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This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
[中文简述(自动翻译):]  该基因编码的甘露糖受体家族包含纤连蛋白II型结构域和多个C型凝集素样结构域的蛋白质的成员。所编码的蛋白在细胞外基质重塑通过介导的胶原蛋白配体的内化和溶酶体降解的作用。这个基因的表达可能在几个恶性肿瘤包括乳腺癌,神经胶质瘤和转移性骨病的肿瘤发生和转移中的作用。 [由RefSeq的,2012年2月提供]
MRC2基因(以及对应的蛋白质)的细胞分布位置:
MRC2基因的本体(GO)信息:
疾病名称 | 关系值 | NofPmids | NofSnps | 来源 |
Animal Mammary Neoplasms | 0.12 | 1 | 0 | CTD_human |
Mammary Neoplasms, Experimental | 0.12 | 1 | 0 | CTD_human |
Squamous cell carcinoma | 0.00272435 | 1 | 0 | LHGDN |
Cancer of Head and Neck | 0.002367032 | 1 | 0 | GAD |
Malignant neoplasm of breast | 0.000271442 | 1 | 0 | BeFree |
Noninfiltrating Intraductal Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Glioma | 0.000271442 | 1 | 0 | BeFree |
Neoplasm Metastasis | 0.000271442 | 1 | 0 | BeFree |
Secondary malignant neoplasm of bone | 0.000271442 | 1 | 0 | BeFree |
Malignant neoplasm of prostate | 0.000271442 | 1 | 0 | BeFree |
Malignant Glioma | 0.000271442 | 1 | 0 | BeFree |
Carcinogenesis | 0.000271442 | 1 | 0 | BeFree |
Prostate carcinoma | 0.000271442 | 1 | 0 | BeFree |
Invasive Ductal Breast Carcinoma | 0.000271442 | 1 | 0 | BeFree |
Epithelioma | 0.000271442 | 1 | 0 | BeFree |
Mammary Neoplasms | 0.000271442 | 1 | 0 | BeFree |
Liver carcinoma | 0.000271442 | 1 | 0 | BeFree |
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