更多...
收起
The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白质属于G蛋白偶联受体家族的激活磷脂??酰钙第二信使系统。结合和药理学研究表明,这种受体结合神经降压素,以及已为神经降压素受体NT1介绍的几种其他配体。然而,不同于NT1受体,该基因识别,以高亲和力,左卡巴斯汀,先前所示的组胺H1受体拮抗剂与神经降压素的低亲和结合在脑部位竞争。这些活动表明该受体可能是生理重要性,对受体的天然激动剂可能存在。 [由RefSeq的,2008年7月提供]
NTSR2基因(以及对应的蛋白质)的细胞分布位置:
NTSR2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Alcoholic Intoxication, Chronic | 0.002367032 | 1 | 0 | GAD |
Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
忘记密码? 点击找回密码.
扫一扫右方二维码,关注微信订阅号,实时查看信息,关注医学生物学动态。