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This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown. [provided by RefSeq, Jul 2008]
[中文简述(自动翻译):]  该基因编码起着多胺代谢的主要作用,是为腺嘌呤和蛋氨酸的打捞重要的酶。因为此基因和肿瘤抑制p16基因是共缺失所编码的酶是在许多癌症中有缺陷。多个可变剪接转录物变体已被用于这个基因的说明,但其全长性质仍然是未知的。 [由RefSeq的,2008年7月提供]
MTAP基因(以及对应的蛋白质)的细胞分布位置:
MTAP基因的本体(GO)信息:
| 疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
| melanoma | 0.257273929 | 15 | 1 | BeFree_CTD_human_GAD_GWASCAT_LHGDN |
| Diaphyseal medullary stenosis with malignant fibrous histiocytoma | 0.24 | 0 | 0 | CLINVAR_ORPHANET |
| Nevus | 0.127372538 | 4 | 1 | BeFree_CTD_human_GAD |
| Prostatic Neoplasms | 0.12 | 1 | 0 | CTD_human |
| Diaphyseal medullary stenosis with bone malignancy | 0.12 | 0 | 0 | ORPHANET |
| Skin Neoplasms | 0.007101096 | 3 | 1 | GAD |
| Liver carcinoma | 0.003810118 | 4 | 0 | BeFree_LHGDN |
| Precursor Cell Lymphoblastic Leukemia Lymphoma | 0.003724241 | 6 | 0 | BeFree_GAD |
| Adenocarcinoma | 0.003267234 | 2 | 0 | BeFree_LHGDN |
| Squamous cell carcinoma | 0.003267234 | 3 | 0 | BeFree_LHGDN |
| Chondrosarcoma | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Pancreatic Neoplasm | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Neuroendocrine Tumors | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 0.002995792 | 1 | 0 | BeFree_LHGDN |
| Mammary Neoplasms | 0.002995792 | 2 | 0 | BeFree_LHGDN |
| Myocardial Infarction | 0.002909916 | 2 | 0 | BeFree_GAD |
| Brain Ischemia | 0.002367032 | 1 | 0 | GAD |
| Diabetes Mellitus | 0.002367032 | 1 | 0 | GAD |
| Diabetes Mellitus, Non-Insulin-Dependent | 0.002367032 | 1 | 0 | GAD |
| Hyperlipidemia | 0.002367032 | 1 | 0 | GAD |
| Hypertensive disease | 0.002367032 | 1 | 0 | GAD |
| Precancerous Conditions | 0.002367032 | 1 | 0 | GAD |
| Sunburn | 0.002367032 | 1 | 1 | GAD |
| Intracranial Embolism | 0.002367032 | 1 | 0 | GAD |
| Solar Erythema | 0.002367032 | 1 | 0 | GAD |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 0.001628651 | 6 | 0 | BeFree |
| Acute lymphocytic leukemia | 0.001357209 | 5 | 0 | BeFree |
| Leukemia, T-Cell | 0.001085767 | 4 | 0 | BeFree |
| Lymphoma | 0.001085767 | 4 | 0 | BeFree |
| Mesothelioma | 0.001085767 | 4 | 0 | BeFree |
| Malignant neoplasm of lung | 0.001085767 | 4 | 0 | BeFree |
| Osteosarcoma of bone | 0.001085767 | 4 | 1 | BeFree |
| Carcinoma of lung | 0.001085767 | 4 | 0 | BeFree |
| Adult T-Cell Lymphoma/Leukemia | 0.000814326 | 3 | 0 | BeFree |
| Malignant neoplasm of stomach | 0.000814326 | 3 | 0 | BeFree |
| Osteosarcoma | 0.000814326 | 3 | 1 | BeFree |
| Carcinogenesis | 0.000814326 | 3 | 0 | BeFree |
| Non-Small Cell Lung Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Glioma | 0.000542884 | 2 | 0 | BeFree |
| Leukemia, Lymphocytic, Acute, L1 | 0.000542884 | 2 | 0 | BeFree |
| Neoplasm Metastasis | 0.000542884 | 2 | 0 | BeFree |
| Melanocytic nevus | 0.000542884 | 2 | 0 | BeFree |
| Diffuse Large B-Cell Lymphoma | 0.000542884 | 2 | 0 | BeFree |
| Pancreatic carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Gastric Adenocarcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant neoplasm of pancreas | 0.000542884 | 2 | 0 | BeFree |
| Stomach Carcinoma | 0.000542884 | 2 | 0 | BeFree |
| Malignant Pleural Mesothelioma | 0.000542884 | 2 | 0 | BeFree |
| Adenoma | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
| Chordoma | 0.000271442 | 1 | 0 | BeFree |
| Keratosis | 0.000271442 | 1 | 0 | BeFree |
| leukemia | 0.000271442 | 1 | 0 | BeFree |
| Leukemia, Myelocytic, Acute | 0.000271442 | 1 | 0 | BeFree |
| Pancreatitis | 0.000271442 | 1 | 0 | BeFree |
| Pleural effusion disorder | 0.000271442 | 1 | 0 | BeFree |
| Retinoblastoma | 0.000271442 | 1 | 0 | BeFree |
| Severe Combined Immunodeficiency | 0.000271442 | 1 | 0 | BeFree |
| Cutaneous Melanoma | 0.000271442 | 1 | 0 | BeFree |
| Tumor Progression | 0.000271442 | 1 | 0 | BeFree |
| Gastrointestinal Stromal Tumors | 0.000271442 | 1 | 0 | BeFree |
| Fibrosis, Liver | 0.000271442 | 1 | 0 | BeFree |
| Thickening of pleura | 0.000271442 | 1 | 0 | BeFree |
| Malignant Bone Neoplasm | 0.000271442 | 1 | 0 | BeFree |
| T-cell childhood acute lymphoblastic leukemia | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma Of Esophagus | 0.000271442 | 1 | 0 | BeFree |
| Laryngeal Squamous Cell Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Adenocarcinoma of pancreas | 0.000271442 | 1 | 0 | BeFree |
| Superficial spreading malignant melanoma of skin | 0.000271442 | 1 | 0 | BeFree |
| Chronic liver disease | 0.000271442 | 1 | 0 | BeFree |
| Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
| Carcinoma of larynx | 0.000271442 | 1 | 0 | BeFree |
| Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Colon Carcinoma | 0.000271442 | 1 | 0 | BeFree |
| Biliary Tract Cancer | 0.000271442 | 1 | 0 | BeFree |
| Hyperkeratosis | 0.000271442 | 1 | 0 | BeFree |
| Gastric hyperplastic polyp | 0.000271442 | 1 | 0 | BeFree |
| Adenoma of large intestine | 0.000271442 | 1 | 1 | BeFree |
| Periampullary Adenocarcinoma | 0.000271442 | 1 | 0 | BeFree |
| Pleural Mesothelioma | 0.000271442 | 1 | 0 | BeFree |
| Hereditary Melanoma | 0.000271442 | 1 | 2 | BeFree |
| Acute lymphoblastic leukemia with lymphomatous features | 0.000271442 | 1 | 0 | BeFree |
| Fibrosis of pleura | 0.000271442 | 1 | 0 | BeFree |
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