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This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. [provided by RefSeq, Jul 2010]
[中文简述(自动翻译):]  该基因编码粘蛋白家族的蛋白质,这是粘液分泌物高度糖基化的大分子成分中的一员。这家人是粘液的主要凝胶形成黏液。这是一个主要贡献者润滑和唾液,正常肺黏液和宫颈粘液的粘弹性。该基因已被发现是上调在一些人类疾病,包括慢性鼻窦炎(CRS),CRS鼻息肉,慢性阻塞性肺疾病(COPD)和幽门螺杆菌有关的胃疾病的鼻窦粘膜,并且它可以是参与这些疾病的发病机制。 [由RefSeq的,2010年7月提供]
MUC5B基因(以及对应的蛋白质)的细胞分布位置:
MUC5B基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Idiopathic Pulmonary Fibrosis | 0.36434307 | 17 | 2 | BeFree_CLINVAR_CTD_human_ORPHANET |
Diffuse panbronchiolitis | 0.120542884 | 2 | 0 | BeFree_ORPHANET |
Nasopharyngeal carcinoma | 0.08 | 1 | 0 | RGD |
Otitis Media with Effusion | 0.005634266 | 3 | 0 | BeFree_GAD_LHGDN |
Otitis Media | 0.005362824 | 2 | 0 | BeFree_GAD_LHGDN |
Chronic Obstructive Airway Disease | 0.003267234 | 3 | 0 | BeFree_LHGDN |
Sinusitis | 0.002995792 | 1 | 0 | BeFree_LHGDN |
Laryngitis | 0.00272435 | 1 | 0 | LHGDN |
Asthma | 0.002638474 | 2 | 0 | BeFree_GAD |
Malignant neoplasm of urinary bladder | 0.002638474 | 1 | 0 | BeFree_GAD |
Bronchiolitis, Viral | 0.002367032 | 1 | 0 | GAD |
Respiratory Syncytial Virus Infections | 0.002367032 | 1 | 0 | GAD |
Pulmonary Fibrosis | 0.001900093 | 7 | 1 | BeFree |
Lung Diseases, Interstitial | 0.001357209 | 5 | 2 | BeFree |
Malignant neoplasm of breast | 0.001085767 | 4 | 0 | BeFree |
Adenocarcinoma | 0.000814326 | 3 | 0 | BeFree |
Nasal Polyps | 0.000814326 | 3 | 0 | BeFree |
Systemic Scleroderma | 0.000814326 | 3 | 0 | BeFree |
Chronic sinusitis | 0.000814326 | 3 | 0 | BeFree |
Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
Breast Carcinoma | 0.000814326 | 3 | 0 | BeFree |
Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
Craniosynostosis | 0.000542884 | 2 | 0 | BeFree |
HIV Infections | 0.000542884 | 2 | 0 | BeFree |
Lung diseases | 0.000542884 | 2 | 0 | BeFree |
Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
Ichthyosis, X-Linked | 0.000542884 | 2 | 0 | BeFree |
Adenocarcinoma of lung (disorder) | 0.000542884 | 2 | 0 | BeFree |
Pneumonia, Interstitial | 0.000542884 | 2 | 0 | BeFree |
Chronic otitis media | 0.000542884 | 2 | 0 | BeFree |
airway disease | 0.000542884 | 2 | 0 | BeFree |
Mammary Neoplasms | 0.000542884 | 2 | 0 | BeFree |
Placental Steroid Sulfatase Deficiency | 0.000542884 | 2 | 0 | BeFree |
Anaplasia | 0.000271442 | 1 | 0 | BeFree |
Cholestasis, Extrahepatic | 0.000271442 | 1 | 0 | BeFree |
Malignant tumor of colon | 0.000271442 | 1 | 0 | BeFree |
Squamous cell carcinoma | 0.000271442 | 1 | 0 | BeFree |
Connective Tissue Diseases | 0.000271442 | 1 | 1 | BeFree |
Crohn Disease | 0.000271442 | 1 | 0 | BeFree |
Cystic Fibrosis | 0.000271442 | 1 | 0 | BeFree |
Cyst | 0.000271442 | 1 | 0 | BeFree |
Inflammatory Bowel Diseases | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of stomach | 0.000271442 | 1 | 0 | BeFree |
Adenomatous Polyposis Coli | 0.000271442 | 1 | 0 | BeFree |
polyps | 0.000271442 | 1 | 0 | BeFree |
Pulmonary Edema | 0.000271442 | 1 | 0 | BeFree |
Sarcoidosis | 0.000271442 | 1 | 0 | BeFree |
Xerostomia | 0.000271442 | 1 | 0 | BeFree |
Hamman-Rich syndrome | 0.000271442 | 1 | 0 | BeFree |
Pancreatic carcinoma | 0.000271442 | 1 | 0 | BeFree |
Adenocarcinoma of colon | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of pancreas | 0.000271442 | 1 | 0 | BeFree |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Stomach Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Nonspecific interstitial pneumonia | 0.000271442 | 1 | 0 | BeFree |
Sjogren's Syndrome | 0.000271442 | 1 | 0 | BeFree |
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