NFKBIB(nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta) 转至新版数据库

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

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基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

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基因染色体位置

基因染色体位置

19q13.1
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]

[中文简述(自动翻译):]  由该基因编码的蛋白质属于NF-卡帕-B抑制剂家族，其通过与络合，并在细胞质中捕获它抑制NF-κ-B点。通过激酶对这些蛋白的丝氨酸残基的磷酸化经由泛素化途径它们标记为破坏，从而使NF-κ-B，其易位至核以充当转录因子的激活。另外剪接转录变体也发现了这种基因。[由RefSeq的，2011年7月提供]

OMIM数据库中对NFKBIB基因的介绍     Wikipedia数据库中对NFKBIB基因的介绍

基因序列

基因序列

NFKBIB基因的碱基序列：[NCBI]

基因突变

基因突变

NFKBIB基因的碱基突变：           显示全部snp
rs1044284       rs3136646       rs3181068       rs12986343       rs17878351       rs17881819       rs17886215       rs113320882       rs118073865       rs138293871       rs141886159       rs143679476       rs147872301       rs149006428       rs180698564       rs183666180       rs184871548       rs188557782       rs199895742       rs201937854       rs201973903       rs375193033       rs376552173       rs376598520       rs527598513       rs531719885       rs532576433       rs532616383       rs541089013       rs544007042       rs548579829       rs550336433       rs553702923       rs555868736       rs561488664       rs565410180       rs577303750      
rs747384272       rs748383174       rs749083832       rs750105012       rs750823307       rs751374607       rs752025295       rs752068938       rs753385932       rs755717206       rs757836952       rs759042553       rs759638016       rs761533876       rs761635530       rs762815768       rs764003595       rs764741991       rs765264659       rs766126438       rs766184921       rs769116132       rs769871272       rs770065311       rs770289700       rs771280682       rs771890953       rs772074446       rs773209288       rs774185572       rs774321298       rs775406362       rs776376208       rs778168546       rs778314365       rs779064065       rs780215861       rs781304607       rs781557345       rs2053071       rs2241704       rs2241705       rs3136639       rs3136640       rs3136641       rs3136642       rs3136643       rs3136644       rs3136645       rs4803006       rs4803013       rs8104984       rs8108039       rs9636109       rs10713585       rs11083484       rs11083485       rs11083487       rs11879872       rs12610409       rs12610805       rs12972925       rs12979755       rs17878267       rs17878402       rs17879408       rs17880395       rs17880452       rs17880526       rs17880569       rs17880730       rs17880870       rs17880968       rs17881451       rs17881574       rs17882062       rs17883178       rs17883392       rs17883664       rs17884442       rs17884677       rs17884685       rs17884772       rs17886226       rs17886254       rs17886432       rs17886984       rs28362605       rs35131017       rs35941401       rs56351357       rs56689256       rs57842338       rs58249749       rs59286558       rs61559005       rs61754993       rs66466147       rs73539687       rs74176475       rs75423238       rs77335353       rs77780712       rs77974825       rs78597201       rs79290677       rs80002489       rs111369032       rs111943225       rs112067344       rs112492606       rs113055550       rs113171098       rs113327546       rs113548864       rs113918655       rs115443618       rs116517276       rs116900177       rs117301980       rs117682758       rs138571899       rs138675980       rs139050682       rs139372587       rs139492623       rs139537365       rs140214237       rs140517797       rs141538336       rs141706130       rs142337920       rs142402942       rs142495119       rs142553626       rs142892558       rs143218424       rs143280013       rs143781834       rs143789480       rs144092295       rs144142165       rs144315689       rs144742262       rs145220553       rs146276752       rs146288310       rs146392056       rs146663213       rs146741297       rs146910497       rs147785336       rs148134026       rs148477227       rs148530152       rs150397032       rs150423716       rs150533078       rs151065788       rs180743519       rs181015437       rs181220380       rs181514665       rs182337122       rs182448351       rs183688961       rs184506258       rs184913601       rs185011164       rs185355535       rs185670171       rs186073026       rs186172967       rs186176204       rs186425152       rs187047566       rs187346322       rs187765742       rs187771978       rs187815932       rs187918389       rs188118242       rs188598602       rs189047012       rs189461298       rs189676135       rs189826170       rs190240321       rs190485176       rs190925604       rs191551379       rs191691809       rs192000195       rs192578522       rs192589819       rs192940515       rs199551325       rs199632215       rs199638442       rs199718651       rs199793891       rs199857400       rs199908107       rs200061585       rs200151971       rs200253341       rs200292161       rs200348640       rs200349639       rs200381723       rs200550654       rs200568693       rs200621905       rs200631728       rs200640455       rs200736620       rs200776267       rs200887226       rs200918307       rs201018844       rs201087488       rs201461162       rs201514301       rs201539242       rs201682459       rs201794306       rs201963521       rs201990071       rs202104698       rs202225244       rs367550422       rs367712458       rs367810334       rs368245350       rs368267090       rs368754017       rs368928450       rs369131977       rs369255718       rs369355055       rs370203292       rs370233723       rs370413270       rs370722187       rs370729219       rs370763896       rs370973644       rs371015711       rs371119134       rs371423502       rs372112776       rs372256941       rs372526035       rs372554217       rs372854982       rs372985883       rs373070182       rs373087158       rs373199604       rs373359665       rs373602938       rs373658066       rs373825296       rs373869376       rs373893343       rs373967675       rs374525594       rs374744495       rs375163007       rs375166067       rs375222019       rs375922088       rs376254464       rs376258456       rs376266663       rs376344622       rs376726532       rs377088213       rs377205021       rs377225970       rs377421437       rs377604569       rs527877389       rs527946983       rs527982343       rs528124029       rs528161401       rs528199067       rs528383193       rs528928638       rs528963000       rs529758714       rs529957919       rs530147125       rs530595256       rs531019284       rs531517889       rs531805453       rs531855649       rs532277766       rs532616494       rs532837981       rs533411032       rs533678761       rs533780978       rs533896617       rs533965157       rs533991394       rs534049178       rs534155225       rs534591241       rs534632598       rs535872703       rs535950513       rs536082813       rs536630766       rs536672627       rs537113003       rs537499094       rs537681320       rs537889747       rs538300200       rs538438950       rs539023319       rs539025092       rs539499302       rs539633343       rs539695373       rs539869771       rs540227296       rs540229274       rs540261948       rs540416242       rs540887146       rs541097945       rs541662815       rs542031380       rs542874466       rs543819871       rs543923386       rs544044006       rs544281158       rs544582105       rs544622694       rs545733361       rs545995637       rs546071067       rs546232239       rs546264702       rs546642129       rs546676941       rs547210509       rs547832111       rs548304325       rs548549404       rs549152742       rs549187697       rs549303919       rs549542118       rs549706024       rs550048505       rs550203922       rs550284212       rs550326877       rs550562760       rs551028583       rs551154897       rs551543726       rs551579877       rs553551505       rs553616418       rs554193184       rs554271339       rs554282340       rs554515514       rs555449654       rs556014945       rs556565259       rs556694616       rs557237279       rs557274317       rs557322866       rs557736943       rs557877860       rs557957478       rs557991772       rs558129468       rs558273641       rs558278035       rs558556014       rs559626700       rs559691262       rs559875158       rs559922172       rs560451216       rs560658617       rs561617282       rs561710619       rs561756058       rs561794645       rs562314762       rs562511454       rs562877095       rs563037687       rs563209299       rs563293633       rs563414632       rs563427629       rs563622532       rs563655675       rs563871676       rs564058387       rs564206676       rs564247522       rs564284282       rs564331079       rs565449793       rs565452934       rs566674953       rs566821803       rs566891232       rs567594250       rs568014170       rs568276613       rs568639576       rs569065580       rs569202167       rs569446263       rs569583132       rs569646722       rs569681833       rs570561110       rs570595512       rs571626892       rs571682928       rs571749718       rs571784584       rs572668229       rs572768266       rs572942685       rs572977589       rs572979069       rs572991857       rs573152806       rs573698875       rs574031843       rs574627299       rs575017190       rs575129255       rs575434062       rs575517636       rs575713334       rs577598959       rs577919425       rs578040963       rs745366346       rs745419273       rs745461925       rs745521753       rs745640175       rs745809795       rs746007846       rs746599036       rs746627354       rs746674509       rs746872375       rs746925867       rs747048893       rs747129153       rs747207859       rs747397652       rs747427661       rs747482569       rs747533922       rs747926685       rs748016506       rs748226384       rs748295317       rs748332087       rs748383232       rs748571999       rs748625293       rs748795116       rs748849926       rs748872953       rs749148012       rs749198602       rs749485890       rs749534878       rs750093332       rs750274055       rs750341530       rs750395571       rs750595727       rs750703860       rs750737920       rs751084253       rs751107236       rs751191975       rs751234833       rs751420371       rs751473484       rs751528785       rs751732605       rs752015628       rs752369515       rs752378363       rs752427640       rs752531289       rs752586323       rs752879690       rs753132086       rs753174721       rs753183550       rs753536690       rs753549272       rs753678677       rs753827894       rs753986182       rs754148657       rs754267599       rs754294471       rs754569859       rs754807268       rs754930221       rs755002565       rs755134889       rs755313937       rs755366933       rs755369123       rs755662158       rs755663711       rs755854039       rs755911965       rs756116382       rs756463777       rs756516919       rs756783470       rs756791587       rs756881775       rs756915146       rs757009990       rs757065178       rs757115883       rs757386064       rs757439180       rs757554312       rs757765123       rs757890436       rs757952537       rs758003425       rs758170872       rs758277006       rs758299215       rs758405350       rs758662538       rs758952298       rs759403398       rs759503597       rs759687798       rs759808364       rs759987725       rs760173523       rs760175644       rs760230683       rs760409922       rs760467102       rs760752198       rs760830914       rs760924406       rs761119108       rs761172584       rs761178868       rs761227715       rs761307805       rs761336298       rs761463748       rs761919016       rs761937900       rs762065761       rs762286917       rs762368206       rs762387958       rs762597339       rs762627151       rs762824349       rs762880969       rs763014413       rs763394190       rs763523655       rs763674065       rs763720626       rs763807047       rs764030062       rs764054923       rs764159675       rs764322441       rs764428689       rs764481638       rs765022984       rs765073855       rs765195500       rs765211245       rs765375783       rs765563980       rs765572197       rs765652605       rs765777830       rs765829183       rs766051556       rs766214015       rs766237895       rs766304605       rs766612357       rs766730808       rs766805125       rs766911675       rs766950397       rs766975129       rs767145459       rs767539361       rs767943290       rs768032105       rs768125377       rs768248112       rs768312303       rs768726182       rs768780356       rs768920310       rs768922226       rs769269943       rs769376621       rs769713276       rs769713396       rs769973475       rs770030573       rs770168537       rs770435150       rs770625244       rs770867834       rs770944743       rs771024718       rs771335588       rs771426336       rs771624425       rs771782234       rs771837240       rs771944401       rs772141210       rs772147919       rs772338303       rs772554095       rs772579196       rs772768309       rs772823835       rs773054763       rs773111957       rs773235280       rs773488851       rs773652866       rs773825111       rs773895310       rs774302544       rs774355470       rs774466413       rs774549307       rs774685373       rs774910712       rs774944229       rs774965794       rs774995182       rs775034585       rs775296382       rs775363005       rs775602280       rs775803089       rs775859267       rs776011126       rs776314748       rs776373115       rs776457541       rs776643132       rs776804608       rs776947131       rs777079237       rs777129444       rs777376352       rs777560427       rs777670677       rs777804338       rs777857243       rs777908799       rs778056635       rs778503172       rs778568843       rs778623900       rs778695272       rs778712532       rs779130282       rs779362764       rs779557571       rs779585012       rs779717488       rs779807189       rs779850254       rs780240161       rs780272772       rs780329722       rs780508380       rs780593114       rs780891154       rs780920695       rs780942601       rs781312182       rs781548354       rs781596903       rs781776389       rs796839526       rs869050568       rs869086811      

基因表达

基因表达

NFKBIB基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
AATGACCTAGGCCAGACAG
59
TTCTCCAAGTCGGAATCGG
60
AATGACCTAGGCCAGACAG
59
CTTCCTTCTCCAAGTCGGA
59
AATGACCTAGGCCAGACAG
59
CTTCTCCAAGTCGGAATCG
58
AATGACCTAGGCCAGACAG
59
TTCTCCAAGTCGGAATCGG
60
AATGACCTAGGCCAGACAG
59
CTTCTCCAAGTCGGAATCG
58
AATGACCTAGGCCAGACAG
59
CTTCTCCAAGTCGGAATCG
58
AATGACCTAGGCCAGACAG
59
CTTCCTTCTCCAAGTCGGA
59
AATGACCTAGGCCAGACAG
59
TTCTCCAAGTCGGAATCGG
60
AATGACCTAGGCCAGACAG
59
TTCTCCAAGTCGGAATCGG
60
AATGACCTAGGCCAGACAG
59
TTCTCCAAGTCGGAATCGG
60

转录因子

转录因子

转录因子
影响类型
PubMed链接
IFNB1
Repression
10074115

基因本体信息

NFKBIB基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

NFKBIB基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0003713
Q15653(UniProtKB)
TAS
GO:0004871
Q15653(UniProtKB)
TAS
GO:0005515
Q15653(UniProtKB)
IPI
GO:0005515
Q15653(UniProtKB)
IPI
GO:0005515
Q15653(UniProtKB)
IPI
GO:0005515
Q15653(UniProtKB)
IPI
GO:0005515
Q15653(UniProtKB)
IPI
GO:0005515
Q15653(UniProtKB)
IPI
GO:0005515
Q15653(UniProtKB)
IPI
GO:0005515
Q15653(UniProtKB)
IPI
GO:0005515
Q15653(UniProtKB)
IPI
GO:0005515
Q15653(UniProtKB)
IPI
GO:0005515
Q15653(UniProtKB)
IPI
GO:0005634
Q15653(UniProtKB)
IEA
GO:0005829
Q15653(UniProtKB)
TAS
GO:0005829
Q15653(UniProtKB)
TAS
GO:0005829
Q15653(UniProtKB)
TAS
GO:0005829
Q15653(UniProtKB)
TAS
GO:0005829
Q15653(UniProtKB)
TAS
GO:0005829
Q15653(UniProtKB)
TAS
GO:0006351
Q15653(UniProtKB)
TAS
GO:0007165
Q15653(UniProtKB)
IEA
GO:0007253
Q15653(UniProtKB)
IEA
GO:0051092
Q15653(UniProtKB)
TAS
GO:0071222
Q15653(UniProtKB)
IEA

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控NFKBIB基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Rheumatoid Arthritis 0.004734064 2 1 GAD
Premature Birth 0.004734064 2 0 GAD
Hepatitis C 0.00272435 1 0 LHGDN
Malignant neoplasm of ovary 0.002638474 1 0 BeFree_GAD
Atherosclerosis 0.002367032 1 0 GAD
Connective Tissue Diseases 0.002367032 1 0 GAD
Fetal Diseases 0.002367032 1 0 GAD
Head and Neck Neoplasms 0.002367032 1 0 GAD
HIV Infections 0.002367032 1 0 GAD
Inflammation 0.002367032 1 0 GAD
Lymphoma, Non-Hodgkin 0.002367032 1 0 GAD
Musculoskeletal Diseases 0.002367032 1 0 GAD
Neoplasm Recurrence, Local 0.002367032 1 0 GAD
Pregnancy Complications, Hematologic 0.002367032 1 0 GAD
Dermatologic disorders 0.002367032 1 0 GAD
Neoplasms, Second Primary 0.002367032 1 0 GAD
Precursor Cell Lymphoblastic Leukemia Lymphoma 0.002367032 1 0 GAD
Celiac Disease 0.000271442 1 0 BeFree
Empyema, Pleural 0.000271442 1 0 BeFree
Chronic Obstructive Airway Disease 0.000271442 1 2 BeFree
Neoplasm Metastasis 0.000271442 1 0 BeFree
Ovarian Carcinoma 0.000271442 1 0 BeFree
Wheezing 0.000271442 1 6 BeFree
Asymptomatic human immunodeficiency virus infection 0.000271442 1 0 BeFree
Epithelial ovarian cancer 0.000271442 1 0 BeFree
Nasopharyngeal carcinoma 0.000271442 1 0 BeFree

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