PAICS(phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

4q12
基因染色体位置图

基因简述

基因简述

This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  该基??因编码含有在其C-末端区域在其N-末端区域phosphoribosylaminoimidazole羧化酶活性和phosphoribosylaminoimidazole succinocarboxamide合成的双功能酶。它催化步骤6和嘌呤生物合成的7。的基因密切相关，并与编码在相同途径中的酶的轨迹趋异转录，而两个基因的转录协同调控。人类基因组中包含该基因的几种假。已发现该基因编码不同亚型的多个抄本变形。 [由RefSeq的，2008年7月提供]

OMIM数据库中对PAICS基因的介绍     Wikipedia数据库中对PAICS基因的介绍

基因序列

基因序列

PAICS基因的碱基序列：[NCBI]

基因突变

基因突变

PAICS基因的碱基突变：           显示全部snp
rs6584       rs1133207       rs1133210       rs1133212       rs1133213       rs1140982       rs1356787       rs1474179       rs1520024       rs1520025       rs1520026       rs1967559       rs3215284       rs3796549       rs3796550       rs3822001       rs4132099       rs4346704       rs4362880       rs4383672       rs4524447       rs4616819       rs4865102       rs6816268       rs6818715       rs6821301       rs6825812       rs6830518       rs6843073       rs7435941       rs7441274       rs7658340       rs7664841       rs7688482       rs7689163       rs7692073       rs7693436      
rs10001639       rs10009543       rs10015221       rs10222686       rs10222713       rs11133442       rs11549974       rs11549976       rs11940993       rs12504291       rs12510712       rs12511770       rs12646703       rs13434512       rs17051687       rs17086769       rs17086773       rs17086776       rs17086785       rs28649329       rs34111955       rs34419817       rs34582745       rs35249885       rs55917205       rs56362514       rs57483094       rs57611254       rs57763717       rs58548914       rs58578896       rs58975286       rs59010837       rs59540428       rs60097571       rs60104031       rs60112184       rs60722002       rs60972582       rs61580407       rs62309291       rs62309292       rs62309293       rs71194108       rs71601626       rs71666127       rs73157744       rs73157754       rs73157767       rs73157769       rs73157772       rs73157774       rs74474324       rs74667955       rs74874408       rs75027589       rs75040417       rs75230149       rs75419976       rs75592337       rs75849947       rs76031863       rs76039912       rs76158909       rs76212030       rs76240425       rs76972393       rs77038947       rs77220807       rs77267784       rs77318586       rs77399495       rs77511777       rs77686991       rs77735708       rs78008326       rs78408814       rs78574419       rs78575140       rs78693360       rs79252302       rs79319986       rs79833238       rs79838544       rs79900552       rs80020548       rs80047333       rs80178890       rs111235658       rs111508334       rs111521045       rs111605908       rs111645281       rs111656992       rs111774353       rs111865601       rs111876630       rs111915669       rs112002138       rs112247832       rs112290681       rs112379966       rs112435810       rs112581011       rs112629919       rs112950419       rs112957174       rs113021519       rs113046828       rs113069392       rs113485157       rs113554531       rs113557080       rs113616835       rs113639407       rs113972787       rs114009770       rs114031772       rs114094388       rs114196546       rs114348547       rs114522181       rs114597391       rs114639637       rs114707003       rs114760085       rs114816761       rs114819970       rs115012255       rs115158819       rs115254895       rs115775299       rs116046946       rs116173318       rs116270103       rs116289969       rs116600135       rs116694777       rs116748832       rs116763872       rs117399222       rs117421175       rs137870283       rs138024676       rs138336305       rs138447153       rs138713000       rs138825626       rs138933625       rs139082037       rs139099287       rs139793828       rs139826531       rs140393077       rs140470145       rs140535854       rs140553587       rs140713490       rs140957510       rs141270803       rs141334609       rs141366792       rs141422564       rs141486829       rs141632329       rs141681469       rs142318175       rs142426361       rs142449383       rs142572514       rs142846691       rs142858085       rs143061331       rs143584338       rs143660808       rs143709683       rs143850451       rs144141427       rs144298967       rs144486996       rs144667609       rs144772547       rs144785850       rs144815075       rs145192165       rs145414331       rs145559632       rs145699521       rs145811760       rs145918956       rs145950771       rs145960194       rs146101313       rs146138532       rs146180142       rs146221824       rs146423280       rs146599327       rs146639631       rs147192044       rs147228122       rs147683392       rs147699486       rs148065628       rs148294378       rs148395925       rs148415216       rs148588555       rs148937263       rs149287439       rs149337797       rs149463549       rs149513586       rs149688947       rs149862445       rs149916276       rs149934760       rs150071128       rs150209690       rs150384474       rs150436855       rs150733374       rs150909196       rs151316310       rs180678976       rs180697833       rs180705924       rs180949774       rs181193549       rs181202030       rs181402773       rs181425442       rs181486919       rs181572102       rs181600626       rs182024285       rs182202418       rs182249070       rs182353360       rs182572109       rs182631274       rs183025486       rs183063993       rs183121431       rs183371040       rs183517898       rs183539293       rs183655799       rs183747540       rs184184471       rs184301354       rs184303595       rs184494736       rs184546460       rs184792356       rs185153188       rs185316289       rs185321245       rs185492092       rs185587073       rs185894591       rs185998169       rs186008890       rs186231099       rs186269408       rs186301287       rs186366013       rs186697598       rs186807813       rs186988037       rs187054445       rs187166356       rs187645125       rs187826741       rs188079621       rs188353232       rs188539150       rs188741488       rs188864380       rs189074520       rs189134562       rs189151953       rs189152163       rs189380054       rs189395293       rs189584032       rs189595550       rs189607421       rs189898983       rs190079421       rs190112558       rs190134373       rs190379455       rs190597886       rs191043313       rs191140507       rs191470939       rs191711845       rs191724511       rs191932996       rs192021025       rs192195681       rs192335998       rs192421550       rs192602445       rs192648456       rs192701104       rs192831239       rs193052609       rs193255256       rs199691030       rs199735757       rs199953702       rs200303380       rs200428268       rs200645694       rs200742942       rs200862087       rs200990375       rs201075940       rs201185562       rs201315571       rs201978310       rs202050294       rs202181751       rs367715287       rs367721204       rs367790847       rs367907184       rs368182733       rs368783236       rs368787644       rs369183397       rs369737448       rs369922081       rs370028662       rs370383263       rs370569487       rs370765017       rs370767700       rs370845471       rs370924640       rs370970867       rs371165175       rs371211011       rs371414302       rs371415862       rs372158302       rs372215434       rs372519972       rs372555470       rs372830899       rs373309605       rs373487112       rs373732474       rs373761081       rs373859289       rs374144553       rs375080631       rs375206193       rs375531523       rs375665446       rs376026175       rs376663984       rs376709144       rs376971719       rs377203074       rs377520975       rs377640783       rs527261913       rs527505353       rs527578041       rs527591524       rs527707859       rs527894712       rs527901982       rs527956301       rs528172474       rs528368888       rs528504116       rs528579353       rs528863422       rs529486562       rs529508616       rs529717036       rs529739478       rs529818910       rs529878558       rs529937958       rs530087056       rs530151226       rs530216388       rs530478213       rs530544521       rs530664399       rs530902136       rs531025840       rs531211606       rs531428035       rs531490913       rs531494399       rs531544734       rs531555069       rs531565024       rs531627926       rs531711976       rs531713338       rs531816070       rs531825155       rs531885961       rs532224414       rs532311533       rs532828978       rs532875880       rs533161345       rs533162729       rs533318593       rs533365272       rs533407238       rs533488234       rs533631332       rs533877629       rs534078771       rs534139507       rs534348712       rs534481436       rs534547488       rs534614976       rs534769383       rs534786334       rs534845180       rs534909183       rs535035176       rs535141583       rs535195504       rs535415472       rs535563175       rs535563210       rs536004858       rs536177155       rs536345175       rs536475013       rs536602911       rs537003841       rs537063714       rs537142985       rs537347224       rs537426007       rs537485914       rs537752262       rs538019046       rs538054719       rs538087197       rs538151956       rs538402314       rs538955366       rs538979176       rs539053870       rs539113812       rs539265042       rs539510367       rs539810711       rs539941321       rs540141982       rs540248785       rs540306927       rs540424854       rs540696608       rs540837233       rs540958517       rs540976298       rs541031726       rs541095363       rs541199537       rs541461683       rs541650490       rs541712740       rs541768879       rs541785781       rs541849185       rs541885554       rs542156434       rs542492832       rs542608017       rs542650181       rs542758758       rs543332899       rs543385278       rs543444326       rs543562214       rs543573422       rs543576385       rs543734641       rs543762217       rs543771982       rs543787986       rs543849988       rs543982613       rs544014526       rs544037832       rs544317948       rs544685329       rs544717491       rs544722192       rs544975327       rs545427823       rs545488407       rs545646484       rs545693516       rs545707483       rs545755204       rs545921348       rs545965187       rs546246299       rs546285630       rs546327370       rs546431367       rs546496448       rs546950603       rs546994128       rs546995757       rs547059050       rs547569468       rs547583282       rs547598547       rs547630983       rs547689640       rs547736974       rs548007787       rs548044971       rs548091169       rs548353694       rs548382031       rs548412501       rs548413183       rs548415465       rs548474252       rs548528618       rs548601718       rs548979988       rs548980475       rs549222790       rs549337208       rs549571725       rs549676093       rs549798182       rs549861306       rs549973708       rs550008642       rs550073938       rs550155543       rs550335438       rs550352907       rs550357995       rs550419427       rs550588064       rs550660257       rs550920003       rs550974253       rs551035734       rs551075599       rs551408848       rs551509981       rs551678021       rs551859766       rs551970323       rs552059824       rs552068861       rs552364557       rs552393555       rs552544804       rs552713157       rs552728756       rs552827578       rs552836772       rs552853457       rs552933460       rs553015777       rs553072440       rs553409504       rs553437516       rs553472600       rs553602007       rs553727160       rs553818015       rs554054205       rs554263527       rs554389201       rs554475742       rs554845204       rs555078164       rs555111187       rs555246303       rs555383179       rs555454613       rs555458891       rs555590067       rs555651349       rs555655275       rs555717915       rs556006995       rs556122092       rs556131896       rs556137761       rs556193079       rs556199181       rs556326054       rs556463928       rs556635605       rs556743851       rs556981348       rs557049520       rs557230817       rs557294252       rs557430012       rs557581176       rs557644315       rs557644403       rs557647896       rs557703972       rs557729881       rs557792269       rs558102937       rs558199894       rs558313709       rs558402022       rs558462528       rs559102291       rs559253791       rs559316626       rs559339241       rs559522108       rs559755357       rs560015720       rs560046489       rs560371062       rs560535379       rs560545553       rs560605007       rs560715442       rs560815065       rs560994261       rs561380291       rs561737224       rs561800386       rs561857049       rs562034010       rs562058132       rs562078005       rs562109279       rs562121018       rs562169887       rs562182914       rs562519099       rs562754907       rs562793738       rs562810617       rs562855157       rs562873038       rs562889516       rs563337373       rs563398796       rs563448388       rs563675586       rs563780174       rs563900228       rs564139141       rs564204007       rs564235783       rs564367114       rs564534228       rs564718145       rs564804738       rs564865808       rs564965003       rs565026062       rs565150683       rs565265358       rs565669753       rs565685877       rs565818527       rs565886029       rs566023689       rs566257383       rs566404473       rs566411839       rs566465944       rs566881422       rs566883400       rs567062635       rs567413520       rs567560498       rs567625701       rs567673985       rs567734314       rs567864487       rs568240318       rs568385304       rs568563877       rs568700337       rs568706228       rs568825135       rs569325646       rs569474898       rs569502669       rs569617886       rs569637380       rs569670334       rs569970265       rs570429980       rs570493088       rs570500342       rs570552262       rs570721542       rs570846311       rs570968762       rs571253806       rs571253913       rs571417770       rs571593143       rs571613220       rs571674165       rs571683087       rs571739885       rs571956607       rs572014157       rs572067966       rs572128434       rs572130245       rs572291878       rs572294753       rs572353430       rs572356951       rs572364107       rs572495042       rs572518861       rs572645450       rs572765723       rs572780888       rs572873876       rs572934981       rs573762279       rs573844517       rs573846566       rs574051389       rs574118846       rs574118865       rs574233720       rs574233940       rs574248239       rs574296133       rs574309101       rs574438008       rs574520232       rs575004098       rs575146333       rs575276357       rs575339610       rs575699835       rs575754032       rs575763486       rs575896321       rs575915771       rs575988617       rs576048790       rs576112767       rs576299664       rs576319463       rs576326899       rs576432979       rs576507121       rs576557158       rs576896548       rs576996798       rs577066584       rs577180841       rs577247593       rs577304792       rs577741055       rs577913106       rs577972842       rs578019784       rs578218798       rs578224042       rs745415728       rs745482355       rs745802914       rs745894323       rs745970882       rs746070974       rs746160982       rs746244172       rs746254840       rs746450411       rs746573083       rs746737970       rs746850249       rs746939298       rs747126936       rs747347691       rs747477192       rs747488260       rs747622592       rs747654837       rs747869565       rs748286211       rs748498890       rs748502044       rs748579905       rs748853744       rs748869153       rs748878127       rs748918494       rs749162002       rs749612783       rs749838681       rs750075251       rs750095191       rs750175213       rs750447785       rs750465341       rs750557169       rs750777072       rs751044168       rs751073813       rs751234928       rs751330271       rs751454386       rs751597050       rs752041122       rs752185680       rs752261717       rs752273829       rs752603269       rs752603839       rs752689448       rs752884317       rs752943431       rs753170856       rs753412614       rs753579684       rs753664851       rs753847420       rs753990520       rs754081885       rs754374739       rs754389538       rs754547945       rs754611620       rs754664792       rs754845652       rs754936603       rs754945589       rs755014046       rs755074583       rs755276569       rs755330401       rs755519249       rs755683625       rs755787806       rs756127275       rs756192619       rs756317430       rs756370715       rs756627780       rs756781025       rs757076250       rs757230006       rs757285114       rs757813470       rs757883135       rs758019237       rs758241618       rs758414050       rs758735153       rs758815876       rs758835088       rs759184086       rs759252229       rs759259369       rs759342051       rs759673559       rs759946495       rs760196186       rs760370774       rs760497195       rs760596362       rs760696805       rs760883049       rs761217137       rs761243513       rs761246399       rs761645139       rs761733180       rs761799315       rs761968553       rs762120789       rs762208515       rs762276221       rs762387719       rs762740712       rs762798410       rs762822699       rs762872223       rs763085698       rs763112448       rs763267836       rs763356434       rs763421838       rs763444167       rs763578528       rs763666397       rs764179393       rs764422195       rs764472966       rs764527981       rs764923107       rs765141296       rs765151186       rs765248477       rs765306022       rs765551603       rs765555896       rs765642098       rs765883096       rs765989683       rs766083595       rs766164374       rs766199132       rs766254021       rs766423126       rs766433121       rs766756958       rs766781959       rs766801836       rs767037962       rs767134289       rs767467300       rs767484098       rs767891808       rs767978002       rs768084727       rs768171255       rs768421711       rs768461994       rs768515346       rs768922437       rs769149702       rs769265062       rs769276604       rs769357091       rs769560440       rs769698501       rs769916779       rs769935522       rs769973255       rs770241161       rs770571895       rs770647186       rs770809983       rs770971780       rs771128512       rs771504681       rs771626621       rs771772138       rs771861747       rs772064224       rs772257038       rs772284340       rs772510577       rs772610832       rs772673782       rs772747599       rs772842876       rs772896399       rs773078210       rs773166026       rs773422374       rs773688517       rs773900006       rs773985258       rs774181819       rs774260057       rs774304478       rs774726007       rs774802084       rs774868196       rs775136932       rs775398647       rs775405273       rs775478666       rs775711628       rs775798687       rs775884727       rs775976662       rs776172497       rs776423311       rs776558906       rs776654985       rs776938734       rs777026500       rs777269199       rs777277118       rs777455868       rs777485420       rs777543623       rs777617990       rs777876017       rs777990562       rs778548327       rs778675120       rs778771563       rs778956686       rs779046474       rs779115235       rs779245880       rs779424819       rs779426382       rs779762217       rs779886575       rs780099290       rs780270261       rs780614478       rs780660173       rs780726261       rs780849275       rs780931477       rs780939352       rs781102384       rs781279911       rs781324117       rs869127756      

基因表达

基因表达

PAICS基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
TTTCTAGAGTTCTGCCTCGC
60
TGTTCAGTACCTCAGCTGTC
60
TTCTAGAGTTCTGCCTCGC
59
ATGTTCAGTACCTCAGCTGTC
60
GACTACCCAGTGGTCTTGG
59
GCTTAACCCAAATATCTGAGCA
59
TTTCTAGAGTTCTGCCTCGC
60
TGTTCAGTACCTCAGCTGTC
60
CCACCAAAGAAATTGTTCTTGC
59
TTTGAGGTCCCGATAAGACTG
60
GGAAGCAGTTACCTCATATAAGTC
59
GGTGCAATGAAAGCTGTCTC
60
GACTACCCAGTGGTCTTGG
59
CTTAACCCAAATATCTGAGCAGC
60
CCACCAAAGAAATTGTTCTTGC
59
GTCCCGATAAGACTGTTTGTC
59
GACTACCCAGTGGTCTTGG
59
CTTAACCCAAATATCTGAGCAGC
60
GACTACCCAGTGGTCTTGG
59
TTAACCCAAATATCTGAGCAGC
59

转录因子

转录因子

      尚未收录相关数据

基因本体信息

PAICS基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

PAICS基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0004639
D6RF62(UniProtKB)
IEA
GO:0005524
D6RF62(UniProtKB)
IEA
GO:0006189
D6RF62(UniProtKB)
IEA
GO:0004639
E9PBS1(UniProtKB)
IEA
GO:0005524
E9PBS1(UniProtKB)
IEA
GO:0006189
E9PBS1(UniProtKB)
IEA
GO:0004638
P22234(UniProtKB)
IBA
GO:0004638
P22234(UniProtKB)
TAS
GO:0004639
P22234(UniProtKB)
TAS
GO:0005515
P22234(UniProtKB)
IPI
GO:0005515
P22234(UniProtKB)
IPI
GO:0005515
P22234(UniProtKB)
IPI
GO:0005515
P22234(UniProtKB)
IPI
GO:0005515
P22234(UniProtKB)
IPI
GO:0005524
P22234(UniProtKB)
IEA
GO:0005829
P22234(UniProtKB)
IBA
GO:0005829
P22234(UniProtKB)
TAS
GO:0005829
P22234(UniProtKB)
TAS
GO:0006189
P22234(UniProtKB)
IBA
GO:0006189
P22234(UniProtKB)
IEA
GO:0009113
P22234(UniProtKB)
TAS
GO:0009168
P22234(UniProtKB)
TAS
GO:0016020
P22234(UniProtKB)
IDA
GO:0042802
P22234(UniProtKB)
IPI
GO:0042802
P22234(UniProtKB)
IPI
GO:0042802
P22234(UniProtKB)
IPI
GO:0042802
P22234(UniProtKB)
IPI
GO:0046084
P22234(UniProtKB)
IBA
GO:0070062
P22234(UniProtKB)
IDA
GO:0070062
P22234(UniProtKB)
IDA
GO:0070062
P22234(UniProtKB)
IDA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控PAICS基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Alcoholic Intoxication, Chronic 0.002367032 1 0 GAD
Schizophrenia 0.002367032 1 0 GAD
Androgen-Insensitivity Syndrome 0.001357209 5 0 BeFree
Testicular Feminization 0.001085767 4 0 BeFree
Reifenstein Syndrome 0.000542884 2 0 BeFree
46, XY Disorders of Sex Development 0.000542884 2 0 BeFree
Gonadal Dysgenesis 0.000271442 1 0 BeFree
Gonadal Dysgenesis, Mixed 0.000271442 1 0 BeFree
Pituitary Diseases 0.000271442 1 0 BeFree
Prostatic Neoplasms 0.000271442 1 0 BeFree
Turner Syndrome 0.000271442 1 0 BeFree
Virilism 0.000271442 1 0 BeFree

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