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This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]
[中文简述(自动翻译):]  该基因属于Nudix结构(二磷酸核苷联X部分)水解酶家族。所编码的酶催化修饰的核苷二磷酸,包括ADP-核糖(ADPR)和含有8 oxoGua -8-氧代 - DADP和-8-氧代dGDP的水解。蛋白结合的ADP核糖可以是有害的细胞,因为它可以修改某些氨基酸残基,导致ATP激活钾通道的抑制。 8 oxoGua是鸟嘌呤的氧化形式,可以通过在RNA的腺嘌呤和胞嘧啶配对可能改变的遗传信息。在由于平移误差RNA导致形成异常蛋白的8 oxoGua的存在。 [由RefSeq的,2013年8月提供]
NUDT5基因(以及对应的蛋白质)的细胞分布位置:
NUDT5基因的本体(GO)信息:
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