PDK4(pyruvate dehydrogenase kinase, isozyme 4) 转至新版数据库

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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7q21.3-q22.1
基因染色体位置图

This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  此基因是PI3K / BCKDK蛋白激酶家族的成员,并且编码线粒体蛋白与组氨酸激酶结构域。该蛋白质位于mitrochondria的基质和通过磷酸化它的子单元之一,从而促进葡萄糖代谢的调节抑制丙酮酸脱氢酶复合物。这个基因的表达是由糖皮质激素,视黄酸和胰岛素调节。 [由RefSeq的,2008年7月提供]

PDK4基因的碱基序列:[NCBI]
PDK4基因的碱基突变:           显示全部snp
rs6930       rs6931       rs721828       rs1057830       rs2073977       rs2073978       rs2073979       rs2073981       rs2073982       rs2073983       rs2301630       rs3214117       rs3214118       rs3779478       rs3807891       rs3807892       rs3807893       rs3815024       rs4727323       rs4729201       rs4729202       rs6956280       rs6961090       rs6967337       rs7455945       rs7777797       rs7790272       rs7794844       rs7802814       rs9791957       rs10085495       rs10085637       rs10085643       rs10085778       rs10085780       rs10226786       rs10236474      
rs10246371       rs10247649       rs10251393       rs10256946       rs10257050       rs10263752       rs10265655       rs10265896       rs10271972       rs11308239       rs11377701       rs11453825       rs11505819       rs11531570       rs11541299       rs11763823       rs11763824       rs11768781       rs12333879       rs12531091       rs12668651       rs12704809       rs13243216       rs13243287       rs16868830       rs17166962       rs17166978       rs17626204       rs17704480       rs17704516       rs28426083       rs34898343       rs34998621       rs35903871       rs41278806       rs45507091       rs55669436       rs55687078       rs55761955       rs55769054       rs55793839       rs55879823       rs56007777       rs56391840       rs56662813       rs57517040       rs57539049       rs59196288       rs60323772       rs61275912       rs71939847       rs73430146       rs73430171       rs73708060       rs73708061       rs73708062       rs73708063       rs74889271       rs75011955       rs75046794       rs75379142       rs75705257       rs75724550       rs75786159       rs76276659       rs76532038       rs76707324       rs76909113       rs77268323       rs77299243       rs77418685       rs77784950       rs78131212       rs78345519       rs78819871       rs79188608       rs79439286       rs79850911       rs80104836       rs80188061       rs80207639       rs111736367       rs111781519       rs111789210       rs111880027       rs112276093       rs112312887       rs112315104       rs112485067       rs112486460       rs112728079       rs112831825       rs112832254       rs112889246       rs113171503       rs113175611       rs113352481       rs113710839       rs113740931       rs113756493       rs113782639       rs113858027       rs114190608       rs114471948       rs114729182       rs114851134       rs115118820       rs116426717       rs117383542       rs117513246       rs117717805       rs117779202       rs117797074       rs117917790       rs117951229       rs118047277       rs138077797       rs138194642       rs138286625       rs138685051       rs138870335       rs138949929       rs139166839       rs139435831       rs139531703       rs139618760       rs139936911       rs140459233       rs140587514       rs140591109       rs140631499       rs140946442       rs141055754       rs141812974       rs141836546       rs142205186       rs142619878       rs142711707       rs142724242       rs142890516       rs143337600       rs143358185       rs143416402       rs143510588       rs144013693       rs144262262       rs144421605       rs144504989       rs145028174       rs145092032       rs145170776       rs145651354       rs146279672       rs146781803       rs147123547       rs147139958       rs147359178       rs147399488       rs147594549       rs147835341       rs148379762       rs148442451       rs148902654       rs149180844       rs149188261       rs149495817       rs149510841       rs149798894       rs149949140       rs150312157       rs150572754       rs151033102       rs151312744       rs180813426       rs180815635       rs180928440       rs181104723       rs181545860       rs181666046       rs181738539       rs181770522       rs182197373       rs182738116       rs182815094       rs182838631       rs182911012       rs183477218       rs183605919       rs183638925       rs184140095       rs184246957       rs184302356       rs184350191       rs184406631       rs185071184       rs185173921       rs185804538       rs185821517       rs185924592       rs186337446       rs186387129       rs186597938       rs186794971       rs187066504       rs187163379       rs187214306       rs187361003       rs187383231       rs187736530       rs188060415       rs188347996       rs188492258       rs188717303       rs188866962       rs188986082       rs189231217       rs189376761       rs189647329       rs190099794       rs190139178       rs190245608       rs190415995       rs190789727       rs191200656       rs191517131       rs191756870       rs191975204       rs192245329       rs192276835       rs192828685       rs193220344       rs199648076       rs199786522       rs199796727       rs199858922       rs200015612       rs200124780       rs200374786       rs200456990       rs200483727       rs200604888       rs200715550       rs201042936       rs201608061       rs202019690       rs202113705       rs368005050       rs368151859       rs368472229       rs368499648       rs368570522       rs368787692       rs369318011       rs369626643       rs369797016       rs369830227       rs369836816       rs371044935       rs371162048       rs371173030       rs371206221       rs371597484       rs371638350       rs371883363       rs372238246       rs372298783       rs372371763       rs372577409       rs372830058       rs373501807       rs373531855       rs373793979       rs374200525       rs375253128       rs375477069       rs375855736       rs376023628       rs376650787       rs377064599       rs377403907       rs377435140       rs377438698       rs397708336       rs527260202       rs527268499       rs528239621       rs528302234       rs528451312       rs528466543       rs528501122       rs528748920       rs529080826       rs529093584       rs529161296       rs529229731       rs529250911       rs529304032       rs530118760       rs530212240       rs530959960       rs531161220       rs531267517       rs532583380       rs532810074       rs532882406       rs532980663       rs533215690       rs533215828       rs533223411       rs533559804       rs533736917       rs533932905       rs534043470       rs534188044       rs534253090       rs534531557       rs534959326       rs535269185       rs535282730       rs535435215       rs535661838       rs535706328       rs536232495       rs536818563       rs536870611       rs537152904       rs537308156       rs537482911       rs537718330       rs538295520       rs538445627       rs538664118       rs539205617       rs539480866       rs539643494       rs539682755       rs539761447       rs539884145       rs540031174       rs540650384       rs540717857       rs541094654       rs541223405       rs541261330       rs541872120       rs542006576       rs542700329       rs543517135       rs544384673       rs544853482       rs544888701       rs544914546       rs544948434       rs544961347       rs545145613       rs546096248       rs546364803       rs546450946       rs547182527       rs547219280       rs547260776       rs547325363       rs547394762       rs547433830       rs547468540       rs547505116       rs547848825       rs548206527       rs549032243       rs549240128       rs549460174       rs549502073       rs549831176       rs549868208       rs549868286       rs550065276       rs550213362       rs550379902       rs551302033       rs551398653       rs551622040       rs551797155       rs551859881       rs551962357       rs552073373       rs552657466       rs552783951       rs552986891       rs553085524       rs553122450       rs553708511       rs553835966       rs553888288       rs554186102       rs554442234       rs554458142       rs555387007       rs555643757       rs555654257       rs555809105       rs555925094       rs556186582       rs556361873       rs556420771       rs556523037       rs557032727       rs557813128       rs557883499       rs557904065       rs558028303       rs558285564       rs558410517       rs559075145       rs559112811       rs559421074       rs559459920       rs559592926       rs559794860       rs559831920       rs560709844       rs560855209       rs560865642       rs561421793       rs561668347       rs561903734       rs562078853       rs563256021       rs563507149       rs563563156       rs563601879       rs564366108       rs564742678       rs564779032       rs564853579       rs565089660       rs565162472       rs565566481       rs565709253       rs565871124       rs566014403       rs566354809       rs566391975       rs566435947       rs566508599       rs567835180       rs567852270       rs567865611       rs568478773       rs568507969       rs568603790       rs568962273       rs569689213       rs569837685       rs569839605       rs569850853       rs569876846       rs570301720       rs570302308       rs570593845       rs570749459       rs570789977       rs570872404       rs571370772       rs571832928       rs571872050       rs572089053       rs572553193       rs572718482       rs572878455       rs573326060       rs574106359       rs574597262       rs574602410       rs574759565       rs574850883       rs575034280       rs575081419       rs575103303       rs575696004       rs575852648       rs575856766       rs576248117       rs576891848       rs576930404       rs576965441       rs576973111       rs577000902       rs577173727       rs577300089       rs577711812       rs577851681       rs745442156       rs745466754       rs745535347       rs745772248       rs745812455       rs746053199       rs746061320       rs746096035       rs746105271       rs746307983       rs746583324       rs746612085       rs746666891       rs746671113       rs746824069       rs746943695       rs747476823       rs747477391       rs747530903       rs747697940       rs747724943       rs747813883       rs747830308       rs747864807       rs747960246       rs748080105       rs748244593       rs748329290       rs748332461       rs748569308       rs748607737       rs748659153       rs748696959       rs748812653       rs748983254       rs749091852       rs749173253       rs749224146       rs749470582       rs749525445       rs749991551       rs750023611       rs750048670       rs750098716       rs750291433       rs750335290       rs750530596       rs750654145       rs750944529       rs750960312       rs750999457       rs751174590       rs751178394       rs751310466       rs751427778       rs751482694       rs751536162       rs751987382       rs752080168       rs752082169       rs752088766       rs752133501       rs752189618       rs752323634       rs752648217       rs752699590       rs752719218       rs752883045       rs752936020       rs753059974       rs753091810       rs753250526       rs753289845       rs753446025       rs753468545       rs753470069       rs754025990       rs754050926       rs754089089       rs754294855       rs754344072       rs754397216       rs754493607       rs754505335       rs754584063       rs754603051       rs754619358       rs754714471       rs754761511       rs754896651       rs755127684       rs755170552       rs755305617       rs755394834       rs755500476       rs755634578       rs755867869       rs755882685       rs756282998       rs756337600       rs756464611       rs756496307       rs756847269       rs757038427       rs757069036       rs757459271       rs757492332       rs757562584       rs757783042       rs757954688       rs758007731       rs758124942       rs758185539       rs758240007       rs758555265       rs758770873       rs758784433       rs758825397       rs758909139       rs759058513       rs759387167       rs759412155       rs759425051       rs759440205       rs759597184       rs759650133       rs759750583       rs759970557       rs760041700       rs760088833       rs760465232       rs760509026       rs760602979       rs760806795       rs760843916       rs760896849       rs760990105       rs761104203       rs761208280       rs761299785       rs761301745       rs761393454       rs761581417       rs761757125       rs761825179       rs762058586       rs762111077       rs762138462       rs762258957       rs762265741       rs762526825       rs762578203       rs762761346       rs762963833       rs762993344       rs763088476       rs763399054       rs763450682       rs763489945       rs763633387       rs764123038       rs764196920       rs764277688       rs764370330       rs764467241       rs764706747       rs764918994       rs764938361       rs764958095       rs764971363       rs765007833       rs765193556       rs765375713       rs765437670       rs765590601       rs765645934       rs765829511       rs765846710       rs765886240       rs766002928       rs766037324       rs766323124       rs766485649       rs766937906       rs767004661       rs767139166       rs767418573       rs767447839       rs767561694       rs767625904       rs767793067       rs767890251       rs768136223       rs768163371       rs768194487       rs768268013       rs768353161       rs768476874       rs768547066       rs768551837       rs768604884       rs768653438       rs768873915       rs768990382       rs769166610       rs769212688       rs769262377       rs769266305       rs769599517       rs769677730       rs769786800       rs769965484       rs769968902       rs770226873       rs770238695       rs770315064       rs770530781       rs770546387       rs770704951       rs770709769       rs771001378       rs771219429       rs771254041       rs771397690       rs771640261       rs771679623       rs771912505       rs771967689       rs772062385       rs772166748       rs772641810       rs772690049       rs772711557       rs772836273       rs772938534       rs773129064       rs773137431       rs773242959       rs773355694       rs773653659       rs773690779       rs773695803       rs773890670       rs774099052       rs774177893       rs774230024       rs774255572       rs774308586       rs774355643       rs774590027       rs774700038       rs774742462       rs775354659       rs775479775       rs775486562       rs775746034       rs775854779       rs775862416       rs775906071       rs776064625       rs776177150       rs776223179       rs776417264       rs776511468       rs776600435       rs776653766       rs776745098       rs776885608       rs776962867       rs777078884       rs777114527       rs777118998       rs777172372       rs777353078       rs777500832       rs777726425       rs777737739       rs777960146       rs778188332       rs778383694       rs778523580       rs778644301       rs778695716       rs778873530       rs778986105       rs779233228       rs779314535       rs779332398       rs779460707       rs779518490       rs779714324       rs779755950       rs779849913       rs779904666       rs780081754       rs780129342       rs780218586       rs780366221       rs780539466       rs780692512       rs780745837       rs780763596       rs780800197       rs780885202       rs780975319       rs781041340       rs781255760       rs781280217       rs781494367       rs781496457       rs781549505       rs869176775      

PDK4基因在不同组织中的表达:    [UniProt]

基因在不同组织中的表达图
正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GCTACTGGACTTTGGTTCAG
59
TTCAGAATGTTGGCGAGTC
58
TGGATAATTCCCGGAATGC
58
AGACGAGAAATTGGCAAGC
59
TGGATAATTCCCGGAATGCT
59
AGACGAGAAATTGGCAAGC
59
ACTCACAGACAGGAAACCC
59
CAAAGGCATCTTGGACCAC
59
CTCACAGACAGGAAACCCA
59
TCAAAGGCATCTTGGACCA
59
CTATTTAAGAATGCAATGCGGG
59
TCCCAAGACAACAATAACCTC
58
CTATTTAAGAATGCAATGCGGG
59
GCGGTCAATAATTCTCAGGG
59
CTATTTAAGAATGCAATGCGGG
59
TTCCCAAGACAACAATAACCTC
59
CTATTTAAGAATGCAATGCGGG
59
TCCCAAGACAACAATAACCTC
58
CTATTTAAGAATGCAATGCGGG
59
TTCCCAAGACAACAATAACCTC
59
      尚未收录相关数据

PDK4基因(以及对应的蛋白质)的细胞分布位置:

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

PDK4基因的本体(GO)信息:

GO库代码
对应的蛋白质
来源代码
GO:0002230
Q16654(UniProtKB)
IMP
GO:0004672
Q16654(UniProtKB)
IDA
GO:0004740
Q16654(UniProtKB)
ISS
GO:0004740
Q16654(UniProtKB)
EXP
GO:0005524
Q16654(UniProtKB)
IDA
GO:0005739
Q16654(UniProtKB)
TAS
GO:0005743
Q16654(UniProtKB)
IEA
GO:0005759
Q16654(UniProtKB)
TAS
GO:0006006
Q16654(UniProtKB)
IEA
GO:0006468
Q16654(UniProtKB)
IEA
GO:0006468
Q16654(UniProtKB)
IEA
GO:0006885
Q16654(UniProtKB)
ISS
GO:0008286
Q16654(UniProtKB)
IMP
GO:0009267
Q16654(UniProtKB)
IDA
GO:0010510
Q16654(UniProtKB)
IMP
GO:0010510
Q16654(UniProtKB)
TAS
GO:0010565
Q16654(UniProtKB)
ISS
GO:0010906
Q16654(UniProtKB)
IMP
GO:0042304
Q16654(UniProtKB)
IMP
GO:0042593
Q16654(UniProtKB)
ISS
GO:0042594
Q16654(UniProtKB)
ISS
GO:0045124
Q16654(UniProtKB)
IEA
GO:0046320
Q16654(UniProtKB)
ISS
GO:0071398
Q16654(UniProtKB)
IMP
GO:0072593
Q16654(UniProtKB)
IMP
GO:0098792
Q16654(UniProtKB)
IMP
GO:2000811
Q16654(UniProtKB)
IMP
基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

可能调控PDK4基因的相关microRNA:     


通路基因列表
疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Diabetes Mellitus, Experimental 0.12 1 0 CTD_human
Myocardial Ischemia 0.12 1 0 CTD_human
Drug-Induced Liver Injury 0.12 1 0 CTD_human
Diabetes Mellitus, Non-Insulin-Dependent 0.003181358 4 0 BeFree_GAD
Obesity 0.001900093 7 0 BeFree
Primary biliary cirrhosis 0.000271442 1 0 BeFree
Diabetes 0.000271442 1 0 BeFree
Diabetes Mellitus 0.000271442 1 0 BeFree
Heart failure 0.000271442 1 0 BeFree
Congestive heart failure 0.000271442 1 0 BeFree
Liver neoplasms 0.000271442 1 0 BeFree
Metabolic Syndrome X 0.000271442 1 0 BeFree
Cardiomyopathies 0.000271442 1 0 BeFree
Liver carcinoma 0.000271442 1 0 BeFree
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