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The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  由该基因编码的蛋白是神经营养因子家族的一员,其控制存活和哺乳动物神经元的分化。这种蛋白质是密切相关的两个神经生长因子,脑源性神经营养因子。它可能是参与维持成人神经系统的,而当它在人胎盘中表达可影响神经元的发育中的胚胎。通过四肢的基因靶向显示严重运动缺陷而产生的NTF3缺陷小鼠。该蛋白质的成熟肽是在所有哺乳动物检查包括人,猪,大鼠和小鼠相同。 [由RefSeq的,2008年7月提供]
NTF3基因(以及对应的蛋白质)的细胞分布位置:
NTF3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Schizophrenia | 0.138359696 | 15 | 0 | BeFree_CTD_human_GAD_LHGDN |
Autistic Disorder | 0.122367032 | 2 | 0 | CTD_human_GAD |
Diabetic Neuropathies | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Down Syndrome | 0.12 | 1 | 0 | CTD_human |
Tonic-Clonic Epilepsy | 0.12 | 1 | 0 | CTD_human |
Hyperalgesia | 0.12 | 1 | 0 | CTD_human |
Nerve Degeneration | 0.12 | 2 | 0 | CTD_human |
Status Epilepticus | 0.12 | 1 | 0 | CTD_human |
hearing impairment | 0.12 | 1 | 0 | CTD_human |
Tetralogy of Fallot | 0.08 | 0 | 0 | MGD |
ATRIAL SEPTAL DEFECT 1 | 0.08 | 0 | 0 | MGD |
Attention deficit hyperactivity disorder | 0.008729747 | 6 | 1 | BeFree_GAD |
Alzheimer's Disease | 0.00617715 | 6 | 0 | BeFree_GAD_LHGDN |
Inflammation | 0.0054487 | 2 | 0 | LHGDN |
melanoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Asthma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Chronic Obstructive Airway Disease | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Ulcerative Colitis | 0.00272435 | 1 | 0 | LHGDN |
Crohn Disease | 0.00272435 | 1 | 0 | LHGDN |
Hydrocephalus | 0.00272435 | 1 | 0 | LHGDN |
Pneumonia | 0.00272435 | 1 | 0 | LHGDN |
Pulmonary Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
Lung Diseases, Interstitial | 0.00272435 | 1 | 0 | LHGDN |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Neurodegenerative Disorders | 0.002171535 | 8 | 0 | BeFree |
Neuropathy | 0.001628651 | 6 | 0 | BeFree |
Amyotrophic Lateral Sclerosis | 0.001085767 | 4 | 0 | BeFree |
Neoplasm Metastasis | 0.001085767 | 4 | 0 | BeFree |
Unipolar Depression | 0.001085767 | 4 | 0 | BeFree |
Myxoid cyst | 0.001085767 | 4 | 0 | BeFree |
Major Depressive Disorder | 0.001085767 | 4 | 0 | BeFree |
Bipolar Disorder | 0.000814326 | 3 | 0 | BeFree |
Cerebral Infarction | 0.000814326 | 3 | 0 | BeFree |
Mental Depression | 0.000814326 | 3 | 0 | BeFree |
Depressive disorder | 0.000814326 | 3 | 0 | BeFree |
Medulloblastoma | 0.000814326 | 3 | 0 | BeFree |
Synovial Cyst | 0.000814326 | 3 | 0 | BeFree |
Cerebral Ischemia | 0.000814326 | 3 | 0 | BeFree |
Anxiety Disorders | 0.000542884 | 2 | 0 | BeFree |
Astrocytoma | 0.000542884 | 2 | 0 | BeFree |
Mental disorders | 0.000542884 | 2 | 0 | BeFree |
Charcot-Marie-Tooth Disease | 0.000542884 | 2 | 0 | BeFree |
Hirschsprung Disease | 0.000542884 | 2 | 0 | BeFree |
Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Psychotic Disorders | 0.000542884 | 2 | 0 | BeFree |
Cerebrovascular accident | 0.000542884 | 2 | 0 | BeFree |
Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
Mood Disorders | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Substance abuse problem | 0.000542884 | 2 | 0 | BeFree |
Hirschsprung disease 1 | 0.000542884 | 2 | 0 | BeFree |
Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Diabetes | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus | 0.000271442 | 1 | 0 | BeFree |
Endometriosis | 0.000271442 | 1 | 0 | BeFree |
Glaucoma | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
nervous system disorder | 0.000271442 | 1 | 0 | BeFree |
Obsessive-Compulsive Disorder | 0.000271442 | 1 | 0 | BeFree |
Osteochondritis Dissecans | 0.000271442 | 1 | 0 | BeFree |
Paresis | 0.000271442 | 1 | 0 | BeFree |
Parkinson Disease | 0.000271442 | 1 | 0 | BeFree |
Pheochromocytoma | 0.000271442 | 1 | 0 | BeFree |
Adenomatous Polyposis Coli | 0.000271442 | 1 | 0 | BeFree |
Prostatic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Tetanus | 0.000271442 | 1 | 0 | BeFree |
Chagas Disease | 0.000271442 | 1 | 0 | BeFree |
Tuberous Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Attention Deficit Disorder | 0.000271442 | 1 | 0 | BeFree |
Motor Neuron Disease | 0.000271442 | 1 | 0 | BeFree |
Pancreatitis, Chronic | 0.000271442 | 1 | 0 | BeFree |
Muscle Weakness | 0.000271442 | 1 | 0 | BeFree |
Adrenoleukodystrophy | 0.000271442 | 1 | 0 | BeFree |
Medulloblastoma, Childhood | 0.000271442 | 1 | 0 | BeFree |
Infantile fibrosarcoma | 0.000271442 | 1 | 0 | BeFree |
Nonorganic psychosis | 0.000271442 | 1 | 0 | BeFree |
Inherited neuropathies | 0.000271442 | 1 | 0 | BeFree |
Dissecting aneurysm of the thoracic aorta | 0.000271442 | 1 | 0 | BeFree |
Adult attention deficit hyperactivity disorder | 0.000271442 | 1 | 0 | BeFree |
Metastatic Prostate Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Ischemic stroke | 0.000271442 | 1 | 0 | BeFree |
Mild cognitive disorder | 0.000271442 | 1 | 0 | BeFree |
Cancer Cell Growth | 0.000271442 | 1 | 0 | BeFree |
Xenograft Model | 0.000271442 | 1 | 0 | BeFree |
AMYOTROPHIC LATERAL SCLEROSIS 1 | 0.000271442 | 1 | 0 | BeFree |
Amyotrophic Lateral Sclerosis, Sporadic | 0.000271442 | 1 | 0 | BeFree |
Ischemic Cerebrovascular Accident | 0.000271442 | 1 | 0 | BeFree |
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