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This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]
[中文简述(自动翻译):]  此基因编码的核和细胞质之间移动的磷蛋白。该基因产物被认为是参与几个过程,包括ARF / p53途径的调节。一些基因是融合配偶已经表征,特别是染色体上的间变性淋巴瘤激酶基因2.在该基因的突变与急性骨髓性白血病有关。该基因的十几假已经确定。选择性剪接结果在多个抄本变形。[由RefSeq的,2009年11月提供]
NPM1基因(以及对应的蛋白质)的细胞分布位置:
NPM1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Leukemia, Myelocytic, Acute | 0.446321629 | 298 | 2 | BeFree_CLINVAR_CTD_human_GAD_LHGDN |
Acute Promyelocytic Leukemia | 0.245700279 | 22 | 0 | BeFree_CTD_human_ORPHANET |
Lymphomatoid Papulosis | 0.120542884 | 2 | 0 | BeFree_ORPHANET |
Stomach Neoplasms | 0.120271442 | 2 | 0 | BeFree_CTD_human |
Lymphoma, Primary Cutaneous Anaplastic Large Cell | 0.120271442 | 1 | 0 | BeFree_ORPHANET |
Ki-1+ Anaplastic Large Cell Lymphoma | 0.042103285 | 128 | 0 | BeFree_LHGDN |
Myeloid Leukemia | 0.036048363 | 17 | 0 | BeFree_GAD |
MYELODYSPLASTIC SYNDROME | 0.022451187 | 16 | 0 | BeFree_GAD_LHGDN |
Lymphoma | 0.016316307 | 32 | 0 | BeFree_LHGDN |
leukemia | 0.016220499 | 41 | 0 | BeFree_GAD_LHGDN |
Preleukemia | 0.012996872 | 17 | 0 | BeFree_GAD |
Neoplasm, Residual | 0.011867498 | 35 | 0 | BeFree_GAD |
Cytogenetically normal acute myeloid leukemia | 0.008957582 | 33 | 0 | BeFree |
Chromosome Aberrations | 0.007101096 | 3 | 0 | GAD |
Carcinogenesis | 0.006786047 | 25 | 0 | BeFree |
Leukemogenesis | 0.006786047 | 25 | 0 | BeFree |
Prostatic Neoplasms | 0.005720142 | 3 | 0 | BeFree_LHGDN |
Leukemia, Myelomonocytic, Chronic | 0.00554839 | 5 | 0 | BeFree_GAD |
Adult Acute Myeloblastic Leukemia | 0.004614512 | 17 | 0 | BeFree |
T-Cell Lymphoma | 0.00408156 | 6 | 0 | BeFree_LHGDN |
Myeloproliferative disease | 0.003810118 | 4 | 0 | BeFree_LHGDN |
Anaplastic Large Cell Lymphoma, ALK-Positive | 0.003800186 | 14 | 0 | BeFree |
Fanconi Anemia | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Granulocytic Sarcoma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Congenital chromosomal disease | 0.003257302 | 12 | 0 | BeFree |
Primary Myelofibrosis | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Blast Phase | 0.002909916 | 3 | 0 | BeFree_GAD |
Malignant neoplasm of breast | 0.002909916 | 3 | 0 | BeFree_GAD |
Japanese Encephalitis | 0.00272435 | 1 | 0 | LHGDN |
Lung Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Osteosarcoma | 0.00272435 | 1 | 0 | LHGDN |
Diffuse Large B-Cell Lymphoma | 0.00272435 | 1 | 0 | LHGDN |
MULTICYSTIC RENAL DYSPLASIA, BILATERAL | 0.002714419 | 10 | 0 | BeFree |
pediatric acute myeloblastic leukemia | 0.002442977 | 9 | 0 | BeFree |
Neoplastic Cell Transformation | 0.002367032 | 1 | 0 | GAD |
Chromosome inversion | 0.002367032 | 1 | 0 | GAD |
Chromosomal translocation | 0.002367032 | 1 | 0 | GAD |
XYY Karyotype | 0.002367032 | 1 | 0 | GAD |
Hematologic Neoplasms | 0.002171535 | 8 | 0 | BeFree |
Nephroblastoma | 0.001628651 | 6 | 0 | BeFree |
Kidney Failure, Acute | 0.001357209 | 5 | 0 | BeFree |
Myelodysplasia | 0.001357209 | 5 | 0 | BeFree |
Acute respiratory failure | 0.001357209 | 5 | 0 | BeFree |
Liver carcinoma | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of stomach | 0.001085767 | 4 | 0 | BeFree |
Neoplasm Metastasis | 0.001085767 | 4 | 0 | BeFree |
Anaplastic large B-cell lymphoma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of urinary bladder | 0.000814326 | 3 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000814326 | 3 | 0 | BeFree |
Tumor Progression | 0.000814326 | 3 | 0 | BeFree |
Solid tumour | 0.000814326 | 3 | 0 | BeFree |
secondary acute myeloid leukemia | 0.000814326 | 3 | 0 | BeFree |
Recurrent tumor | 0.000814326 | 3 | 0 | BeFree |
Stomach Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Carcinoma of bladder | 0.000814326 | 3 | 0 | BeFree |
Promyelocytic leukemia | 0.000814326 | 3 | 0 | BeFree |
Acute myeloid leukemia with mutated NPM1 | 0.000814326 | 3 | 0 | BeFree |
FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) | 0.000814326 | 3 | 0 | BeFree |
Adenoma | 0.000542884 | 2 | 0 | BeFree |
Astrocytoma | 0.000542884 | 2 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Colorectal Carcinoma | 0.000542884 | 2 | 0 | BeFree |
HIV Infections | 0.000542884 | 2 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000542884 | 2 | 0 | BeFree |
Multiple Myeloma | 0.000542884 | 2 | 0 | BeFree |
Neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
B-Cell Lymphomas | 0.000542884 | 2 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000542884 | 2 | 0 | BeFree |
Acute leukemia | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of mouth | 0.000542884 | 2 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000542884 | 2 | 0 | BeFree |
Prostate carcinoma | 0.000542884 | 2 | 0 | BeFree |
Breast Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Central neuroblastoma | 0.000542884 | 2 | 0 | BeFree |
Sarcoma | 0.000542884 | 2 | 0 | BeFree |
M5b Acute differentiated monocytic leukemia | 0.000542884 | 2 | 0 | BeFree |
Systemic Anaplastic Large Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Treatment related acute myeloid leukaemia | 0.000542884 | 2 | 0 | BeFree |
Non-Neoplastic Disorder | 0.000542884 | 2 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of endometrium | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of prostate | 0.000271442 | 1 | 0 | BeFree |
Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Exanthema | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Graft-vs-Host Disease | 0.000271442 | 1 | 0 | BeFree |
Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
Hepatoma, Novikoff | 0.000271442 | 1 | 0 | BeFree |
Malignant histiocytosis | 0.000271442 | 1 | 0 | BeFree |
Hodgkin Disease | 0.000271442 | 1 | 0 | BeFree |
Immunologic Deficiency Syndromes | 0.000271442 | 1 | 0 | BeFree |
Influenza | 0.000271442 | 1 | 0 | BeFree |
Chronic Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Acute monocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myeloid, Chronic-Phase | 0.000271442 | 1 | 0 | BeFree |
Acute myelomonocytic leukemia | 0.000271442 | 1 | 0 | BeFree |
Liver Cirrhosis | 0.000271442 | 1 | 0 | BeFree |
Liver neoplasms | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Non-Hodgkin | 0.000271442 | 1 | 0 | BeFree |
Mastocytosis | 0.000271442 | 1 | 0 | BeFree |
Monosomy | 0.000271442 | 1 | 0 | BeFree |
Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
Kaposi Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Skin Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Urticaria Pigmentosa | 0.000271442 | 1 | 0 | BeFree |
Xeroderma Pigmentosum | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, T-Cell, Cutaneous | 0.000271442 | 1 | 0 | BeFree |
Monocytosis | 0.000271442 | 1 | 0 | BeFree |
Acute myeloid leukemia in remission | 0.000271442 | 1 | 0 | BeFree |
Chronic myeloid leukemia in remission | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Hemangioma of liver | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of lung | 0.000271442 | 1 | 0 | BeFree |
Coinfection | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of colon stage IV | 0.000271442 | 1 | 0 | BeFree |
Liver and Intrahepatic Biliary Tract Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Focal Nodular Hyperplasia | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Myofibroblastic Tumor | 0.000271442 | 1 | 0 | BeFree |
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Sarcoma of breast | 0.000271442 | 1 | 0 | BeFree |
Endometrial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma of lung | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Chromosome 8, monosomy 8p | 0.000271442 | 1 | 0 | BeFree |
Spots on skin | 0.000271442 | 1 | 0 | BeFree |
Adenomatous polyp of colon | 0.000271442 | 1 | 0 | BeFree |
Rhabdoid Tumor of the Kidney | 0.000271442 | 1 | 0 | BeFree |
Primary Effusion Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Acute myeloid leukemia with multilineage dysplasia | 0.000271442 | 1 | 0 | BeFree |
Chronic myeloproliferative disorder | 0.000271442 | 1 | 0 | BeFree |
Therapy-related myelodysplastic syndrome | 0.000271442 | 1 | 0 | BeFree |
Anaplastic large cell lymphoma, ALK negative | 0.000271442 | 1 | 0 | BeFree |
Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Colorectal Cancer | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma Multiforme | 0.000271442 | 1 | 0 | BeFree |
FRIEDREICH ATAXIA 1 | 0.000271442 | 1 | 0 | BeFree |
Uterine Corpus Cancer | 0.000271442 | 1 | 0 | BeFree |
Extramedullary Hematopoiesis (disorder) | 0.000271442 | 1 | 0 | BeFree |
Acute myeloid leukemia with mutated CEBPA | 0.000271442 | 1 | 0 | BeFree |
Nasopharyngeal carcinoma | 0.000271442 | 1 | 0 | BeFree |
Myeloid neoplasm | 0.000271442 | 1 | 0 | BeFree |
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