886349       rs191928369       rs192051497       rs192175681       rs192590868       rs192640678       rs192695946       rs192759122       rs192804641       rs192943338       rs192988574       rs193143600       rs193234530       rs193294435       rs199564348       rs199652286       rs199700937       rs199714014       rs199722325       rs199893469       rs199931363       rs200080448       rs200235696       rs200240324       rs200269450       rs200362087       rs200483747       rs200517654       rs200666435       rs200699550       rs200758571       rs200809973       rs200901163       rs200911504       rs201001884       rs201044693       rs201110872       rs201240901       rs201269070       rs201276939       rs201396040       rs201417050       rs201487012       rs201729561       rs201850722       rs201878894       rs201957555       rs202025113       rs202052371       rs202137836       rs202139419       rs202149100       rs367831695       rs367980347       rs367987133       rs368173522       rs368203997       rs368211965       rs368232953       rs368259601       rs368351595       rs368383952       rs368390449       rs368429672       rs368492680       rs368493401       rs368504995       rs368825459       rs368837257       rs369234901       rs369332885       rs369660408       rs369770123       rs369830635       rs370174396       rs370240765       rs370286212       rs370306581       rs370394719       rs370422762       rs370466943       rs370508953       rs370570633       rs370725057       rs370833416       rs371074690       rs371234146       rs371237535       rs371391519       rs371501961       rs371635178       rs371738308       rs371924985       rs371999507       rs372148879       rs372428009       rs372557808       rs372621164       rs372924528       rs373296390       rs373301868       rs373466659       rs373472473       rs373568677       rs373734556       rs373832742       rs373865025       rs373878170       rs373969318       rs374038539       rs374061882       rs374079970       rs374252100       rs374439073       rs374547175       rs374573264       rs374742937       rs374934247       rs374983269       rs375243008       rs375351860       rs375397808       rs375510178       rs375610533       rs375795424       rs375821245       rs375856749       rs376081486       rs376169267       rs376228365       rs376240448       rs376424760       rs376434591       rs376435555       rs376800687       rs376820840       rs376889709       rs376903734       rs376925374       rs377086278       rs377280561       rs377350701       rs377378366       rs377550837       rs397750506       rs397762811       rs527303584       rs527304685       rs527445913       rs527543194       rs527704101       rs527858795       rs527889248       rs528041055       rs528155089       rs528191857       rs528300417       rs528374878       rs528384137       rs528497030       rs528556518       rs528652091       rs528785409       rs528880288       rs529097657       rs529215249       rs529255243       rs529351229       rs529362860       rs529533266       rs529586490       rs529645722       rs529647665       rs529664624       rs529778001       rs529794857       rs529879403       rs529957138       rs530055307       rs530057215       rs530167183       rs530191306       rs530242163       rs530312205       rs530312345       rs530395377       rs530583490       rs530682885       rs530706484       rs530855034       rs530858969       rs531067191       rs531226246       rs531297320       rs531334003       rs531487877       rs531548549       rs531569714       rs531710741       rs531754021       rs531874035       rs531948253       rs531960467       rs532012450       rs532035745       rs532231770       rs532257170       rs532281236       rs532323458       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rs761188201       rs761259786       rs761345187       rs761380567       rs761537497       rs761550399       rs761650506       rs761831197       rs762097015       rs762102278       rs762186384       rs762272947       rs762277061       rs762445569       rs762500107       rs762529151       rs762614324       rs762873657       rs762892972       rs762959999       rs763043449       rs763255522       rs763326986       rs763341581       rs763360269       rs763423694       rs763511852       rs763519323       rs763559031       rs763651947       rs763685440       rs763886252       rs763920578       rs763934697       rs763976877       rs763984756       rs764023717       rs764049165       rs764173651       rs764177106       rs764192402       rs764263300       rs764267197       rs764441910       rs764493387       rs764583299       rs764651896       rs764660457       rs764673837       rs764749834       rs764836700       rs764855081       rs764890712       rs765035116       rs765036721       rs765089594       rs765128228       rs765201156       rs765219768       rs765367424       rs765398880       rs765599803       rs765728026       rs765840248       rs765860156       rs765909200       rs766006505       rs766153228       rs766211415       rs766301432       rs766338409       rs766471685       rs766558012       rs766636539       rs766753955       rs766754087       rs766907817       rs766937782       rs766951876       rs767018388       rs767037463       rs767119057       rs767288976       rs767305648       rs767315302       rs767436537       rs767485435       rs767583943       rs767665086       rs767775929       rs767797359       rs767860693       rs767930885       rs767982799       rs768085574       rs768238400       rs768351450       rs768555950       rs768572193       rs768705660       rs768723677       rs768903592       rs769025171       rs769086489       rs769092387       rs769125407       rs769173206       rs769204191       rs769235036       rs769465082       rs769483356       rs769497692       rs769652373       rs769776567       rs769816758       rs769845525       rs769907023       rs770099007       rs770113342       rs770180166       rs770226231       rs770228473       rs770318124       rs770373963       rs770374061       rs770491946       rs770522438       rs770560244       rs770566811       rs770733438       rs770872328       rs770905601       rs770934117       rs770942652       rs770970111       rs770977759       rs771050145       rs771233275       rs771286369       rs771445603       rs771660113       rs771753601       rs771795023       rs771936929       rs771938973       rs772026790       rs772028326       rs772075087       rs772116941       rs772208444       rs772256355       rs772400689       rs772418774       rs772479545       rs772581663       rs772673359       rs772683929       rs772759643       rs772977018       rs773074087       rs773199400       rs773241424       rs773361035       rs773378962       rs773466247       rs773613236       rs773743947       rs773770735       rs773903795       rs773987532       rs774072374       rs774170638       rs774273284       rs774350560       rs774352658       rs774477609       rs774512642       rs774581441       rs774632326       rs774949798       rs774950170       rs774953465       rs775039662       rs775219089       rs775222842       rs775366058       rs775413453       rs775425249       rs775429737       rs775487245       rs775535860       rs775616682       rs775973822       rs776024148       rs776061783       rs776089105       rs776216880       rs776296163       rs776369522       rs776451211       rs776499998       rs776563979       rs776571331       rs776582412       rs776741129       rs776811345       rs776841656       rs776857635       rs776927615       rs776928187       rs777114064       rs777159575       rs777244033       rs777404108       rs777433140       rs777531418       rs777576259       rs777720748       rs777797262       rs777805045       rs778106956       rs778195069       rs778197987       rs778285155       rs778448700       rs778452600       rs778483393       rs778496226       rs778669007       rs778687294       rs778689199       rs778828027       rs778954772       rs779065776       rs779115076       rs779118246       rs779142564       rs779242193       rs779314487       rs779390483       rs779520683       rs779669819       rs779707177       rs779818182       rs779834380       rs779972554       rs780009774       rs780085839       rs780176161       rs780293632       rs780374255       rs780380722       rs780399188       rs780468419       rs780541078       rs780650771       rs780665577       rs780777202       rs780815539       rs780882851       rs780905072       rs781226061       rs781330042       rs781437930       rs781681480       rs781753104       rs796267615      

PFKFB2基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
AGAAATGTTCATGGGCCTC
58
AGTTTCTTGGACACGTAGG
57
GCTCCATAGAAATATACCAAGTCTC
59
TGACTTTGGAAATCCTCCCT
59
ATCGTAGGACATCTGAAGAGC
60
CTCTGACATTCGAAGATTTGGG
60
TCAGAGAAGAAATGTTGCTGG
59
AGTTCAAGGTTGCAGTGAG
58
GCTCCATAGAAATATACCAAGTCTC
59
CTGACTTTGGAAATCCTCCCT
60
AGATCGTAGGACATCTGAAGAG
59
TCTGACATTCGAAGATTTGGG
59
AGAAACGGTACCCAGAAGAG
59
GTTTCCACTTTGCACCCTC
59
CAGAGAAGAAATGTTGCTGGA
59
GAGTTCAAGGTTGCAGTGAG
59
CAGAGAAGAAATGTTCATGGG
57
ATCATAACGATCAGAGTCGG
57
AGAAGAAATGTTGCTGGAGTG
59
CAGGAGTTCAAGGTTGCAG
59
      尚未收录相关数据

PFKFB2基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

PFKFB2基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0003824
A0A087X2H4(UniProtKB)
IEA
GO:0005524
A0A087X2H4(UniProtKB)
IEA
GO:0006003
A0A087X2H4(UniProtKB)
IEA
GO:0003873
F6RAZ1(UniProtKB)
IEA
GO:0005524
F6RAZ1(UniProtKB)
IEA
GO:0006000
F6RAZ1(UniProtKB)
IEA
GO:0006003
F6RAZ1(UniProtKB)
IEA
GO:0046835
F6RAZ1(UniProtKB)
IEA
GO:0003873
F6XNB3(UniProtKB)
IEA
GO:0005524
F6XNB3(UniProtKB)
IEA
GO:0006000
F6XNB3(UniProtKB)
IEA
GO:0006003
F6XNB3(UniProtKB)
IEA
GO:0046835
F6XNB3(UniProtKB)
IEA
GO:0003873
O60825(UniProtKB)
EXP
GO:0003873
O60825(UniProtKB)
IDA
GO:0003873
O60825(UniProtKB)
EXP
GO:0003873
O60825(UniProtKB)
EXP
GO:0003873
O60825(UniProtKB)
EXP
GO:0004331
O60825(UniProtKB)
IEA
GO:0005515
O60825(UniProtKB)
IPI
GO:0005524
O60825(UniProtKB)
IEA
GO:0005829
O60825(UniProtKB)
TAS
GO:0006000
O60825(UniProtKB)
IEA
GO:0006003
O60825(UniProtKB)
IEA
GO:0006089
O60825(UniProtKB)
IEA
GO:0006096
O60825(UniProtKB)
IDA
GO:0009749
O60825(UniProtKB)
IEA
GO:0016311
O60825(UniProtKB)
IEA
GO:0019901
O60825(UniProtKB)
IPI
GO:0019901
O60825(UniProtKB)
IPI
GO:0032024
O60825(UniProtKB)
IEA
GO:0033133
O60825(UniProtKB)
IEA
GO:0046835
O60825(UniProtKB)
IEA
GO:0061621
O60825(UniProtKB)
TAS
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控PFKFB2基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Diabetes Mellitus, Non-Insulin-Dependent 0.000271442 1 0 BeFree
Diabetic Nephropathy 0.000271442 1 0 BeFree
Carcinogenesis 0.000271442 1 0 BeFree
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