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This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
[中文简述(自动翻译):]  这个基因家族的Rho鸟嘌呤核苷酸交换因子的一部分。这个家庭的成员通过催化GDP的GTP用于交换的Rho激活蛋白。由该基因编码的蛋白质与RhoA的细胞核内相互作用并在电离辐射后修复DNA损伤中起一定作用。该基因的假基因位于染色体7 1,并在多个转录变异体编码不同的蛋白质亚型18选择性剪接结果的长臂。 [由RefSeq的,2012年7月提供]
NET1基因(以及对应的蛋白质)的细胞分布位置:
NET1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Attention deficit hyperactivity disorder | 0.005819831 | 5 | 0 | BeFree_GAD |
Liver carcinoma | 0.00408156 | 5 | 0 | BeFree_LHGDN |
Neoplasm Metastasis | 0.003810118 | 4 | 0 | BeFree_LHGDN |
Adenocarcinoma | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Mammary Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Malignant neoplasm of breast | 0.001357209 | 5 | 0 | BeFree |
Breast Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Gastric Adenocarcinoma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000814326 | 3 | 0 | BeFree |
Stomach Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Dentinogenesis Imperfecta | 0.000542884 | 2 | 0 | BeFree |
Brain Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Dengue Fever | 0.000271442 | 1 | 0 | BeFree |
Dentin Dysplasia | 0.000271442 | 1 | 0 | BeFree |
Oppositional Defiant Disorder | 0.000271442 | 1 | 0 | BeFree |
Cervical Intraepithelial Neoplasia | 0.000271442 | 1 | 0 | BeFree |
Carcinoma breast stage IV | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of esophagus | 0.000271442 | 1 | 0 | BeFree |
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