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This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
[中文简述(自动翻译):]  该基因是IV型,环AMP(cAMP)的特异性,环核苷酸磷酸二酯酶(PDE)家族的一个成员。所编码的蛋白质调节环核苷酸的细胞浓度,从而起到信号传导的作用。这种蛋白质的改变的活性已经与精神分裂症和双相情感障碍有关。选择性剪接和使用在多个转录替代的启动子的结果变体编码不同同种型。 [由RefSeq的,2014年7月提供]
PDE4B基因(以及对应的蛋白质)的细胞分布位置:
PDE4B基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Schizophrenia | 0.144894164 | 19 | 0 | BeFree_CTD_human_GAD_LHGDN |
| Bipolar Disorder | 0.123181358 | 3 | 0 | BeFree_CTD_human_GAD |
| Alcoholic Intoxication, Chronic | 0.122367032 | 2 | 0 | CTD_human_GAD |
| Asthma | 0.120271442 | 2 | 0 | BeFree_CTD_human |
| Autistic Disorder | 0.120271442 | 1 | 0 | BeFree_CTD_human |
| Leukemia, Myelocytic, Acute | 0.12 | 1 | 0 | CTD_human |
| Dermatologic disorders | 0.12 | 1 | 0 | CTD_human |
| Myocardial Ischemia | 0.12 | 1 | 0 | CTD_human |
| Amphetamine-Related Disorders | 0.12 | 1 | 0 | CTD_human |
| Arsenic Poisoning | 0.12 | 1 | 0 | CTD_human |
| Staphylococcus aureus infection | 0.12 | 1 | 1 | GWASCAT |
| Multiple Sclerosis | 0.004734064 | 2 | 0 | GAD |
| B-Cell Lymphomas | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Chronic Lymphocytic Leukemia | 0.00272435 | 1 | 0 | LHGDN |
| Major Depressive Disorder | 0.002638474 | 1 | 0 | BeFree_GAD |
| Amyotrophic Lateral Sclerosis | 0.002367032 | 1 | 2 | GAD |
| Carotid Artery Diseases | 0.002367032 | 1 | 2 | GAD |
| Dyskinesia, Drug-Induced | 0.002367032 | 1 | 0 | GAD |
| Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
| Blood pressure finding | 0.002367032 | 1 | 1 | GAD |
| Systemic arterial pressure | 0.002367032 | 1 | 1 | GAD |
| Fibrinogen Adverse Event | 0.002367032 | 1 | 1 | GAD |
| Mental disorders | 0.001357209 | 5 | 0 | BeFree |
| Mental Depression | 0.001085767 | 4 | 0 | BeFree |
| Depressive disorder | 0.001085767 | 4 | 0 | BeFree |
| Diffuse Large B-Cell Lymphoma | 0.001085767 | 4 | 0 | BeFree |
| Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Leukopenia | 0.000271442 | 1 | 4 | BeFree |
| Neutropenia | 0.000271442 | 1 | 4 | BeFree |
| Respiration Disorders | 0.000271442 | 1 | 0 | BeFree |
| Unipolar Depression | 0.000271442 | 1 | 0 | BeFree |
| Lingual-Facial-Buccal Dyskinesia | 0.000271442 | 1 | 0 | BeFree |
| Autoimmune thyroid disease | 0.000271442 | 1 | 0 | BeFree |
| Tardive Dyskinesia | 0.000271442 | 1 | 0 | BeFree |
| Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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