MSTN(myostatin)

基因基本信息

基因基本信息

基因简称(symbol)
    [HGNC]     [GeneCards]     [NCBI]
基因种类(locus group)
同源简称(alias symbol)
基因家族代码(gene_family_id)
    [HGNC]     [GenScript]
omim代码
entrez码
    [Vega]
vega基因码
ensembl基因码
    [Ensembl]
基因家族(gene family)
refseq数据库代号

更多...

基因种类(locus_type)
基因名称状态(status)
location_sortable
同源基因名称(alias name)
基因名称批准使用时间(date_approved_reserved)
基因简称更名时间(date_symbol_changed)
基因名称更名时间(date_name_changed)
更新时间(date_modified)
ucsc码
ena
ccds数据码
uniprot数据码
pubmed代码
mgd码
rgd码
生命科学数据库(lsdb)
更新时间(date modified)
cosmic
mirbase
基因曾用简称(prev symbol)
基因曾用名称(prev name)
homeodb
cosmic
snornabase
bioparadigms slc
orphanet
假基因信息(pseudogeneorg)
horde id
merops
imgt
iuphar
kznf基因类别
mamit-trnadb
cd
LncRNA数据库
酶代码
中间纤维数据库

收起

基因染色体位置

基因染色体位置

2q32.1
基因染色体位置图

基因简述

基因简述

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. [provided by RefSeq, Jul 2008]

[中文简述(自动翻译):]  由该基因编码的蛋白是骨形态发生蛋白（BMP）家族和TGF-β超家族的一个成员。该组蛋白的特征在于它被裂解以产生含有7个保守的半胱氨酸残基的成熟蛋白的多元蛋白水解加工位点。这个家庭的成员是在胚胎和成体组织细胞生长和分化的调节。该基因被认为编码一种分泌蛋白，其负调控骨骼肌生长。 [由RefSeq的，2008年7月提供]

OMIM数据库中对MSTN基因的介绍     Wikipedia数据库中对MSTN基因的介绍

基因序列

基因序列

MSTN基因的碱基序列：[NCBI]

基因突变

基因突变

MSTN基因的碱基突变：           显示全部snp
rs1805085       rs1805086       rs2140607       rs2293284       rs3187415       rs3762546       rs3762547       rs3791781       rs3791782       rs3791783       rs3791784       rs3791785       rs3828268       rs3834785       rs7570532       rs7596995       rs10184778       rs10187974       rs10497708       rs11333758       rs11681628       rs12105165       rs13413342       rs13428131       rs16823986       rs16823988       rs16832285       rs16832286       rs16832287       rs16832288       rs16832292       rs34094280       rs34191156       rs34780010       rs35321585       rs35493945       rs35781413      
rs55777905       rs56124807       rs59937732       rs60490864       rs62186768       rs71023732       rs71401232       rs72909336       rs72909342       rs73047898       rs75459005       rs79721347       rs80210337       rs112492309       rs112990150       rs113165572       rs113794972       rs114081646       rs114308260       rs114536441       rs114597606       rs115760476       rs116742118       rs116742892       rs138300785       rs138328192       rs138343163       rs138408456       rs138442596       rs139356608       rs139729351       rs140230417       rs140869261       rs141411451       rs141554114       rs141652279       rs142074324       rs142195885       rs142198675       rs142395017       rs142934479       rs143242500       rs143313615       rs143809682       rs144000994       rs144086952       rs144167726       rs144217292       rs144348365       rs144835343       rs144876323       rs146162833       rs146209367       rs147068830       rs147377735       rs147813198       rs148380604       rs148890508       rs149366335       rs149443243       rs149462136       rs150145410       rs150185464       rs150195507       rs151004519       rs151205793       rs180671401       rs180921345       rs181396471       rs181592134       rs182023327       rs182074560       rs182279834       rs183194006       rs183476664       rs183758582       rs184077347       rs184181942       rs184391415       rs185047567       rs185201680       rs185608116       rs185765690       rs186458339       rs186481238       rs186878620       rs187012519       rs187196288       rs187828298       rs188199560       rs188505204       rs188760163       rs189330430       rs189939536       rs189983083       rs190133755       rs190474368       rs191294210       rs191779769       rs191871755       rs192672909       rs192915720       rs199602321       rs199733558       rs199775511       rs199964059       rs200189586       rs200820992       rs200908904       rs201743687       rs201887141       rs202118061       rs368131833       rs368592643       rs368949692       rs369212974       rs369218409       rs369290669       rs369432924       rs369459186       rs370312652       rs370587186       rs370652180       rs370978355       rs371576724       rs372571172       rs372790208       rs373589762       rs373630758       rs374256136       rs374273494       rs374299078       rs374890095       rs375117601       rs375435525       rs375666149       rs375856593       rs377503267       rs377546143       rs527241796       rs527243303       rs527416343       rs528391865       rs529168466       rs530230572       rs530890952       rs531287013       rs531891025       rs532511547       rs532853915       rs533091207       rs533241314       rs533868287       rs534040559       rs534202566       rs534589899       rs535148115       rs535281498       rs535776509       rs536111532       rs536592895       rs537894585       rs537925465       rs537956645       rs538307628       rs539527155       rs539538532       rs541715082       rs542249746       rs543163866       rs543235626       rs543431223       rs544101628       rs544421930       rs544658563       rs545331281       rs545864978       rs546894075       rs547866762       rs548344790       rs548379422       rs548559622       rs548991016       rs549016463       rs549822364       rs550184899       rs550342723       rs550802707       rs550928430       rs551554150       rs551592533       rs551672978       rs552564837       rs552974136       rs553275157       rs553428678       rs553508886       rs553989292       rs554144181       rs555334554       rs555451978       rs555490646       rs555868182       rs556280896       rs557100152       rs557193197       rs557688509       rs559214765       rs559451938       rs560155610       rs560316186       rs561085338       rs561309853       rs561882384       rs561885399       rs561908619       rs561951489       rs562684119       rs562815480       rs563683761       rs563747575       rs564709962       rs565034145       rs565894305       rs566599254       rs567041313       rs567560486       rs567929899       rs567937068       rs568057853       rs568890201       rs569077630       rs569839283       rs572348706       rs572404676       rs573037946       rs573883915       rs574074575       rs574445018       rs574510248       rs575323464       rs575523122       rs576318428       rs576515091       rs577625650       rs577865814       rs578136956       rs745781869       rs745869779       rs745957429       rs746286678       rs746519464       rs747024902       rs747240208       rs747269695       rs747305835       rs748009956       rs748033945       rs748274574       rs748335492       rs748362537       rs748557222       rs749046927       rs749060188       rs749141789       rs749291285       rs749509789       rs749802472       rs750136925       rs750361333       rs750779494       rs750936563       rs751268573       rs751275361       rs751360421       rs751448366       rs751609507       rs752096753       rs752470300       rs752542788       rs752729720       rs753143992       rs753241714       rs754186571       rs754729728       rs754885423       rs754970235       rs755626074       rs755715730       rs755983197       rs756074984       rs756105934       rs756553031       rs756728994       rs757027065       rs757078479       rs757093012       rs757480660       rs757486437       rs758189505       rs758277625       rs758476023       rs758879725       rs758969290       rs759355620       rs759643603       rs759857200       rs760332180       rs760865305       rs761053215       rs761141037       rs761528049       rs761832176       rs762101359       rs762191502       rs762279211       rs762366961       rs762492739       rs762554695       rs762670202       rs763246848       rs763683193       rs763773161       rs763949397       rs763988846       rs764230030       rs764607128       rs764734901       rs765088834       rs765513543       rs765715434       rs766029675       rs766187062       rs766727311       rs767299841       rs767327429       rs767391353       rs768350810       rs768730023       rs768820223       rs768872289       rs768909803       rs768963457       rs768995951       rs769113436       rs769839343       rs769867063       rs770103165       rs770350441       rs770535740       rs771117616       rs771302281       rs771339825       rs772090278       rs772317945       rs772442097       rs772465821       rs772646099       rs772926315       rs773406441       rs773422984       rs773512887       rs773630476       rs773967756       rs773978578       rs774072279       rs774263948       rs774592036       rs774680071       rs774765974       rs775178188       rs775242311       rs776267734       rs776358005       rs776836835       rs776915480       rs777312622       rs777766023       rs778083631       rs778544642       rs778930519       rs779053077       rs779085524       rs779141554       rs779290063       rs779712124       rs779966989       rs780064368       rs780079197       rs780167334       rs780410129       rs780565488       rs780648804       rs780653122       rs780738962       rs781109320       rs781131536       rs781216051       rs781220890       rs781590083       rs60490864      

基因表达

基因表达

MSTN基因在不同组织中的表达：    [UniProt]

基因在不同组织中的表达图

基因引物

基因引物

正向引物序列
正向引物Tm值
反向引物序列
反向引物Tm值
rank
GAGAAGATGGGCTGAATCC
58
GCTCATCACAGTCAAGACC
58
GAAGATGGGCTGAATCCGT
60
GTGCTCATCACAGTCAAGAC
59
GAGAAGATGGGCTGAATCC
58
TGCTCATCACAGTCAAGAC
58

转录因子

转录因子

      尚未收录相关数据

基因本体信息

MSTN基因（以及对应的蛋白质）的细胞分布位置：

[UniProt]     [GenomeNet]

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
  • 溶酶体
  • 内涵体
  • 细胞核
  • 细胞质
  • 液泡
  • 细胞膜
  • 细胞外基质
  • 内质网
  • 线粒体
  • 高尔基体
  • 细胞骨架

MSTN基因的本体（GO）信息：

GO库代码
对应的蛋白质
来源代码
GO:0002230
O14793(UniProtKB)
IMP
GO:0005102
O14793(UniProtKB)
IPI
GO:0005102
O14793(UniProtKB)
IPI
GO:0005102
O14793(UniProtKB)
IPI
GO:0005125
O14793(UniProtKB)
IBA
GO:0005160
O14793(UniProtKB)
IBA
GO:0005515
O14793(UniProtKB)
IPI
GO:0005515
O14793(UniProtKB)
IPI
GO:0005515
O14793(UniProtKB)
IPI
GO:0005515
O14793(UniProtKB)
IPI
GO:0005515
O14793(UniProtKB)
IPI
GO:0005515
O14793(UniProtKB)
IPI
GO:0005615
O14793(UniProtKB)
IBA
GO:0005737
O14793(UniProtKB)
IEA
GO:0007179
O14793(UniProtKB)
IEA
GO:0007517
O14793(UniProtKB)
TAS
GO:0008083
O14793(UniProtKB)
IEA
GO:0008201
O14793(UniProtKB)
IEA
GO:0009408
O14793(UniProtKB)
IEA
GO:0009629
O14793(UniProtKB)
IEA
GO:0010862
O14793(UniProtKB)
IBA
GO:0014732
O14793(UniProtKB)
IEA
GO:0014732
O14793(UniProtKB)
IEA
GO:0014741
O14793(UniProtKB)
IEA
GO:0014850
O14793(UniProtKB)
IEA
GO:0022602
O14793(UniProtKB)
IEA
GO:0033574
O14793(UniProtKB)
IEA
GO:0033673
O14793(UniProtKB)
IEA
GO:0042802
O14793(UniProtKB)
IPI
GO:0042981
O14793(UniProtKB)
IBA
GO:0043403
O14793(UniProtKB)
IEA
GO:0043408
O14793(UniProtKB)
IBA
GO:0043627
O14793(UniProtKB)
IEA
GO:0045471
O14793(UniProtKB)
IEA
GO:0045662
O14793(UniProtKB)
IDA
GO:0045893
O14793(UniProtKB)
IDA
GO:0046627
O14793(UniProtKB)
IEA
GO:0046716
O14793(UniProtKB)
IDA
GO:0048468
O14793(UniProtKB)
IBA
GO:0048632
O14793(UniProtKB)
IMP
GO:0051602
O14793(UniProtKB)
IEA
GO:0051898
O14793(UniProtKB)
IDA
GO:0060395
O14793(UniProtKB)
IBA
GO:0071549
O14793(UniProtKB)
IEA
GO:0098779
O14793(UniProtKB)
IGI
GO:0098792
O14793(UniProtKB)
IMP
GO:1902723
O14793(UniProtKB)
ISS
GO:1902725
O14793(UniProtKB)
ISS
GO:2000818
O14793(UniProtKB)
ISS

基因相互作用关系

基因相互作用关系

基因与其他基因之间的相互作用关系图
序号 作用方式 资源库来源/分值 基因名称 基因名称

基因相关microRNA

基因相关microRNA

可能调控MSTN基因的相关microRNA：     

基因通路图

基因通路图

基因的通路属性图
通路基因列表

基因相关疾病

基因相关疾病

疾病名称 关系值 NofPmids NofSnps 来源
疾病名称 关系值 NofPmids NofSnps 来源
Myostatin-related muscle hypertrophy 0.24 2 0 CTD_human_ORPHANET
Heart failure 0.200271442 2 0 BeFree_CTD_human_RGD
Muscular Atrophy 0.087600372 30 0 BeFree_RGD
Cachexia 0.081628651 7 0 BeFree_RGD
Amyotrophic Lateral Sclerosis 0.080271442 1 0 BeFree_RGD
Hypothyroidism 0.08 1 0 RGD
Peripheral Vascular Diseases 0.08 1 0 RGD
Muscle hypertrophy 0.08 0 0 MGD
Muscular Dystrophy 0.004071628 15 0 BeFree
Rhabdomyosarcoma 0.003267234 2 0 BeFree_LHGDN
Muscular Dystrophy, Duchenne 0.001900093 7 0 BeFree
Obesity 0.001900093 7 1 BeFree
Diabetes Mellitus, Non-Insulin-Dependent 0.000814326 3 0 BeFree
Congestive heart failure 0.000814326 3 0 BeFree
Myopathy 0.000814326 3 0 BeFree
Chronic Obstructive Airway Disease 0.000542884 2 0 BeFree
Metabolic Diseases 0.000542884 2 0 BeFree
Chronic heart failure 0.000542884 2 0 BeFree
Muscle fibrosis 0.000542884 2 0 BeFree
Arteriosclerosis 0.000271442 1 0 BeFree
Cardiovascular Diseases 0.000271442 1 0 BeFree
Choriocarcinoma 0.000271442 1 0 BeFree
Colorectal Carcinoma 0.000271442 1 0 BeFree
Mental Depression 0.000271442 1 0 BeFree
Depressive disorder 0.000271442 1 0 BeFree
Ehlers-Danlos Syndrome 0.000271442 1 0 BeFree
Fatty Liver 0.000271442 1 0 BeFree
Glycogen Storage Disease Type V 0.000271442 1 1 BeFree
Heart Diseases 0.000271442 1 0 BeFree
HIV Infections 0.000271442 1 0 BeFree
Hyperinsulinism 0.000271442 1 0 BeFree
Intestinal Polyps 0.000271442 1 0 BeFree
Fibroid Tumor 0.000271442 1 0 BeFree
Spinal Muscular Atrophy 0.000271442 1 0 BeFree
Nodule 0.000271442 1 0 BeFree
Uremia 0.000271442 1 0 BeFree
Uterine Fibroids 0.000271442 1 0 BeFree
Lateral Sclerosis 0.000271442 1 0 BeFree
Muscle degeneration 0.000271442 1 0 BeFree
Inclusion Body Myositis (disorder) 0.000271442 1 0 BeFree
Carcinoma, Lewis Lung 0.000271442 1 0 BeFree
Dissection of aorta 0.000271442 1 0 BeFree
Endometriosis of uterus 0.000271442 1 0 BeFree
HIV Wasting Syndrome 0.000271442 1 0 BeFree
Severe chronic obstructive pulmonary disease 0.000271442 1 0 BeFree
Inclusion Body Myopathy, Sporadic 0.000271442 1 0 BeFree
Becker Muscular Dystrophy 0.000271442 1 0 BeFree
Degenerative disorder 0.000271442 1 0 BeFree
Colorectal Cancer 0.000271442 1 0 BeFree
Steatohepatitis 0.000271442 1 0 BeFree

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