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The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Jun 2014]
[中文简述(自动翻译):]  由该基因编码的蛋白质是一种膜糖蛋白,其介导细胞 - 细胞信号传导和起着多器官系统的增长和发展的关键作用。非凡多种不同的亚型是由该基因通过替代启动子用法和拼接产生的。这些同种型在组织特异性方式表达,并在它们的结构显著不同,并且被分类为类型I,II,III,IV,V和VI。这个基因的失调已被链接到的疾病,如癌症,精神分裂症和双相性精神障碍(BPD)。 [由RefSeq的,2014年6月提供]
NRG1基因(以及对应的蛋白质)的细胞分布位置:
NRG1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Schizophrenia | 0.330216746 | 209 | 5 | BeFree_CTD_human_GAD_LHGDN |
Mammary Neoplasms | 0.137703311 | 11 | 0 | BeFree_CTD_human_LHGDN |
Hirschsprung Disease | 0.124538567 | 9 | 1 | BeFree_CTD_human_GAD |
Heart failure | 0.121085767 | 4 | 0 | BeFree_CTD_human |
Thyroid carcinoma | 0.120271442 | 2 | 2 | BeFree_GWASCAT |
Neoplastic Cell Transformation | 0.12 | 1 | 0 | CTD_human |
Contact Dermatitis | 0.12 | 1 | 0 | CTD_human |
Movement Disorders | 0.12 | 1 | 0 | CTD_human |
Neoplasm Invasiveness | 0.12 | 1 | 0 | CTD_human |
Pain | 0.12 | 1 | 0 | CTD_human |
Polycystic Ovary Syndrome | 0.12 | 1 | 0 | CTD_human |
Gastric ulcer | 0.12 | 1 | 0 | CTD_human |
Amphetamine-Related Disorders | 0.12 | 1 | 0 | CTD_human |
Juvenile arthritis | 0.12 | 1 | 0 | CTD_human |
Seizures | 0.080271442 | 2 | 0 | BeFree_RGD |
Diabetic Neuropathies | 0.08 | 1 | 0 | RGD |
Hyperalgesia | 0.08 | 1 | 0 | RGD |
Sciatic Neuropathy | 0.08 | 1 | 0 | RGD |
Median Neuropathy | 0.08 | 1 | 0 | RGD |
Diabetic Cardiomyopathies | 0.08 | 1 | 0 | RGD |
Overactive Bladder | 0.08 | 1 | 0 | RGD |
Neointima | 0.08 | 1 | 0 | RGD |
Bipolar Disorder | 0.031171003 | 28 | 0 | BeFree_GAD_LHGDN |
Psychotic Disorders | 0.011248669 | 24 | 3 | BeFree_GAD |
Alzheimer's Disease | 0.010454206 | 3 | 0 | BeFree_GAD_LHGDN |
Malignant neoplasm of breast | 0.005971721 | 22 | 0 | BeFree |
Nonorganic psychosis | 0.005157396 | 19 | 3 | BeFree |
Breast Carcinoma | 0.005157396 | 19 | 0 | BeFree |
melanoma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Glioma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Atherosclerosis | 0.002909916 | 2 | 0 | BeFree_GAD |
Noninfiltrating Intraductal Carcinoma | 0.00272435 | 1 | 0 | LHGDN |
Cessation of life | 0.00272435 | 1 | 0 | LHGDN |
Gliosis | 0.00272435 | 1 | 0 | LHGDN |
Inflammation | 0.00272435 | 1 | 0 | LHGDN |
Pancreatic Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Parkinson Disease | 0.00272435 | 1 | 0 | LHGDN |
Sarcoma, Clear Cell | 0.00272435 | 1 | 0 | LHGDN |
ovarian neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Coronary Artery Disease | 0.00272435 | 1 | 0 | LHGDN |
Asthma | 0.002638474 | 1 | 2 | BeFree_GAD |
Cerebrovascular accident | 0.002638474 | 1 | 1 | BeFree_GAD |
As If Personality | 0.002367032 | 1 | 0 | GAD |
Autistic Disorder | 0.002367032 | 1 | 0 | GAD |
Diabetes Mellitus, Non-Insulin-Dependent | 0.002367032 | 1 | 1 | GAD |
Neonatal disorder | 0.002367032 | 1 | 0 | GAD |
Marijuana Abuse | 0.002367032 | 1 | 0 | GAD |
Osteoporosis | 0.002367032 | 1 | 1 | GAD |
Psychoses, Substance-Induced | 0.002367032 | 1 | 0 | GAD |
Schizotypal Personality Disorder | 0.002367032 | 1 | 0 | GAD |
Thyroid Neoplasm | 0.002367032 | 1 | 1 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Hematocrit level | 0.002367032 | 1 | 1 | GAD |
Hirschsprung disease 1 | 0.002171535 | 8 | 0 | BeFree |
Mental disorders | 0.001900093 | 7 | 0 | BeFree |
Carcinogenesis | 0.001357209 | 5 | 1 | BeFree |
Psychotic symptom | 0.001357209 | 5 | 0 | BeFree |
Congestive heart failure | 0.001085767 | 4 | 0 | BeFree |
Neoplasm Metastasis | 0.001085767 | 4 | 0 | BeFree |
Malignant Peripheral Nerve Sheath Tumor | 0.001085767 | 4 | 0 | BeFree |
Amyotrophic Lateral Sclerosis | 0.000814326 | 3 | 0 | BeFree |
Myocardial Infarction | 0.000814326 | 3 | 0 | BeFree |
neurofibroma | 0.000814326 | 3 | 0 | BeFree |
Ovarian Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of lung | 0.000814326 | 3 | 0 | BeFree |
Manic | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000814326 | 3 | 0 | BeFree |
Carcinoma of lung | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000814326 | 3 | 0 | BeFree |
Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
Arteriosclerosis | 0.000542884 | 2 | 0 | BeFree |
Borderline Personality Disorder | 0.000542884 | 2 | 0 | BeFree |
Bronchopulmonary Dysplasia | 0.000542884 | 2 | 0 | BeFree |
Atrial Septal Defects | 0.000542884 | 2 | 2 | BeFree |
Acute Erythroblastic Leukemia | 0.000542884 | 2 | 0 | BeFree |
Multiple Sclerosis | 0.000542884 | 2 | 0 | BeFree |
Neurilemmoma | 0.000542884 | 2 | 0 | BeFree |
Unipolar Depression | 0.000542884 | 2 | 1 | BeFree |
Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
Bipolar I disorder | 0.000542884 | 2 | 0 | BeFree |
Major Depressive Disorder | 0.000542884 | 2 | 1 | BeFree |
Anaplasia | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000271442 | 1 | 0 | BeFree |
Cannabis Dependence | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000271442 | 1 | 1 | BeFree |
Mucinous Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cerebral Palsy | 0.000271442 | 1 | 0 | BeFree |
Delusions | 0.000271442 | 1 | 0 | BeFree |
Epilepsy | 0.000271442 | 1 | 0 | BeFree |
Fragile X Syndrome | 0.000271442 | 1 | 0 | BeFree |
Ischemia | 0.000271442 | 1 | 0 | BeFree |
Lung Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Mydriasis | 0.000271442 | 1 | 0 | BeFree |
nervous system disorder | 0.000271442 | 1 | 1 | BeFree |
Neurofibromatosis 2 | 0.000271442 | 1 | 0 | BeFree |
Acoustic Neuroma | 0.000271442 | 1 | 0 | BeFree |
Prolactinoma | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Edema | 0.000271442 | 1 | 0 | BeFree |
Schizophrenia, Childhood | 0.000271442 | 1 | 0 | BeFree |
Shared Paranoid Disorder | 0.000271442 | 1 | 0 | BeFree |
Subarachnoid Hemorrhage | 0.000271442 | 1 | 0 | BeFree |
Depressive Symptoms | 0.000271442 | 1 | 0 | BeFree |
Left Ventricular Hypertrophy | 0.000271442 | 1 | 0 | BeFree |
Manic psychosis | 0.000271442 | 1 | 0 | BeFree |
Cutaneous Melanoma | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Medullary carcinoma | 0.000271442 | 1 | 0 | BeFree |
Nerve Sheath Tumors | 0.000271442 | 1 | 0 | BeFree |
Metastatic malignant neoplasm to brain | 0.000271442 | 1 | 0 | BeFree |
Chronic schizophrenia | 0.000271442 | 1 | 0 | BeFree |
Speech impairment | 0.000271442 | 1 | 0 | BeFree |
Hallucinations, Auditory | 0.000271442 | 1 | 0 | BeFree |
Congenital diaphragmatic hernia | 0.000271442 | 1 | 0 | BeFree |
Papillary thyroid carcinoma | 0.000271442 | 1 | 1 | BeFree |
Carcinoma, Small Cell | 0.000271442 | 1 | 0 | BeFree |
Expressed Emotion | 0.000271442 | 1 | 1 | BeFree |
Impaired cognition | 0.000271442 | 1 | 0 | BeFree |
Developmental delay (disorder) | 0.000271442 | 1 | 0 | BeFree |
Sleep Apnea, Obstructive | 0.000271442 | 1 | 0 | BeFree |
Neurodegenerative Disorders | 0.000271442 | 1 | 0 | BeFree |
Ewings sarcoma-primitive neuroectodermal tumor (PNET) | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of bladder | 0.000271442 | 1 | 0 | BeFree |
Middle Cerebral Artery Occlusion | 0.000271442 | 1 | 0 | BeFree |
Invasive breast carcinoma | 0.000271442 | 1 | 0 | BeFree |
Rhabdoid Tumor of the Kidney | 0.000271442 | 1 | 0 | BeFree |
Post MI | 0.000271442 | 1 | 0 | BeFree |
Ischemic stroke | 0.000271442 | 1 | 0 | BeFree |
Differentiated Thyroid Gland Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Autism Spectrum Disorders | 0.000271442 | 1 | 0 | BeFree |
Tumor Angiogenesis | 0.000271442 | 1 | 0 | BeFree |
NEUROTICISM | 0.000271442 | 1 | 0 | BeFree |
Central Nervous System Sensitization | 0.000271442 | 1 | 0 | BeFree |
Ischemic Cerebrovascular Accident | 0.000271442 | 1 | 0 | BeFree |
Neuroepithelioma, Peripheral | 0.000271442 | 1 | 0 | BeFree |
Intellectual Disability | 0.000271442 | 1 | 0 | BeFree |
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