PAX4(paired box 4) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

7q32.1
基因染色体位置图

基因简述

基因简述

This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  此基因是配对盒（PAX）家族的转录因子的成员。此基因家族成员通常包含配对盒结构域，八肽，以及一个成对型同源异型域。这些基因发挥胎儿的发育和肿瘤生长过程中的关键作用。配对盒4基因参与胰岛发育和小鼠的研究已经证明了该基因在产生胰岛素的β细胞的分化的作用。 [由RefSeq的，2008年7月提供]

OMIM数据库中对PAX4基因的介绍     Wikipedia数据库中对PAX4基因的介绍

基因序列

基因序列

PAX4基因的碱基序列：[NCBI]

基因突变

基因突变

PAX4基因的碱基突变：           显示全部snp
rs327509       rs327510       rs327511       rs327512       rs327513       rs327514       rs327515       rs327516       rs327517       rs327518       rs327519       rs327520       rs382443       rs537972       rs594141       rs698406       rs712699       rs712700       rs712701       rs712702       rs712703       rs712704       rs731833       rs806192       rs806193       rs2233574       rs2233575       rs2233576       rs2233577       rs2233578       rs2233579       rs2233580       rs2233581       rs2233582       rs2233583       rs2233584       rs2233585      
rs3824004       rs3835004       rs10261185       rs11977988       rs12669223       rs35155575       rs36159526       rs56356800       rs57944222       rs59241875       rs61538758       rs61749955       rs66998513       rs67752012       rs68012321       rs71546767       rs71546768       rs73234859       rs76173463       rs76326274       rs76693174       rs77039439       rs77110930       rs77164632       rs78594665       rs111573327       rs111652274       rs112061448       rs112078693       rs112478865       rs113127723       rs113561315       rs114202595       rs114315130       rs114416157       rs115157546       rs115621771       rs115864475       rs115887120       rs115923648       rs115941984       rs116124047       rs116607543       rs116676303       rs116882316       rs117823055       rs118030438       rs121917718       rs137872167       rs137917577       rs138025870       rs138411312       rs138703541       rs138902071       rs139263730       rs139309837       rs139470303       rs140070434       rs140726036       rs141051694       rs141227670       rs141407429       rs141710101       rs141782994       rs142426878       rs142975710       rs143084654       rs143090521       rs143156250       rs144792551       rs145135658       rs145284016       rs145329757       rs145468905       rs145655964       rs145705280       rs146097333       rs146150953       rs146298807       rs146924944       rs146942031       rs147279315       rs147670794       rs147927868       rs148207752       rs148264743       rs148791016       rs149178280       rs149291099       rs149391952       rs149708455       rs149820585       rs149974365       rs150084440       rs150578361       rs150850990       rs151008936       rs151108202       rs180753137       rs180876225       rs182678274       rs182725231       rs183059219       rs183190194       rs183488997       rs184852743       rs184999923       rs185606390       rs185987773       rs186078309       rs186078853       rs186198065       rs186407012       rs186731142       rs187345521       rs187985124       rs188115583       rs188819594       rs189121379       rs189333246       rs190464191       rs190548982       rs191836422       rs192350658       rs192603429       rs192903841       rs199542176       rs199578800       rs199607802       rs200090810       rs200195172       rs200387507       rs200430538       rs200541148       rs200757052       rs200911735       rs201126026       rs201233537       rs201466901       rs201607054       rs201794988       rs367652731       rs367730675       rs367777575       rs367787870       rs368051485       rs368901575       rs368914755       rs368968015       rs369041737       rs369407060       rs369459316       rs369573488       rs369651243       rs369708414       rs370095957       rs370406503       rs370467107       rs370549495       rs370905134       rs370988777       rs371082134       rs371715169       rs371793784       rs372497946       rs372560810       rs372751660       rs372984330       rs373130489       rs373305844       rs373306441       rs373473544       rs373523878       rs373754596       rs373842309       rs373939873       rs374507653       rs374622378       rs374722022       rs374900462       rs375269956       rs375391009       rs375404897       rs375472849       rs375766027       rs376039555       rs376403180       rs376633274       rs377152445       rs377207550       rs377416034       rs377581770       rs377689842       rs527472040       rs527912599       rs528066662       rs528075802       rs529481393       rs529928838       rs529976183       rs530024410       rs530313929       rs530407257       rs530444364       rs530519338       rs530789508       rs531565466       rs531729557       rs531787168       rs532262987       rs532408011       rs532608733       rs532736202       rs533462973       rs533553015       rs533765338       rs534392927       rs534923988       rs534949402       rs535322211       rs535479857       rs535682534       rs535717062       rs536280685       rs536286906       rs536319430       rs536677108       rs537070047       rs537097766       rs537106802       rs537243933       rs537843646       rs538255526       rs538309998       rs538509475       rs538616946       rs538664131       rs538718089       rs539092016       rs539482625       rs539918539       rs540372906       rs540732716       rs541266143       rs541336209       rs541764798       rs541806218       rs541865213       rs542077117       rs542078276       rs542124872       rs542749192       rs543286105       rs543393497       rs543729867       rs544007103       rs544022344       rs544027410       rs544751693       rs545528956       rs545892477       rs546052846       rs546091623       rs546252663       rs547550269       rs547681910       rs547884547       rs548245172       rs548283411       rs548291523       rs548474559       rs548810830       rs549603800       rs549998311       rs550808586       rs550938720       rs551501339       rs551726148       rs551999726       rs552026794       rs552188467       rs552199947       rs553160977       rs553243873       rs553371660       rs553447165       rs553897058       rs554031770       rs554055774       rs554647327       rs555225182       rs555263558       rs555836943       rs555879720       rs556405587       rs557217651       rs557221290       rs557282819       rs557297016       rs557793305       rs557970062       rs558024683       rs558085866       rs558220333       rs558844898       rs558975913       rs559279560       rs559443563       rs559717388       rs559857078       rs561444415       rs561603997       rs562471797       rs562501159       rs563100027       rs563293394       rs563562817       rs563629470       rs563707409       rs563744581       rs563843277       rs563953698       rs564077493       rs565008983       rs565569718       rs565689557       rs567083748       rs567087185       rs567124593       rs567639160       rs568286726       rs568328416       rs569550568       rs569678813       rs569771621       rs569840544       rs570255406       rs570681325       rs571138281       rs571619646       rs571691015       rs572475892       rs572527637       rs573164294       rs573421681       rs574223866       rs574505094       rs574703431       rs574831496       rs575375428       rs575565741       rs575648863       rs576069097       rs576593326       rs576694559       rs577335273       rs577510768       rs587780414       rs745307055       rs745500024       rs745550034       rs745600253       rs745694136       rs746007873       rs746120631       rs746127810       rs746150203       rs746285934       rs746299567       rs746461104       rs746838156       rs746872756       rs747060539       rs747167314       rs747222285       rs747315698       rs747438402       rs747695794       rs747727099       rs747805740       rs747881945       rs748004814       rs748006842       rs748137480       rs748192471       rs748242435       rs748497196       rs748573868       rs748686016       rs748810538       rs748891484       rs748974134       rs749036941       rs749146376       rs749450069       rs749541765       rs749613623       rs750109613       rs750170912       rs750647185       rs750699282       rs750974972       rs751121931       rs751287216       rs751472336       rs751789061       rs751911193       rs752023141       rs752253116       rs752351677       rs752481584       rs752575834       rs752605856       rs752662359       rs752882171       rs752884051       rs752986446       rs753106111       rs753159405       rs753408567       rs753456498       rs753683077       rs753738088       rs754086585       rs754144782       rs754213669       rs754395382       rs754627370       rs754908134       rs755239110       rs755268335       rs755590582       rs755659149       rs755766047       rs755819729       rs755862083       rs755901398       rs755989994       rs756403936       rs756528689       rs756623427       rs756900663       rs756955546       rs756956116       rs757013212       rs757329944       rs757480911       rs757601172       rs757705365       rs757919082       rs758121984       rs758195602       rs758317971       rs758327882       rs758373083       rs758421447       rs758463100       rs758518306       rs758825767       rs758888941       rs759061457       rs759356147       rs759379107       rs759657201       rs759665910       rs759939065       rs760234370       rs760419117       rs760507507       rs760675886       rs760704606       rs760814783       rs761002384       rs761042337       rs761232531       rs761341133       rs761394041       rs761445704       rs761631577       rs761723195       rs761843506       rs761845414       rs761898311       rs762002896       rs762091729       rs762226816       rs762559260       rs762823646       rs762869940       rs762979771       rs763061017       rs763135599       rs763179058       rs763200800       rs763228284       rs763356440       rs763534879       rs763782806       rs764124826       rs764152837       rs764355761       rs764432356       rs764518230       rs764634371       rs764742580       rs764848780       rs764864069       rs764886795       rs764926333       rs764971754       rs765113001       rs765164506       rs765317853       rs765497552       rs765561668       rs765665871       rs765857498       rs765877670       rs766014675       rs766091265       rs766184275       rs766248121       rs766469751       rs766512208       rs766663900       rs766864347       rs766970639       rs767181337       rs767217005       rs767435981       rs767666046       rs767864600       rs767945503       rs768075684       rs768130181       rs768289923       rs768401433       rs768461242       rs768474025       rs768530495       rs768675340       rs769383606       rs769610651       rs769660681       rs769817009       rs769885290       rs770055887       rs770354965       rs770355154       rs770477634       rs770487003       rs770747318       rs770923465       rs770946559       rs771108079       rs771130040       rs771178255       rs771306071       rs771413349       rs771742890       rs771808032       rs771876463       rs771882622       rs772045949       rs772082055       rs772271770       rs772356889       rs772495023       rs772585175       rs772618805       rs772669535       rs772889981       rs773214232       rs773308230       rs773372875       rs773550968       rs773621758       rs773666750       rs774007847       rs774019192       rs774175653       rs774231194       rs774356065       rs774406819       rs774581985       rs774976552       rs775000410       rs775082590       rs775132687       rs775185778       rs775337512       rs775498683       rs775532475       rs775814187       rs776053996       rs776151854       rs776286904       rs776614041       rs776756538       rs776890980       rs776926505       rs776955589       rs777242420       rs777298002       rs777410850       rs777573970       rs777621698       rs777681355       rs777746244       rs777873433       rs777932742       rs778014028       rs778203063       rs778236731       rs778254299       rs778463380       rs778643442       rs778666797       rs778673698       rs778724109       rs778775289       rs778828303       rs778838939       rs779103801       rs779345188       rs779540860       rs779598053       rs779638012       rs779692271       rs779811011       rs780379553       rs780430420       rs780432644       rs780680605       rs780727606       rs780825142       rs780951992       rs781049909       rs781273660       rs781343313       rs781407603       rs781424215      

基因表达

基因表达

PAX4基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GGATCCTTAAGGTATCTAATGGCT
60
CTGGACACTCACCCTTCAG
60
GGATCCTTAAGGTATCTAATGGCT
60
CTGGACACTCACCCTTCAG
60
CTCTTTGCCTGGGAAATCC
59
TTGATGGAGGAGACACTGG
59
TCTTTGCCTGGGAAATCCA
59
TTGATGGAGGAGACACTGG
59
CTCTTTGCCTGGGAAATCC
59
GTTGATGGAGGAGACACTG
58
GATCCTTAAGGTATCTAATGGCTG
59
GATTTCCCAGGCAAAGAGG
59
CTCTTTGCCTGGGAAATCC
59
TTGATGGAGGAGACACTGG
59
CTCTTTGCCTGGGAAATCC
59
GTTGATGGAGGAGACACTG
58
GATCCTTAAGGTATCTAATGGCTG
59
GATTTCCCAGGCAAAGAGG
59
GATCAGCAGCATGAACCAG
59
CATTAGATACCTTAAGGATCCGTG
59

转录因子

转录因子

转录因子
影响类型
PubMed链接
GCG
Repression
17426099
INS
Repression
17426099
INS
Unknown
10601637
ISL1
Unknown
15161765

基因本体信息

PAX4基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

PAX4基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0005634
A0A0A0MRB6(UniProtKB)
IEA
GO:0006351
A0A0A0MRB6(UniProtKB)
IEA
GO:0006355
A0A0A0MRB6(UniProtKB)
IEA
GO:0007275
A0A0A0MRB6(UniProtKB)
IEA
GO:0043565
A0A0A0MRB6(UniProtKB)
IEA
GO:0005634
G3V4Q1(UniProtKB)
IEA
GO:0006351
G3V4Q1(UniProtKB)
IEA
GO:0006355
G3V4Q1(UniProtKB)
IEA
GO:0007275
G3V4Q1(UniProtKB)
IEA
GO:0043565
G3V4Q1(UniProtKB)
IEA
GO:0005634
J3KPG0(UniProtKB)
IEA
GO:0006351
J3KPG0(UniProtKB)
IEA
GO:0006355
J3KPG0(UniProtKB)
IEA
GO:0007275
J3KPG0(UniProtKB)
IEA
GO:0043565
J3KPG0(UniProtKB)
IEA
GO:0000122
O43316(UniProtKB)
IEA
GO:0000980
O43316(UniProtKB)
IEA
GO:0001206
O43316(UniProtKB)
IEA
GO:0003677
O43316(UniProtKB)
TAS
GO:0005654
O43316(UniProtKB)
TAS
GO:0006351
O43316(UniProtKB)
IEA
GO:0007623
O43316(UniProtKB)
IEA
GO:0009887
O43316(UniProtKB)
TAS
GO:0030154
O43316(UniProtKB)
IEA
GO:0031018
O43316(UniProtKB)
TAS
GO:0042493
O43316(UniProtKB)
IEA
GO:0043066
O43316(UniProtKB)
IEA
GO:0045597
O43316(UniProtKB)
IEA
GO:0051591
O43316(UniProtKB)
IEA
GO:0060041
O43316(UniProtKB)
IEA
GO:0005515
Q3KNR5(UniProtKB)
IPI
GO:0005634
Q3KNR5(UniProtKB)
IEA
GO:0006351
Q3KNR5(UniProtKB)
IEA
GO:0006355
Q3KNR5(UniProtKB)
IEA
GO:0007275
Q3KNR5(UniProtKB)
IEA
GO:0043565
Q3KNR5(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控PAX4基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Diabetes Mellitus, Non-Insulin-Dependent 0.458002378 15 4 BeFree_CLINVAR_CTD_human_GAD_RGD_UNIPROT
MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 9 (disorder) 0.36 1 1 CLINVAR_CTD_human_UNIPROT
Diabetes Mellitus, Insulin-Dependent 0.251368221 8 1 BeFree_CTD_human_GAD_UNIPROT
melanoma 0.122995792 1 0 BeFree_CTD_human_LHGDN
Hematologic Neoplasms 0.002995792 1 0 BeFree_LHGDN
Insulin Resistance 0.002367032 1 0 GAD
Kidney Failure, Chronic 0.002367032 1 0 GAD
Metabolic Syndrome X 0.002367032 1 0 GAD
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.002367032 1 0 GAD
Diabetes Mellitus 0.001628651 6 0 BeFree
Diabetes 0.001357209 5 0 BeFree
Maturity onset diabetes mellitus in young 0.001357209 5 1 BeFree
Hyperglycemia 0.000271442 1 0 BeFree
Ketosis 0.000271442 1 0 BeFree
Nevus 0.000271442 1 0 BeFree
Melanocytic nevus 0.000271442 1 0 BeFree
Neonatal diabetes mellitus 0.000271442 1 0 BeFree
Multiple tumors 0.000271442 1 0 BeFree
Wolcott-Rallison syndrome 0.000271442 1 0 BeFree
Benign melanocytic nevus 0.000271442 1 0 BeFree
Melanocytic nevus of skin 0.000271442 1 0 BeFree

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