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Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  肌球蛋白是通过ATP的水解化学能转换成机械能的主要收缩蛋白。肌球蛋白是一对肌球蛋白重链(MYH)和两对非恒轻链组成的六聚体蛋白。肌球蛋白重链通过一个多基因家族编码。在哺乳动物中,至少10个不同的肌球蛋白重链(MYH)同种型已经从横纹肌,光滑,非肌肉细胞中所述。这些同种型显示的开发过程中,空间上和时间调节的表达。 [由RefSeq的,2008年7月提供]
MYH1基因(以及对应的蛋白质)的细胞分布位置:
MYH1基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Colorectal Cancer | 0.014202192 | 6 | 0 | GAD |
Adenomatous Polyposis Coli | 0.007101096 | 3 | 0 | GAD |
Cholangiocarcinoma | 0.004734064 | 2 | 0 | GAD |
Malignant neoplasm of stomach | 0.002638474 | 2 | 0 | BeFree_GAD |
Adenocarcinoma | 0.002367032 | 1 | 0 | GAD |
Bile Duct Neoplasms | 0.002367032 | 1 | 0 | GAD |
Cholangitis, Sclerosing | 0.002367032 | 1 | 0 | GAD |
Congenital clubfoot | 0.002367032 | 1 | 0 | GAD |
Colonic Polyps | 0.002367032 | 1 | 0 | GAD |
Colorectal Neoplasms | 0.002367032 | 1 | 0 | GAD |
DNA Damage | 0.002367032 | 1 | 0 | GAD |
Occupational Diseases | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of liver | 0.002367032 | 1 | 0 | GAD |
Adenoma of large intestine | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Hernia | 0.000271442 | 1 | 0 | BeFree |
Hearing Loss, Mixed Conductive-Sensorineural | 0.000271442 | 1 | 0 | BeFree |
Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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