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Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]
[中文简述(自动翻译):]  环核苷酸磷酸二酯酶(PDE)通过调节通过cAMP和/或cGMP的水解细胞内环核苷酸的浓度,以它们各自的核苷5‘单磷酸起到信号传导的作用。在PDE1家族成员,如PDE1A,为Ca(2 +)/钙调蛋白(见CALM1; MIM 114180)是由钙调素在钙的存在(2+)(Michibata等激活依赖偏微分方程(CAM-偏微分方程)人,2001年[考研11342109]。Fidock等,2002 [考研11747989])[由OMIM,2009年10月提供]
PDE1A基因(以及对应的蛋白质)的细胞分布位置:
PDE1A基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Mental Depression | 0.004734064 | 2 | 0 | GAD |
Atherosclerosis | 0.00272435 | 1 | 0 | LHGDN |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Acute lymphocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Generalized Anxiety Disorder | 0.000271442 | 1 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000271442 | 1 | 0 | BeFree |
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