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The protein encoded by this gene is a transcriptional regulator that binds as a homodimer to activating transcription factor (ATF) sites in many cellular and viral promoters. The encoded protein represses PER1 and PER2 expression and therefore plays a role in the regulation of circadian rhythm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014]
[中文简述(自动翻译):]  由该基因编码的蛋白质是结合作为同二聚体以激活转录因子(ATF)在许多细胞和病毒启动子位点的转录调节子。所编码的蛋白质压制PER1和PER2表达,因此,起着昼夜节律的调节作用。已发现了该基因编码的蛋白质相同的三个抄本变形。 [由RefSeq的,2014年2月提供]
NFIL3基因(以及对应的蛋白质)的细胞分布位置:
NFIL3基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Bone Diseases | 0.00272435 | 1 | 0 | LHGDN |
Bipolar Disorder | 0.002367032 | 1 | 0 | GAD |
Mental Depression | 0.002367032 | 1 | 0 | GAD |
Schizophrenia | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Sleep Disorders | 0.002367032 | 1 | 0 | GAD |
Attention deficit hyperactivity disorder | 0.002367032 | 1 | 0 | GAD |
Amyotrophic Lateral Sclerosis | 0.000271442 | 1 | 0 | BeFree |
Rheumatoid Arthritis | 0.000271442 | 1 | 0 | BeFree |
Autoimmune Diseases | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Colitis | 0.000271442 | 1 | 0 | BeFree |
Ulcerative Colitis | 0.000271442 | 1 | 0 | BeFree |
Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
Hereditary Sensory Autonomic Neuropathy, Type 1 | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Precursor B-cell lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
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