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The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质是代表一个家庭保守PDZ和LIM结构域组成的蛋白质的。 LIM结构域提出在蛋白质 - 蛋白质识别的功能在各种上下文包括基因的转录和发展,并在细胞骨架相互作用。这种蛋白质结合至蛋白激酶的LIM结构域,而PDZ结构域结合到肌动蛋白丝。该基因产物参与了RET / PTC2有丝分裂信号的传输的肌动蛋白丝相关复合必不可少的组件。生物学功能可能是,一个适配器,与PDZ结构域定位的LIM结合蛋白对肌动蛋白两者骨骼肌和非肌肉组织中的长丝。这个基因的选择性剪接的结果在多个转录变体。 [由RefSeq的,2008年7月提供]
PDLIM7基因(以及对应的蛋白质)的细胞分布位置:
PDLIM7基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Nasopharyngeal carcinoma | 0.046688002 | 172 | 0 | BeFree |
Lymphoma | 0.019272373 | 71 | 0 | BeFree |
Epstein-Barr Virus Infections | 0.011943442 | 44 | 0 | BeFree |
Carcinogenesis | 0.007328931 | 27 | 0 | BeFree |
Burkitt Lymphoma | 0.00434307 | 16 | 0 | BeFree |
Neoplasm Metastasis | 0.003800186 | 14 | 0 | BeFree |
T-Cell Lymphoma | 0.003800186 | 14 | 0 | BeFree |
Hodgkin Disease | 0.003528744 | 13 | 0 | BeFree |
HIV Infections | 0.003257302 | 12 | 0 | BeFree |
Infectious Mononucleosis | 0.003257302 | 12 | 0 | BeFree |
Lymphoproliferative Disorders | 0.002985861 | 11 | 0 | BeFree |
B-Cell Lymphomas | 0.002985861 | 11 | 0 | BeFree |
Pulpitis | 0.00272435 | 1 | 0 | LHGDN |
latent infection | 0.002714419 | 10 | 0 | BeFree |
Leukemogenesis | 0.002171535 | 8 | 0 | BeFree |
Nasal Type Extranodal NK/T-Cell Lymphoma | 0.001900093 | 7 | 0 | BeFree |
Stomach Carcinoma | 0.001900093 | 7 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.001628651 | 6 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.001628651 | 6 | 0 | BeFree |
Lymphoma, AIDS-Related | 0.001357209 | 5 | 0 | BeFree |
Hodgkin's disease, nodular sclerosis (clinical) | 0.001357209 | 5 | 0 | BeFree |
Breast Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Acquired Immunodeficiency Syndrome | 0.001085767 | 4 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.001085767 | 4 | 0 | BeFree |
Lymphohistiocytosis, Hemophagocytic | 0.001085767 | 4 | 0 | BeFree |
Tumor Progression | 0.001085767 | 4 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.001085767 | 4 | 0 | BeFree |
Primary Effusion Lymphoma | 0.001085767 | 4 | 0 | BeFree |
Epithelioma | 0.001085767 | 4 | 0 | BeFree |
Non-Neoplastic Disorder | 0.001085767 | 4 | 0 | BeFree |
Adenocarcinoma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
Squamous cell carcinoma | 0.000814326 | 3 | 0 | BeFree |
Peripheral T-Cell Lymphoma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of nasopharynx | 0.000814326 | 3 | 0 | BeFree |
Ki-1+ Anaplastic Large Cell Lymphoma | 0.000814326 | 3 | 0 | BeFree |
Cancer of Nasopharynx | 0.000814326 | 3 | 0 | BeFree |
Coinfection | 0.000814326 | 3 | 0 | BeFree |
Lymphoepithelial carcinoma | 0.000814326 | 3 | 0 | BeFree |
Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000542884 | 2 | 0 | BeFree |
leukemia | 0.000542884 | 2 | 0 | BeFree |
Reticulosarcoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000542884 | 2 | 0 | BeFree |
Precancerous Conditions | 0.000542884 | 2 | 0 | BeFree |
Undifferentiated carcinoma | 0.000542884 | 2 | 0 | BeFree |
Leukoplakia, Hairy | 0.000542884 | 2 | 0 | BeFree |
Hantavirus Infections | 0.000542884 | 2 | 0 | BeFree |
Hyperplasia of tonsils | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma, keratinizing | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Post-transplant lymphoproliferative disorder | 0.000542884 | 2 | 0 | BeFree |
Nasal and nasal-type NK/T-cell lymphoma | 0.000542884 | 2 | 0 | BeFree |
Chemical Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Classical Hodgkin's Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Xenograft Model | 0.000542884 | 2 | 0 | BeFree |
Leukemia, B-Cell | 0.000542884 | 2 | 0 | BeFree |
Adenolymphoma | 0.000271442 | 1 | 0 | BeFree |
AIDS related complex | 0.000271442 | 1 | 0 | BeFree |
Ataxia Telangiectasia | 0.000271442 | 1 | 0 | BeFree |
Autoimmune Diseases | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
Epidermodysplasia Verruciformis | 0.000271442 | 1 | 0 | BeFree |
Gastritis, Atrophic | 0.000271442 | 1 | 0 | BeFree |
Angioimmunoblastic Lymphadenopathy | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Lyme Disease | 0.000271442 | 1 | 0 | BeFree |
Lymphocytosis | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Non-Hodgkin | 0.000271442 | 1 | 0 | BeFree |
Myasthenia Gravis | 0.000271442 | 1 | 0 | BeFree |
Neurofibromatosis 2 | 0.000271442 | 1 | 0 | BeFree |
Opportunistic Infections | 0.000271442 | 1 | 0 | BeFree |
Otitis Media with Effusion | 0.000271442 | 1 | 0 | BeFree |
Papilloma | 0.000271442 | 1 | 0 | BeFree |
Rheumatism | 0.000271442 | 1 | 0 | BeFree |
Superinfection | 0.000271442 | 1 | 0 | BeFree |
Immunoblastic Large-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Benign Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Lymphomatoid Papulosis | 0.000271442 | 1 | 0 | BeFree |
Melanoma, Amelanotic | 0.000271442 | 1 | 0 | BeFree |
Nevi and Melanomas | 0.000271442 | 1 | 0 | BeFree |
Adult Hodgkin Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000271442 | 1 | 0 | BeFree |
Primary central nervous system lymphoma | 0.000271442 | 1 | 0 | BeFree |
Lymphoid hyperplasia | 0.000271442 | 1 | 0 | BeFree |
African Burkitt's lymphoma | 0.000271442 | 1 | 0 | BeFree |
Asymptomatic human immunodeficiency virus infection | 0.000271442 | 1 | 0 | BeFree |
Intrahepatic Cholangiocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Skin callus | 0.000271442 | 1 | 0 | BeFree |
Hematologic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Recurrent tumor | 0.000271442 | 1 | 0 | BeFree |
Increased drug resistance | 0.000271442 | 1 | 0 | BeFree |
Thyroid carcinoma | 0.000271442 | 1 | 0 | BeFree |
Oropharyngeal disorders | 0.000271442 | 1 | 0 | BeFree |
Lymphoid neoplasm | 0.000271442 | 1 | 0 | BeFree |
Progressive Neoplastic Disease | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Central nervous system lymphoma | 0.000271442 | 1 | 0 | BeFree |
Pharyngeal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
Primary Cutaneous Follicle Center Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Epstein-Barr Virus-Related Hodgkin Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Low Grade B-Cell Non-Hodgkin's Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Tumor Angiogenesis | 0.000271442 | 1 | 0 | BeFree |
Pyothorax-Associated Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Extranodal NK-T-Cell | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
Gastric Carcinoma with Lymphoid Stroma | 0.000271442 | 1 | 0 | BeFree |
Progressive cGVHD | 0.000271442 | 1 | 0 | BeFree |
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