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This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基??因编码,在唾液酸的生物合成途径的功能的酶。在体外,编码的蛋白质使用N-乙酰甘露糖胺-6-磷酸和甘露糖-6-磷酸作为底物,以产生N-乙酰神经氨酸的磷酸化形式(的Neu5Ac)和2-酮-3-脱氧-D-甘油-D-半乳 - nononic酸(KDN),分别;然而,它显示出朝向的Neu5Ac磷酸盐产物高得多的活性。在昆虫细胞中的Neu5Ac和KDN生产该基因的表达导致。这种基因是关系到大肠杆菌唾液酸交流编号合酶基因neuB,它可以部分地在大肠杆菌neuB阴性突变体恢复唾液酸合酶活性。 [由RefSeq的,2008年7月提供]
NANS基因(以及对应的蛋白质)的细胞分布位置:
NANS基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Squamous cell carcinoma of the head and neck | 0.002171535 | 8 | 0 | BeFree |
Malignant neoplasm of mouth | 0.001628651 | 6 | 0 | BeFree |
Squamous cell carcinoma | 0.001357209 | 5 | 0 | BeFree |
Malignant neoplasm of tongue | 0.001357209 | 5 | 0 | BeFree |
Lip and Oral Cavity Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Tongue Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Sarcoma | 0.001357209 | 5 | 0 | BeFree |
Osteosarcoma | 0.000814326 | 3 | 0 | BeFree |
Osteosarcoma of bone | 0.000814326 | 3 | 0 | BeFree |
Glioblastoma | 0.000542884 | 2 | 0 | BeFree |
Leukemia, Myelocytic, Acute | 0.000542884 | 2 | 0 | BeFree |
Soft Tissue Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Bone neoplasms | 0.000271442 | 1 | 0 | BeFree |
Mental Depression | 0.000271442 | 1 | 0 | BeFree |
Depressive disorder | 0.000271442 | 1 | 0 | BeFree |
Epilepsy | 0.000271442 | 1 | 0 | BeFree |
Herpes Simplex Infections | 0.000271442 | 1 | 0 | BeFree |
HIV Infections | 0.000271442 | 1 | 0 | BeFree |
liposarcoma | 0.000271442 | 1 | 0 | BeFree |
Lymphatic Metastasis | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
synovial sarcoma | 0.000271442 | 1 | 0 | BeFree |
Oral Cavity Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Cancer of Head and Neck | 0.000271442 | 1 | 0 | BeFree |
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of lymph node | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Attention deficit hyperactivity disorder | 0.000271442 | 1 | 0 | BeFree |
Bone Surface (Peripheral) Osteosarcoma | 0.000271442 | 1 | 0 | BeFree |
Liposarcoma, well differentiated | 0.000271442 | 1 | 0 | BeFree |
Motor disturbances | 0.000271442 | 1 | 0 | BeFree |
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