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The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
[中文简述(自动翻译):]  肝脏X受体体LXRα(NR1H3; MIM 602423)和LXRB,形成核受体超家族的亚家族,并且巨噬细胞功能的关键调节剂,控制参与脂质稳态和炎症转录程序。可诱导的体LXRα在肝脏,肾上腺,小肠,脂肪组织,巨噬细胞,肺和肾脏中高表达,而LXRB被普遍表达。配体激活LXRs形成具有类视黄醇X受体的专性异源二聚体(RXRs;见MIM 180245),并调节含有LXR应答元件的靶基因的表达(通过科尔夫总结等,2009 [搜索PubMed 19436111])[由OMIM,2010年1月提供。 ]
NR1H2基因(以及对应的蛋白质)的细胞分布位置:
NR1H2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Liver carcinoma | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Cholestasis | 0.12 | 1 | 0 | CTD_human |
Alzheimer's Disease | 0.009468128 | 4 | 0 | GAD |
Diabetes Mellitus, Non-Insulin-Dependent | 0.00554839 | 3 | 0 | BeFree_GAD |
Xeroderma Pigmentosum | 0.005157396 | 19 | 0 | BeFree |
Obesity | 0.002909916 | 2 | 0 | BeFree_GAD |
Cockayne Syndrome | 0.002442977 | 9 | 0 | BeFree |
Atherosclerosis | 0.002367032 | 1 | 0 | GAD |
Coronary heart disease | 0.002367032 | 1 | 0 | GAD |
Inflammation | 0.002367032 | 1 | 0 | GAD |
Insulin Resistance | 0.002367032 | 1 | 0 | GAD |
Lymphoma, Non-Hodgkin | 0.002367032 | 1 | 0 | GAD |
XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C | 0.001628651 | 6 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of breast | 0.001357209 | 5 | 0 | BeFree |
Colorectal Carcinoma | 0.001357209 | 5 | 2 | BeFree |
melanoma | 0.001357209 | 5 | 0 | BeFree |
Breast Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Carcinoma of bladder | 0.001357209 | 5 | 0 | BeFree |
Colorectal Cancer | 0.001357209 | 5 | 2 | BeFree |
Malignant neoplasm of prostate | 0.001085767 | 4 | 0 | BeFree |
Carcinogenesis | 0.001085767 | 4 | 0 | BeFree |
Prostate carcinoma | 0.001085767 | 4 | 0 | BeFree |
Trichothiodystrophy Syndromes | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of larynx | 0.000814326 | 3 | 0 | BeFree |
Malignant neoplasm of skin | 0.000814326 | 3 | 0 | BeFree |
Paroxysmal atrial tachycardia | 0.000814326 | 3 | 4 | BeFree |
Carcinoma of larynx | 0.000814326 | 3 | 0 | BeFree |
Cockayne Syndrome, Type II | 0.000814326 | 3 | 0 | BeFree |
Squamous cell carcinoma | 0.000542884 | 2 | 0 | BeFree |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Xeroderma pigmentosum, group A | 0.000542884 | 2 | 0 | BeFree |
Solid tumour | 0.000542884 | 2 | 0 | BeFree |
Neurodegenerative Disorders | 0.000542884 | 2 | 0 | BeFree |
Skin carcinoma | 0.000542884 | 2 | 2 | BeFree |
Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 3 | BeFree |
Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
CNS disorder | 0.000271442 | 1 | 0 | BeFree |
Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
Epilepsy | 0.000271442 | 1 | 0 | BeFree |
Tonic-Clonic Epilepsy | 0.000271442 | 1 | 0 | BeFree |
Esophageal Neoplasms | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
Precancerous Conditions | 0.000271442 | 1 | 0 | BeFree |
Seizures | 0.000271442 | 1 | 0 | BeFree |
Esophageal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of mouth | 0.000271442 | 1 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Brittle hair | 0.000271442 | 1 | 0 | BeFree |
Turcot syndrome (disorder) | 0.000271442 | 1 | 0 | BeFree |
Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma Of Esophagus | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of oropharynx | 0.000271442 | 1 | 3 | BeFree |
Endometrial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Tonic - clonic seizures | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
ovarian neoplasm | 0.000271442 | 1 | 0 | BeFree |
Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of urinary bladder, superficial | 0.000271442 | 1 | 0 | BeFree |
Neurodevelopmental Disorders | 0.000271442 | 1 | 0 | BeFree |
UV-Sensitive Syndrome | 0.000271442 | 1 | 0 | BeFree |
Uterine Corpus Cancer | 0.000271442 | 1 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Experimental Organism Basal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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