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Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]
[中文简述(自动翻译):]  鸟苷酸环化酶,催化从GTP生产的cGMP的,被分类为可溶性和膜的形式(Garbers和洛韦,1994 [搜索PubMed 7982997])。膜鸟苷酸环化酶,通常被称为鸟苷酸环化酶A到F,可以形成一个家族的细胞表面受体的具有类似地形结构:包含一种蛋白激酶的细胞外配体结合域,单个跨膜结构域和细胞内区域样结构域和环化酶催化域。 GC-A和GC-B作为受体,钠尿肽;他们也被称为心房利钠肽受体A(NPR1)和B型(NPR2; MIM 108961)。也见NPR3(MIM 108962),其编码的蛋白质仅与配体结合跨膜和37个氨基酸的胞质域。 NPR1是一种膜结合的鸟苷酸环化酶是(分别ANP(MIM 108780)和BNP(MIM 600295),)作为受体为心房和脑利尿钠肽。[由OMIM,2009年5月供给]
NPR1基因(以及对应的蛋白质)的细胞分布位置:
NPR1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Hypertensive disease | 0.219183953 | 13 | 0 | BeFree_CTD_human_GAD_LHGDN_RGD |
Heart failure | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Fibrosis | 0.12 | 1 | 0 | CTD_human |
Cardiomegaly | 0.12 | 1 | 0 | CTD_human |
Kidney Diseases | 0.12 | 1 | 0 | CTD_human |
Left Ventricular Hypertrophy | 0.080271442 | 2 | 0 | BeFree_RGD |
Myocardial Infarction | 0.007458414 | 2 | 0 | GAD_LHGDN |
Cardiovascular Diseases | 0.005634266 | 3 | 0 | BeFree_GAD_LHGDN |
Myocardial Ischemia | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Colorectal Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Coronary Artery Disease | 0.002638474 | 1 | 0 | BeFree_GAD |
Carotid Stenosis | 0.002367032 | 1 | 0 | GAD |
Chorioamnionitis | 0.002367032 | 1 | 0 | GAD |
Fetal Membranes, Premature Rupture | 0.002367032 | 1 | 0 | GAD |
Heart Diseases | 0.002367032 | 1 | 0 | GAD |
Premature Obstetric Labor | 0.002367032 | 1 | 0 | GAD |
Pre-Eclampsia | 0.002367032 | 1 | 0 | GAD |
Premature Birth | 0.002367032 | 1 | 0 | GAD |
Ventricular Dysfunction | 0.002367032 | 1 | 0 | GAD |
Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 0.002367032 | 1 | 0 | GAD |
Congestive heart failure | 0.000542884 | 2 | 0 | BeFree |
Ovarian Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Essential Hypertension | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of esophagus | 0.000542884 | 2 | 1 | BeFree |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
Diabetes Mellitus, Non-Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
HIV Infections | 0.000271442 | 1 | 0 | BeFree |
melanoma | 0.000271442 | 1 | 0 | BeFree |
Obesity | 0.000271442 | 1 | 0 | BeFree |
Hypertensive heart disease | 0.000271442 | 1 | 0 | BeFree |
pediatric AIDS | 0.000271442 | 1 | 0 | BeFree |
Interstitial fibrosis | 0.000271442 | 1 | 0 | BeFree |
Aortic valve calcification | 0.000271442 | 1 | 0 | BeFree |
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