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This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
[中文简述(自动翻译):]  这个基因编码的转录因子,它是MYB家族的转录因子基因的一个成员。该蛋白包含三个结构域,N-末端DNA结合结构域,一个中央转录激活结构域和参与转录抑制的C-末端结构域。这种蛋白在血细胞生成的调节中起重要作用,并且可以起到在肿瘤发生的作用。选择性剪接结果在多个抄本变形。 [由RefSeq的,2009年06月提供]
MYB基因(以及对应的蛋白质)的细胞分布位置:
MYB基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Adenoid Cystic Carcinoma | 0.125971721 | 23 | 0 | BeFree_CTD_human |
Asthma | 0.125005506 | 3 | 0 | BeFree_CTD_human_GAD |
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.121900093 | 7 | 0 | BeFree_CTD_human |
Glioma | 0.120542884 | 3 | 0 | BeFree_CTD_human |
Acute Basophilic Leukemia | 0.12 | 0 | 0 | ORPHANET |
Myelofibrosis | 0.08 | 0 | 0 | MGD |
Anemia, Sickle Cell | 0.011368221 | 8 | 0 | BeFree_GAD |
leukemia | 0.005981653 | 13 | 0 | BeFree_LHGDN |
beta Thalassemia | 0.00554839 | 5 | 0 | BeFree_GAD |
Blast Phase | 0.003538676 | 3 | 0 | BeFree_LHGDN |
Colonic Neoplasms | 0.003538676 | 4 | 0 | BeFree_LHGDN |
Agenesis of corpus callosum | 0.003528744 | 13 | 0 | BeFree |
Myeloid Leukemia | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Myeloproliferative disease | 0.002995792 | 2 | 2 | BeFree_LHGDN |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Malignant neoplasm of breast | 0.002985861 | 11 | 0 | BeFree |
Breast Carcinoma | 0.002985861 | 11 | 0 | BeFree |
alpha-Thalassemia | 0.002909916 | 3 | 6 | BeFree_GAD |
Acute Erythroblastic Leukemia | 0.00272435 | 1 | 0 | LHGDN |
Hypertensive disease | 0.002367032 | 1 | 0 | GAD |
Myocardial Infarction | 0.002367032 | 1 | 0 | GAD |
Nasal Polyps | 0.002367032 | 1 | 0 | GAD |
Obesity | 0.002367032 | 1 | 0 | GAD |
Pain | 0.002367032 | 1 | 0 | GAD |
Thalassemia | 0.002367032 | 1 | 0 | GAD |
Peripheral Vascular Diseases | 0.002367032 | 1 | 0 | GAD |
Hematocrit level | 0.002367032 | 1 | 1 | GAD |
Finding of Mean Corpuscular Hemoglobin | 0.002367032 | 1 | 1 | GAD |
Leukemia, Myelocytic, Acute | 0.002171535 | 8 | 0 | BeFree |
melanoma | 0.001900093 | 7 | 1 | BeFree |
Leukemogenesis | 0.001357209 | 5 | 0 | BeFree |
Mammary Neoplasms | 0.001357209 | 5 | 0 | BeFree |
Myeloid Leukemia, Chronic | 0.001085767 | 4 | 0 | BeFree |
Lymphoma | 0.001085767 | 4 | 0 | BeFree |
Neuroblastoma | 0.001085767 | 4 | 0 | BeFree |
Central neuroblastoma | 0.001085767 | 4 | 0 | BeFree |
Colorectal Cancer | 0.001085767 | 4 | 0 | BeFree |
Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
Colorectal Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Acute leukemia | 0.000814326 | 3 | 0 | BeFree |
Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
Primary Myelofibrosis | 0.000542884 | 2 | 0 | BeFree |
Cardiac Arrest | 0.000542884 | 2 | 0 | BeFree |
Acute lymphocytic leukemia | 0.000542884 | 2 | 0 | BeFree |
Leukemia, T-Cell | 0.000542884 | 2 | 0 | BeFree |
Adult T-Cell Lymphoma/Leukemia | 0.000542884 | 2 | 0 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Tumor Progression | 0.000542884 | 2 | 0 | BeFree |
myeloblastosis | 0.000542884 | 2 | 0 | BeFree |
Colon Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Epithelioma | 0.000542884 | 2 | 0 | BeFree |
alpha^+^ Thalassemia | 0.000542884 | 2 | 6 | BeFree |
Congenital arteriovenous malformation | 0.000271442 | 1 | 0 | BeFree |
Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Congenital chromosomal disease | 0.000271442 | 1 | 0 | BeFree |
Coronary Arteriosclerosis | 0.000271442 | 1 | 0 | BeFree |
Coronary heart disease | 0.000271442 | 1 | 0 | BeFree |
Eosinophilia | 0.000271442 | 1 | 0 | BeFree |
Glioblastoma | 0.000271442 | 1 | 0 | BeFree |
Lymphoid leukemia | 0.000271442 | 1 | 0 | BeFree |
Leukemia, Myelomonocytic, Chronic | 0.000271442 | 1 | 0 | BeFree |
Malaria | 0.000271442 | 1 | 0 | BeFree |
Melanocytic nevus | 0.000271442 | 1 | 0 | BeFree |
Pituitary Adenoma | 0.000271442 | 1 | 0 | BeFree |
Preleukemia | 0.000271442 | 1 | 0 | BeFree |
Salivary Gland Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Systemic Scleroderma | 0.000271442 | 1 | 0 | BeFree |
Sickle Cell Trait | 0.000271442 | 1 | 2 | BeFree |
Lymphoma, T-Cell, Cutaneous | 0.000271442 | 1 | 0 | BeFree |
Gestational Diabetes | 0.000271442 | 1 | 0 | BeFree |
Cutaneous Melanoma | 0.000271442 | 1 | 0 | BeFree |
Allergic asthma | 0.000271442 | 1 | 0 | BeFree |
Carcinoma, Lobular | 0.000271442 | 1 | 0 | BeFree |
Childhood asthma | 0.000271442 | 1 | 0 | BeFree |
Adenoid cystic carcinoma of salivary gland | 0.000271442 | 1 | 0 | BeFree |
Solid tumour | 0.000271442 | 1 | 0 | BeFree |
Arteriovenous hemangioma | 0.000271442 | 1 | 0 | BeFree |
Pilocytic Astrocytoma | 0.000271442 | 1 | 0 | BeFree |
Hematopoietic Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
Ductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Polymorphous low grade adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Chronic myeloproliferative disorder | 0.000271442 | 1 | 2 | BeFree |
Eccrine dermal cylindroma | 0.000271442 | 1 | 0 | BeFree |
Eosinophilic disorder | 0.000271442 | 1 | 0 | BeFree |
Adenoid cystic breast carcinoma | 0.000271442 | 1 | 0 | BeFree |
Sporadic Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Disorder characterized by eosinophilia | 0.000271442 | 1 | 0 | BeFree |
Coronary Artery Disease | 0.000271442 | 1 | 0 | BeFree |
MYELODYSPLASTIC SYNDROME | 0.000271442 | 1 | 0 | BeFree |
Experimental Organism Basal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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