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This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
[中文简述(自动翻译):]  这个基因编码的细胞粘着蛋白,其是免疫球蛋白超家族中的一员。所编码的蛋白质是发育和分化过程中参与细胞 - 细胞相互作用,以及细胞 - 基质相互作用。所编码的蛋白质已经显示参与神经系统的发展,为参与T细胞和树突细胞,其在免疫监视中起重要作用的扩张的细胞。选择性剪接结果在多个抄本变形。 [由RefSeq的,2011年6月提供]
NCAM1基因(以及对应的蛋白质)的细胞分布位置:
NCAM1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Spontaneous abortion | 0.12 | 1 | 0 | CTD_human |
Neoplasm Invasiveness | 0.12 | 1 | 0 | CTD_human |
Heart failure | 0.080542884 | 3 | 0 | BeFree_RGD |
Hypothyroidism | 0.080271442 | 2 | 0 | BeFree_RGD |
Leukemia, Myelocytic, Acute | 0.015220608 | 37 | 0 | BeFree_LHGDN |
Lymphoma | 0.011400559 | 42 | 0 | BeFree |
Multiple Myeloma | 0.01114898 | 23 | 0 | BeFree_LHGDN |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.008715934 | 3 | 0 | BeFree_LHGDN |
Bipolar Disorder | 0.008544182 | 5 | 0 | BeFree_GAD_LHGDN |
Schizophrenia | 0.007620235 | 9 | 1 | BeFree_LHGDN |
leukemia | 0.007338862 | 17 | 0 | BeFree_LHGDN |
Neuroblastoma | 0.005971721 | 22 | 0 | BeFree |
Central neuroblastoma | 0.005971721 | 22 | 0 | BeFree |
Mood Disorders | 0.005362824 | 1 | 0 | BeFree_GAD_LHGDN |
Alcoholic Intoxication, Chronic | 0.005005506 | 2 | 0 | BeFree_GAD |
T-Cell Lymphoma | 0.004885954 | 18 | 0 | BeFree |
Nephroblastoma | 0.00408156 | 6 | 0 | BeFree_LHGDN |
B-Cell Lymphomas | 0.003810118 | 5 | 0 | BeFree_LHGDN |
Sarcoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Small cell carcinoma of lung | 0.003257302 | 12 | 0 | BeFree |
CNS disorder | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Myopathy | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Myocardial Ischemia | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Ganglioneuroblastoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Brain Neoplasms | 0.00272435 | 1 | 0 | LHGDN |
Merkel cell carcinoma | 0.00272435 | 1 | 0 | LHGDN |
Adenoid Cystic Carcinoma | 0.00272435 | 1 | 0 | LHGDN |
Down Syndrome | 0.00272435 | 1 | 0 | LHGDN |
Fibrosis | 0.00272435 | 1 | 0 | LHGDN |
Ganglioneuroma | 0.00272435 | 1 | 0 | LHGDN |
Inflammation | 0.00272435 | 1 | 0 | LHGDN |
Leukemia, Plasma Cell | 0.00272435 | 1 | 0 | LHGDN |
Peripheral T-Cell Lymphoma | 0.002442977 | 9 | 0 | BeFree |
Blastic plasmacytoid dendritic cell neoplasm | 0.002442977 | 9 | 0 | BeFree |
Alzheimer's Disease | 0.002367032 | 1 | 1 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Substance-Related Disorders | 0.002367032 | 1 | 0 | GAD |
Creatinine finding | 0.002367032 | 1 | 1 | GAD |
HIV Infections | 0.001900093 | 7 | 0 | BeFree |
Monoclonal Gammopathy of Undetermined Significance | 0.001628651 | 6 | 0 | BeFree |
Glioma | 0.001357209 | 5 | 0 | BeFree |
Myeloid Leukemia | 0.001357209 | 5 | 0 | BeFree |
Neoplasm Metastasis | 0.001357209 | 5 | 0 | BeFree |
Hematologic Neoplasms | 0.001357209 | 5 | 0 | BeFree |
Carcinogenesis | 0.001357209 | 5 | 0 | BeFree |
Carcinoma of lung | 0.001357209 | 5 | 0 | BeFree |
Leukemia, Large Granular Lymphocytic | 0.001357209 | 5 | 0 | BeFree |
T-Cell Large Granular Lymphocyte Leukemia | 0.001357209 | 5 | 0 | BeFree |
Congenital chromosomal disease | 0.001085767 | 4 | 0 | BeFree |
Glioblastoma | 0.001085767 | 4 | 0 | BeFree |
Acute Promyelocytic Leukemia | 0.001085767 | 4 | 0 | BeFree |
Multiple Sclerosis | 0.001085767 | 4 | 0 | BeFree |
Acute leukemia | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of lung | 0.001085767 | 4 | 0 | BeFree |
Nasal Type Extranodal NK/T-Cell Lymphoma | 0.001085767 | 4 | 0 | BeFree |
Adenocarcinoma | 0.000814326 | 3 | 0 | BeFree |
Adenoma | 0.000814326 | 3 | 0 | BeFree |
Autistic Disorder | 0.000814326 | 3 | 0 | BeFree |
Mental disorders | 0.000814326 | 3 | 0 | BeFree |
Hepatitis C | 0.000814326 | 3 | 0 | BeFree |
Malignant histiocytosis | 0.000814326 | 3 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000814326 | 3 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.000814326 | 3 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000814326 | 3 | 0 | BeFree |
Lymphohistiocytosis, Hemophagocytic | 0.000814326 | 3 | 0 | BeFree |
Monosomy | 0.000814326 | 3 | 0 | BeFree |
Ki-1+ Anaplastic Large Cell Lymphoma | 0.000814326 | 3 | 0 | BeFree |
Subcutaneous panniculitis-like T-cell lymphoma | 0.000814326 | 3 | 0 | BeFree |
NONAKA MYOPATHY | 0.000814326 | 3 | 0 | BeFree |
Rheumatoid Arthritis | 0.000542884 | 2 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Cardiomyopathy, Dilated | 0.000542884 | 2 | 0 | BeFree |
Congestive heart failure | 0.000542884 | 2 | 0 | BeFree |
Hepatitis, Chronic | 0.000542884 | 2 | 0 | BeFree |
Intestinal Diseases | 0.000542884 | 2 | 0 | BeFree |
Lown-Ganong-Levine Syndrome | 0.000542884 | 2 | 0 | BeFree |
Lung Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Lymphocytosis | 0.000542884 | 2 | 0 | BeFree |
Reticulosarcoma | 0.000542884 | 2 | 0 | BeFree |
Lymphoproliferative Disorders | 0.000542884 | 2 | 0 | BeFree |
melanoma | 0.000542884 | 2 | 0 | BeFree |
Pituitary Diseases | 0.000542884 | 2 | 0 | BeFree |
Pituitary Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Pleural effusion disorder | 0.000542884 | 2 | 0 | BeFree |
Preleukemia | 0.000542884 | 2 | 0 | BeFree |
Rhabdomyosarcoma | 0.000542884 | 2 | 0 | BeFree |
Substance Dependence | 0.000542884 | 2 | 0 | BeFree |
Virus Diseases | 0.000542884 | 2 | 0 | BeFree |
Diffuse Large B-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Severe Combined Immunodeficiency | 0.000542884 | 2 | 0 | BeFree |
Granulocytic Sarcoma | 0.000542884 | 2 | 0 | BeFree |
Lymphomatoid Papulosis | 0.000542884 | 2 | 0 | BeFree |
Neuroectodermal Tumor, Primitive | 0.000542884 | 2 | 0 | BeFree |
Neuroendocrine Tumors | 0.000542884 | 2 | 0 | BeFree |
Adult Acute Myeloblastic Leukemia | 0.000542884 | 2 | 0 | BeFree |
Papillary thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
Carcinoma, Small Cell | 0.000542884 | 2 | 0 | BeFree |
Extraosseous Ewings sarcoma-primitive neuroepithelial tumor | 0.000542884 | 2 | 0 | BeFree |
Ischemic cardiomyopathy | 0.000542884 | 2 | 0 | BeFree |
Enteropathy-Associated T-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
Hepatitis C, Chronic | 0.000542884 | 2 | 0 | BeFree |
Thyroid carcinoma | 0.000542884 | 2 | 0 | BeFree |
Histiocytosis haematophagic | 0.000542884 | 2 | 0 | BeFree |
Monoclonal Gammapathies | 0.000542884 | 2 | 0 | BeFree |
Attention deficit hyperactivity disorder | 0.000542884 | 2 | 0 | BeFree |
Cutaneous lymphoma | 0.000542884 | 2 | 0 | BeFree |
Primary cutaneous lymphoma | 0.000542884 | 2 | 0 | BeFree |
Liver carcinoma | 0.000542884 | 2 | 0 | BeFree |
MYELODYSPLASTIC SYNDROME | 0.000542884 | 2 | 0 | BeFree |
Cytogenetically normal acute myeloid leukemia | 0.000542884 | 2 | 0 | BeFree |
Ameloblastoma | 0.000271442 | 1 | 0 | BeFree |
Anemia | 0.000271442 | 1 | 0 | BeFree |
Aplastic Anemia | 0.000271442 | 1 | 0 | BeFree |
Refractory anaemia with excess blasts | 0.000271442 | 1 | 0 | BeFree |
Anxiety Disorders | 0.000271442 | 1 | 0 | BeFree |
Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Ataxia Telangiectasia | 0.000271442 | 1 | 0 | BeFree |
Biliary Atresia | 0.000271442 | 1 | 0 | BeFree |
Blast Phase | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of thyroid | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Papillary | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Hypertrophic Cardiomyopathy | 0.000271442 | 1 | 0 | BeFree |
Cholesterol Ester Storage Disease | 0.000271442 | 1 | 0 | BeFree |
Colorectal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Common Variable Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Cytomegalovirus Infections | 0.000271442 | 1 | 0 | BeFree |
Diabetes Mellitus, Insulin-Dependent | 0.000271442 | 1 | 0 | BeFree |
Disseminated Intravascular Coagulation | 0.000271442 | 1 | 0 | BeFree |
Endometriosis | 0.000271442 | 1 | 0 | BeFree |
Graves Disease | 0.000271442 | 1 | 0 | BeFree |
Hepatitis | 0.000271442 | 1 | 0 | BeFree |
Hepatitis A | 0.000271442 | 1 | 0 | BeFree |
Hepatitis B | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
Ischemia | 0.000271442 | 1 | 0 | BeFree |
Kartagener Syndrome | 0.000271442 | 1 | 0 | BeFree |
Lymphoid leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, T-Cell | 0.000271442 | 1 | 0 | BeFree |
Liver diseases | 0.000271442 | 1 | 0 | BeFree |
Lupus Erythematosus, Systemic | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Non-Hodgkin | 0.000271442 | 1 | 0 | BeFree |
Myasthenia Gravis | 0.000271442 | 1 | 0 | BeFree |
Mycobacterium Infections | 0.000271442 | 1 | 0 | BeFree |
Myocarditis | 0.000271442 | 1 | 0 | BeFree |
Nicotine Dependence | 0.000271442 | 1 | 0 | BeFree |
Odontogenic Cysts | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Neoplasm | 0.000271442 | 1 | 0 | BeFree |
Paresis | 0.000271442 | 1 | 0 | BeFree |
Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
Plasmacytoma | 0.000271442 | 1 | 0 | BeFree |
Prolactinoma | 0.000271442 | 1 | 0 | BeFree |
Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
Salmonella infections | 0.000271442 | 1 | 0 | BeFree |
Sarcoidosis | 0.000271442 | 1 | 0 | BeFree |
Sarcoidosis, Pulmonary | 0.000271442 | 1 | 0 | BeFree |
Seizures | 0.000271442 | 1 | 0 | BeFree |
Skin Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Teratoma | 0.000271442 | 1 | 0 | BeFree |
Wolman Disease | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, Large-Cell, Follicular | 0.000271442 | 1 | 0 | BeFree |
Lymphoma, AIDS-Related | 0.000271442 | 1 | 0 | BeFree |
Plasmacytosis | 0.000271442 | 1 | 0 | BeFree |
Muscle Weakness | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000271442 | 1 | 0 | BeFree |
Alveolar rhabdomyosarcoma | 0.000271442 | 1 | 0 | BeFree |
Teratocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Adrenal Cortical Adenoma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Neuroendocrine | 0.000271442 | 1 | 0 | BeFree |
pediatric acute myeloblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Inclusion Body Myositis (disorder) | 0.000271442 | 1 | 0 | BeFree |
Interstitial fibrosis | 0.000271442 | 1 | 0 | BeFree |
Age related macular degeneration | 0.000271442 | 1 | 0 | BeFree |
stage, neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Diffuse Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Pilocytic Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Sialuria | 0.000271442 | 1 | 0 | BeFree |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
Hematopoietic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of liver | 0.000271442 | 1 | 0 | BeFree |
Ewings sarcoma | 0.000271442 | 1 | 0 | BeFree |
Nasal and nasal-type NK/T-cell lymphoma | 0.000271442 | 1 | 0 | BeFree |
Primary sclerosing cholangitis | 0.000271442 | 1 | 0 | BeFree |
Muscular Dystrophies, Limb-Girdle | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
early pregnancy | 0.000271442 | 1 | 0 | BeFree |
Adult Acute Lymphocytic Leukemia | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathies | 0.000271442 | 1 | 0 | BeFree |
Colorectal cancer metastatic | 0.000271442 | 1 | 0 | BeFree |
Sialic Acid Storage Disease, Finnish Type (disorder) | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000271442 | 1 | 0 | BeFree |
Orthokeratinized odontogenic cyst | 0.000271442 | 1 | 0 | BeFree |
Daughter cyst | 0.000271442 | 1 | 0 | BeFree |
Aggressive natural killer-cell leukemia | 0.000271442 | 1 | 0 | BeFree |
Myelodysplastic-Myeloproliferative Diseases | 0.000271442 | 1 | 0 | BeFree |
Aggressive Non-Hodgkin Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Neuroblastic Tumor | 0.000271442 | 1 | 0 | BeFree |
Treatment related acute myeloid leukaemia | 0.000271442 | 1 | 0 | BeFree |
Differentiated Thyroid Gland Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cardiomyopathy, Familial Idiopathic | 0.000271442 | 1 | 0 | BeFree |
Drug Dependence | 0.000271442 | 1 | 0 | BeFree |
Keratocystic Odontogenic Tumor | 0.000271442 | 1 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 2 | 0.000271442 | 1 | 0 | BeFree |
MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA | 0.000271442 | 1 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 1 | 0.000271442 | 1 | 0 | BeFree |
Plasma Cell Neoplasm | 0.000271442 | 1 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 4 | 0.000271442 | 1 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 5 | 0.000271442 | 1 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 6 | 0.000271442 | 1 | 0 | BeFree |
Polymorphic Reticulosis | 0.000271442 | 1 | 0 | BeFree |
Chronic thromboembolic pulmonary hypertension | 0.000271442 | 1 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 7 | 0.000271442 | 1 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 8 | 0.000271442 | 1 | 0 | BeFree |
MAJOR AFFECTIVE DISORDER 9 | 0.000271442 | 1 | 0 | BeFree |
Adult onset autosomal dominant leukodystrophy | 0.000271442 | 1 | 0 | BeFree |
Monomorphic CD56+ Intestinal T-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
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