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This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
[中文简述(自动翻译):] 这个基因编码是在中枢神经系统和影响许多生理过程中广泛表达的神经肽,包括皮质兴奋性,应激反应,食物摄入量,昼夜节律和心血管功能。通过G蛋白偶联型受体的神经肽的功能以抑制腺苷酸环化酶,激活促分裂原活化蛋白激酶(MAPK),调节细胞内钙水平,并激活钾通道。在该基因导致亮氨酸7至脯氨酸在信号肽的变化的多态性与胆固醇水平升高,高级醇消耗量相关联,并且可以是用于各种代谢和心血管疾病的危险因素。该蛋白也显示出对细菌和真菌的抗微生物活性。 [由RefSeq的,2014年10月提供]
NPY基因(以及对应的蛋白质)的细胞分布位置:
NPY基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Alcoholic Intoxication, Chronic | 0.219088146 | 20 | 2 | BeFree_CTD_human_GAD_RGD |
Depressive disorder | 0.203528744 | 16 | 1 | BeFree_CTD_human_RGD |
Seizures | 0.202714419 | 14 | 0 | BeFree_CTD_human_RGD |
Anorexia | 0.201628651 | 10 | 0 | BeFree_CTD_human_RGD |
Alzheimer's Disease | 0.200271442 | 3 | 0 | BeFree_CTD_human_RGD |
Cerebral Infarction | 0.2 | 2 | 0 | CTD_human_RGD |
Cardiovascular Diseases | 0.128815624 | 8 | 1 | BeFree_CTD_human_GAD_LHGDN |
Anxiety Disorders | 0.126786047 | 26 | 0 | BeFree_CTD_human |
Substance Withdrawal Syndrome | 0.122367032 | 2 | 0 | CTD_human_GAD |
Cocaine-Related Disorders | 0.122367032 | 2 | 0 | CTD_human_GAD |
Epilepsy | 0.121357209 | 7 | 0 | BeFree_CTD_human |
Epilepsy, Temporal Lobe | 0.120814326 | 4 | 0 | BeFree_CTD_human |
Asthma | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Bronchitis, Chronic | 0.12 | 1 | 0 | CTD_human |
Memory Disorders | 0.12 | 1 | 0 | CTD_human |
Muscle Rigidity | 0.12 | 1 | 0 | CTD_human |
Nasal obstruction present finding | 0.12 | 1 | 0 | CTD_human |
Peripheral Neuropathy | 0.12 | 1 | 0 | CTD_human |
Rhinitis | 0.12 | 1 | 0 | CTD_human |
Substance-Related Disorders | 0.12 | 1 | 0 | CTD_human |
Hyperactive behavior | 0.12 | 1 | 0 | CTD_human |
Weight decreased | 0.12 | 1 | 0 | CTD_human |
Obesity | 0.107307347 | 61 | 8 | BeFree_GAD_RGD |
Hypertensive disease | 0.09036833 | 7 | 0 | BeFree_GAD_LHGDN_RGD |
Huntington Disease | 0.082995792 | 3 | 0 | BeFree_LHGDN_RGD |
Febrile Convulsions | 0.082638474 | 2 | 0 | BeFree_GAD_RGD |
Heart failure | 0.080542884 | 3 | 0 | BeFree_RGD |
Diabetes Mellitus, Experimental | 0.08 | 1 | 0 | RGD |
Absence Epilepsy | 0.08 | 1 | 0 | RGD |
Hyperalgesia | 0.08 | 1 | 0 | RGD |
Status Epilepticus | 0.08 | 1 | 0 | RGD |
Endotoxemia | 0.08 | 1 | 0 | RGD |
Median Neuropathy | 0.08 | 1 | 0 | RGD |
Primary Graft Dysfunction | 0.08 | 1 | 0 | RGD |
Cerebral Hemorrhage | 0.08 | 1 | 0 | RGD |
Diabetes Mellitus, Non-Insulin-Dependent | 0.017459494 | 13 | 1 | BeFree_GAD |
Schizophrenia | 0.015721222 | 14 | 6 | BeFree_GAD_LHGDN |
Cerebrovascular accident | 0.010639772 | 4 | 1 | BeFree_GAD_LHGDN |
Mental Depression | 0.010358398 | 13 | 1 | BeFree_GAD |
Alcohol abuse | 0.00973957 | 5 | 0 | BeFree_GAD |
Atherosclerosis | 0.009172942 | 6 | 1 | BeFree_GAD_LHGDN |
Prostatic Neoplasms | 0.008173051 | 3 | 0 | LHGDN |
Diabetes Mellitus, Insulin-Dependent | 0.007372538 | 3 | 1 | BeFree_GAD |
Coronary heart disease | 0.006448592 | 6 | 2 | BeFree_GAD_LHGDN |
Diabetic Nephropathy | 0.005362824 | 2 | 1 | BeFree_GAD_LHGDN |
Diabetic Retinopathy | 0.005276948 | 4 | 1 | BeFree_GAD |
Hypercholesterolemia | 0.005276948 | 2 | 3 | BeFree_GAD |
Lymphoma, Non-Hodgkin | 0.005005506 | 2 | 0 | BeFree_GAD |
Brain Ischemia | 0.004734064 | 2 | 0 | GAD |
Neuroblastoma | 0.004071628 | 15 | 0 | BeFree |
Metabolic Syndrome X | 0.003995683 | 7 | 2 | BeFree_GAD |
Central neuroblastoma | 0.003800186 | 14 | 0 | BeFree |
Coronary Arteriosclerosis | 0.003724241 | 6 | 2 | BeFree_GAD |
Overweight | 0.003724241 | 5 | 3 | BeFree_GAD |
Post-Traumatic Stress Disorder | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Alcohol withdrawal syndrome | 0.003181358 | 3 | 0 | BeFree_GAD |
Diabetic Neuropathies | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Myocardial Infarction | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Obesity, Morbid | 0.002909916 | 3 | 0 | BeFree_GAD |
Dermatitis, Atopic | 0.00272435 | 1 | 0 | LHGDN |
Ptosis | 0.00272435 | 1 | 0 | LHGDN |
Urinary Incontinence | 0.00272435 | 1 | 0 | LHGDN |
Kidney Failure, Chronic | 0.002638474 | 1 | 0 | BeFree_GAD |
Marijuana Abuse | 0.002638474 | 2 | 0 | BeFree_GAD |
Left Ventricular Hypertrophy | 0.002638474 | 1 | 0 | BeFree_GAD |
Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
Hyperlipidemia | 0.002367032 | 1 | 0 | GAD |
Insulin Resistance | 0.002367032 | 1 | 0 | GAD |
Premature Obstetric Labor | 0.002367032 | 1 | 0 | GAD |
Pain, Postoperative | 0.002367032 | 1 | 0 | GAD |
Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
Psychoses, Substance-Induced | 0.002367032 | 1 | 0 | GAD |
Reflex Sympathetic Dystrophy | 0.002367032 | 1 | 0 | GAD |
Thinness | 0.002367032 | 1 | 0 | GAD |
Vascular Diseases | 0.002367032 | 1 | 0 | GAD |
Premature Birth | 0.002367032 | 1 | 0 | GAD |
Amphetamine-Related Disorders | 0.002367032 | 1 | 0 | GAD |
body mass | 0.002367032 | 1 | 0 | GAD |
Blood pressure finding | 0.002367032 | 1 | 0 | GAD |
Systemic arterial pressure | 0.002367032 | 1 | 0 | GAD |
Weight Loss Adverse Event | 0.002367032 | 1 | 0 | GAD |
Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
Hyperphagia | 0.001900093 | 7 | 0 | BeFree |
Unipolar Depression | 0.001900093 | 7 | 2 | BeFree |
Pheochromocytoma | 0.001628651 | 6 | 0 | BeFree |
Major Depressive Disorder | 0.001628651 | 6 | 2 | BeFree |
Arteriosclerosis | 0.001357209 | 5 | 1 | BeFree |
Malignant neoplasm of breast | 0.001357209 | 5 | 0 | BeFree |
Diabetes | 0.001357209 | 5 | 1 | BeFree |
Diabetes Mellitus | 0.001357209 | 5 | 1 | BeFree |
Mood Disorders | 0.001357209 | 5 | 0 | BeFree |
Breast Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Coronary Artery Disease | 0.001357209 | 5 | 2 | BeFree |
Malignant neoplasm of prostate | 0.001085767 | 4 | 0 | BeFree |
Ischemic stroke | 0.001085767 | 4 | 0 | BeFree |
Ischemic Cerebrovascular Accident | 0.001085767 | 4 | 0 | BeFree |
Dyslipidemias | 0.000814326 | 3 | 0 | BeFree |
Prostate carcinoma | 0.000814326 | 3 | 0 | BeFree |
Astrocytoma | 0.000542884 | 2 | 0 | BeFree |
Cachexia | 0.000542884 | 2 | 0 | BeFree |
IGA Glomerulonephritis | 0.000542884 | 2 | 0 | BeFree |
Congestive heart failure | 0.000542884 | 2 | 0 | BeFree |
Hyperinsulinism | 0.000542884 | 2 | 0 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Periodontitis | 0.000542884 | 2 | 0 | BeFree |
Psychotic Disorders | 0.000542884 | 2 | 0 | BeFree |
Retinal Diseases | 0.000542884 | 2 | 1 | BeFree |
Essential Hypertension | 0.000542884 | 2 | 0 | BeFree |
Hypokinesia | 0.000542884 | 2 | 0 | BeFree |
Benign Neoplasm | 0.000542884 | 2 | 0 | BeFree |
Withdrawal Symptoms | 0.000542884 | 2 | 0 | BeFree |
Neuroectodermal Tumors | 0.000542884 | 2 | 0 | BeFree |
Neuroendocrine Tumors | 0.000542884 | 2 | 0 | BeFree |
Mixed anxiety and depressive disorder | 0.000542884 | 2 | 0 | BeFree |
Nonorganic psychosis | 0.000542884 | 2 | 0 | BeFree |
Ewings sarcoma | 0.000542884 | 2 | 0 | BeFree |
Agoraphobia | 0.000271442 | 1 | 2 | BeFree |
Alcohol Withdrawal Delirium | 0.000271442 | 1 | 0 | BeFree |
Mental disorders | 0.000271442 | 1 | 0 | BeFree |
Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carotid Stenosis | 0.000271442 | 1 | 0 | BeFree |
Diphtheria | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Hallucinations | 0.000271442 | 1 | 0 | BeFree |
Von Hippel-Lindau Syndrome | 0.000271442 | 1 | 0 | BeFree |
Hunger | 0.000271442 | 1 | 0 | BeFree |
Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Hypertension | 0.000271442 | 1 | 0 | BeFree |
Hypertensive crisis | 0.000271442 | 1 | 0 | BeFree |
Ischemia | 0.000271442 | 1 | 0 | BeFree |
Kidney Neoplasm | 0.000271442 | 1 | 0 | BeFree |
leukemia | 0.000271442 | 1 | 0 | BeFree |
Myeloid Leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, T-Cell | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Follicular | 0.000271442 | 1 | 0 | BeFree |
Multiple Endocrine Neoplasia Type 2a | 0.000271442 | 1 | 0 | BeFree |
Nephroblastoma | 0.000271442 | 1 | 0 | BeFree |
oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
Panic Disorder | 0.000271442 | 1 | 0 | BeFree |
Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
Pituitary Diseases | 0.000271442 | 1 | 0 | BeFree |
Prader-Willi Syndrome | 0.000271442 | 1 | 0 | BeFree |
Prolactinoma | 0.000271442 | 1 | 0 | BeFree |
Prostatic Diseases | 0.000271442 | 1 | 0 | BeFree |
Kidney Failure | 0.000271442 | 1 | 0 | BeFree |
Schizoaffective Disorder | 0.000271442 | 1 | 0 | BeFree |
Stress, Psychological | 0.000271442 | 1 | 0 | BeFree |
Substance Dependence | 0.000271442 | 1 | 0 | BeFree |
Substance Use Disorders | 0.000271442 | 1 | 0 | BeFree |
Vitiligo | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Large-Cell, Follicular | 0.000271442 | 1 | 0 | BeFree |
Hypoalgesia | 0.000271442 | 1 | 0 | BeFree |
Mood swings | 0.000271442 | 1 | 0 | BeFree |
Acute leukemia | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Cholera | 0.000271442 | 1 | 0 | BeFree |
Ganglioneuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Alcohol-Related Disorders | 0.000271442 | 1 | 0 | BeFree |
Drug usage | 0.000271442 | 1 | 0 | BeFree |
Chronic Periodontitis | 0.000271442 | 1 | 3 | BeFree |
Generalized Anxiety Disorder | 0.000271442 | 1 | 0 | BeFree |
Disseminated neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Obesity, Abdominal | 0.000271442 | 1 | 1 | BeFree |
Adenocarcinoma of colon | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
After pains | 0.000271442 | 1 | 0 | BeFree |
Benign pheochromocytoma | 0.000271442 | 1 | 0 | BeFree |
Neurodegenerative Disorders | 0.000271442 | 1 | 0 | BeFree |
Carotid Atherosclerosis | 0.000271442 | 1 | 1 | BeFree |
Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
Mild depression | 0.000271442 | 1 | 0 | BeFree |
Cocaine Dependence | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Substance abuse problem | 0.000271442 | 1 | 0 | BeFree |
Chronic drug abuse | 0.000271442 | 1 | 0 | BeFree |
Hypothalamic Dysfunction Syndromes | 0.000271442 | 1 | 0 | BeFree |
Well Differentiated Oligodendroglioma | 0.000271442 | 1 | 0 | BeFree |
Bardet-Biedl Syndrome | 0.000271442 | 1 | 0 | BeFree |
Stage 4S neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
High-Grade Prostatic Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
Low Grade Prostatic Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
Attention deficit hyperactivity disorder | 0.000271442 | 1 | 0 | BeFree |
Neoplasms, Intracranial | 0.000271442 | 1 | 0 | BeFree |
Peripheral Arterial Diseases | 0.000271442 | 1 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000271442 | 1 | 0 | BeFree |
Dystonia 3, Torsion, X-Linked | 0.000271442 | 1 | 0 | BeFree |
NEUROTICISM | 0.000271442 | 1 | 0 | BeFree |
VITILIGO-ASSOCIATED MULTIPLE AUTOIMMUNE DISEASE SUSCEPTIBILITY 1 (finding) | 0.000271442 | 1 | 0 | BeFree |
PANIC DISORDER 1 | 0.000271442 | 1 | 0 | BeFree |
Chronic kidney disease stage 5 | 0.000271442 | 1 | 0 | BeFree |
Pediatric Obesity | 0.000271442 | 1 | 0 | BeFree |
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