NOTCH4基因详情-基因数据库-基因云馆

NOTCH4(notch 4) 转至新版数据库

基因简称(symbol)

NOTCH4 [HGNC] [GeneCards] [NCBI]

基因种类(locus group)

protein-coding gene

同源简称(alias symbol)

基因家族代码(gene_family_id)

403 [HGNC] [GenScript]

omim代码

164951

entrez码

4855 [Vega]

vega基因码

OTTHUMG00000031044

ensembl基因码

ENSG00000204301 [Ensembl]

基因家族(gene family)

Ankyrin repeat domain containing

refseq数据库代号

NM_004557

更多...

基因种类(locus_type)

gene with protein product

基因名称状态(status)

Approved

location_sortable

06p21.3

同源基因名称(alias name)

基因名称批准使用时间(date_approved_reserved)

1994-07-04T00:00:00Z

基因简称更名时间(date_symbol_changed)

基因名称更名时间(date_name_changed)

2010-06-24T00:00:00Z

更新时间(date_modified)

2013-01-10T00:00:00Z

ucsc码

uc003obb.3

ena

ccds数据码

CCDS34420

uniprot数据码

Q99466

pubmed代码

7835890

mgd码

MGI:107471

rgd码

RGD:1303282

生命科学数据库(lsdb)

更新时间(date modified)

2013-01-10T00:00:00Z

cosmic

NOTCH4

mirbase

基因曾用简称(prev symbol)

INT3

基因曾用名称(prev name)

Notch (Drosophila) homolog 4|Notch homolog 4 (Drosophila)

homeodb

cosmic

NOTCH4

snornabase

bioparadigms slc

orphanet

假基因信息(pseudogeneorg)

horde id

merops

imgt

iuphar

kznf基因类别

mamit-trnadb

cd

LncRNA数据库

酶代码

中间纤维数据库

收起

6p21.3

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):] 该基因编码所述Notch家族的一个成员。这种类型1的跨膜蛋白家族的成员共有的结构特征，包括由多个表皮生长因子样（EGF）的胞外域重复，和由多个不同的域类型的细胞内结构域。缺口家族成员通过控制细胞命运决定发挥各种发育过程中的作用。 Notch信号网络是其调节物理相邻细胞间的相互作用的进化上保守的细胞间信号传导途径。在Drosophilia，其细胞结合的配体（三角形，锯齿）缺口交互规定，起着发展的重要作用，细胞间信号通路。缺口配体的同系物也已在人确定，但这些配体与人Notch同源物之间的精确相互作用仍有待确定。这种蛋白质被裂解反式高尔基网络中，并呈现在细胞表面作为异二聚体上。该蛋白质的功能，作为膜结合配体的受体，和可能在血管，肾和肝发育的作用。该基因可以用易感性的情况下的一小部分被关联到精神分裂症。备选剪接变体已被描述，但其生物性质尚未确定。 [由RefSeq的，2008年7月提供]

OMIM数据库中对NOTCH4基因的介绍 Wikipedia数据库中对NOTCH4基因的介绍

NOTCH4基因的碱基序列：[NCBI]

NOTCH4基因的碱基突变：显示全部snp

rs1044507 rs1044507 rs1044507 rs1044507 rs1044507 rs1044507 rs2071279 rs2071279 rs2071279 rs2071279 rs2071279 rs2071279 rs2071280 rs2071280 rs2071280 rs2071280 rs2071280 rs2071280 rs8192576 rs8192576 rs8192576 rs8192576 rs8192576 rs8192576 rs8192577 rs8192577 rs8192577 rs8192577 rs8192577 rs8192577 rs8192578 rs8192578 rs8192578 rs8192578 rs8192578 rs8192578 rs8192579

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rs138411307 rs138411307 rs138457708 rs138457708 rs138457708 rs138457708 rs138457708 rs138457708 rs138986166 rs138986166 rs138986166 rs138986166 rs138986166 rs138986166 rs139392477 rs139392477 rs139392477 rs139392477 rs139392477 rs139392477 rs141525894 rs141525894 rs141525894 rs141525894 rs141525894 rs141525894 rs141575260 rs141575260 rs141575260 rs141575260 rs141575260 rs141575260 rs141656129 rs141656129 rs141656129 rs141656129 rs141656129 rs141656129 rs142575217 rs142575217 rs142575217 rs142575217 rs142575217 rs142575217 rs142586922 rs142586922 rs142586922 rs142586922 rs142586922 rs142586922 rs143991041 rs143991041 rs143991041 rs143991041 rs143991041 rs143991041 rs144441716 rs144441716 rs144441716 rs144441716 rs144441716 rs144441716 rs146281071 rs146281071 rs146281071 rs146281071 rs146281071 rs146281071 rs146395161 rs146395161 rs146395161 rs146395161 rs146395161 rs146395161 rs148012848 rs148012848 rs148012848 rs148012848 rs148012848 rs148012848 rs148437659 rs148437659 rs148437659 rs148437659 rs148437659 rs148437659 rs148746475 rs148746475 rs148746475 rs148746475 rs148746475 rs148746475 rs150089454 rs150089454 rs150089454 rs150089454 rs150089454 rs150089454 rs150527902 rs150527902 rs150527902 rs150527902 rs150527902 rs150527902 rs180676159 rs180676159 rs180676159 rs180676159 rs180676159 rs180676159 rs181660200 rs181660200 rs181660200 rs181660200 rs181660200 rs181660200 rs182937662 rs182937662 rs182937662 rs182937662 rs182937662 rs182937662 rs182940608 rs182940608 rs182940608 rs182940608 rs182940608 rs182940608 rs185949640 rs185949640 rs185949640 rs185949640 rs185949640 rs185949640 rs186315784 rs186315784 rs186315784 rs186315784 rs186315784 rs186315784 rs186698039 rs186698039 rs186698039 rs186698039 rs186698039 rs186698039 rs187570181 rs187570181 rs187570181 rs187570181 rs187570181 rs187570181 rs190390420 rs190390420 rs190390420 rs190390420 rs190390420 rs190390420 rs199672847 rs199672847 rs199672847 rs199672847 rs199672847 rs199672847 rs200223154 rs200223154 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rs370586098 rs370586098 rs370586098 rs370586098 rs370586098 rs371720441 rs371720441 rs371720441 rs371720441 rs371720441 rs371720441 rs372404251 rs372404251 rs372404251 rs372404251 rs372404251 rs372404251 rs372435598 rs372435598 rs372435598 rs372435598 rs372435598 rs372435598 rs373173038 rs373173038 rs373173038 rs373173038 rs373173038 rs373173038 rs373534418 rs373534418 rs373534418 rs373534418 rs373534418 rs373534418 rs374317137 rs374317137 rs374317137 rs374317137 rs374317137 rs374317137 rs375070515 rs375070515 rs375070515 rs375070515 rs375070515 rs375070515 rs375923017 rs375923017 rs375923017 rs375923017 rs375923017 rs375923017 rs376773696 rs376773696 rs376773696 rs376773696 rs376773696 rs376773696 rs529856697 rs529856697 rs529856697 rs529856697 rs529856697 rs529856697 rs529966299 rs529966299 rs529966299 rs529966299 rs529966299 rs529966299 rs530633372 rs530633372 rs530633372 rs530633372 rs530633372 rs530633372 rs530682383 rs530682383 rs530682383 rs530682383 rs530682383 rs530682383 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rs547042778 rs547103731 rs547103731 rs547103731 rs547103731 rs547103731 rs547103731 rs547664010 rs547664010 rs547664010 rs547664010 rs547664010 rs547664010 rs548076896 rs548076896 rs548076896 rs548076896 rs548076896 rs548076896 rs549543275 rs549543275 rs549543275 rs549543275 rs549543275 rs549543275 rs549790395 rs549790395 rs549790395 rs549790395 rs549790395 rs549790395 rs552600265 rs552600265 rs552600265 rs552600265 rs552600265 rs552600265 rs553655972 rs553655972 rs553655972 rs553655972 rs553655972 rs553655972 rs553715797 rs553715797 rs553715797 rs553715797 rs553715797 rs553715797 rs553717397 rs553717397 rs553717397 rs553717397 rs553717397 rs553717397 rs554601057 rs554601057 rs554601057 rs554601057 rs554601057 rs554601057 rs557632279 rs557632279 rs557632279 rs557632279 rs557632279 rs557632279 rs558909566 rs558909566 rs558909566 rs558909566 rs558909566 rs558909566 rs559217481 rs559217481 rs559217481 rs559217481 rs559217481 rs559217481 rs560030168 rs560030168 rs560030168 rs560030168 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rs745395384 rs745395384 rs745450320 rs745450320 rs745450320 rs745450320 rs745450320 rs745450320 rs745710360 rs745710360 rs745710360 rs745710360 rs745710360 rs745710360 rs745811347 rs745811347 rs745811347 rs745811347 rs745811347 rs745811347 rs746245617 rs746245617 rs746245617 rs746245617 rs746245617 rs746245617 rs746415736 rs746415736 rs746415736 rs746415736 rs746415736 rs746415736 rs746563549 rs746563549 rs746563549 rs746563549 rs746563549 rs746563549 rs747110906 rs747110906 rs747110906 rs747110906 rs747110906 rs747110906 rs747165626 rs747165626 rs747165626 rs747165626 rs747165626 rs747165626 rs747469940 rs747469940 rs747469940 rs747469940 rs747469940 rs747469940 rs747595966 rs747595966 rs747595966 rs747595966 rs747595966 rs747595966 rs747603566 rs747603566 rs747603566 rs747603566 rs747603566 rs747603566 rs747836052 rs747836052 rs747836052 rs747836052 rs747836052 rs747836052 rs748008498 rs748008498 rs748008498 rs748008498 rs748008498 rs748008498 rs748019252 rs748019252 rs748019252 rs748019252 rs748019252 rs748019252 rs748207894 rs748207894 rs748207894 rs748207894 rs748207894 rs748207894 rs748538853 rs748538853 rs748538853 rs748538853 rs748538853 rs748538853 rs748589573 rs748589573 rs748589573 rs748589573 rs748589573 rs748589573 rs748829728 rs748829728 rs748829728 rs748829728 rs748829728 rs748829728 rs748941744 rs748941744 rs748941744 rs748941744 rs748941744 rs748941744 rs749140039 rs749140039 rs749140039 rs749140039 rs749140039 rs749140039 rs749288289 rs749288289 rs749288289 rs749288289 rs749288289 rs749288289 rs749675272 rs749675272 rs749675272 rs749675272 rs749675272 rs749675272 rs749726670 rs749726670 rs749726670 rs749726670 rs749726670 rs749726670 rs750198320 rs750198320 rs750198320 rs750198320 rs750198320 rs750198320 rs750431124 rs750431124 rs750431124 rs750431124 rs750431124 rs750431124 rs750474813 rs750474813 rs750474813 rs750474813 rs750474813 rs750474813 rs750527905 rs750527905 rs750527905 rs750527905 rs750527905 rs750527905 rs750797312 rs750797312 rs750797312 rs750797312 rs750797312 rs750797312 rs750952836 rs750952836 rs750952836 rs750952836 rs750952836 rs750952836 rs751010175 rs751010175 rs751010175 rs751010175 rs751010175 rs751010175 rs751197788 rs751197788 rs751197788 rs751197788 rs751197788 rs751197788 rs751250725 rs751250725 rs751250725 rs751250725 rs751250725 rs751250725 rs751826890 rs751826890 rs751826890 rs751826890 rs751826890 rs751826890 rs751963033 rs751963033 rs751963033 rs751963033 rs751963033 rs751963033 rs751988342 rs751988342 rs751988342 rs751988342 rs751988342 rs751988342 rs752105876 rs752105876 rs752105876 rs752105876 rs752105876 rs752105876 rs752207666 rs752207666 rs752207666 rs752207666 rs752207666 rs752207666 rs752540222 rs752540222 rs752540222 rs752540222 rs752540222 rs752540222 rs752664803 rs752664803 rs752664803 rs752664803 rs752664803 rs752664803 rs752717843 rs752717843 rs752717843 rs752717843 rs752717843 rs752717843 rs752898443 rs752898443 rs752898443 rs752898443 rs752898443 rs752898443 rs752907370 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rs775185758 rs775185758 rs775185758 rs775193414 rs775193414 rs775193414 rs775193414 rs775193414 rs775193414 rs775207648 rs775207648 rs775207648 rs775207648 rs775207648 rs775207648 rs775333757 rs775333757 rs775333757 rs775333757 rs775333757 rs775333757 rs775420805 rs775420805 rs775420805 rs775420805 rs775420805 rs775420805 rs775439461 rs775439461 rs775439461 rs775439461 rs775439461 rs775439461 rs775440106 rs775440106 rs775440106 rs775440106 rs775440106 rs775440106 rs775447127 rs775447127 rs775447127 rs775447127 rs775447127 rs775447127 rs775462558 rs775462558 rs775462558 rs775462558 rs775462558 rs775462558 rs775488332 rs775488332 rs775488332 rs775488332 rs775488332 rs775488332 rs775555192 rs775555192 rs775555192 rs775555192 rs775555192 rs775555192 rs775564540 rs775564540 rs775564540 rs775564540 rs775564540 rs775564540 rs775573404 rs775573404 rs775573404 rs775573404 rs775573404 rs775573404 rs775577732 rs775577732 rs775577732 rs775577732 rs775577732 rs775577732 rs775810277 rs775810277 rs775810277 rs775810277 rs775810277 rs775810277 rs775822560 rs775822560 rs775822560 rs775822560 rs775822560 rs775822560 rs775875028 rs775875028 rs775875028 rs775875028 rs775875028 rs775875028 rs775875277 rs775875277 rs775875277 rs775875277 rs775875277 rs775875277 rs775975129 rs775975129 rs775975129 rs775975129 rs775975129 rs775975129 rs776017114 rs776017114 rs776017114 rs776017114 rs776017114 rs776017114 rs776072162 rs776072162 rs776072162 rs776072162 rs776072162 rs776072162 rs776072177 rs776072177 rs776072177 rs776072177 rs776072177 rs776072177 rs776140208 rs776140208 rs776140208 rs776140208 rs776140208 rs776140208 rs776161068 rs776161068 rs776161068 rs776161068 rs776161068 rs776161068 rs776195186 rs776195186 rs776195186 rs776195186 rs776195186 rs776195186 rs776196048 rs776196048 rs776196048 rs776196048 rs776196048 rs776196048 rs776201108 rs776201108 rs776201108 rs776201108 rs776201108 rs776201108 rs776326321 rs776326321 rs776326321 rs776326321 rs776326321 rs776326321 rs776531260 rs776531260 rs776531260 rs776531260 rs776531260 rs776531260 rs776576557 rs776576557 rs776576557 rs776576557 rs776576557 rs776576557 rs776583688 rs776583688 rs776583688 rs776583688 rs776583688 rs776583688 rs776610037 rs776610037 rs776610037 rs776610037 rs776610037 rs776610037 rs776612776 rs776612776 rs776612776 rs776612776 rs776612776 rs776612776 rs776623079 rs776623079 rs776623079 rs776623079 rs776623079 rs776623079 rs776678401 rs776678401 rs776678401 rs776678401 rs776678401 rs776678401 rs776688381 rs776688381 rs776688381 rs776688381 rs776688381 rs776688381 rs776692365 rs776692365 rs776692365 rs776692365 rs776692365 rs776692365 rs776714201 rs776714201 rs776714201 rs776714201 rs776714201 rs776714201 rs776841044 rs776841044 rs776841044 rs776841044 rs776841044 rs776841044 rs776907901 rs776907901 rs776907901 rs776907901 rs776907901 rs776907901 rs776957249 rs776957249 rs776957249 rs776957249 rs776957249 rs776957249 rs776974248 rs776974248 rs776974248 rs776974248 rs776974248 rs776974248 rs777013247 rs777013247 rs777013247 rs777013247 rs777013247 rs777013247 rs777164939 rs777164939 rs777164939 rs777164939 rs777164939 rs777164939 rs777193021 rs777193021 rs777193021 rs777193021 rs777193021 rs777193021 rs777216374 rs777216374 rs777216374 rs777216374 rs777216374 rs777216374 rs777232877 rs777232877 rs777232877 rs777232877 rs777232877 rs777232877 rs777267478 rs777267478 rs777267478 rs777267478 rs777267478 rs777267478 rs777281026 rs777281026 rs777281026 rs777281026 rs777281026 rs777281026 rs777366188 rs777366188 rs777366188 rs777366188 rs777366188 rs777366188 rs777423381 rs777423381 rs777423381 rs777423381 rs777423381 rs777423381 rs777448068 rs777448068 rs777448068 rs777448068 rs777448068 rs777448068 rs777501570 rs777501570 rs777501570 rs777501570 rs777501570 rs777501570 rs777520438 rs777520438 rs777520438 rs777520438 rs777520438 rs777520438 rs777583421 rs777583421 rs777583421 rs777583421 rs777583421 rs777583421 rs777607269 rs777607269 rs777607269 rs777607269 rs777607269 rs777607269 rs777662167 rs777662167 rs777662167 rs777662167 rs777662167 rs777662167 rs777675400 rs777675400 rs777675400 rs777675400 rs777675400 rs777675400 rs777681383 rs777681383 rs777681383 rs777681383 rs777681383 rs777681383 rs777684671 rs777684671 rs777684671 rs777684671 rs777684671 rs777684671 rs777703426 rs777703426 rs777703426 rs777703426 rs777703426 rs777703426 rs777832615 rs777832615 rs777832615 rs777832615 rs777832615 rs777832615 rs777865677 rs777865677 rs777865677 rs777865677 rs777865677 rs777865677 rs777877265 rs777877265 rs777877265 rs777877265 rs777877265 rs777877265 rs777926230 rs777926230 rs777926230 rs777926230 rs777926230 rs777926230 rs777973090 rs777973090 rs777973090 rs777973090 rs777973090 rs777973090 rs778114064 rs778114064 rs778114064 rs778114064 rs778114064 rs778114064 rs778120987 rs778120987 rs778120987 rs778120987 rs778120987 rs778120987 rs778157617 rs778157617 rs778157617 rs778157617 rs778157617 rs778157617 rs778244594 rs778244594 rs778244594 rs778244594 rs778244594 rs778244594 rs778245247 rs778245247 rs778245247 rs778245247 rs778245247 rs778245247 rs778245882 rs778245882 rs778245882 rs778245882 rs778245882 rs778245882 rs778297168 rs778297168 rs778297168 rs778297168 rs778297168 rs778297168 rs778297647 rs778297647 rs778297647 rs778297647 rs778297647 rs778297647 rs778334917 rs778334917 rs778334917 rs778334917 rs778334917 rs778334917 rs778409133 rs778409133 rs778409133 rs778409133 rs778409133 rs778409133 rs778415999 rs778415999 rs778415999 rs778415999 rs778415999 rs778415999 rs778445247 rs778445247 rs778445247 rs778445247 rs778445247 rs778445247 rs778627326 rs778627326 rs778627326 rs778627326 rs778627326 rs778627326 rs778683490 rs778683490 rs778683490 rs778683490 rs778683490 rs778683490 rs778701085 rs778701085 rs778701085 rs778701085 rs778701085 rs778701085 rs778726524 rs778726524 rs778726524 rs778726524 rs778726524 rs778726524 rs778752427 rs778752427 rs778752427 rs778752427 rs778752427 rs778752427 rs778805886 rs778805886 rs778805886 rs778805886 rs778805886 rs778805886 rs778807846 rs778807846 rs778807846 rs778807846 rs778807846 rs778807846 rs778859083 rs778859083 rs778859083 rs778859083 rs778859083 rs778859083 rs778996700 rs778996700 rs778996700 rs778996700 rs778996700 rs778996700 rs779012808 rs779012808 rs779012808 rs779012808 rs779012808 rs779012808 rs779016849 rs779016849 rs779016849 rs779016849 rs779016849 rs779016849 rs779085624 rs779085624 rs779085624 rs779085624 rs779085624 rs779085624 rs779136516 rs779136516 rs779136516 rs779136516 rs779136516 rs779136516 rs779153494 rs779153494 rs779153494 rs779153494 rs779153494 rs779153494 rs779162554 rs779162554 rs779162554 rs779162554 rs779162554 rs779162554 rs779188122 rs779188122 rs779188122 rs779188122 rs779188122 rs779188122 rs779257242 rs779257242 rs779257242 rs779257242 rs779257242 rs779257242 rs779321619 rs779321619 rs779321619 rs779321619 rs779321619 rs779321619 rs779377595 rs779377595 rs779377595 rs779377595 rs779377595 rs779377595 rs779395709 rs779395709 rs779395709 rs779395709 rs779395709 rs779395709 rs779411581 rs779411581 rs779411581 rs779411581 rs779411581 rs779411581 rs779444965 rs779444965 rs779444965 rs779444965 rs779444965 rs779444965 rs779473169 rs779473169 rs779473169 rs779473169 rs779473169 rs779473169 rs779579784 rs779579784 rs779579784 rs779579784 rs779579784 rs779579784 rs779661107 rs779661107 rs779661107 rs779661107 rs779661107 rs779661107 rs779719376 rs779719376 rs779719376 rs779719376 rs779719376 rs779719376 rs779832460 rs779832460 rs779832460 rs779832460 rs779832460 rs779832460 rs779851987 rs779851987 rs779851987 rs779851987 rs779851987 rs779851987 rs779873838 rs779873838 rs779873838 rs779873838 rs779873838 rs779873838 rs779938032 rs779938032 rs779938032 rs779938032 rs779938032 rs779938032 rs779957367 rs779957367 rs779957367 rs779957367 rs779957367 rs779957367 rs780010333 rs780010333 rs780010333 rs780010333 rs780010333 rs780010333 rs780136923 rs780136923 rs780136923 rs780136923 rs780136923 rs780136923 rs780145569 rs780145569 rs780145569 rs780145569 rs780145569 rs780145569 rs780149009 rs780149009 rs780149009 rs780149009 rs780149009 rs780149009 rs780182328 rs780182328 rs780182328 rs780182328 rs780182328 rs780182328 rs780201189 rs780201189 rs780201189 rs780201189 rs780201189 rs780201189 rs780232367 rs780232367 rs780232367 rs780232367 rs780232367 rs780232367 rs780243878 rs780243878 rs780243878 rs780243878 rs780243878 rs780243878 rs780411806 rs780411806 rs780411806 rs780411806 rs780411806 rs780411806 rs780465301 rs780465301 rs780465301 rs780465301 rs780465301 rs780465301 rs780520669 rs780520669 rs780520669 rs780520669 rs780520669 rs780520669 rs780588939 rs780588939 rs780588939 rs780588939 rs780588939 rs780588939 rs780589692 rs780589692 rs780589692 rs780589692 rs780589692 rs780589692 rs780607020 rs780607020 rs780607020 rs780607020 rs780607020 rs780607020 rs780829867 rs780829867 rs780829867 rs780829867 rs780829867 rs780829867 rs780911923 rs780911923 rs780911923 rs780911923 rs780911923 rs780911923 rs780920781 rs780920781 rs780920781 rs780920781 rs780920781 rs780920781 rs780962412 rs780962412 rs780962412 rs780962412 rs780962412 rs780962412 rs780986769 rs780986769 rs780986769 rs780986769 rs780986769 rs780986769 rs781006813 rs781006813 rs781006813 rs781006813 rs781006813 rs781006813 rs781040938 rs781040938 rs781040938 rs781040938 rs781040938 rs781040938 rs781043049 rs781043049 rs781043049 rs781043049 rs781043049 rs781043049 rs781054848 rs781054848 rs781054848 rs781054848 rs781054848 rs781054848 rs781090926 rs781090926 rs781090926 rs781090926 rs781090926 rs781090926 rs781130823 rs781130823 rs781130823 rs781130823 rs781130823 rs781130823 rs781146643 rs781146643 rs781146643 rs781146643 rs781146643 rs781146643 rs781213120 rs781213120 rs781213120 rs781213120 rs781213120 rs781213120 rs781213233 rs781213233 rs781213233 rs781213233 rs781213233 rs781213233 rs781289433 rs781289433 rs781289433 rs781289433 rs781289433 rs781289433 rs781344689 rs781344689 rs781344689 rs781344689 rs781344689 rs781344689 rs781345939 rs781345939 rs781345939 rs781345939 rs781345939 rs781345939 rs781366061 rs781366061 rs781366061 rs781366061 rs781366061 rs781366061 rs781373579 rs781373579 rs781373579 rs781373579 rs781373579 rs781373579 rs781446988 rs781446988 rs781446988 rs781446988 rs781446988 rs781446988 rs781449959 rs781449959 rs781449959 rs781449959 rs781449959 rs781449959 rs781558726 rs781558726 rs781558726 rs781558726 rs781558726 rs781558726 rs781620251 rs781620251 rs781620251 rs781620251 rs781620251 rs781620251 rs781656422 rs781656422 rs781656422 rs781656422 rs781656422 rs781656422 rs781692513 rs781692513 rs781692513 rs781692513 rs781692513 rs781692513 rs781717654 rs781717654 rs781717654 rs781717654 rs781717654 rs781717654 rs781724895 rs781724895 rs781724895 rs781724895 rs781724895 rs781724895

NOTCH4基因在不同组织中的表达： [UniProt]

正向引物序列

正向引物Tm值

反向引物序列

反向引物Tm值

rank

TGCCAGAGAAAGACTCCAC

59

TCTGGGCCTATGAAACCTG

59

CATTGGTCTCAAGGCACTG

58

GCACATCACAACTCCATCC

58

CTACAGGCTACACAGGACC

59

GTGCAGTAGTAGCCTCCAG

59

GAAGAACTGATTGCAGCCC

59

GTCCTGGGCATCTTTATCG

58

ATGCCAGAGAAAGACTCCAC

59

TCTGGGCCTATGAAACCTG

59

ACTGAGCCAAGGCATAGAC

59

AGTGGCAGAAATAGGAGGG

58

ATGCCAGAGAAAGACTCCA

58

TCTGGGCCTATGAAACCTG

59

TGAAGAACTGATTGCAGCC

58

TCCTGGGCATCTTTATCGG

59

CATTGGTCTCAAGGCACTG

58

CACCACTCAGAGACCAGAG

59

ACTGAGCCAAGGCATAGAC

59

GGCAGTGGCAGAAATAGGA

59

尚未收录相关数据

NOTCH4基因（以及对应的蛋白质）的细胞分布位置：

[UniProt] [GenomeNet]

溶酶体
内涵体
细胞核
细胞质
液泡
细胞膜
细胞外基质
内质网
线粒体
高尔基体
细胞骨架

NOTCH4基因的本体（GO）信息：

GO库代码

对应的蛋白质

来源代码

GO:0004872

A0A140T8Y6(UniProtKB)

IEA

GO:0005509

A0A140T8Y6(UniProtKB)

IEA

GO:0006355

A0A140T8Y6(UniProtKB)

IEA

GO:0007219

A0A140T8Y6(UniProtKB)

IEA

GO:0007275

A0A140T8Y6(UniProtKB)

IEA

GO:0016021

A0A140T8Y6(UniProtKB)

IEA

GO:0030154

A0A140T8Y6(UniProtKB)

IEA

GO:0004872

A0A140T920(UniProtKB)

IEA

GO:0005509

A0A140T920(UniProtKB)

IEA

GO:0006355

A0A140T920(UniProtKB)

IEA

GO:0007219

A0A140T920(UniProtKB)

IEA

GO:0007275

A0A140T920(UniProtKB)

IEA

GO:0016021

A0A140T920(UniProtKB)

IEA

GO:0030154

A0A140T920(UniProtKB)

IEA

GO:0004872

A0A140T9R5(UniProtKB)

IEA

GO:0005509

A0A140T9R5(UniProtKB)

IEA

GO:0006355

A0A140T9R5(UniProtKB)

IEA

GO:0007219

A0A140T9R5(UniProtKB)

IEA

GO:0007275

A0A140T9R5(UniProtKB)

IEA

GO:0016021

A0A140T9R5(UniProtKB)

IEA

GO:0030154

A0A140T9R5(UniProtKB)

IEA

GO:0000139

Q99466(UniProtKB)

TAS

GO:0000139

Q99466(UniProtKB)

TAS

GO:0001569

Q99466(UniProtKB)

ISS

GO:0001709

Q99466(UniProtKB)

TAS

GO:0001763

Q99466(UniProtKB)

ISS

GO:0001886

Q99466(UniProtKB)

IEA

GO:0004872

Q99466(UniProtKB)

TAS

GO:0005509

Q99466(UniProtKB)

TAS

GO:0005515

Q99466(UniProtKB)

IPI

GO:0005515

Q99466(UniProtKB)

IPI

GO:0005576

Q99466(UniProtKB)

TAS

GO:0005576

Q99466(UniProtKB)

TAS

GO:0005576

Q99466(UniProtKB)

TAS

GO:0005634

Q99466(UniProtKB)

TAS

GO:0005654

Q99466(UniProtKB)

TAS

GO:0005789

Q99466(UniProtKB)

TAS

GO:0005829

Q99466(UniProtKB)

TAS

GO:0005886

Q99466(UniProtKB)

TAS

GO:0005886

Q99466(UniProtKB)

TAS

GO:0005886

Q99466(UniProtKB)

TAS

GO:0005886

Q99466(UniProtKB)

TAS

GO:0005887

Q99466(UniProtKB)

TAS

GO:0006367

Q99466(UniProtKB)

TAS

GO:0007219

Q99466(UniProtKB)

TAS

GO:0007220

Q99466(UniProtKB)

TAS

GO:0007220

Q99466(UniProtKB)

TAS

GO:0007221

Q99466(UniProtKB)

TAS

GO:0009790

Q99466(UniProtKB)

ISS

GO:0009986

Q99466(UniProtKB)

IDA

GO:0030097

Q99466(UniProtKB)

TAS

GO:0030154

Q99466(UniProtKB)

NAS

GO:0030879

Q99466(UniProtKB)

IDA

GO:0045596

Q99466(UniProtKB)

NAS

GO:0045602

Q99466(UniProtKB)

ISS

GO:0045893

Q99466(UniProtKB)

TAS

GO:0046982

Q99466(UniProtKB)

TAS

序号	作用方式	资源库来源/分值	基因名称	基因名称

可能调控NOTCH4基因的相关microRNA：

hsa-miR-181c hsa-miR-181c* hsa-miR-27b hsa-miR-27b* hsa-miR-34b hsa-miR-34c hsa-miR-18a* hsa-miR-34c-5p

通路基因列表

疾病名称

关系值

NofPmids

NofSnps

来源

疾病名称	关系值	NofPmids	NofSnps	来源
Schizophrenia	0.197169077	41	5	BeFree_GAD_GWASCAT_LHGDN
Mammary Neoplasms	0.122995792	4	0	BeFree_CTD_human_LHGDN
Systemic Scleroderma	0.122638474	1	2	BeFree_GAD_GWASCAT
Age related macular degeneration	0.122638474	1	6	BeFree_GAD_GWASCAT
Asthma	0.122367032	1	1	GAD_GWASCAT
Obesity	0.12	1	1	GWASCAT
Malignant neoplasm of prostate	0.12	1	1	GWASCAT
Hepatitis B, Chronic	0.12	1	1	GWASCAT
Carcinoma, Pancreatic Ductal	0.12	1	0	CTD_human
AIDS-Associated Nephropathy	0.08	1	0	RGD
Arteriovenous Malformations, Cerebral	0.08	0	0	MGD
Rheumatoid Arthritis	0.010825337	9	2	BeFree_GAD
Lupus Erythematosus, Systemic	0.00973957	4	7	BeFree_GAD
Diabetes Mellitus, Insulin-Dependent	0.007101096	2	8	GAD
Alopecia Areata	0.005634266	2	0	BeFree_GAD_LHGDN
Mood Disorders	0.005091382	1	0	GAD_LHGDN
Alzheimer's Disease	0.004734064	2	0	GAD
Liver carcinoma	0.003267234	3	0	BeFree_LHGDN
Multiple Sclerosis	0.002909916	3	6	BeFree_GAD
Pulmonary Fibrosis	0.00272435	1	0	LHGDN
Psoriasis	0.002638474	1	4	BeFree_GAD
Spontaneous abortion	0.002367032	1	0	GAD
Ulcerative Colitis	0.002367032	1	0	GAD
IGA Glomerulonephritis	0.002367032	1	1	GAD
Hepatitis C	0.002367032	1	0	GAD
Meningococcal Infections	0.002367032	1	0	GAD
Weight Gain	0.002367032	1	0	GAD
Sepsis	0.002367032	1	0	GAD
Weight Gain Adverse Event	0.002367032	1	0	GAD
Malignant neoplasm of breast	0.001628651	6	0	BeFree
Breast Carcinoma	0.001628651	6	0	BeFree
Bipolar Disorder	0.001085767	4	1	BeFree
Carcinogenesis	0.001085767	4	0	BeFree
Adenoid Cystic Carcinoma	0.000542884	2	0	BeFree
Triple Negative Breast Neoplasms	0.000542884	2	0	BeFree
Malignant neoplasm of endometrium	0.000271442	1	0	BeFree
Noninfiltrating Intraductal Carcinoma	0.000271442	1	6	BeFree
Presenile dementia	0.000271442	1	0	BeFree
Demyelinating Diseases	0.000271442	1	1	BeFree
Endometriosis	0.000271442	1	0	BeFree
Glioma	0.000271442	1	0	BeFree
granulosa cell tumor	0.000271442	1	0	BeFree
Graves Disease	0.000271442	1	0	BeFree
Hepatitis, Chronic	0.000271442	1	0	BeFree
HIV Infections	0.000271442	1	2	BeFree
leukemia	0.000271442	1	0	BeFree
Liver Cirrhosis	0.000271442	1	0	BeFree
melanoma	0.000271442	1	0	BeFree
Pancreatic Neoplasm	0.000271442	1	0	BeFree
Seminoma	0.000271442	1	0	BeFree
Thyroid Neoplasm	0.000271442	1	0	BeFree
Vasculitis	0.000271442	1	0	BeFree
Acute leukemia	0.000271442	1	0	BeFree
Migraine Disorders	0.000271442	1	0	BeFree
Tumor Progression	0.000271442	1	0	BeFree
Pancreatic carcinoma	0.000271442	1	0	BeFree
Metastatic melanoma	0.000271442	1	0	BeFree
Diffuse Astrocytoma	0.000271442	1	0	BeFree
Malignant neoplasm of pancreas	0.000271442	1	0	BeFree
Endometrial Carcinoma	0.000271442	1	0	BeFree
Dementia	0.000271442	1	0	BeFree
Inclusion Body Myopathy, Sporadic	0.000271442	1	0	BeFree
Invasive Ductal Breast Carcinoma	0.000271442	1	6	BeFree
Cirrhosis	0.000271442	1	0	BeFree
early onset schizophrenia	0.000271442	1	0	BeFree
Non-Neoplastic Disorder	0.000271442	1	0	BeFree
MAJOR AFFECTIVE DISORDER 2	0.000271442	1	0	BeFree
MAJOR AFFECTIVE DISORDER 1	0.000271442	1	0	BeFree
Uterine Corpus Cancer	0.000271442	1	0	BeFree
MAJOR AFFECTIVE DISORDER 4	0.000271442	1	0	BeFree
MAJOR AFFECTIVE DISORDER 5	0.000271442	1	0	BeFree
MAJOR AFFECTIVE DISORDER 6	0.000271442	1	0	BeFree
MAJOR AFFECTIVE DISORDER 7	0.000271442	1	0	BeFree
MAJOR AFFECTIVE DISORDER 8	0.000271442	1	0	BeFree
MAJOR AFFECTIVE DISORDER 9	0.000271442	1	0	BeFree