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This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码神经元钙传感器(NCS)家族钙结合蛋白的成员。该蛋白含有N端豆蔻酰化信号和四个EF-手钙结合环。该蛋白质是在静息钙水平胞质;然而,升高的细胞内钙水平诱导暴露该肉豆蔻酰基,导致与膜和部分共定位与核周反式高尔基体网络蛋白质关联的构象变化。该蛋白被认为是G蛋白偶联受体信号转导的调节剂。这个基因的几种可变剪接变体已被确定,所有这些都编码相同的蛋白质;额外变体可以存在,但它们的生物有效性尚未确定。 [由RefSeq的,2008年7月提供]
NCALD基因(以及对应的蛋白质)的细胞分布位置:
NCALD基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Diabetic Nephropathy | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Diabetes Mellitus, Non-Insulin-Dependent | 0.002367032 | 1 | 0 | GAD |
Diabetic Neuropathies | 0.002367032 | 1 | 0 | GAD |
Tobacco Use Disorder | 0.002367032 | 1 | 0 | GAD |
Celiac Disease | 0.000271442 | 1 | 0 | BeFree |
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