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Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  细胞粘附分子(凸轮)是免疫球蛋白超家族的成员。该基因编码具有多个免疫球蛋白样C2型结构域和纤连蛋白III型结构域的神经细胞粘附分子。此锚蛋白结合蛋白是参与神经元的神经元的粘附和促进轴突锥生长期间定向信令。这种基因也表示在非神经组织,并且可以通过定向细胞迁移期间将其胞内结构域的肌动蛋白细胞骨架信号在细胞 - 细胞通信的一般作用。这种基因的等位基因变异已与自闭症和成瘾漏洞有关。在多个转录剪接变异体导致编码不同亚型。 [由RefSeq的,2008年7月提供]
NRCAM基因(以及对应的蛋白质)的细胞分布位置:
NRCAM基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Autistic Disorder | 0.206091273 | 6 | 0 | BeFree_CTD_human_GAD_MGD |
Colorectal Neoplasms | 0.12 | 2 | 0 | CTD_human |
Substance-Related Disorders | 0.12 | 1 | 0 | CTD_human |
Mammary Neoplasms | 0.12 | 1 | 0 | CTD_human |
Schizophrenia | 0.005005506 | 2 | 1 | BeFree_GAD |
melanoma | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Adenoma | 0.00272435 | 1 | 0 | LHGDN |
Colonic Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Thyroid Neoplasm | 0.00272435 | 1 | 0 | LHGDN |
Focal Nodular Hyperplasia | 0.00272435 | 1 | 0 | LHGDN |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Melanoma, B16 | 0.000542884 | 2 | 0 | BeFree |
Hydrocephalus | 0.000542884 | 2 | 0 | BeFree |
Mental Retardation | 0.000542884 | 2 | 0 | BeFree |
X-linked hydrocephalus syndrome | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Substance abuse problem | 0.000542884 | 2 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 1 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Substance Dependence | 0.000271442 | 1 | 0 | BeFree |
Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
Weaver syndrome | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 1 | BeFree |
Polysubstance abuse | 0.000271442 | 1 | 0 | BeFree |
Drug Dependence | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
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