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This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
[中文简述(自动翻译):]  该基因编码的拱顶复合物的主要成分。保管库是可参与核质运输多亚基核蛋白结构。所编码的蛋白质可通过调节MAP激酶,JAK / STAT和磷酸肌醇3-激酶/ Akt信号途径发挥多种细胞过程的作用。所编码的蛋白质也起着多药耐药的作用,并且该基因的表达可以是几种类型的癌症的预后标记。可变剪接转录物变体已经观察到这种基因。 [由RefSeq的,2012年5月提供]
MVP基因(以及对应的蛋白质)的细胞分布位置:
MVP基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Degenerative polyarthritis | 0.12 | 1 | 0 | CTD_human |
Leukemia, Myelocytic, Acute | 0.009248887 | 16 | 0 | BeFree_LHGDN |
leukemia | 0.008715934 | 5 | 0 | BeFree_LHGDN |
Mammary Neoplasms | 0.008444493 | 4 | 0 | BeFree_LHGDN |
Adult T-Cell Lymphoma/Leukemia | 0.003810118 | 4 | 0 | BeFree_LHGDN |
Astrocytoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Multiple Myeloma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Lymphoma | 0.002995792 | 2 | 0 | BeFree_LHGDN |
Osteosarcoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Ganglioglioma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
MYELODYSPLASTIC SYNDROME | 0.00272435 | 1 | 0 | LHGDN |
Non-Small Cell Lung Carcinoma | 0.002714419 | 10 | 0 | BeFree |
Malignant neoplasm of lung | 0.001900093 | 7 | 0 | BeFree |
Carcinoma of lung | 0.001900093 | 7 | 0 | BeFree |
Acute lymphocytic leukemia | 0.001357209 | 5 | 0 | BeFree |
Neoplasm Metastasis | 0.001357209 | 5 | 0 | BeFree |
Ovarian Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Colon Carcinoma | 0.001357209 | 5 | 0 | BeFree |
Liver carcinoma | 0.001357209 | 5 | 0 | BeFree |
Alzheimer's Disease | 0.001085767 | 4 | 0 | BeFree |
HIV Infections | 0.001085767 | 4 | 0 | BeFree |
Leukemia, Lymphocytic, Acute, L1 | 0.001085767 | 4 | 0 | BeFree |
Liver neoplasms | 0.001085767 | 4 | 0 | BeFree |
Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.001085767 | 4 | 0 | BeFree |
Malignant neoplasm of breast | 0.000814326 | 3 | 0 | BeFree |
Malignant tumor of colon | 0.000814326 | 3 | 0 | BeFree |
Glioblastoma | 0.000814326 | 3 | 0 | BeFree |
Leukemia, T-Cell | 0.000814326 | 3 | 0 | BeFree |
Liposarcoma, Myxoid | 0.000814326 | 3 | 0 | BeFree |
Refractory cancer | 0.000814326 | 3 | 0 | BeFree |
Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Drug Resistant Epilepsy | 0.000814326 | 3 | 0 | BeFree |
Brain Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Epilepsy | 0.000542884 | 2 | 3 | BeFree |
Glioma | 0.000542884 | 2 | 0 | BeFree |
Ischemia | 0.000542884 | 2 | 0 | BeFree |
Mitral Valve Prolapse Syndrome | 0.000542884 | 2 | 0 | BeFree |
Nephroblastoma | 0.000542884 | 2 | 0 | BeFree |
Tuberculosis | 0.000542884 | 2 | 0 | BeFree |
Virus Diseases | 0.000542884 | 2 | 0 | BeFree |
Acute leukemia | 0.000542884 | 2 | 0 | BeFree |
Small cell carcinoma of lung | 0.000542884 | 2 | 0 | BeFree |
Carcinogenesis | 0.000542884 | 2 | 0 | BeFree |
Epithelial ovarian cancer | 0.000542884 | 2 | 0 | BeFree |
Malignant neoplasm of ovary | 0.000542884 | 2 | 0 | BeFree |
Squamous cell carcinoma of the head and neck | 0.000542884 | 2 | 0 | BeFree |
Hippocampal sclerosis | 0.000542884 | 2 | 0 | BeFree |
Coronary Artery Disease | 0.000542884 | 2 | 0 | BeFree |
Renal Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of cervix | 0.000271442 | 1 | 0 | BeFree |
Presenile dementia | 0.000271442 | 1 | 0 | BeFree |
Hepatitis C | 0.000271442 | 1 | 0 | BeFree |
HTLV-I Infections | 0.000271442 | 1 | 0 | BeFree |
Hyperlipidemia | 0.000271442 | 1 | 0 | BeFree |
Myocardial Infarction | 0.000271442 | 1 | 0 | BeFree |
Neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
T-Cell Lymphoma | 0.000271442 | 1 | 0 | BeFree |
Epstein-Barr Virus Infections | 0.000271442 | 1 | 0 | BeFree |
Cervix carcinoma | 0.000271442 | 1 | 0 | BeFree |
Uterine Corpus Sarcoma | 0.000271442 | 1 | 0 | BeFree |
Impaired cognition | 0.000271442 | 1 | 0 | BeFree |
Endometrial Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Dementia | 0.000271442 | 1 | 0 | BeFree |
Increased drug resistance | 0.000271442 | 1 | 0 | BeFree |
Osteosarcoma of bone | 0.000271442 | 1 | 0 | BeFree |
Tumor Initiation | 0.000271442 | 1 | 0 | BeFree |
Central neuroblastoma | 0.000271442 | 1 | 0 | BeFree |
Dysembryoplastic neuroepithelial tumor | 0.000271442 | 1 | 0 | BeFree |
Pancreatic Ductal Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
Hepatocarcinogenesis | 0.000271442 | 1 | 0 | BeFree |
ALZHEIMER DISEASE 2 | 0.000271442 | 1 | 0 | BeFree |
Oropharyngeal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
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