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The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
[中文简述(自动翻译):]  由该基因编码的蛋白质是信令和含有Src同源2和3(SH2和SH3结构)域变换蛋白之一。它位于细胞质,是参与转导的受体酪氨酸激酶信号到下游信号接收者,如RAS的衔接蛋白。已发现编码不同亚型选择性剪接转录变异体。 [由RefSeq的,2010年6月提供]
NCK1基因(以及对应的蛋白质)的细胞分布位置:
NCK1基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| Albuminuria | 0.12 | 1 | 0 | CTD_human |
| Nephrotic Syndrome | 0.12 | 1 | 0 | CTD_human |
| Proteinuria | 0.12 | 1 | 0 | CTD_human |
| Wiskott-Aldrich Syndrome | 0.00272435 | 1 | 0 | LHGDN |
| Liver carcinoma | 0.000814326 | 3 | 0 | BeFree |
| Diabetic Nephropathy | 0.000271442 | 1 | 0 | BeFree |
| Hyperglycemia | 0.000271442 | 1 | 0 | BeFree |
| Kidney Diseases | 0.000271442 | 1 | 0 | BeFree |
| Obesity | 0.000271442 | 1 | 0 | BeFree |
| Metastatic melanoma | 0.000271442 | 1 | 0 | BeFree |
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