PDHB(pyruvate dehydrogenase (lipoamide) beta)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

3p21.1-p14.2
基因染色体位置图

基因简述

基因简述

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012]

[中文简述(自动翻译):]  的丙酮酸脱氢酶（PDH）复合物是核编码的线粒体多酶复合催化丙酮酸的总转化为乙酰-CoA和二氧化碳，并提供了糖酵解和三羧酸（TCA）循环之间的主要链路。 PDH复合物是由三个酶组分的多个拷贝：丙酮酸脱氢酶（E1），二氢硫辛酰胺乙酰转移酶（E2）和硫辛酰胺脱氢酶（E3）。将E1酶是两个α和两个β亚基的异四聚体。这个基因编码的E1β亚基。在这种基因突变与丙酮酸脱氢酶的E1-β缺乏有关。另外剪接转录变体也发现了这种基因。 [由RefSeq的，2012年3月提供]

OMIM数据库中对PDHB基因的介绍     Wikipedia数据库中对PDHB基因的介绍

基因序列

基因序列

PDHB基因的碱基序列：[NCBI]

基因突变

基因突变

PDHB基因的碱基突变：           显示全部snp
rs4228       rs7230       rs7231       rs13446       rs1126551       rs1126722       rs1126735       rs1126737       rs2070662       rs2070663       rs4264746       rs4519721       rs4585221       rs6445980       rs6793328       rs7636609       rs7644348       rs7644457       rs9843505       rs9859048       rs11130640       rs11130641       rs11130642       rs11448807       rs11542399       rs11542400       rs11542403       rs11714342       rs11719957       rs11924677       rs11925862       rs34086582       rs35021151       rs35161513       rs55646457       rs57698587       rs59707053      
rs62259772       rs62259773       rs71311871       rs73837619       rs74961525       rs75014325       rs75734796       rs75997072       rs76395768       rs80150118       rs111261470       rs111470467       rs111528004       rs112241256       rs112386401       rs113030830       rs113153897       rs114307676       rs114356889       rs114418136       rs115303242       rs116112173       rs116447404       rs116531008       rs117036213       rs138014477       rs138128142       rs138621975       rs138623728       rs138764163       rs139242990       rs139835904       rs140169849       rs140189381       rs140744404       rs140921216       rs141320959       rs141665413       rs142371617       rs142435308       rs143575120       rs143765288       rs143972496       rs144642159       rs145795547       rs145876456       rs146173916       rs146343258       rs146644840       rs146996786       rs147692835       rs147702713       rs147868319       rs148770511       rs148957406       rs149508713       rs149830613       rs150033697       rs150167131       rs150354906       rs150509703       rs151247980       rs180863888       rs181172651       rs181475983       rs181728113       rs181791863       rs182733445       rs182746311       rs183127876       rs183256025       rs183736416       rs185009343       rs185323973       rs185973684       rs186327119       rs186502576       rs186680097       rs187368956       rs187835871       rs187914052       rs188012228       rs188592703       rs189229629       rs189772994       rs189919009       rs190336011       rs191022498       rs191037973       rs191325669       rs192604927       rs192925800       rs193153485       rs199983136       rs200016955       rs200429396       rs200470565       rs200752186       rs200879699       rs201105914       rs201199166       rs201243189       rs201419993       rs201470762       rs202068841       rs202179460       rs202185395       rs202236415       rs367624729       rs367846961       rs368051123       rs368600391       rs368608656       rs369190855       rs369381070       rs369597245       rs369848168       rs370072205       rs370791038       rs370951271       rs370978658       rs371049788       rs371327763       rs371610965       rs371641536       rs372542473       rs372743787       rs372901315       rs373027442       rs373647605       rs373907802       rs374476885       rs374998876       rs375277648       rs375372930       rs375533042       rs375651141       rs375739181       rs375893467       rs376110096       rs376172219       rs377063331       rs377553050       rs377559288       rs377743897       rs527914728       rs527954769       rs528568497       rs529671428       rs530262800       rs530309201       rs530791570       rs530847041       rs531403748       rs532046529       rs532597315       rs532600354       rs533227902       rs533249609       rs533351698       rs533543785       rs533811754       rs534238658       rs534562086       rs534688111       rs534706661       rs535462676       rs535497534       rs535653740       rs535839290       rs536665920       rs536872599       rs537044531       rs537466954       rs537881892       rs537906921       rs539491929       rs539695774       rs540612962       rs540649170       rs540844519       rs541790635       rs541827758       rs541866818       rs542002290       rs542039224       rs542355452       rs542992413       rs543027212       rs543146348       rs544645994       rs545763314       rs545829568       rs545965871       rs546430652       rs546485141       rs546960117       rs547008035       rs547747406       rs547981359       rs548018522       rs548113809       rs548152504       rs548188250       rs548321877       rs549485819       rs550044537       rs550325164       rs550641076       rs550893110       rs551057370       rs551263757       rs551493298       rs552120699       rs552159384       rs553102391       rs553284689       rs554441383       rs555536762       rs555858023       rs556808640       rs557082585       rs558261690       rs559350810       rs559406419       rs559443383       rs560435862       rs560471742       rs561421099       rs561873251       rs563648869       rs563856964       rs564392651       rs565597873       rs565649436       rs565786614       rs566585235       rs566760661       rs567363262       rs567740260       rs568065584       rs568840906       rs568877543       rs568989787       rs569429778       rs569995418       rs570116773       rs570638099       rs570821545       rs571268780       rs571916423       rs571955200       rs572029073       rs572780674       rs572913729       rs573178040       rs573561603       rs573987651       rs574586426       rs575047606       rs575355121       rs575620964       rs575626121       rs575695756       rs576758341       rs577058311       rs577439548       rs577477453       rs578068165       rs745316732       rs745472320       rs745487481       rs745590589       rs745760468       rs746151723       rs746264903       rs746327054       rs746496960       rs746720442       rs746733180       rs746797295       rs746925158       rs747019479       rs747186193       rs747302644       rs747573712       rs747619112       rs747916943       rs748243880       rs748366089       rs748490971       rs748810067       rs748895863       rs748951756       rs749094591       rs749197773       rs749285624       rs749527278       rs749682039       rs749945707       rs750131192       rs750430342       rs750473348       rs750557535       rs750640383       rs750694855       rs750784388       rs750876078       rs751111486       rs751173808       rs751210948       rs751592623       rs751689672       rs751921912       rs751928661       rs752036587       rs752056463       rs752257037       rs752332234       rs752488385       rs752521945       rs752534681       rs752966556       rs753010923       rs753203123       rs753206504       rs753447396       rs753484780       rs753535352       rs753672410       rs753757096       rs753764192       rs754190213       rs754359135       rs754446937       rs754460400       rs754519817       rs754609532       rs754765239       rs755045002       rs755440612       rs755528489       rs755530531       rs755616546       rs755756637       rs756086285       rs756246761       rs756488021       rs756497263       rs756767523       rs756859963       rs756931309       rs757232232       rs757249455       rs757394994       rs757583494       rs757645498       rs757871580       rs757927904       rs758123959       rs758137448       rs758213613       rs758352130       rs758607444       rs758723673       rs758735231       rs758817438       rs759053641       rs759461639       rs759539954       rs759598078       rs759802905       rs760034027       rs760143249       rs760257449       rs760280654       rs760374916       rs760451644       rs760789048       rs760966357       rs761028060       rs761142168       rs761435735       rs761614417       rs761623331       rs761809361       rs761923972       rs762195573       rs762371237       rs762581609       rs762644804       rs762766442       rs762854351       rs762870333       rs762944918       rs762964497       rs763021302       rs763209074       rs763235215       rs763659400       rs763818341       rs763842440       rs763844372       rs763932421       rs764153948       rs764281059       rs764495667       rs764583964       rs764720857       rs764990413       rs765078544       rs765368254       rs765442576       rs765457802       rs765703598       rs765951512       rs766040401       rs766151501       rs766412593       rs766540951       rs766625162       rs766717235       rs766730807       rs766780930       rs767104647       rs767174898       rs767190387       rs767192593       rs767280392       rs767589310       rs767645261       rs767702098       rs767789838       rs767832452       rs767836122       rs767911301       rs768102131       rs768436316       rs768584790       rs768663547       rs768738492       rs768916456       rs769091152       rs769095344       rs769187141       rs769325692       rs769394650       rs769662255       rs769880461       rs770012349       rs770061802       rs770144405       rs770308835       rs770328219       rs770329762       rs770545101       rs770760887       rs770804747       rs770940287       rs771426412       rs771466468       rs771604602       rs771813233       rs771853453       rs771858838       rs771901438       rs771948680       rs772084220       rs772087134       rs772267416       rs772328849       rs772841047       rs772873112       rs772939767       rs773027388       rs773139051       rs773256169       rs773433623       rs773610612       rs773743155       rs773743199       rs774007894       rs774045622       rs774096539       rs774186597       rs774212597       rs774300247       rs774472788       rs774756909       rs774790423       rs774836997       rs774966195       rs775303009       rs775351153       rs775425923       rs775492700       rs775631842       rs775723468       rs775789707       rs775884188       rs775907917       rs775909374       rs776545975       rs776671828       rs776938446       rs776940070       rs777024340       rs777056005       rs777117759       rs777401294       rs777477549       rs777514148       rs777639555       rs777698544       rs777786689       rs777897790       rs777985591       rs778048353       rs778464488       rs778465584       rs778552746       rs778727916       rs778741789       rs778745122       rs779577082       rs779611285       rs779699743       rs779872594       rs779962985       rs780059698       rs780150185       rs780170320       rs780552911       rs780726798       rs780733289       rs780834096       rs780920031       rs781299313       rs781599347       rs781681934       rs781736851      

基因表达

基因表达

PDHB基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
AGGAGCTGGAAAGAGATGAG
58
CTCGACTAACCTTGTATGCC
58
GGAGCTGGAAAGAGATGAG
57
CCTCGACTAACCTTGTATGC
58
CCCATATCAGAGATGGGCT
58
GGTCATAAATTCACAAATGGGC
58
AGGAGCTGGAAAGAGATGAG
58
CCTCGACTAACCTTGTATGC
58
TCCCATATCAGAGATGGGC
58
GTCATAAATTCACAAATGGGCC
58
CACTCCCATATCAGAGATGG
57
ATAAATTCACAAATGGGCCG
57

转录因子

转录因子

      尚未收录相关数据

基因本体信息

PDHB基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

PDHB基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004739
C9J634(UniProtKB)
IEA
GO:0005654
C9J634(UniProtKB)
IDA
GO:0005739
C9J634(UniProtKB)
IDA
GO:0006086
C9J634(UniProtKB)
IEA
GO:0055114
C9J634(UniProtKB)
IEA
GO:0004739
F8WF02(UniProtKB)
IEA
GO:0006086
F8WF02(UniProtKB)
IEA
GO:0055114
F8WF02(UniProtKB)
IEA
GO:0004738
P11177(UniProtKB)
IDA
GO:0004739
P11177(UniProtKB)
IEA
GO:0005515
P11177(UniProtKB)
IPI
GO:0005634
P11177(UniProtKB)
IDA
GO:0005654
P11177(UniProtKB)
IDA
GO:0005739
P11177(UniProtKB)
IDA
GO:0005759
P11177(UniProtKB)
TAS
GO:0005759
P11177(UniProtKB)
TAS
GO:0005759
P11177(UniProtKB)
TAS
GO:0005759
P11177(UniProtKB)
TAS
GO:0006006
P11177(UniProtKB)
IEA
GO:0006086
P11177(UniProtKB)
IDA
GO:0006090
P11177(UniProtKB)
TAS
GO:0006099
P11177(UniProtKB)
IDA
GO:0010510
P11177(UniProtKB)
TAS
GO:0045254
P11177(UniProtKB)
IDA
GO:0046487
P11177(UniProtKB)
TAS
GO:0061732
P11177(UniProtKB)
IC
GO:0070062
P11177(UniProtKB)
IDA
GO:0034604
P11177(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控PDHB基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Pyruvate Dehydrogenase E1-Beta Deficiency 0.24 1 2 ORPHANET_UNIPROT
Pyruvate Dehydrogenase Complex Deficiency Disease 0.120271442 2 0 BeFree_CTD_human
Renal Cell Carcinoma 0.12 1 0 CTD_human

基因相关文献

基因相关文献

基因相关服务

基因相关服务

基因评论

基因评论

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