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The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]
[中文简述(自动翻译):]  外致密纤维包围在中间片和精子尾部的主段轴丝骨架结构。该纤维的功能在维持精子尾部的弹性结构和反冲以及在附睾运输和射精期间保护从剪切力的尾巴。在外部密集纤维缺陷导致精子形态异常和不育。该基因编码的主要外致密的纤维蛋白之一。选择性剪接结果在多个抄本变形。较长的转录物,也被称为‘Cenexins‘,编码的蛋白质具有C-末端延伸被差分定位到体中心粒并认为是微管组织中心的形成至关重要。 [由RefSeq的,2010年10月提供]
ODF2基因(以及对应的蛋白质)的细胞分布位置:
ODF2基因的本体(GO)信息:
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